PharmaCoNets of Phenylephrine (SPCN: 47.09 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Phenylephrinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Phenylephrinehsa00220Arginine biosynthesis1.43E-022P05089, P49448ARG1, GLUD2More
Phenylephrinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Phenylephrinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Phenylephrinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Phenylephrinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Phenylephrinehsa01522Endocrine resistance2.16E-021P04049RAF1More
Phenylephrinehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Phenylephrinehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Phenylephrinehsa04014Ras signaling pathway3.65E-021P04049RAF1More
Phenylephrinehsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Phenylephrinehsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Phenylephrinehsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Phenylephrinehsa04062Chemokine signaling pathway3.98E-021P04049RAF1More
Phenylephrinehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Phenylephrinehsa04071Sphingolipid signaling pathway3.35E-035P04049, P21453, Q9H228, P01375, Q13362RAF1, S1PR1, EDG8, TNF, PPP2R5CMore
Phenylephrinehsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Phenylephrinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Phenylephrinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Phenylephrinehsa04140Autophagy - animal2.82E-021P04049RAF1More
Phenylephrinehsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Phenylephrinehsa04210Apoptosis2.16E-021P04049RAF1More
Phenylephrinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Phenylephrinehsa04218Cellular senescence2.49E-021P04049RAF1More
Phenylephrinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Phenylephrinehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Phenylephrinehsa04360Axon guidance2.49E-021P04049RAF1More
Phenylephrinehsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Phenylephrinehsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Phenylephrinehsa04510Focal adhesion3.48E-021P04049RAF1More
Phenylephrinehsa04540Gap junction1.33E-021P04049RAF1More
Phenylephrinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Phenylephrinehsa04612Antigen processing and presentation2.86E-057Q14953, P26715, P26717, Q07444, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, TNFMore
Phenylephrinehsa04613Neutrophil extracellular trap formation2.65E-021P04049RAF1More
Phenylephrinehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Phenylephrinehsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Phenylephrinehsa04650Natural killer cell mediated cytotoxicity7.19E-0911P01375, P06239, P20963, P04049, Q13241, P26718, O14931, P26717, Q07444, Q14953, P26715TNF, LCK, CD247, RAF1, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KIR2DS5, KLRC1More
Phenylephrinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Phenylephrinehsa04658Th1 and Th2 cell differentiation7.09E-057Q04759, P20963, P09693, P06239, P23771, Q9UL17, Q13761PRKCQ, CD247, CD3G, LCK, GATA3, TBX21, RUNX3More
Phenylephrinehsa04659Th17 cell differentiation2.34E-036Q04759, P06239, Q9UL17, P23771, P09693, P20963PRKCQ, LCK, TBX21, GATA3, CD3G, CD247More
Phenylephrinehsa04660T cell receptor signaling pathway3.84E-058Q04759, O95267, Q08881, P20963, P09693, P01732, P06239, P04049PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, LCK, RAF1More
Phenylephrinehsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Phenylephrinehsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Phenylephrinehsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Phenylephrinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Phenylephrinehsa04720Long-term potentiation1.66E-021P04049RAF1More
Phenylephrinehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Phenylephrinehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Phenylephrinehsa04730Long-term depression1.16E-021P04049RAF1More
Phenylephrinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Phenylephrinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Phenylephrinehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Phenylephrinehsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Phenylephrinehsa04912GnRH signaling pathway1.82E-021P04049RAF1More
Phenylephrinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Phenylephrinehsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Phenylephrinehsa04915Estrogen signaling pathway2.99E-021P04049RAF1More
Phenylephrinehsa04916Melanogenesis1.33E-021P04049RAF1More
Phenylephrinehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Phenylephrinehsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Phenylephrinehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Phenylephrinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Phenylephrinehsa04926Relaxin signaling pathway6.24E-035P18848, P22694, P14780, P04049, P30679ATF4, PRKACB, MMP9, RAF1, GNA15More
Phenylephrinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Phenylephrinehsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Phenylephrinehsa04929GnRH secretion4.98E-031P04049RAF1More
Phenylephrinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Phenylephrinehsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Phenylephrinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Phenylephrinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Phenylephrinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Phenylephrinehsa05034Alcoholism2.49E-021P04049RAF1More
Phenylephrinehsa05132Salmonella infection4.98E-021P04049RAF1More
Phenylephrinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Phenylephrinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Phenylephrinehsa05146Amoebiasis1.73E-038P09341, P19875, P01375, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, TNF, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Phenylephrinehsa05152Tuberculosis3.98E-021P04049RAF1More
Phenylephrinehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Phenylephrinehsa05161Hepatitis B1.99E-021P04049RAF1More
Phenylephrinehsa05163Human cytomegalovirus infection4.98E-021P04049RAF1More
Phenylephrinehsa05164Influenza A3.65E-021P04049RAF1More
Phenylephrinehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Phenylephrinehsa05170Human immunodeficiency virus 1 infection3.48E-021P04049RAF1More
Phenylephrinehsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Phenylephrinehsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Phenylephrinehsa05210Colorectal cancer1.66E-021P04049RAF1More
Phenylephrinehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Phenylephrinehsa05212Pancreatic cancer1.16E-021P04049RAF1More
Phenylephrinehsa05213Endometrial cancer9.95E-031P04049RAF1More
Phenylephrinehsa05214Glioma9.95E-031P04049RAF1More
Phenylephrinehsa05215Prostate cancer1.33E-021P04049RAF1More
Phenylephrinehsa05218Melanoma6.63E-031P04049RAF1More
Phenylephrinehsa05219Bladder cancer4.98E-031P04049RAF1More
Phenylephrinehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Phenylephrinehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Phenylephrinehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Phenylephrinehsa05224Breast cancer1.49E-021P04049RAF1More
Phenylephrinehsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Phenylephrinehsa05226Gastric cancer8.29E-031P04049RAF1More
Phenylephrinehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Phenylephrinehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Phenylephrinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer5.53E-046O95267, P20963, P09693, P06239, P04049, Q04759RASGRP1, CD247, CD3G, LCK, RAF1, PRKCQMore
Phenylephrinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Phenylephrinehsa05322Systemic lupus erythematosus1.57E-024P08311, P62807, Q16778, P12814CTSG, HIST1H2BC, HIST2H2BE, ACTN1More
Phenylephrinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Phenylephrinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More

Community members of Phenylephrine (SDC: 3.35)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)