PharmaCoNets of Phenyltoloxamine (SPCN: 101.66 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Phenyltoloxaminehsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Phenyltoloxaminehsa00190Oxidative phosphorylation4.83E-063Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Phenyltoloxaminehsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Phenyltoloxaminehsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Phenyltoloxaminehsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Phenyltoloxaminehsa00565Ether lipid metabolism3.94E-021Q8N661TMEM86BMore
Phenyltoloxaminehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Phenyltoloxaminehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Phenyltoloxaminehsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Phenyltoloxaminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Phenyltoloxaminehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Phenyltoloxaminehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Phenyltoloxaminehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Phenyltoloxaminehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Phenyltoloxaminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Phenyltoloxaminehsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Phenyltoloxaminehsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Phenyltoloxaminehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Phenyltoloxaminehsa03013RNA transport9.49E-0714O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FXR1More
Phenyltoloxaminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Phenyltoloxaminehsa03050Proteasome1.21E-021P28074PSMB5More
Phenyltoloxaminehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Phenyltoloxaminehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Phenyltoloxaminehsa04064NF-kappa B signaling pathway1.90E-0312O00463, P14778, P19174, Q04759, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, P19875, Q06643TRAF5, IL1R1, PLCG1, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CXCL2, LTBMore
Phenyltoloxaminehsa04071Sphingolipid signaling pathway2.55E-037P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Phenyltoloxaminehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Phenyltoloxaminehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Phenyltoloxaminehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Phenyltoloxaminehsa04120Ubiquitin mediated proteolysis2.51E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Phenyltoloxaminehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Phenyltoloxaminehsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Phenyltoloxaminehsa04145Phagosome1.62E-049Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Phenyltoloxaminehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Phenyltoloxaminehsa04213Longevity regulating pathway - multiple species4.41E-034P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Phenyltoloxaminehsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Phenyltoloxaminehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Phenyltoloxaminehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Phenyltoloxaminehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Phenyltoloxaminehsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Phenyltoloxaminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Phenyltoloxaminehsa04613Neutrophil extracellular trap formation2.15E-0511P11215, Q13547, P04908, Q93077, P58876, P62807, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Phenyltoloxaminehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Phenyltoloxaminehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Phenyltoloxaminehsa04650Natural killer cell mediated cytotoxicity3.09E-0715P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Phenyltoloxaminehsa04657IL-17 signaling pathway3.33E-038O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Phenyltoloxaminehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Phenyltoloxaminehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Phenyltoloxaminehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Phenyltoloxaminehsa04666Fc gamma R-mediated phagocytosis2.42E-025P23528, P06396, O14494, P14598, P17252CFL1, GSN, PLPP1, NCF1, PRKCAMore
Phenyltoloxaminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Phenyltoloxaminehsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Phenyltoloxaminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Phenyltoloxaminehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Phenyltoloxaminehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Phenyltoloxaminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Phenyltoloxaminehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Phenyltoloxaminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Phenyltoloxaminehsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Phenyltoloxaminehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Phenyltoloxaminehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Phenyltoloxaminehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Phenyltoloxaminehsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Phenyltoloxaminehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Phenyltoloxaminehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Phenyltoloxaminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Phenyltoloxaminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Phenyltoloxaminehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Phenyltoloxaminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Phenyltoloxaminehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Phenyltoloxaminehsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Phenyltoloxaminehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Phenyltoloxaminehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Phenyltoloxaminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Phenyltoloxaminehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Phenyltoloxaminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Phenyltoloxaminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Phenyltoloxaminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Phenyltoloxaminehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Phenyltoloxaminehsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Phenyltoloxaminehsa05132Salmonella infection2.93E-0210P51617, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Phenyltoloxaminehsa05133Pertussis3.51E-021P0C0L4C4AMore
Phenyltoloxaminehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Phenyltoloxaminehsa05140Leishmaniasis4.74E-0510O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4More
Phenyltoloxaminehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Phenyltoloxaminehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Phenyltoloxaminehsa05146Amoebiasis4.70E-0612P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Phenyltoloxaminehsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Phenyltoloxaminehsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Phenyltoloxaminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Phenyltoloxaminehsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Phenyltoloxaminehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Phenyltoloxaminehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Phenyltoloxaminehsa05170Human immunodeficiency virus 1 infection1.24E-0417Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5, P20333MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2, TNFRSF1BMore
Phenyltoloxaminehsa05202Transcriptional misregulation in cancer4.29E-0315Q12778, Q15532, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, Q13547, P12980FOXO1, SS18, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, HDAC1, LYL1More
Phenyltoloxaminehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Phenyltoloxaminehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Phenyltoloxaminehsa05205Proteoglycans in cancer1.39E-0313Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63More
Phenyltoloxaminehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Phenyltoloxaminehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Phenyltoloxaminehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Phenyltoloxaminehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Phenyltoloxaminehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.15E-0311P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4More
Phenyltoloxaminehsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Phenyltoloxaminehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Phenyltoloxaminehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Phenyltoloxaminehsa05323Rheumatoid arthritis2.00E-023Q13488, P10747, O60603TCIRG1, CD28, TLR2More
Phenyltoloxaminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Phenyltoloxaminehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Phenyltoloxaminehsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Phenyltoloxaminehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Phenyltoloxaminehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Phenyltoloxaminehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Phenyltoloxamine (SDC: 7.49)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P12271RLBP1RetinaldehydeNonebinding protein 1Predicted00.0840.106200.2543
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)