PharmaCoNets of Phenprocoumon (SPCN: 229.32 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Phenprocoumonhsa00010Glycolysis / Gluconeogenesis4.41E-024P04075, P06733, P04406, P60174ALDOA, ENO1, GAPDH, TPI1More
Phenprocoumonhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Phenprocoumonhsa00051Fructose and mannose metabolism2.08E-034P15121, O14772, P60174, P04075AKR1B1, FPGT, TPI1, ALDOAMore
Phenprocoumonhsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Phenprocoumonhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Phenprocoumonhsa00190Oxidative phosphorylation8.33E-044Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Phenprocoumonhsa00220Arginine biosynthesis5.81E-073P15104, P05089, P49448GLUL, ARG1, GLUD2More
Phenprocoumonhsa00230Purine metabolism1.56E-023Q7LG56, P51828, Q9Y227RRM2B, ADCY7, ENTPD4More
Phenprocoumonhsa00240Pyrimidine metabolism1.45E-022Q7LG56, Q9Y227RRM2B, ENTPD4More
Phenprocoumonhsa00250Alanine, aspartate and glutamate metabolism2.61E-022P49448, P15104GLUD2, GLULMore
Phenprocoumonhsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Phenprocoumonhsa00310Lysine degradation1.98E-033Q96KQ7, Q02809, P51648EHMT2, PLOD1, ALDH3A2More
Phenprocoumonhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Phenprocoumonhsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Phenprocoumonhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Phenprocoumonhsa00500Starch and sucrose metabolism5.48E-073O43451, P46976, P06737MGAM, GYG1, PYGLMore
Phenprocoumonhsa00512Mucin type O-glycan biosynthesis3.19E-033O95395, Q8N4A0, Q9NY28GCNT3, GALNT4, GALNT8More
Phenprocoumonhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Phenprocoumonhsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Phenprocoumonhsa00562Inositol phosphate metabolism2.00E-024P27987, P19174, P42338, Q02252ITPKB, PLCG1, PIK3CB, ALDH6A1More
Phenprocoumonhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Phenprocoumonhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Phenprocoumonhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Phenprocoumonhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Phenprocoumonhsa00600Sphingolipid metabolism3.70E-035P07602, Q9BX95, Q13510, O14494, P06280PSAP, SGPP1, ASAH1, PLPP1, GLAMore
Phenprocoumonhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Phenprocoumonhsa00620Pyruvate metabolism3.90E-022P07195, P11766LDHB, ADH5More
Phenprocoumonhsa00630Glyoxylate and dicarboxylate metabolism2.08E-062P40925, P15104MDH1, GLULMore
Phenprocoumonhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Phenprocoumonhsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Phenprocoumonhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Phenprocoumonhsa00830Retinol metabolism1.50E-044P00325, P00352, Q9BPW9, O75911ADH1B, ALDH1A1, DHRS9, DHRS3More
Phenprocoumonhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Phenprocoumonhsa00910Nitrogen metabolism1.42E-033P22748, P15104, P49448CA4, GLUL, GLUD2More
Phenprocoumonhsa00920Sulfur metabolism7.29E-041Q16762TSTMore
Phenprocoumonhsa00970Aminoacyl-tRNA biosynthesis2.41E-054O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Phenprocoumonhsa00980Metabolism of xenobiotics by cytochrome P4501.05E-055Q16772, P78417, P28332, P09211, P11712GSTA3, GSTO1, ADH6, GSTP1, CYP2C9More
Phenprocoumonhsa00982Drug metabolism - cytochrome P4501.75E-055P11712, Q16772, P09211, P78417, P28332CYP2C9, GSTA3, GSTP1, GSTO1, ADH6More
Phenprocoumonhsa00983Drug metabolism - other enzymes1.28E-055P04183, P32320, P05164, Q16772, P09211TK1, CDA, MPO, GSTA3, GSTP1More
Phenprocoumonhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Phenprocoumonhsa01100Metabolic pathways4.14E-0441Q9NR34, P35790, Q9Y259, P05089, Q16772, P09211, Q9UJ14, P30041, P32320, Q13956, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P05186, P24666, P15121, P49619, O95954, Q9HCC0, P33121, Q02318, Q9UHK6, Q86VZ5, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737, Q9BQB6MAN1C1, CHKA, CHKB, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, CDA, PDE6H, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, ALPL, ACP1, AKR1B1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, AMACR, SGMS1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL, VKORC1More
Phenprocoumonhsa01200Carbon metabolism5.71E-037P04075, P04406, P60174, P06733, O14521, Q9P2R7, Q02252ALDOA, GAPDH, TPI1, ENO1, SDHD, SUCLA2, ALDH6A1More
Phenprocoumonhsa012102-Oxocarboxylic acid metabolism6.96E-041P50213IDH3AMore
Phenprocoumonhsa01230Biosynthesis of amino acids8.65E-047P60174, P04406, P06733, P04075, P60891, Q99707, P37837TPI1, GAPDH, ENO1, ALDOA, PRPS1, MTR, TALDO1More
Phenprocoumonhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Phenprocoumonhsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Phenprocoumonhsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Phenprocoumonhsa01524Platinum drug resistance4.95E-046O15392, Q16772, P09211, P78417, P11388, P52701BIRC5, GSTA3, GSTP1, GSTO1, TOP2A, MSH6More
Phenprocoumonhsa02010ABC transporters2.17E-031Q8IZY2ABCA7More
Phenprocoumonhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Phenprocoumonhsa03010Ribosome4.60E-0616P62753, P42677, P25398, P32969, P30050, P40429, P62829, P46776, Q9H0U6, Q07020, P62910, P18077, P36578, P05386, P62249, P23396RPS6, RPS27, RPS12, RPL9, RPL12, RPL13A, RPL23, RPL27A, MRPL18, RPL18, RPL32, RPL35A, RPL4, RPLP1, RPS16, RPS3More
Phenprocoumonhsa03013RNA transport8.36E-1222P62826, O14980, P52298, Q09161, O14893, P61326, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, P47813, Q14152, O75822, P78345, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1, FXR1More
Phenprocoumonhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Phenprocoumonhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Phenprocoumonhsa03020RNA polymerase2.43E-064P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Phenprocoumonhsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Phenprocoumonhsa03040Spliceosome1.06E-1014Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Phenprocoumonhsa03060Protein export1.76E-054Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Phenprocoumonhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Phenprocoumonhsa03410Base excision repair4.17E-022P49005, P29372POLD2, MPGMore
Phenprocoumonhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Phenprocoumonhsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Phenprocoumonhsa04012ErbB signaling pathway5.67E-055P16333, P17252, P19174, P42338, P01106NCK1, PRKCA, PLCG1, PIK3CB, MYCMore
Phenprocoumonhsa04014Ras signaling pathway3.72E-0914P42338, P20827, Q9NRA1, P49767, P08069, Q13009, P17252, P14921, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, PRKCA, ETS1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Phenprocoumonhsa04015Rap1 signaling pathway6.70E-0715P20827, Q9NRA1, P49767, P08069, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P0DP23, P08514, P17252, P19174EFNA1, PDGFC, VEGFC, IGF1R, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, CALM1, ITGA2B, PRKCA, PLCG1More
Phenprocoumonhsa04020Calcium signaling pathway3.71E-0714P27987, Q08828, P21796, P17252, P30679, O15399, P19174, P61073, P0DP23, P05141, P51828, P23634, Q9NRA1, P49767ITPKB, ADCY1, VDAC1, PRKCA, GNA15, GRIN2D, PLCG1, CXCR4, CALM1, SLC25A5, ADCY7, ATP2B4, PDGFC, VEGFCMore
Phenprocoumonhsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Phenprocoumonhsa04024cAMP signaling pathway4.64E-039Q08828, P51828, P42338, P31751, P0DP23, Q13370, O15399, P25963, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1More
Phenprocoumonhsa04060Cytokine-cytokine receptor interaction7.03E-0516P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P01375, P09341, P18510, P01730, Q93038IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNF, CXCL1, IL1RN, CD4, TNFRSF25More
Phenprocoumonhsa04061Viral protein interaction with cytokine and cytokine receptor2.49E-0610Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Phenprocoumonhsa04062Chemokine signaling pathway1.55E-1121P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P14598, P42224, P25963, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, PIK3R5More
Phenprocoumonhsa04064NF-kappa B signaling pathway1.28E-0921P10415, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Phenprocoumonhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Phenprocoumonhsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Phenprocoumonhsa04070Phosphatidylinositol signaling system3.22E-079P19174, P0DP23, P42338, O14986, P23743, Q16760, P48426, P27987, P17252PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKD, PIP4K2A, ITPKB, PRKCAMore
Phenprocoumonhsa04071Sphingolipid signaling pathway2.90E-0610P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Phenprocoumonhsa04072Phospholipase D signaling pathway1.51E-0516P31751, P42338, Q9UQC2, P43657, P25024, P25025, P19174, O14986, Q14344, Q8WYR1, Q15438, Q08828, P51828, P23743, Q16760, Q9NRA1AKT2, PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNA13, PIK3R5, PSCD1, ADCY1, ADCY7, DGKA, DGKD, PDGFCMore
Phenprocoumonhsa04080Neuroactive ligand-receptor interaction1.17E-0311P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, Q16581, P14416, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, C3AR1, DRD2, ADMMore
Phenprocoumonhsa04110Cell cycle4.34E-058Q9UBD5, P06493, O75293, P30304, P33981, P42773, P01106, Q13547ORC3, CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Phenprocoumonhsa04114Oocyte meiosis6.20E-0611Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Phenprocoumonhsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Phenprocoumonhsa04120Ubiquitin mediated proteolysis4.82E-032Q9UBT2, Q14669SAE2, TRIP12More
Phenprocoumonhsa04122Sulfur relay system7.29E-041Q16762TSTMore
Phenprocoumonhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Phenprocoumonhsa04140Autophagy - animal4.41E-036P08069, P31751, Q7L523, O75460, Q96GC9, Q8TEV9IGF1R, AKT2, RRAGA, ERN1, TMEM49, SMCR8More
Phenprocoumonhsa04141Protein processing in endoplasmic reticulum1.54E-0412P18848, P30101, P07384, O95487, O60337, P60604, P11142, P07900, P08238, O95816, Q9H173, Q9UNL2ATF4, PDIA3, CAPN1, SEC24B, MARH6, UBE2G2, HSPA8, HSP90AA1, HSP90AB1, BAG2, SIL1, SSR3More
Phenprocoumonhsa04142Lysosome2.23E-024P22304, Q13510, Q04900, Q9Y227IDS, ASAH1, CD164, ENTPD4More
Phenprocoumonhsa04144Endocytosis2.57E-036O75351, P62491, P42566, Q15438, Q14161, Q9UNH7VPS4B, RAB11A, EPS15, PSCD1, GIT2, SNX6More
Phenprocoumonhsa04145Phagosome9.18E-049P11215, P60709, Q15075, Q15080, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, ACTB, EEA1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Phenprocoumonhsa04146Peroxisome2.92E-036O43933, O96011, P56589, Q9UKG9, O75521, P33121PEX1, PEX11B, PEX3, CROT, ECI2, ACSL1More
Phenprocoumonhsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Phenprocoumonhsa04151PI3K-Akt signaling pathway8.01E-0622P42338, P43657, P01106, O43521, P20827, Q9NRA1, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, P14784, P23458, P01568, P17252, Q6ZUJ8, P30281PIK3CB, P2RY5, MYC, BCL2L11, EFNA1, PDGFC, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, IL2RB, JAK1, IFNA21, PRKCA, PIK3AP1, CCND3More
Phenprocoumonhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Phenprocoumonhsa04210Apoptosis5.05E-0310Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Phenprocoumonhsa04211Longevity regulating pathway5.00E-035P31751, P08069, Q08828, P51828, P18848AKT2, IGF1R, ADCY1, ADCY7, ATF4More
Phenprocoumonhsa04213Longevity regulating pathway - multiple species4.91E-059P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Phenprocoumonhsa04217Necroptosis1.85E-0412P01568, Q13489, P42224, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q13557, O43633IFNA21, BIRC3, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, CAMK2D, CHMP2AMore
Phenprocoumonhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Phenprocoumonhsa04261Adrenergic signaling in cardiomyocytes2.09E-049P09493, Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23, P23634TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, ATP2B4More
Phenprocoumonhsa04270Vascular smooth muscle contraction2.68E-023Q08828, P35579, P35318ADCY1, MYH9, ADMMore
Phenprocoumonhsa04310Wnt signaling pathway5.60E-033P30279, Q13485, O43318CCND2, SMAD4, MAP3K7More
Phenprocoumonhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Phenprocoumonhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Phenprocoumonhsa04360Axon guidance3.38E-069P16333, P20827, O95631, P17252, P42338, P07332, P23528, P19174, Q06124NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, CFL1, PLCG1, PTPN11More
Phenprocoumonhsa04370VEGF signaling pathway1.13E-066P19174, P16298, P42338, P17252, Q05397, Q02750PLCG1, PPP3CB, PIK3CB, PRKCA, PTK2, MAP2K1More
Phenprocoumonhsa04371Apelin signaling pathway4.69E-0813P62873, P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23GNB1, GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1More
Phenprocoumonhsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Phenprocoumonhsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Phenprocoumonhsa04510Focal adhesion2.69E-0310P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P08069, P49767ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, IGF1R, VEGFCMore
Phenprocoumonhsa04512ECM-receptor interaction1.70E-032P07359, P08514GP1BA, ITGA2BMore
Phenprocoumonhsa04514Cell adhesion molecules7.40E-043P16109, P56750, O00501SELP, CLDN17, CLDN5More
Phenprocoumonhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Phenprocoumonhsa04530Tight junction2.04E-078Q8TEU7, P63261, P16989, P56750, O00501, Q9Y478, Q92974, Q14247RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, PRKAB1, ARHGEF2, CTTNMore
Phenprocoumonhsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Phenprocoumonhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Phenprocoumonhsa04610Complement and coagulation cascades1.22E-053P25116, P09871, P0C0L4F2R, C1S, C4AMore
Phenprocoumonhsa04611Platelet activation3.01E-097P25116, Q9Y490, P08514, Q15746, Q08828, Q8WYR1, P07359F2R, TLN1, ITGA2B, MYLK, ADCY1, PIK3R5, GP1BAMore
Phenprocoumonhsa04612Antigen processing and presentation8.94E-0914P04233, P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P01889, P10321, Q06323, P01375CD74, HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, HLA-B, HLA-C, PSME1, TNFMore
Phenprocoumonhsa04613Neutrophil extracellular trap formation4.78E-0828P42338, P19174, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q99878, Q93077, P62807, Q93079, O60814, P68431, P21796, P14598, Q15080, P20160, P08311, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PIK3CB, PLCG1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, H2AC14, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Phenprocoumonhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Phenprocoumonhsa04620Toll-like receptor signaling pathway4.12E-047P01568, P01584, P31751, P42224, P25963, P42338, Q8NHW4IFNA21, IL1B, AKT2, STAT1, NFKBIA, PIK3CB, CCL4L2More
Phenprocoumonhsa04621NOD-like receptor signaling pathway3.19E-023P23458, Q9H3M7, P43490JAK1, TXNIP, PBEF1More
Phenprocoumonhsa04623Cytosolic DNA-sensing pathway1.23E-075P01584, P01568, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, NFKBIA, POLR3H, CCL4L2More
Phenprocoumonhsa04625C-type lectin receptor signaling pathway7.57E-0511Q9ULY5, P01584, Q9NQC7, P42224, P20749, P25963, P01375, P42338, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, STAT1, BCL3, NFKBIA, TNF, PIK3CB, AKT2, CALM1, MAPK14More
Phenprocoumonhsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Phenprocoumonhsa04640Hematopoietic cell lineage3.60E-0713P13612, P21926, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375ITGA4, CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNFMore
Phenprocoumonhsa04650Natural killer cell mediated cytotoxicity8.35E-1416P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Phenprocoumonhsa04657IL-17 signaling pathway2.08E-0810P07900, O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Phenprocoumonhsa04658Th1 and Th2 cell differentiation1.95E-2315P25963, Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Phenprocoumonhsa04659Th17 cell differentiation3.52E-1919P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Phenprocoumonhsa04660T cell receptor signaling pathway5.02E-1314P01375, Q04759, P42338, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Phenprocoumonhsa04662B cell receptor signaling pathway5.25E-046P25963, P42338, P60033, P07948, P21854, Q8N149NFKBIA, PIK3CB, CD81, LYN, CD72, LILRA2More
Phenprocoumonhsa04664Fc epsilon RI signaling pathway2.14E-0810P01375, P04141, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P09917, P20292TNF, CSF2, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, ALOX5, ALOX5APMore
Phenprocoumonhsa04666Fc gamma R-mediated phagocytosis6.21E-046P07948, P42338, P19174, P23528, P14598, P17252LYN, PIK3CB, PLCG1, CFL1, NCF1, PRKCAMore
Phenprocoumonhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Phenprocoumonhsa04713Circadian entrainment1.09E-058O15399, P0DP23, P17252, P62873, P63218, P50151, Q08828, P51828GRIN2D, CALM1, PRKCA, GNB1, GNG5, GNG10, ADCY1, ADCY7More
Phenprocoumonhsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Phenprocoumonhsa04720Long-term potentiation1.81E-046P16298, P0DP23, P51812, P18848, Q08828, Q02750PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1More
Phenprocoumonhsa04724Glutamatergic synapse2.86E-056O15399, P17252, P62873, P63218, P50151, P15104GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLULMore
Phenprocoumonhsa04725Cholinergic synapse2.46E-0512Q08828, P51828, P22694, Q14643, P17252, P62873, P63218, P50151, P18848, P42338, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, PIK3CB, AKT2, BCL2More
Phenprocoumonhsa04726Serotonergic synapse2.52E-036P17252, P62873, P63218, P50151, P33260, P09917PRKCA, GNB1, GNG5, GNG10, CYP2C18, ALOX5More
Phenprocoumonhsa04727GABAergic synapse2.90E-065P62873, P63218, P50151, P15104, P17252GNB1, GNG5, GNG10, GLUL, PRKCAMore
Phenprocoumonhsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Phenprocoumonhsa04730Long-term depression1.95E-023Q14344, P08069, P07948GNA13, IGF1R, LYNMore
Phenprocoumonhsa04744Phototransduction2.08E-062P62873, P0DP23GNB1, CALM1More
Phenprocoumonhsa04750Inflammatory mediator regulation of TRP channels9.94E-079P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Phenprocoumonhsa04810Regulation of actin cytoskeleton2.63E-039P12814, Q15746, Q13009, P42338, P08514, P11215, Q14344, Q9NRA1, P25116ACTN1, MYLK, TIAM1, PIK3CB, ITGA2B, ITGAM, GNA13, PDGFC, F2RMore
Phenprocoumonhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Phenprocoumonhsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Phenprocoumonhsa04912GnRH signaling pathway7.29E-046Q08828, P51828, P18848, P0DP24, P0DP23, P45985ADCY1, ADCY7, ATF4, CALM2, CALM1, MAP2K4More
Phenprocoumonhsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Phenprocoumonhsa04914Progesterone-mediated oocyte maturation5.80E-0610P08069, Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750IGF1R, CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1More
Phenprocoumonhsa04915Estrogen signaling pathway3.98E-0513Q99527, P14780, P22694, P18848, Q08828, P51828, P31751, P0DMV8, P11142, Q14643, P0DP23, Q15788, P10415GPER1, MMP9, PRKACB, ATF4, ADCY1, ADCY7, AKT2, HSPA1A, HSPA8, ITPR1, CALM1, NCOA1, BCL2More
Phenprocoumonhsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Phenprocoumonhsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Phenprocoumonhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Phenprocoumonhsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Phenprocoumonhsa04921Oxytocin signaling pathway3.84E-034Q15746, Q08828, Q96RR4, Q8WYR1MYLK, ADCY1, CAMKK2, PIK3R5More
Phenprocoumonhsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Phenprocoumonhsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Phenprocoumonhsa04926Relaxin signaling pathway6.40E-0612P31751, P25963, P42338, P62873, P63218, P50151, P18848, P49767, Q08828, P51828, P17252, P30679AKT2, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, ATF4, VEGFC, ADCY1, ADCY7, PRKCA, GNA15More
Phenprocoumonhsa04927Cortisol synthesis and secretion5.17E-045Q14643, P18848, Q08828, P51828, P22694ITPR1, ATF4, ADCY1, ADCY7, PRKACBMore
Phenprocoumonhsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Phenprocoumonhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Phenprocoumonhsa04932Non-alcoholic fatty liver disease8.11E-059P31751, O43521, P18848, O75460, P01584, P13073, P12074, O15239, O95298AKT2, BCL2L11, ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2More
Phenprocoumonhsa04933AGE-RAGE signaling pathway in diabetic complications2.76E-037P84022, Q13485, P42224, P42338, P49767, P17252, P19174SMAD3, SMAD4, STAT1, PIK3CB, VEGFC, PRKCA, PLCG1More
Phenprocoumonhsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Phenprocoumonhsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Phenprocoumonhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Phenprocoumonhsa04964Proximal tubule bicarbonate reclamation1.25E-054P22748, P00918, P49448, P40925CA4, CA2, GLUD2, MDH1More
Phenprocoumonhsa04966Collecting duct acid secretion2.17E-031P00918CA2More
Phenprocoumonhsa04970Salivary secretion1.71E-045Q08828, P51828, P23634, P0DP23, P0DP24ADCY1, ADCY7, ATP2B4, CALM1, CALM2More
Phenprocoumonhsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Phenprocoumonhsa04972Pancreatic secretion1.51E-032Q08828, P62491ADCY1, RAB11AMore
Phenprocoumonhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Phenprocoumonhsa04976Bile secretion1.15E-046O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Phenprocoumonhsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Phenprocoumonhsa05012Parkinson disease4.68E-0412O15239, P13073, P05141, P21796, P60604, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509, P68371NDUFA1, COX4I1, SLC25A5, VDAC1, UBE2G2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Phenprocoumonhsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Phenprocoumonhsa05016Huntington disease2.14E-039O15239, O95298, P13073, P24928, P30876, P62487, P05141, O75460, P28070NDUFA1, NDUFC2, COX4I1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Phenprocoumonhsa05017Spinocerebellar ataxia1.71E-036O75460, Q8TB72, P31751, P28070, P05141, P21796ERN1, PUM2, AKT2, PSMB4, SLC25A5, VDAC1More
Phenprocoumonhsa05020Prion disease9.85E-059P13591, P01584, P11142, O15239, P13073, Q92736, P18848, P05141, O60282NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, RYR2, ATF4, SLC25A5, KIF5CMore
Phenprocoumonhsa05022Pathways of neurodegeneration - multiple diseases1.94E-0312O15239, O95298, P13073, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, Q13557, P28070NDUFA1, NDUFC2, COX4I1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, CAMK2D, PSMB4More
Phenprocoumonhsa05032Morphine addiction1.66E-056P62873, P63218, P50151, Q13370, P17252, P43250GNB1, GNG5, GNG10, PDE3B, PRKCA, GRK6More
Phenprocoumonhsa05034Alcoholism8.95E-0713Q02930, Q13547, P0DP23, P62873, P63218, P50151, Q9BTM1, Q93077, P62807, Q93079, Q16778, O60814, P68431CREB5, HDAC1, CALM1, GNB1, GNG5, GNG10, H2AFJ, HIST1H2AC, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Phenprocoumonhsa05110Vibrio cholerae infection3.28E-044Q13488, P17252, P19174, P60709TCIRG1, PRKCA, PLCG1, ACTBMore
Phenprocoumonhsa05120Epithelial cell signaling in Helicobacter pylori infection8.10E-079Q16539, P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Phenprocoumonhsa05130Pathogenic Escherichia coli infection4.88E-0514Q71U36, Q14247, P56750, O00501, P16333, Q92974, Q13509, P68371, P63261, P25116, Q14344, P25963, Q06124, O95487TUBA1A, CTTN, CLDN17, CLDN5, NCK1, ARHGEF2, TUBB3, TUBB2C, ACTG1, F2R, GNA13, NFKBIA, PTPN11, SEC24BMore
Phenprocoumonhsa05132Salmonella infection5.23E-0411P25963, P08238, P01106, P42338, O00471, O75369, O60282, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, MYC, PIK3CB, EXOC5, FLNB, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41More
Phenprocoumonhsa05133Pertussis1.45E-043P09871, P0C0L4, Q02556C1S, C4A, IRF8More
Phenprocoumonhsa05134Legionellosis5.14E-068P01584, P25963, Q9NR31, P11215, P68104, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Phenprocoumonhsa05140Leishmaniasis6.77E-0512O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Phenprocoumonhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Phenprocoumonhsa05144Malaria2.98E-036P69905, P68871, O60603, P01375, P35443, P26718HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Phenprocoumonhsa05145Toxoplasmosis1.46E-039P25963, Q13489, P23458, P42224, P09917, Q8WYR1, Q13751, P0DMV8, P11142NFKBIA, BIRC3, JAK1, STAT1, ALOX5, PIK3R5, LAMB3, HSPA1A, HSPA8More
Phenprocoumonhsa05146Amoebiasis3.17E-1112P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Phenprocoumonhsa05150Staphylococcus aureus infection2.37E-0610P0C0L4, P21462, O75015, P13646, Q14532, P16109, P59665, P59666, P12838, P49913C4A, FPR1, FCGR3B, KRT13, KRT32, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Phenprocoumonhsa05162Measles2.64E-0513P01568, P25963, P23458, P42224, P14784, P07766, P42338, P0DMV8, P11142, P01584, Q13191, P67870, Q9NP90IFNA21, NFKBIA, JAK1, STAT1, IL2RB, CD3E, PIK3CB, HSPA1A, HSPA8, IL1B, CBLB, CSNK2B, RAB9BMore
Phenprocoumonhsa05163Human cytomegalovirus infection8.22E-1227P31751, P42338, P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P01106, P14778, P01584, P17252, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568AKT2, PIK3CB, TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, MYC, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21More
Phenprocoumonhsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Phenprocoumonhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Phenprocoumonhsa05167Kaposi sarcoma-associated herpesvirus infection4.28E-1117P01568, P42224, P25963, P42338, P40189, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P04141, P0DP23, P0CG47IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CSF2, CALM1, UBBMore
Phenprocoumonhsa05168Herpes simplex virus 1 infection2.39E-0517P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Phenprocoumonhsa05169Epstein-Barr virus infection3.18E-0618P13765, P01106, Q13547, O00463, P25963, P42338, P07948, O00232, P30101, Q13761, P24522, O75293, P42224, P01568, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, NFKBIA, PIK3CB, LYN, PSMD12, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, OAS2, CD3E, CD3G, CD247More
Phenprocoumonhsa05170Human immunodeficiency virus 1 infection8.76E-0817P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P17252, P30101, P01568, P25963, P19174, P23528, P07766, P20333PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PRKCA, PDIA3, IFNA21, NFKBIA, PLCG1, CFL1, CD3E, TNFRSF1BMore
Phenprocoumonhsa05171Coronavirus disease - COVID-196.13E-0523P01584, P25963, P42224, P01568, P23396, P62753, P25398, P62249, P42677, P40429, P36578, P32969, P30050, Q07020, P46776, P62910, P18077, P05386, P62829, P40189, P42338, P19174, P17252IL1B, NFKBIA, STAT1, IFNA21, RPS3, RPS6, RPS12, RPS16, RPS27, RPL13A, RPL4, RPL9, RPL12, RPL18, RPL27A, RPL32, RPL35A, RPLP1, RPL23, IL6ST, PIK3CB, PLCG1, PRKCAMore
Phenprocoumonhsa05200Pathways in cancer5.67E-1133Q13751, P42338, P08238, P42224, P25963, P19174, P01106, P17252, P43246, P84022, Q13485, P20585, P52701, Q13547, P10826, P14923, P30279, P30281, Q13489, P49767, P14921, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, PRKCA, MSH2, SMAD3, SMAD4, MSH3, MSH6, HDAC1, RARB, JUP, CCND2, CCND3, BIRC3, VEGFC, ETS1, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Phenprocoumonhsa05202Transcriptional misregulation in cancer9.68E-0717Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Phenprocoumonhsa05203Viral carcinogenesis3.67E-0822Q12933, Q02930, P23458, P42229, P42338, P06746, P07948, P27348, P29083, Q7KZF4, Q13547, Q15283, P06396, P12814, P25963, P01889, P10321, P06493, P62807, Q93079, Q16778, O60814TRAF2, CREB5, JAK1, STAT5A, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, SND1, HDAC1, RASA2, GSN, ACTN1, NFKBIA, HLA-B, HLA-C, CDK1, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12More
Phenprocoumonhsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Phenprocoumonhsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Phenprocoumonhsa05206MicroRNAs in cancer2.79E-027P30304, P09493, P01106, P42338, Q13547, P20827, P19174CDC25A, TPM1, MYC, PIK3CB, HDAC1, EFNA1, PLCG1More
Phenprocoumonhsa05210Colorectal cancer4.94E-022Q13485, P52701SMAD4, MSH6More
Phenprocoumonhsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Phenprocoumonhsa05212Pancreatic cancer8.78E-059P42338, P31751, Q15311, P23458, P42224, P37173, P84022, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, STAT1, TGFBR2, SMAD3, SMAD4, GADD45BMore
Phenprocoumonhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Phenprocoumonhsa05214Glioma2.42E-066P08069, P0DP23, P17252, P42338, P19174, O75293IGF1R, CALM1, PRKCA, PIK3CB, PLCG1, GADD45BMore
Phenprocoumonhsa05215Prostate cancer1.33E-021P08069IGF1RMore
Phenprocoumonhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Phenprocoumonhsa05218Melanoma2.77E-034P08069, Q9NRA1, P42338, O75293IGF1R, PDGFC, PIK3CB, GADD45BMore
Phenprocoumonhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Phenprocoumonhsa05220Chronic myeloid leukemia1.15E-037Q13547, P01106, Q13485, P25963, P84022, P42338, O75293HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45BMore
Phenprocoumonhsa05222Small cell lung cancer1.10E-026P10826, P42338, Q13751, Q13489, P25963, O75293RARB, PIK3CB, LAMB3, BIRC3, NFKBIA, GADD45BMore
Phenprocoumonhsa05223Non-small cell lung cancer3.64E-067P17252, O43524, P42338, P19174, P10826, Q9HC35, O75293PRKCA, FOXO3, PIK3CB, PLCG1, RARB, EML4, GADD45BMore
Phenprocoumonhsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Phenprocoumonhsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Phenprocoumonhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Phenprocoumonhsa05231Choline metabolism in cancer8.22E-0911P31751, P42338, Q9NRA1, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494, P17252AKT2, PIK3CB, PDGFC, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1, PRKCAMore
Phenprocoumonhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.52E-1314P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Phenprocoumonhsa05310Asthma3.20E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Phenprocoumonhsa05321Inflammatory bowel disease1.06E-046P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Phenprocoumonhsa05322Systemic lupus erythematosus6.08E-0611P08246, P08311, P09871, P01375, P13765, Q93077, P62807, Q16778, O60814, P68431, P12814ELA2, CTSG, C1S, TNF, HLA-DOB, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Phenprocoumonhsa05332Graft-versus-host disease9.64E-055P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Phenprocoumonhsa05340Primary immunodeficiency2.01E-065P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Phenprocoumonhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Phenprocoumonhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Phenprocoumonhsa05415Diabetic cardiomyopathy6.93E-0310P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q13557, P04406PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, CAMK2D, GAPDHMore
Phenprocoumonhsa05418Fluid shear stress and atherosclerosis2.60E-058Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Phenprocoumon (SDC: 9.15)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9BQB6VKORC1Vitamin K epoxide reductase complex subunit 1Reported00.28060.040.16970.39
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P18054ALOX12Polyunsaturated fatty acid lipoxygenase ALOX12Predicted00.00750.37030.24160.986
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P04406GAPDHGlyceraldehydeNone3Nonephosphate dehydrogenasePredicted00.45350.12230.46660.938
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
Q16549PCSK7Proprotein convertase subtilisin/kexin type 7Predicted00.27460.027900.1931
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
O95271TNKSPoly [ADPNoneribose] polymerase tankyraseNone1Predicted00.10170.222400.4957
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P13612ITGA4Integrin alphaNone4Predicted00.11650.23860.68621.2217
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
Q9GZR1SENP6SentrinNonespecific protease 6Predicted00.38440.078400.349
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P16109SELPPNoneselectinPredicted10.15230.07220.57330.7938
P08575PTPRCReceptorNonetype tyrosineNoneprotein phosphatase CPredicted10.27330.13580.41320.8216
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P29350PTPN6TyrosineNoneprotein phosphatase nonNonereceptor type 6Predicted10.28070.24590.56831.2004
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P40925MDH1Malate dehydrogenase, cytoplasmicPredicted00.35660.27460.24260.97
P42892ECE1EndothelinNoneconverting enzyme 1Predicted00.48530.092200.4269
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P37840SNCAAlphaNonesynucleinPredicted10.08530.13240.33210.6395
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P08311CTSGCathepsin GPredicted00.49490.18740.64781.2701
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q8WUM9SLC20A1SodiumNonedependent phosphate transporter 1Predicted00.69560.02700.4018
Q08357SLC20A2SodiumNonedependent phosphate transporter 2Predicted00.08530.02700.0966
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)