PharmaCoNets of Pimecrolimus (SPCN: 36.26 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pimecrolimushsa00052Galactose metabolism1.12E-042P06280, O43451GLA, MGAMMore
Pimecrolimushsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Pimecrolimushsa00500Starch and sucrose metabolism3.16E-042O43451, P06737MGAM, PYGLMore
Pimecrolimushsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Pimecrolimushsa00730Thiamine metabolism2.53E-052P05186, P24666ALPL, ACP1More
Pimecrolimushsa00770Pantothenate and CoA biosynthesis5.59E-032O95498, O95497VNN2, VNN1More
Pimecrolimushsa00980Metabolism of xenobiotics by cytochrome P4503.20E-022P78417, P11766GSTO1, ADH5More
Pimecrolimushsa00982Drug metabolism - cytochrome P4503.20E-022P78417, P11766GSTO1, ADH5More
Pimecrolimushsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Pimecrolimushsa01521EGFR tyrosine kinase inhibitor resistance2.60E-022P17252, Q9NRA1PRKCA, PDGFCMore
Pimecrolimushsa03013RNA transport4.13E-026Q09161, P35658, P47813, Q14152, O75822, P51114NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1More
Pimecrolimushsa03060Protein export4.22E-022P37108, Q15005SRP14, SPCS2More
Pimecrolimushsa04014Ras signaling pathway5.92E-045Q9NRA1, P49767, P17252, Q14644, P62873PDGFC, VEGFC, PRKCA, RASA3, GNB1More
Pimecrolimushsa04015Rap1 signaling pathway4.88E-045Q9NRA1, P49767, P25116, P08514, P17252PDGFC, VEGFC, F2R, ITGA2B, PRKCAMore
Pimecrolimushsa04020Calcium signaling pathway2.39E-034P17252, P25116, Q9NRA1, P49767PRKCA, F2R, PDGFC, VEGFCMore
Pimecrolimushsa04060Cytokine-cytokine receptor interaction3.62E-024P27930, P14778, P25024, P25025IL1R2, IL1R1, CXCR1, CXCR2More
Pimecrolimushsa04061Viral protein interaction with cytokine and cytokine receptor2.60E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Pimecrolimushsa04064NF-kappa B signaling pathway4.09E-035P01584, P67870, P63279, Q8NHW4, Q9NQC7IL1B, CSNK2B, UBE2I, CCL4L2, CYLDMore
Pimecrolimushsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Pimecrolimushsa04072Phospholipase D signaling pathway6.69E-057Q9UQC2, P25116, P25024, P25025, P17252, P23743, Q9NRA1GAB2, F2R, CXCR1, CXCR2, PRKCA, DGKA, PDGFCMore
Pimecrolimushsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Pimecrolimushsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Pimecrolimushsa04151PI3K-Akt signaling pathway1.71E-036P25116, Q9NRA1, P49767, P62873, P08514, P17252F2R, PDGFC, VEGFC, GNB1, ITGA2B, PRKCAMore
Pimecrolimushsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Pimecrolimushsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Pimecrolimushsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Pimecrolimushsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Pimecrolimushsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Pimecrolimushsa04371Apelin signaling pathway4.39E-024P63218, P50151, Q14344, Q13485GNG5, GNG10, GNA13, SMAD4More
Pimecrolimushsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Pimecrolimushsa04510Focal adhesion8.11E-034P08514, P17252, Q9NRA1, P49767ITGA2B, PRKCA, PDGFC, VEGFCMore
Pimecrolimushsa04512ECM-receptor interaction3.19E-022P07359, P08514GP1BA, ITGA2BMore
Pimecrolimushsa04540Gap junction2.29E-033P17252, P68371, Q9NRA1PRKCA, TUBB2C, PDGFCMore
Pimecrolimushsa04611Platelet activation7.90E-033P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Pimecrolimushsa04612Antigen processing and presentation4.78E-026P48382, P26715, P26717, Q13241, O43908, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, TNFMore
Pimecrolimushsa04613Neutrophil extracellular trap formation2.31E-024P17252, O60814, P08514, P07359PRKCA, H2BC12, ITGA2B, GP1BAMore
Pimecrolimushsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Pimecrolimushsa04623Cytosolic DNA-sensing pathway1.54E-022P01584, Q8NHW4IL1B, CCL4L2More
Pimecrolimushsa04640Hematopoietic cell lineage2.96E-023P07359, P08514, P04141GP1BA, ITGA2B, CSF2More
Pimecrolimushsa04650Natural killer cell mediated cytotoxicity7.08E-0411P16298, P50591, P01375, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715PPP3CB, TNFSF10, TNF, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Pimecrolimushsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Pimecrolimushsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Pimecrolimushsa04664Fc epsilon RI signaling pathway2.60E-022P04141, P17252CSF2, PRKCAMore
Pimecrolimushsa04713Circadian entrainment4.51E-022P17252, P62873PRKCA, GNB1More
Pimecrolimushsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Pimecrolimushsa04723Retrograde endocannabinoid signaling3.83E-022P17252, P62873PRKCA, GNB1More
Pimecrolimushsa04724Glutamatergic synapse3.09E-033P17252, P62873, Q9NSB8PRKCA, GNB1, HOMER2More
Pimecrolimushsa04725Cholinergic synapse3.83E-022P17252, P62873PRKCA, GNB1More
Pimecrolimushsa04726Serotonergic synapse6.44E-033P17252, P62873, P18054PRKCA, GNB1, ALOX12More
Pimecrolimushsa04727GABAergic synapse2.06E-022P62873, P17252GNB1, PRKCAMore
Pimecrolimushsa04730Long-term depression3.20E-022Q14344, P07948GNA13, LYNMore
Pimecrolimushsa04750Inflammatory mediator regulation of TRP channels4.51E-022P18054, P17252ALOX12, PRKCAMore
Pimecrolimushsa04810Regulation of actin cytoskeleton2.06E-023P08514, Q9NRA1, P25116ITGA2B, PDGFC, F2RMore
Pimecrolimushsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Pimecrolimushsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Pimecrolimushsa04918Thyroid hormone synthesis1.14E-022P17252, P27824PRKCA, CANXMore
Pimecrolimushsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Pimecrolimushsa04926Relaxin signaling pathway1.14E-023P62873, P49767, P17252GNB1, VEGFC, PRKCAMore
Pimecrolimushsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Pimecrolimushsa04932Non-alcoholic fatty liver disease1.24E-026O43521, O75460, P01584, P13073, P12074, O15239BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1More
Pimecrolimushsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Pimecrolimushsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Pimecrolimushsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Pimecrolimushsa05010Alzheimer disease2.21E-0210O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4More
Pimecrolimushsa05032Morphine addiction1.20E-036P62873, P63218, P50151, Q07343, P17252, P43250GNB1, GNG5, GNG10, PDE4B, PRKCA, GRK6More
Pimecrolimushsa05120Epithelial cell signaling in Helicobacter pylori infection3.73E-022P25024, P25025CXCR1, CXCR2More
Pimecrolimushsa05130Pathogenic Escherichia coli infection3.65E-023Q14247, P68371, P25116CTTN, TUBB2C, F2RMore
Pimecrolimushsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Pimecrolimushsa05144Malaria3.12E-024P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Pimecrolimushsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Pimecrolimushsa05150Staphylococcus aureus infection8.13E-058P21730, P21462, O75015, Q14532, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Pimecrolimushsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Pimecrolimushsa05163Human cytomegalovirus infection2.89E-027P0DP23, Q8NHW4, Q08828, P23458, P01584, P61073, Q13651CALM1, CCL4L2, ADCY1, JAK1, IL1B, CXCR4, IL10RAMore
Pimecrolimushsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Pimecrolimushsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Pimecrolimushsa05200Pathways in cancer1.37E-026P08514, P17252, P49767, P25116, P62873, P78417ITGA2B, PRKCA, VEGFC, F2R, GNB1, GSTO1More
Pimecrolimushsa05205Proteoglycans in cancer4.43E-023Q12955, Q14247, P17252ANK3, CTTN, PRKCAMore
Pimecrolimushsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Pimecrolimushsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Pimecrolimushsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Pimecrolimushsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Pimecrolimushsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Pimecrolimushsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Pimecrolimushsa05231Choline metabolism in cancer2.29E-033Q9NRA1, P23743, P17252PDGFC, DGKA, PRKCAMore

Community members of Pimecrolimus (SDC: 3.34)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1AReported10.4320.269500.7551
P68106FKBP1BPeptidylNoneprolyl cisNonetrans isomerase FKBP1BPredicted00.08140.038100.1169
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q13451FKBP5PeptidylNoneprolyl cisNonetrans isomerase FKBP5Predicted00.22890.05860.14230.374
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q53EL6PDCD4Programmed cell death protein 4Predicted00.38990.06530.32020.6457
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P26358DNMT1DNAPredicted00.34040.28090.26590.998
P68106FKBP1BPeptidylNoneprolyl cisNonetrans isomerase FKBP1BPredicted00.08140.038100.1169
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)