PharmaCoNets of Phentermine (SPCN: 22.19 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Mephenterminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Mephenterminehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Mephenterminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Mephenterminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Mephenterminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Mephenterminehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Mephenterminehsa03015mRNA surveillance pathway2.95E-023O94913, Q9H307, Q13148PCF11, PNN, TARDBPMore
Mephenterminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Mephenterminehsa04020Calcium signaling pathway1.39E-024P30679, O15399, P07550, P23634GNA15, GRIN2D, ADRB2, ATP2B4More
Mephenterminehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Mephenterminehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Mephenterminehsa04120Ubiquitin mediated proteolysis3.42E-036Q14145, Q13042, P30260, Q13191, P62837, Q15751KEAP1, CDC16, CDC27, CBLB, UBE2D2, HERC1More
Mephenterminehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Mephenterminehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Mephenterminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Mephenterminehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Mephenterminehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Mephenterminehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Mephenterminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Mephenterminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Mephenterminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Mephenterminehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Mephenterminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Mephenterminehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Mephenterminehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Mephenterminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Mephenterminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Mephenterminehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Mephenterminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Mephenterminehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Mephenterminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Mephenterminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Mephenterminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Mephenterminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Mephenterminehsa05033Nicotine addiction1.22E-022P28472, O15399GABRB3, GRIN2DMore
Mephenterminehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Mephenterminehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Mephenterminehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Mephenterminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Mephenterminehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Mephenterminehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Mephenterminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Mephenterminehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Mephenterminehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Phenterminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Phenterminehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Phenterminehsa00531Glycosaminoglycan degradation8.18E-042P15586, P34059GNS, GALNSMore
Phenterminehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.92E-021Q9Y2C2USTMore
Phenterminehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Phenterminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Phenterminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Phenterminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Phenterminehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Phenterminehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Phenterminehsa03008Ribosome biogenesis in eukaryotes2.06E-022Q9NYH9, Q9BVP2UTP6, GNL3More
Phenterminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Phenterminehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Phenterminehsa04071Sphingolipid signaling pathway8.46E-047P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Phenterminehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Phenterminehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Phenterminehsa04142Lysosome1.14E-023P43234, P15586, P34059CTSO, GNS, GALNSMore
Phenterminehsa04210Apoptosis9.18E-034P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Phenterminehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Phenterminehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Phenterminehsa04340Hedgehog signaling pathway1.80E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Phenterminehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Phenterminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Phenterminehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Phenterminehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Phenterminehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Phenterminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Phenterminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Phenterminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Phenterminehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Phenterminehsa04924Renin secretion3.43E-033P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Phenterminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Phenterminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Phenterminehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Phenterminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Phenterminehsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Phenterminehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Phenterminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Phenterminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Phenterminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Phenterminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Phenterminehsa05133Pertussis4.94E-021P0C0L4C4AMore
Phenterminehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Phenterminehsa05144Malaria3.02E-034O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Phenterminehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Phenterminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Phenterminehsa05205Proteoglycans in cancer4.79E-038P63261, P04637, P14780, P01375, P23588, Q06124, Q13635, P22694ACTG1, TP53, MMP9, TNF, EIF4B, PTPN11, PTCH1, PRKACBMore
Phenterminehsa05211Renal cell carcinoma7.75E-032Q06124, Q99814PTPN11, EPAS1More
Phenterminehsa05212Pancreatic cancer2.60E-022P04637, P24522TP53, GADD45AMore
Phenterminehsa05213Endometrial cancer2.60E-022P04637, P24522TP53, GADD45AMore
Phenterminehsa05214Glioma2.60E-022P04637, P24522TP53, GADD45AMore
Phenterminehsa05216Thyroid cancer1.14E-022P04637, P24522TP53, GADD45AMore
Phenterminehsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Phenterminehsa05218Melanoma3.41E-045P09619, Q9GZP0, P04637, Q02750, P24522PDGFRB, PDGFD, TP53, MAP2K1, GADD45AMore
Phenterminehsa05220Chronic myeloid leukemia7.90E-033Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Phenterminehsa05223Non-small cell lung cancer3.19E-022P04637, P24522TP53, GADD45AMore
Phenterminehsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Phenterminehsa05225Hepatocellular carcinoma3.30E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Phenterminehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Phenterminehsa05321Inflammatory bowel disease3.02E-034O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Phenterminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Phenterminehsa05332Graft-versus-host disease5.46E-055P48023, P10747, P01375, P26715, Q13241FASLG, CD28, TNF, KLRC1, KLRD1More
Phenterminehsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Phenterminehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Phenterminehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Phentermine (SDC: 2.85)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)