PharmaCoNets of Phentolamine (SPCN: 67.05 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Phentolaminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Phentolaminehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Phentolaminehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Phentolaminehsa00240Pyrimidine metabolism3.59E-032P31350, P04818RRM2, TYMSMore
Phentolaminehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Phentolaminehsa00670One carbon pool by folate4.14E-021P04818TYMSMore
Phentolaminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Phentolaminehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Phentolaminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Phentolaminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Phentolaminehsa01522Endocrine resistance4.74E-023P22694, P10415, Q13323PRKACB, BCL2, BIKMore
Phentolaminehsa01523Antifolate resistance1.43E-032Q92820, P04818GGH, TYMSMore
Phentolaminehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Phentolaminehsa03015mRNA surveillance pathway1.37E-036Q13362, Q14738, O94913, Q9UBU9, Q9H307, Q13148PPP2R5C, PPP2R5D, PCF11, NXF1, PNN, TARDBPMore
Phentolaminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Phentolaminehsa04020Calcium signaling pathway1.39E-024P30679, O15399, P07550, P23634GNA15, GRIN2D, ADRB2, ATP2B4More
Phentolaminehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Phentolaminehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Phentolaminehsa04064NF-kappa B signaling pathway7.27E-0411Q13489, Q13546, P14778, P19174, Q04759, Q9UDY8, P06239, P09341, P19875, Q06643, Q9UNE0BIRC3, RIPK1, IL1R1, PLCG1, PRKCQ, MALT1, LCK, CXCL1, CXCL2, LTB, EDARMore
Phentolaminehsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Phentolaminehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Phentolaminehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Phentolaminehsa04080Neuroactive ligand-receptor interaction2.95E-048P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Phentolaminehsa04110Cell cycle1.97E-057P06493, O60566, O75293, P30304, P33981, P42773, P01106CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Phentolaminehsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Phentolaminehsa04115p53 signaling pathway1.69E-022P31350, P06493RRM2, CDK1More
Phentolaminehsa04120Ubiquitin mediated proteolysis3.42E-036Q14145, Q13042, P30260, Q13191, P62837, Q15751KEAP1, CDC16, CDC27, CBLB, UBE2D2, HERC1More
Phentolaminehsa04140Autophagy - animal4.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Phentolaminehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Phentolaminehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Phentolaminehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Phentolaminehsa04217Necroptosis1.85E-037P01375, P01568, P48023, Q13489, Q13546, Q14765, Q99878TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC14More
Phentolaminehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Phentolaminehsa04261Adrenergic signaling in cardiomyocytes3.75E-036P07550, P22694, P18848, Q13362, Q14738, P0DP23ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5D, CALM1More
Phentolaminehsa04340Hedgehog signaling pathway9.74E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Phentolaminehsa04540Gap junction2.86E-023P22694, P68371, Q14643PRKACB, TUBB2C, ITPR1More
Phentolaminehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Phentolaminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Phentolaminehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Phentolaminehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Phentolaminehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Phentolaminehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Phentolaminehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Phentolaminehsa04640Hematopoietic cell lineage2.46E-0410P21926, P14778, P27930, P11215, P25063, P07766, P01732, P01730, P06127, P09564CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD5, CD7More
Phentolaminehsa04650Natural killer cell mediated cytotoxicity5.49E-0612P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Phentolaminehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Phentolaminehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Phentolaminehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Phentolaminehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Phentolaminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Phentolaminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Phentolaminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Phentolaminehsa04725Cholinergic synapse3.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Phentolaminehsa04728Dopaminergic synapse2.66E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Phentolaminehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Phentolaminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Phentolaminehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Phentolaminehsa04913Ovarian steroidogenesis1.27E-032P42330, P22694AKR1C3, PRKACBMore
Phentolaminehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Phentolaminehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Phentolaminehsa04924Renin secretion2.90E-043P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Phentolaminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Phentolaminehsa04927Cortisol synthesis and secretion1.27E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Phentolaminehsa04928Parathyroid hormone synthesis, secretion and action1.02E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Phentolaminehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Phentolaminehsa04934Cushing syndrome4.74E-023Q14643, P22694, P04628ITPR1, PRKACB, WNT1More
Phentolaminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Phentolaminehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Phentolaminehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Phentolaminehsa04970Salivary secretion9.44E-044P07550, P22694, Q14643, P49913ADRB2, PRKACB, ITPR1, CAMPMore
Phentolaminehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Phentolaminehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Phentolaminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Phentolaminehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Phentolaminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Phentolaminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Phentolaminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Phentolaminehsa05033Nicotine addiction1.22E-022P28472, O15399GABRB3, GRIN2DMore
Phentolaminehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Phentolaminehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Phentolaminehsa05133Pertussis4.20E-021P0C0L4C4AMore
Phentolaminehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Phentolaminehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Phentolaminehsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Phentolaminehsa05146Amoebiasis2.05E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Phentolaminehsa05152Tuberculosis3.52E-022Q15075, Q13651EEA1, IL10RAMore
Phentolaminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Phentolaminehsa05167Kaposi sarcoma-associated herpesvirus infection4.82E-023P23458, Q13469, P0DP23JAK1, NFATC2, CALM1More
Phentolaminehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Phentolaminehsa05212Pancreatic cancer4.16E-022Q15311, P23458RALBP1, JAK1More
Phentolaminehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Phentolaminehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Phentolaminehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.99E-048P42338, P19174, P07766, P20963, P06239, Q04759, Q9HC35, P01730PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ, EML4, CD4More
Phentolaminehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Phentolaminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Phentolaminehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Phentolaminehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Phentolaminehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Phentolaminehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Phentolamine (SDC: 5.41)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P30679GNA15Guanine nucleotideNonebinding protein subunit alphaNone15Predicted00.03730.11460.28910.5369
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q06609RAD51DNA repair protein RAD51 homolog 1Predicted00.10220.09540.27250.5144
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)