PharmaCoNets of Phenylalanine (SPCN: 28.50 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Phenylalaninehsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Phenylalaninehsa00512Mucin type O-glycan biosynthesis2.03E-033O95395, O43286, Q8N4A0GCNT3, B4GALT5, GALNT4More
Phenylalaninehsa00531Glycosaminoglycan degradation8.18E-042P15586, P34059GNS, GALNSMore
Phenylalaninehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.92E-021Q9Y2C2USTMore
Phenylalaninehsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Phenylalaninehsa00730Thiamine metabolism1.25E-033Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Phenylalaninehsa00970Aminoacyl-tRNA biosynthesis3.62E-022O95363, Q15046FARS2, KARSMore
Phenylalaninehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Phenylalaninehsa03008Ribosome biogenesis in eukaryotes2.06E-022Q9NYH9, Q9BVP2UTP6, GNL3More
Phenylalaninehsa03010Ribosome1.03E-022P46777, P50914RPL5, RPL14More
Phenylalaninehsa03020RNA polymerase9.80E-052Q9GZM3, P52435POLR2J2, POLR2JMore
Phenylalaninehsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Phenylalaninehsa03050Proteasome1.20E-022P55036, P40306PSMD4, PSMB10More
Phenylalaninehsa03060Protein export4.36E-021Q15005SPCS2More
Phenylalaninehsa03450Non-homologous end-joining3.29E-021P13010XRCC5More
Phenylalaninehsa04024cAMP signaling pathway4.65E-022P23634, Q09472ATP2B4, EP300More
Phenylalaninehsa04062Chemokine signaling pathway1.01E-027P25024, P25025, P07948, P42338, P50151, P49407, P49841CXCR1, CXCR2, LYN, PIK3CB, GNG10, ARRB1, GSK3BMore
Phenylalaninehsa04071Sphingolipid signaling pathway1.94E-026Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Phenylalaninehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Phenylalaninehsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Phenylalaninehsa04142Lysosome1.06E-034P43234, Q9UBR2, P15586, P34059CTSO, CTSZ, GNS, GALNSMore
Phenylalaninehsa04150mTOR signaling pathway4.24E-023P42338, Q13322, P49841PIK3CB, GRB10, GSK3BMore
Phenylalaninehsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Phenylalaninehsa04210Apoptosis9.18E-034P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Phenylalaninehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Phenylalaninehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Phenylalaninehsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Phenylalaninehsa04340Hedgehog signaling pathway1.80E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Phenylalaninehsa04370VEGF signaling pathway3.62E-022P42338, Q16539PIK3CB, MAPK14More
Phenylalaninehsa04512ECM-receptor interaction4.78E-021Q16787LAMA3More
Phenylalaninehsa04630JAK-STAT signaling pathway1.44E-024P01106, Q09472, P48551, P16871MYC, EP300, IFNAR2, IL7RMore
Phenylalaninehsa04640Hematopoietic cell lineage1.75E-038P21926, P20023, P11836, P07766, P09693, P01730, P09564, P16871CD9, CR2, MS4A1, CD3E, CD3G, CD4, CD7, IL7RMore
Phenylalaninehsa04650Natural killer cell mediated cytotoxicity4.40E-026P78314, P06239, O60880, P20963, P26718, O75015SH3BP2, LCK, SH2D1A, CD247, KLRK1, FCGR3BMore
Phenylalaninehsa04658Th1 and Th2 cell differentiation9.73E-036P20963, P09693, Q16539, P06239, Q9UL17, P13765CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOBMore
Phenylalaninehsa04659Th17 cell differentiation7.42E-037Q16539, P06239, P13765, P14778, Q9UL17, P09693, P20963MAPK14, LCK, HLA-DOB, IL1R1, TBX21, CD3G, CD247More
Phenylalaninehsa04660T cell receptor signaling pathway4.08E-025P42338, P07766, P01730, Q16539, P49841PIK3CB, CD3E, CD4, MAPK14, GSK3BMore
Phenylalaninehsa04662B cell receptor signaling pathway2.74E-046P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Phenylalaninehsa04664Fc epsilon RI signaling pathway3.90E-034Q16539, P42338, P07948, P09917MAPK14, PIK3CB, LYN, ALOX5More
Phenylalaninehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Phenylalaninehsa04724Glutamatergic synapse9.00E-034P48058, P43003, P50151, P15104GRIA4, SLC1A3, GNG10, GLULMore
Phenylalaninehsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Phenylalaninehsa04728Dopaminergic synapse1.95E-038P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, P48058GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, GRIA4More
Phenylalaninehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Phenylalaninehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Phenylalaninehsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Phenylalaninehsa04917Prolactin signaling pathway3.15E-023P42338, Q16539, P49841PIK3CB, MAPK14, GSK3BMore
Phenylalaninehsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Phenylalaninehsa04919Thyroid hormone signaling pathway4.44E-023P60709, Q09472, P01106ACTB, EP300, MYCMore
Phenylalaninehsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Phenylalaninehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Phenylalaninehsa04926Relaxin signaling pathway4.06E-037P42338, P50151, Q99941, P18848, P51828, Q16539, P49407PIK3CB, GNG10, CREBL1, ATF4, ADCY7, MAPK14, ARRB1More
Phenylalaninehsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Phenylalaninehsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Phenylalaninehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Phenylalaninehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Phenylalaninehsa04973Carbohydrate digestion and absorption1.88E-033P13866, O43451, P42338SLC5A1, MGAM, PIK3CBMore
Phenylalaninehsa04976Bile secretion4.19E-021P13866SLC5A1More
Phenylalaninehsa05016Huntington disease1.07E-023Q9GZM3, P52435, P55036POLR2J2, POLR2J, PSMD4More
Phenylalaninehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Phenylalaninehsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Phenylalaninehsa05120Epithelial cell signaling in Helicobacter pylori infection1.22E-046Q16539, Q99437, P25024, P25025, P41240, P07948MAPK14, ATP6V0B, CXCR1, CXCR2, CSK, LYNMore
Phenylalaninehsa05135Yersinia infection3.62E-024Q16539, P42338, P49841, P01730MAPK14, PIK3CB, GSK3B, CD4More
Phenylalaninehsa05144Malaria1.91E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Phenylalaninehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Phenylalaninehsa05163Human cytomegalovirus infection1.87E-026P42338, P50151, P49841, P14778, P25025, Q16539PIK3CB, GNG10, GSK3B, IL1R1, CXCR2, MAPK14More
Phenylalaninehsa05164Influenza A8.62E-034Q09472, P48551, P29728, P60709EP300, IFNAR2, OAS2, ACTBMore
Phenylalaninehsa05169Epstein-Barr virus infection2.92E-0312P20023, P13765, P01106, Q13547, O00463, Q16539, P24522, P48551, O60603, P29728, P09693, P20963CR2, HLA-DOB, MYC, HDAC1, TRAF5, MAPK14, GADD45A, IFNAR2, TLR2, OAS2, CD3G, CD247More
Phenylalaninehsa05171Coronavirus disease - COVID-191.93E-024P48551, P29728, P46777, P50914IFNAR2, OAS2, RPL5, RPL14More
Phenylalaninehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Phenylalaninehsa05205Proteoglycans in cancer4.43E-023P63261, P04637, Q06124ACTG1, TP53, PTPN11More
Phenylalaninehsa05211Renal cell carcinoma2.76E-043Q06124, Q09472, Q99814PTPN11, EP300, EPAS1More
Phenylalaninehsa05212Pancreatic cancer2.60E-022P04637, P24522TP53, GADD45AMore
Phenylalaninehsa05213Endometrial cancer2.60E-022P04637, P24522TP53, GADD45AMore
Phenylalaninehsa05214Glioma2.60E-022P04637, P24522TP53, GADD45AMore
Phenylalaninehsa05216Thyroid cancer1.08E-034P01106, P04637, P24522, O75293MYC, TP53, GADD45A, GADD45BMore
Phenylalaninehsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Phenylalaninehsa05218Melanoma1.14E-022P04637, P24522TP53, GADD45AMore
Phenylalaninehsa05220Chronic myeloid leukemia7.90E-033Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Phenylalaninehsa05222Small cell lung cancer4.78E-021Q16787LAMA3More
Phenylalaninehsa05223Non-small cell lung cancer1.06E-035P10826, Q9HC35, P04637, P24522, O75293RARB, EML4, TP53, GADD45A, GADD45BMore
Phenylalaninehsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Phenylalaninehsa05225Hepatocellular carcinoma3.30E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Phenylalaninehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.18E-049P42338, P07766, P20963, P09693, P06239, O60603, Q16539, Q9HC35, P01730PIK3CB, CD3E, CD247, CD3G, LCK, TLR2, MAPK14, EML4, CD4More
Phenylalaninehsa05321Inflammatory bowel disease4.92E-024O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Phenylalaninehsa05332Graft-versus-host disease1.80E-024P10747, P01375, P26715, Q13241CD28, TNF, KLRC1, KLRD1More
Phenylalaninehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Phenylalaninehsa05418Fluid shear stress and atherosclerosis1.93E-025Q16539, P42338, P10599, P14778, P27930MAPK14, PIK3CB, TXN, IL1R1, IL1R2More

Community members of Phenylalanine (SDC: 2.57)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O95363FARS2PhenylalanineNoneNonetRNA ligase, mitochondrialReported00.09080.00670.00270.0614
P07101THTyrosine 3NonemonooxygenaseReported00.04320.08880.49370.6929
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
P40306PSMB10Proteasome subunit beta typeNone10Predicted00.26880.0510.01830.2548
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
Q92536SLC7A6Y+L amino acid transporter 2Predicted00.57710.026600.3418
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)