PharmaCoNets of Phenmetrazine (SPCN: 6.82 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Phenmetrazinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Phenmetrazinehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Phenmetrazinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Phenmetrazinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Phenmetrazinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Phenmetrazinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Phenmetrazinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Phenmetrazinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Phenmetrazinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Phenmetrazinehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Phenmetrazinehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Phenmetrazinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Phenmetrazinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Phenmetrazinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Phenmetrazinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Phenmetrazinehsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Phenmetrazinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Phenmetrazinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Phenmetrazinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Phenmetrazinehsa05133Pertussis4.94E-021P0C0L4C4AMore
Phenmetrazinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Phenmetrazinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Phenmetrazinehsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Phenmetrazinehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Phenmetrazinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Phenmetrazinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Phenmetrazinehsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Phenmetrazinehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Phenmetrazinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Phenmetrazine (SDC: 2.22)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)