PharmaCoNets of Phenoxybenzamine (SPCN: 87.40 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Phenoxybenzaminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Phenoxybenzaminehsa00190Oxidative phosphorylation5.61E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Phenoxybenzaminehsa00230Purine metabolism6.19E-036Q13370, P36959, P20839, Q02153, Q13956, P27707PDE3B, GMPR, IMPDH1, GUCY1B3, PDE6H, DCKMore
Phenoxybenzaminehsa00240Pyrimidine metabolism4.50E-022P32320, P27707CDA, DCKMore
Phenoxybenzaminehsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Phenoxybenzaminehsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin4.77E-021Q7LGA3HS2ST1More
Phenoxybenzaminehsa00565Ether lipid metabolism3.94E-021Q8N661TMEM86BMore
Phenoxybenzaminehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Phenoxybenzaminehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Phenoxybenzaminehsa00670One carbon pool by folate3.99E-022O95954, Q99707FTCD, MTRMore
Phenoxybenzaminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Phenoxybenzaminehsa00920Sulfur metabolism3.01E-021O95571ETHE1More
Phenoxybenzaminehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Phenoxybenzaminehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Phenoxybenzaminehsa01100Metabolic pathways3.95E-0223Q9Y234, Q99707, P29218, P11310, P27707, Q13370, P36959, Q13956, P30043, Q02252, O60701, O14772, O95954, Q02318, P04406, O15466, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809LIPT1, MTR, IMPA1, ACADM, DCK, PDE3B, GMPR, PDE6H, BLVRB, ALDH6A1, UGDH, FPGT, FTCD, CYP27A1, GAPDH, ST8SIA5, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1More
Phenoxybenzaminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Phenoxybenzaminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Phenoxybenzaminehsa01524Platinum drug resistance4.45E-024P10415, Q13489, P78417, P43246BCL2, BIRC3, GSTO1, MSH2More
Phenoxybenzaminehsa02010ABC transporters1.63E-033P45844, P08183, Q99758ABCG1, ABCB1, ABCA3More
Phenoxybenzaminehsa03013RNA transport1.12E-0211P62826, P52298, Q09161, O14893, Q7Z3B4, P35658, P63279, Q14152, O75822, P78345, Q9Y6A5RAN, NCBP2, NCBP1, GEMIN2, NUP54, NUP214, UBE2I, EIF3A, EIF3J, RPP38, TACC3More
Phenoxybenzaminehsa03015mRNA surveillance pathway3.62E-023O43148, P61326, P52298RNMT, MAGOH, NCBP2More
Phenoxybenzaminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Phenoxybenzaminehsa03040Spliceosome1.11E-0718Q14562, O43143, O60508, P17844, O14776, P08579, O75940, P52298, P09651, Q15365, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, P61326DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, MAGOHMore
Phenoxybenzaminehsa03050Proteasome5.53E-032P43686, P28070PSMC4, PSMB4More
Phenoxybenzaminehsa03320PPAR signaling pathway2.18E-022O00767, Q02318SCD, CYP27A1More
Phenoxybenzaminehsa03460Fanconi anemia pathway3.70E-033Q9NPI8, O60673, Q9UNA4FANCF, REV3L, POLIMore
Phenoxybenzaminehsa04014Ras signaling pathway2.65E-039P31751, P20827, P49767, Q13009, P17252, Q15311, P0DP23, P62873, P19174AKT2, EFNA1, VEGFC, TIAM1, PRKCA, RALBP1, CALM1, GNB1, PLCG1More
Phenoxybenzaminehsa04015Rap1 signaling pathway5.41E-039P20827, P49767, Q13009, Q08828, P51828, P31751, P0DP23, P17252, P19174EFNA1, VEGFC, TIAM1, ADCY1, ADCY7, AKT2, CALM1, PRKCA, PLCG1More
Phenoxybenzaminehsa04020Calcium signaling pathway1.04E-0611P27987, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P51828, P23634, P49767ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, VEGFCMore
Phenoxybenzaminehsa04024cAMP signaling pathway3.01E-039Q08828, P51828, P31751, P0DP23, P23634, Q13557, Q13370, O15399, Q13009ADCY1, ADCY7, AKT2, CALM1, ATP2B4, CAMK2D, PDE3B, GRIN2D, TIAM1More
Phenoxybenzaminehsa04062Chemokine signaling pathway2.04E-0210P51684, Q8NHW4, P19174, P62873, Q08828, P51828, Q13009, P14598, P42224, P31751CCR6, CCL4L2, PLCG1, GNB1, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2More
Phenoxybenzaminehsa04064NF-kappa B signaling pathway2.28E-049P10415, Q13489, P51617, P01584, P29965, P19174, O75293, Q8NHW4, Q9NQC7BCL2, BIRC3, IRAK1, IL1B, CD40LG, PLCG1, GADD45B, CCL4L2, CYLDMore
Phenoxybenzaminehsa04070Phosphatidylinositol signaling system5.66E-046P19174, P0DP23, P23743, P48426, P27987, P17252PLCG1, CALM1, DGKA, PIP4K2A, ITPKB, PRKCAMore
Phenoxybenzaminehsa04071Sphingolipid signaling pathway1.60E-039P17252, P21453, Q9H228, P01375, Q13510, Q13362, P10415, Q9UQC2, P01042PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, BCL2, GAB2, KNG1More
Phenoxybenzaminehsa04072Phospholipase D signaling pathway2.03E-028P31751, P19174, P17252, Q15438, Q08828, P51828, P23743, P00734AKT2, PLCG1, PRKCA, PSCD1, ADCY1, ADCY7, DGKA, F2More
Phenoxybenzaminehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Phenoxybenzaminehsa04120Ubiquitin mediated proteolysis2.51E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Phenoxybenzaminehsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Phenoxybenzaminehsa04140Autophagy - animal2.58E-027P31751, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9AKT2, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8More
Phenoxybenzaminehsa04144Endocytosis8.99E-0312P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6More
Phenoxybenzaminehsa04145Phagosome6.51E-0512P60709, P63261, Q15075, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Phenoxybenzaminehsa04151PI3K-Akt signaling pathway4.68E-0318O43521, P27348, P20827, P49767, Q13362, P08238, P62873, P16144, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, Q6ZUJ8BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AB1, GNB1, ITGB4, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, PIK3AP1More
Phenoxybenzaminehsa04210Apoptosis6.18E-033P07384, P60709, P63261CAPN1, ACTB, ACTG1More
Phenoxybenzaminehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Phenoxybenzaminehsa04217Necroptosis3.83E-1121P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P08238, P01584, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351, Q08752TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4B, PPIDMore
Phenoxybenzaminehsa04261Adrenergic signaling in cardiomyocytes4.46E-0713P09493, P07550, Q08828, P51828, P22694, P31751, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Phenoxybenzaminehsa04360Axon guidance8.44E-048P61073, P16333, P20827, O95631, P17252, Q13557, P23528, P19174CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, CFL1, PLCG1More
Phenoxybenzaminehsa04371Apelin signaling pathway3.08E-027P62873, P31751, Q08828, P51828, Q13370, Q13485, P0DP23GNB1, AKT2, ADCY1, ADCY7, PDE3B, SMAD4, CALM1More
Phenoxybenzaminehsa04380Osteoclast differentiation4.18E-027Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1More
Phenoxybenzaminehsa04390Hippo signaling pathway2.80E-022P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa04510Focal adhesion3.76E-027P16144, O75369, Q15942, P17252, Q13489, P10415, P49767ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, VEGFCMore
Phenoxybenzaminehsa04520Adherens junction1.58E-022P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa04530Tight junction6.83E-046P60709, P63261, P16989, P56750, Q14247, P60660ACTB, ACTG1, CSDA, CLDN17, CTTN, MYL6More
Phenoxybenzaminehsa04540Gap junction4.08E-025P17252, Q13509, P68371, Q08828, P51828PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7More
Phenoxybenzaminehsa04611Platelet activation2.61E-022P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Phenoxybenzaminehsa04613Neutrophil extracellular trap formation2.15E-0511P11215, Q13547, P04908, Q93077, P58876, P62807, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Phenoxybenzaminehsa04620Toll-like receptor signaling pathway1.33E-025P51617, P01568, P31751, P42224, Q8NHW4IRAK1, IFNA21, AKT2, STAT1, CCL4L2More
Phenoxybenzaminehsa04621NOD-like receptor signaling pathway3.16E-029P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, P43490, P10415IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, PBEF1, BCL2More
Phenoxybenzaminehsa04623Cytosolic DNA-sensing pathway3.39E-033P01568, P25963, Q8NHW4IFNA21, NFKBIA, CCL4L2More
Phenoxybenzaminehsa04630JAK-STAT signaling pathway1.16E-028P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21More
Phenoxybenzaminehsa04640Hematopoietic cell lineage2.82E-034P08514, P21926, P07766, P09564ITGA2B, CD9, CD3E, CD7More
Phenoxybenzaminehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Phenoxybenzaminehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Phenoxybenzaminehsa04662B cell receptor signaling pathway3.68E-022P25963, P20023NFKBIA, CR2More
Phenoxybenzaminehsa04666Fc gamma R-mediated phagocytosis2.58E-038P08575, P19174, P23528, P06396, O14494, Q9UQC2, P14598, P17252PTPRC, PLCG1, CFL1, GSN, PLPP1, GAB2, NCF1, PRKCAMore
Phenoxybenzaminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Phenoxybenzaminehsa04670Leukocyte transendothelial migration4.07E-022P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Phenoxybenzaminehsa04713Circadian entrainment5.61E-057O15399, P0DP23, Q13557, P17252, P62873, Q08828, P51828GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, ADCY1, ADCY7More
Phenoxybenzaminehsa04714Thermogenesis3.66E-058Q16539, P15336, P60709, P63261, P33121, Q16718, O14521, P36542MAPK14, ATF2, ACTB, ACTG1, ACSL1, NDUFA5, SDHD, ATP5C1More
Phenoxybenzaminehsa04720Long-term potentiation3.26E-036P17252, Q13557, P0DP23, P18848, O15399, Q08828PRKCA, CAMK2D, CALM1, ATF4, GRIN2D, ADCY1More
Phenoxybenzaminehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Phenoxybenzaminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Phenoxybenzaminehsa04724Glutamatergic synapse5.91E-037P48058, O15399, Q08828, P51828, P17252, P62873, P15104GRIA4, GRIN2D, ADCY1, ADCY7, PRKCA, GNB1, GLULMore
Phenoxybenzaminehsa04725Cholinergic synapse4.42E-048Q08828, P51828, P17252, P62873, P18848, Q13557, P31751, P10415ADCY1, ADCY7, PRKCA, GNB1, ATF4, CAMK2D, AKT2, BCL2More
Phenoxybenzaminehsa04727GABAergic synapse4.08E-025Q08828, P51828, P62873, P46459, P17252ADCY1, ADCY7, GNB1, NSF, PRKCAMore
Phenoxybenzaminehsa04740Olfactory transduction5.88E-034P62873, Q9H255, Q13557, P0DP23GNB1, OR51E2, CAMK2D, CALM1More
Phenoxybenzaminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Phenoxybenzaminehsa04744Phototransduction4.66E-072P62873, P0DP23GNB1, CALM1More
Phenoxybenzaminehsa04750Inflammatory mediator regulation of TRP channels4.32E-058P01584, Q08828, P51828, Q13557, P19174, P17252, P0DP23, P01042IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PRKCA, CALM1, KNG1More
Phenoxybenzaminehsa04911Insulin secretion3.47E-024Q08828, P17252, P18848, Q13557ADCY1, PRKCA, ATF4, CAMK2DMore
Phenoxybenzaminehsa04912GnRH signaling pathway2.85E-025P17252, Q08828, P18848, Q13557, P0DP23PRKCA, ADCY1, ATF4, CAMK2D, CALM1More
Phenoxybenzaminehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Phenoxybenzaminehsa04914Progesterone-mediated oocyte maturation3.26E-026Q08828, P51828, P31751, Q13370, Q9UJX4, P08238ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, HSP90AB1More
Phenoxybenzaminehsa04915Estrogen signaling pathway3.28E-039P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2More
Phenoxybenzaminehsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Phenoxybenzaminehsa04919Thyroid hormone signaling pathway3.20E-022P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa04921Oxytocin signaling pathway1.77E-033P60660, P60709, P63261MYL6, ACTB, ACTG1More
Phenoxybenzaminehsa04923Regulation of lipolysis in adipocytes2.12E-024Q08828, P51828, Q13370, P31751ADCY1, ADCY7, PDE3B, AKT2More
Phenoxybenzaminehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Phenoxybenzaminehsa04925Aldosterone synthesis and secretion6.45E-047P18848, Q08828, P51828, P0DP23, P17252, Q13557, P23634ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B4More
Phenoxybenzaminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Phenoxybenzaminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Phenoxybenzaminehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Phenoxybenzaminehsa04933AGE-RAGE signaling pathway in diabetic complications2.04E-068Q13485, P01584, P42224, P10415, P31751, P49767, P17252, P19174SMAD4, IL1B, STAT1, BCL2, AKT2, VEGFC, PRKCA, PLCG1More
Phenoxybenzaminehsa04935Growth hormone synthesis, secretion and action3.93E-026P19174, Q08828, P51828, P17252, P31751, P42224PLCG1, ADCY1, ADCY7, PRKCA, AKT2, STAT1More
Phenoxybenzaminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Phenoxybenzaminehsa04970Salivary secretion9.40E-058P07550, Q08828, P51828, P22694, P23634, P17252, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ATP2B4, PRKCA, CALM1, CAMPMore
Phenoxybenzaminehsa04971Gastric acid secretion1.02E-022P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa04972Pancreatic secretion1.92E-035P23634, P17252, Q08828, P51828, P62491ATP2B4, PRKCA, ADCY1, ADCY7, RAB11AMore
Phenoxybenzaminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Phenoxybenzaminehsa05014Amyotrophic lateral sclerosis2.98E-023P36542, P60709, P63261ATP5C1, ACTB, ACTG1More
Phenoxybenzaminehsa05017Spinocerebellar ataxia3.80E-038P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12More
Phenoxybenzaminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Phenoxybenzaminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Phenoxybenzaminehsa05031Amphetamine addiction3.62E-037O15399, P0DP23, Q13557, P22694, P18848, P17252, Q13547GRIN2D, CALM1, CAMK2D, PRKACB, ATF4, PRKCA, HDAC1More
Phenoxybenzaminehsa05032Morphine addiction4.08E-025Q08828, P51828, P62873, Q13370, P17252ADCY1, ADCY7, GNB1, PDE3B, PRKCAMore
Phenoxybenzaminehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Phenoxybenzaminehsa05100Bacterial invasion of epithelial cells1.02E-022P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa05110Vibrio cholerae infection3.95E-032P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa05131Shigellosis1.91E-023P60709, P63261, P07384ACTB, ACTG1, CAPN1More
Phenoxybenzaminehsa05132Salmonella infection6.81E-0516P51617, P01584, P08238, Q9UJU2, Q96RF0, Q13489, P10415, P08575, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371, P49754, Q9NP90IRAK1, IL1B, HSP90AB1, LEF1, SNAG1, BIRC3, BCL2, PTPRC, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41, RAB9BMore
Phenoxybenzaminehsa05133Pertussis3.94E-045P0DP23, P01584, P23528, P09871, P51617CALM1, IL1B, CFL1, C1S, IRAK1More
Phenoxybenzaminehsa05135Yersinia infection3.88E-033P60709, P63261, Q16513ACTB, ACTG1, PKN2More
Phenoxybenzaminehsa05140Leishmaniasis1.10E-036P14598, P42224, O60603, P25963, P29350, Q15080NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4More
Phenoxybenzaminehsa05143African trypanosomiasis3.56E-035P01375, P01584, P48023, P17252, P01042TNF, IL1B, FASLG, PRKCA, KNG1More
Phenoxybenzaminehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Phenoxybenzaminehsa05145Toxoplasmosis5.28E-059P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RAMore
Phenoxybenzaminehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Phenoxybenzaminehsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Phenoxybenzaminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Phenoxybenzaminehsa05161Hepatitis B1.31E-0410P17252, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617PRKCA, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1More
Phenoxybenzaminehsa05162Measles1.74E-0410P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2More
Phenoxybenzaminehsa05163Human cytomegalovirus infection2.59E-0314P31751, P62873, P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, P17252, Q13651, P18848, P61769, P01568AKT2, GNB1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, PRKCA, IL10RA, ATF4, B2M, IFNA21More
Phenoxybenzaminehsa05164Influenza A7.10E-033P48551, P60709, P63261IFNAR2, ACTB, ACTG1More
Phenoxybenzaminehsa05168Herpes simplex virus 1 infection4.65E-0723P25963, P01568, P01584, Q05823, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P61769, P31751, Q13398, Q9HCX3, Q6P280, Q03923, P52738, O75820, Q9UDV6, P10415, Q14232NFKBIA, IFNA21, IL1B, RNASEL, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, B2M, AKT2, ZNF211, ZNF304, ZNF529, ZNF85, ZNF140, ZNF189, ZNF212, BCL2, EIF2B1More
Phenoxybenzaminehsa05170Human immunodeficiency virus 1 infection8.60E-0716P31751, P62873, P0DP23, P61073, P17252, O00463, P61769, Q14643, P01568, P51617, O60603, P19174, P23528, P10415, Q93034, Q9Y6Q5AKT2, GNB1, CALM1, CXCR4, PRKCA, TRAF5, B2M, ITPR1, IFNA21, IRAK1, TLR2, PLCG1, CFL1, BCL2, CUL5, AP1M2More
Phenoxybenzaminehsa05200Pathways in cancer4.30E-0928P23458, P08238, P42224, P19174, Q15311, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P31751, Q08828, P51828, P62873, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042JAK1, HSP90AB1, STAT1, PLCG1, RALBP1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, AKT2, ADCY1, ADCY7, GNB1, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1More
Phenoxybenzaminehsa05202Transcriptional misregulation in cancer4.29E-0315Q12778, Q15532, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, Q13547, P12980FOXO1, SS18, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, HDAC1, LYL1More
Phenoxybenzaminehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Phenoxybenzaminehsa05204Chemical carcinogenesis2.59E-044P00325, P78417, P11712, P33260ADH1B, GSTO1, CYP2C9, CYP2C18More
Phenoxybenzaminehsa05205Proteoglycans in cancer1.39E-0313Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63More
Phenoxybenzaminehsa05206MicroRNAs in cancer4.07E-022P15311, P63279VIL2, UBE2IMore
Phenoxybenzaminehsa05212Pancreatic cancer5.55E-036P31751, Q15311, P23458, P42224, Q13485, O75293AKT2, RALBP1, JAK1, STAT1, SMAD4, GADD45BMore
Phenoxybenzaminehsa05214Glioma1.87E-056P0DP23, Q13557, P17252, P31751, P19174, O75293CALM1, CAMK2D, PRKCA, AKT2, PLCG1, GADD45BMore
Phenoxybenzaminehsa05225Hepatocellular carcinoma4.07E-022P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Phenoxybenzaminehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Phenoxybenzaminehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Phenoxybenzaminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Phenoxybenzaminehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Phenoxybenzaminehsa05340Primary immunodeficiency2.68E-022P11912, P07766CD79A, CD3EMore
Phenoxybenzaminehsa05410Hypertrophic cardiomyopathy1.02E-022P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa05412Arrhythmogenic right ventricular cardiomyopathy8.96E-032P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa05414Dilated cardiomyopathy1.73E-022P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Phenoxybenzaminehsa05416Viral myocarditis8.96E-032P60709, P63261ACTB, ACTG1More
Phenoxybenzaminehsa05418Fluid shear stress and atherosclerosis3.64E-038P14598, P78417, P60709, P63261, P10415, P0DP23, P08238, Q92974NCF1, GSTO1, ACTB, ACTG1, BCL2, CALM1, HSP90AB1, ARHGEF2More

Community members of Phenoxybenzamine (SDC: 4.35)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P0DP23CALM1CalmodulinNone1Reported00.45520.147911.5235
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P0DP25CALM3CalmodulinNone3Predicted00.56610.147900.5789
P0DP24CALM2CalmodulinNone2Predicted00.43760.147900.5147
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P60660MYL6Myosin light polypeptide 6Predicted00.55950.06870.21750.6346
P24844MYL9Myosin regulatory light polypeptide 9Predicted00.00640.0630.60260.7318
P14649MYL6BMyosin light chain 6BPredicted00.04770.06530.21750.3719
P05976MYL1Myosin light chain 1/3, skeletal muscle isoformPredicted00.25810.061900.2528
O15182CETN3CentrinNone3Predicted00.18720.059400.2123
Q96A32MYLPFMyosin regulatory light chain 2, skeletal muscle isoformPredicted00.01350.04730.54120.6425
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
ADRB2P07550Ki>10000