PharmaCoNets of Phenobarbital (SPCN: 34.63 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Methylphenobarbitalhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Methylphenobarbitalhsa00500Starch and sucrose metabolism2.86E-022O43451, P46976MGAM, GYG1More
Methylphenobarbitalhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Methylphenobarbitalhsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Methylphenobarbitalhsa00770Pantothenate and CoA biosynthesis1.78E-022O95498, O95497VNN2, VNN1More
Methylphenobarbitalhsa00983Drug metabolism - other enzymes3.59E-023P04183, P32320, P05164TK1, CDA, MPOMore
Methylphenobarbitalhsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Methylphenobarbitalhsa03008Ribosome biogenesis in eukaryotes2.86E-036Q9NYH9, P19784, P67870, P78345, Q9BVP2, Q9GZY0UTP6, CSNK2A2, CSNK2B, RPP38, GNL3, NXF2; NXF2BMore
Methylphenobarbitalhsa03013RNA transport3.27E-028P52298, P61326, Q9GZY0, Q14152, O75822, P78345, Q9Y6A5, Q53GS7NCBP2, MAGOH, NXF2; NXF2B, EIF3A, EIF3J, RPP38, TACC3, GLE1More
Methylphenobarbitalhsa03015mRNA surveillance pathway9.78E-036O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Methylphenobarbitalhsa03050Proteasome1.40E-021P55036PSMD4More
Methylphenobarbitalhsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Methylphenobarbitalhsa04071Sphingolipid signaling pathway3.88E-039P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2More
Methylphenobarbitalhsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Methylphenobarbitalhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Methylphenobarbitalhsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Methylphenobarbitalhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Methylphenobarbitalhsa04145Phagosome3.27E-049P63261, Q15080, P14598, Q13509, P68371, P05164, O60603, P35443, P13765ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, TLR2, THBS4, HLA-DOBMore
Methylphenobarbitalhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Methylphenobarbitalhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Methylphenobarbitalhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Methylphenobarbitalhsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Methylphenobarbitalhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Methylphenobarbitalhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Methylphenobarbitalhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Methylphenobarbitalhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Methylphenobarbitalhsa04540Gap junction3.53E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Methylphenobarbitalhsa04612Antigen processing and presentation2.40E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Methylphenobarbitalhsa04613Neutrophil extracellular trap formation3.45E-0316P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, P63261, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, ACTG1, AQP9, MAPK14More
Methylphenobarbitalhsa04621NOD-like receptor signaling pathway4.94E-0313Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P59665, P59666, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA1; DEFA1B, DEFA3, DEFA4More
Methylphenobarbitalhsa04640Hematopoietic cell lineage4.27E-024P08514, P14778, P01730, P13765ITGA2B, IL1R1, CD4, HLA-DOBMore
Methylphenobarbitalhsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Methylphenobarbitalhsa04657IL-17 signaling pathway3.91E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Methylphenobarbitalhsa04658Th1 and Th2 cell differentiation1.12E-028Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Methylphenobarbitalhsa04659Th17 cell differentiation2.33E-037P25963, Q16539, P01730, P13765, P14778, P84022, Q13485NFKBIA, MAPK14, CD4, HLA-DOB, IL1R1, SMAD3, SMAD4More
Methylphenobarbitalhsa04660T cell receptor signaling pathway3.76E-0311P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Methylphenobarbitalhsa04666Fc gamma R-mediated phagocytosis9.96E-035P23528, P49006, P06396, P14598, P17252CFL1, MARCKSL1, GSN, NCF1, PRKCAMore
Methylphenobarbitalhsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Methylphenobarbitalhsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Methylphenobarbitalhsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Methylphenobarbitalhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Methylphenobarbitalhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Methylphenobarbitalhsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Methylphenobarbitalhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Methylphenobarbitalhsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Methylphenobarbitalhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Methylphenobarbitalhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Methylphenobarbitalhsa04972Pancreatic secretion3.42E-035Q14643, P20020, P17252, P63092, P61586ITPR1, ATP2B1, PRKCA, GNAS, RHOAMore
Methylphenobarbitalhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Methylphenobarbitalhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Methylphenobarbitalhsa05132Salmonella infection2.05E-0310P25963, Q9UJU2, P63261, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371NFKBIA, LEF1, ACTG1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Methylphenobarbitalhsa05140Leishmaniasis2.14E-039P13612, O75015, P14598, P13765, O60603, P01375, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MARCKSL1, MAPK14, NCF4More
Methylphenobarbitalhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Methylphenobarbitalhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Methylphenobarbitalhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Methylphenobarbitalhsa05146Amoebiasis3.91E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Methylphenobarbitalhsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Methylphenobarbitalhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Methylphenobarbitalhsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Methylphenobarbitalhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Methylphenobarbitalhsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Methylphenobarbitalhsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Methylphenobarbitalhsa05202Transcriptional misregulation in cancer8.43E-0420Q12778, Q15532, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, SS18, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Methylphenobarbitalhsa05205Proteoglycans in cancer2.66E-028Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63More
Methylphenobarbitalhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Methylphenobarbitalhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Methylphenobarbitalhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Methylphenobarbitalhsa05216Thyroid cancer3.59E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Methylphenobarbitalhsa05217Basal cell carcinoma1.46E-024Q13635, Q9UJU2, P04637, P24522PTCH1, LEF1, TP53, GADD45AMore
Methylphenobarbitalhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Methylphenobarbitalhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Methylphenobarbitalhsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Methylphenobarbitalhsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Methylphenobarbitalhsa05321Inflammatory bowel disease3.16E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Methylphenobarbitalhsa05323Rheumatoid arthritis3.53E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Methylphenobarbitalhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Methylphenobarbitalhsa05332Graft-versus-host disease4.38E-035P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Methylphenobarbitalhsa05340Primary immunodeficiency1.58E-023P01730, P11912, Q8WV28CD4, CD79A, BLNKMore
Methylphenobarbitalhsa05418Fluid shear stress and atherosclerosis4.26E-026P14598, P14780, P63261, P04637, P10415, Q92974NCF1, MMP9, ACTG1, TP53, BCL2, ARHGEF2More
Phenobarbitalhsa00310Lysine degradation1.53E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Phenobarbitalhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Phenobarbitalhsa00500Starch and sucrose metabolism2.86E-022O43451, P46976MGAM, GYG1More
Phenobarbitalhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Phenobarbitalhsa00562Inositol phosphate metabolism2.54E-034P27987, Q13572, Q96PE3, P42338ITPKB, ITPK1, INPP4A, PIK3CBMore
Phenobarbitalhsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Phenobarbitalhsa00770Pantothenate and CoA biosynthesis1.78E-022O95498, O95497VNN2, VNN1More
Phenobarbitalhsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Phenobarbitalhsa01522Endocrine resistance4.55E-025P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Phenobarbitalhsa03040Spliceosome3.94E-048Q14562, O43143, O60508, P08579, P26368, Q13595, Q01130, O43447DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, PPIHMore
Phenobarbitalhsa03050Proteasome1.40E-021P55036PSMD4More
Phenobarbitalhsa04014Ras signaling pathway3.62E-025P42338, P49767, P0DP23, P63218, P50151PIK3CB, VEGFC, CALM1, GNG5, GNG10More
Phenobarbitalhsa04020Calcium signaling pathway5.15E-058P27987, P21796, Q16566, P30679, O15399, P0DP23, P23634, P49767ITPKB, VDAC1, CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Phenobarbitalhsa04024cAMP signaling pathway1.49E-025P42338, P0DP23, P23634, Q16566, O15399PIK3CB, CALM1, ATP2B4, CAMK4, GRIN2DMore
Phenobarbitalhsa04064NF-kappa B signaling pathway9.28E-0310P10415, Q13489, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P24522BCL2, BIRC3, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, GADD45AMore
Phenobarbitalhsa04070Phosphatidylinositol signaling system1.49E-035P0DP23, P42338, Q96PE3, Q13572, P27987CALM1, PIK3CB, INPP4A, ITPK1, ITPKBMore
Phenobarbitalhsa04071Sphingolipid signaling pathway8.09E-048P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Phenobarbitalhsa04080Neuroactive ligand-receptor interaction4.72E-028P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1More
Phenobarbitalhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Phenobarbitalhsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Phenobarbitalhsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Phenobarbitalhsa04145Phagosome1.08E-028O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOBMore
Phenobarbitalhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Phenobarbitalhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Phenobarbitalhsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Phenobarbitalhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Phenobarbitalhsa04371Apelin signaling pathway7.45E-035P63218, P50151, Q13485, Q16566, P0DP23GNG5, GNG10, SMAD4, CAMK4, CALM1More
Phenobarbitalhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Phenobarbitalhsa04612Antigen processing and presentation2.40E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Phenobarbitalhsa04613Neutrophil extracellular trap formation6.32E-0416P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Phenobarbitalhsa04621NOD-like receptor signaling pathway4.94E-0313Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P59665, P59666, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA1; DEFA1B, DEFA3, DEFA4More
Phenobarbitalhsa04640Hematopoietic cell lineage4.27E-024P08514, P14778, P01730, P13765ITGA2B, IL1R1, CD4, HLA-DOBMore
Phenobarbitalhsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Phenobarbitalhsa04657IL-17 signaling pathway3.91E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Phenobarbitalhsa04658Th1 and Th2 cell differentiation1.12E-028Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Phenobarbitalhsa04659Th17 cell differentiation2.33E-037P25963, Q16539, P01730, P13765, P14778, P84022, Q13485NFKBIA, MAPK14, CD4, HLA-DOB, IL1R1, SMAD3, SMAD4More
Phenobarbitalhsa04660T cell receptor signaling pathway3.76E-0311P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Phenobarbitalhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Phenobarbitalhsa04666Fc gamma R-mediated phagocytosis3.62E-038O75015, P07948, P42338, P23528, P06396, O14494, P14598, P17252FCGR3B, LYN, PIK3CB, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Phenobarbitalhsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Phenobarbitalhsa04713Circadian entrainment8.43E-034O15399, P0DP23, P63218, P50151GRIN2D, CALM1, GNG5, GNG10More
Phenobarbitalhsa04720Long-term potentiation6.32E-046Q16566, P16298, P0DP23, P51812, O15399, Q02750CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1More
Phenobarbitalhsa04724Glutamatergic synapse4.10E-023O15399, P63218, P50151GRIN2D, GNG5, GNG10More
Phenobarbitalhsa04725Cholinergic synapse5.94E-034P63218, P50151, Q16566, P42338GNG5, GNG10, CAMK4, PIK3CBMore
Phenobarbitalhsa04726Serotonergic synapse1.52E-024P63218, P50151, P33260, P09917GNG5, GNG10, CYP2C18, ALOX5More
Phenobarbitalhsa04728Dopaminergic synapse4.47E-024P63218, P50151, P0DP23, O00327GNG5, GNG10, CALM1, ARNTLMore
Phenobarbitalhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Phenobarbitalhsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Phenobarbitalhsa04925Aldosterone synthesis and secretion3.14E-023P0DP23, Q16566, P23634CALM1, CAMK4, ATP2B4More
Phenobarbitalhsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P30679PIK3CB, GNG5, GNG10, VEGFC, GNA15More
Phenobarbitalhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Phenobarbitalhsa04940Type I diabetes mellitus2.61E-034P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Phenobarbitalhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Phenobarbitalhsa05017Spinocerebellar ataxia5.94E-034Q8TB72, O15399, P42338, P21796PUM2, GRIN2D, PIK3CB, VDAC1More
Phenobarbitalhsa05032Morphine addiction1.09E-022P78334, P32298GABRE, GRK4More
Phenobarbitalhsa05034Alcoholism3.62E-025O15399, Q16566, P0DP23, P63218, P50151GRIN2D, CAMK4, CALM1, GNG5, GNG10More
Phenobarbitalhsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Phenobarbitalhsa05140Leishmaniasis4.75E-049P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4More
Phenobarbitalhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Phenobarbitalhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Phenobarbitalhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Phenobarbitalhsa05146Amoebiasis3.91E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Phenobarbitalhsa05150Staphylococcus aureus infection1.29E-039P21730, P21462, O75015, P13765, Q16581, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Phenobarbitalhsa05152Tuberculosis8.54E-039O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Phenobarbitalhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Phenobarbitalhsa05163Human cytomegalovirus infection4.19E-025P42338, P63218, P50151, P0DP23, P30101PIK3CB, GNG5, GNG10, CALM1, PDIA3More
Phenobarbitalhsa05167Kaposi sarcoma-associated herpesvirus infection2.44E-039P42338, P62879, P63218, P50151, P16298, Q02750, P07948, P0DP23, P0CG47PIK3CB, GNB2, GNG5, GNG10, PPP3CB, MAP2K1, LYN, CALM1, UBBMore
Phenobarbitalhsa05170Human immunodeficiency virus 1 infection7.38E-0411P42338, Q02750, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P23528, P20333PIK3CB, MAP2K1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, CFL1, TNFRSF1BMore
Phenobarbitalhsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Phenobarbitalhsa05202Transcriptional misregulation in cancer2.28E-0317Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Phenobarbitalhsa05204Chemical carcinogenesis4.62E-022P78417, P33260GSTO1, CYP2C18More
Phenobarbitalhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Phenobarbitalhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Phenobarbitalhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Phenobarbitalhsa05214Glioma2.32E-023P0DP23, Q16566, P42338CALM1, CAMK4, PIK3CBMore
Phenobarbitalhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Phenobarbitalhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Phenobarbitalhsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Phenobarbitalhsa05310Asthma9.08E-043P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Phenobarbitalhsa05321Inflammatory bowel disease9.03E-056O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Phenobarbitalhsa05322Systemic lupus erythematosus2.82E-028O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Phenobarbitalhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Phenobarbitalhsa05332Graft-versus-host disease2.45E-046P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Phenobarbitalhsa05340Primary immunodeficiency1.58E-023P01730, P11912, Q8WV28CD4, CD79A, BLNKMore

Community members of Phenobarbital (SDC: 3.01)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O15399GRIN2DGlutamate receptor ionotropic, NMDA 2DReported00.10350.15650.64481.0095
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Reported10.03150.949301.9143
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P48058GRIA4Glutamate receptor 4Predicted00.40370.12090.37480.8184
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonPredicted00.13940.40970.15791.0469
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Predicted00.15590.43870.16951.1248
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)