PharmaCoNets of Pindolol (SPCN: 51.88 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pindololhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Pindololhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Pindololhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Pindololhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Pindololhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Pindololhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Pindololhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Pindololhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Pindololhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Pindololhsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Pindololhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Pindololhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Pindololhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Pindololhsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Pindololhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Pindololhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Pindololhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Pindololhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Pindololhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Pindololhsa04217Necroptosis4.24E-0510P01375, P48023, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557TNF, FASLG, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2DMore
Pindololhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Pindololhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Pindololhsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Pindololhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Pindololhsa04613Neutrophil extracellular trap formation3.76E-0410P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Pindololhsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Pindololhsa04657IL-17 signaling pathway2.73E-047P07900, P49841, P19875, P14780, P80188, P01375, P01584HSP90AA1, GSK3B, CXCL2, MMP9, LCN2, TNF, IL1BMore
Pindololhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Pindololhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Pindololhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Pindololhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Pindololhsa04742Taste transduction1.01E-021P30939HTR1FMore
Pindololhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Pindololhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Pindololhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Pindololhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Pindololhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Pindololhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Pindololhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Pindololhsa04932Non-alcoholic fatty liver disease6.73E-059P01375, P49841, P18848, P48023, P01584, P13073, O15239, Q16718, O14521TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Pindololhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Pindololhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Pindololhsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Pindololhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Pindololhsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Pindololhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Pindololhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Pindololhsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Pindololhsa05022Pathways of neurodegeneration - multiple diseases1.47E-0312P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2DMore
Pindololhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Pindololhsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Pindololhsa05133Pertussis3.51E-021P0C0L4C4AMore
Pindololhsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Pindololhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Pindololhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Pindololhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Pindololhsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Pindololhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Pindololhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Pindololhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Pindololhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Pindololhsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Pindololhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Pindololhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Pindololhsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Pindololhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Pindololhsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Pindololhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Pindololhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Pindololhsa05415Diabetic cardiomyopathy1.02E-038P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2DMore

Community members of Pindolol (SDC: 5.54)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
ADRB2P07550Ki0.4
ADRB2P07550Ki4.8
ADRB2P07550Kd0.537032
ADRB2P07550Kd0.660693