PharmaCoNets

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Brompheniramine

hsa00630

Glyoxylate and dicarboxylate metabolism

4.29E-03

P40925, P15104

MDH1, GLUL

Brompheniramine

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Brompheniramine

Drug metabolism - other enzymes

3.50E-02

P04183, P32320, P05164

TK1, CDA, MPO

Brompheniramine

hsa01100

Metabolic pathways

4.11E-02

P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6

PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95931	CBX7	Chromobox protein homolog 7	P30041	PRDX6	Peroxiredoxin-6	0.72
O95931	CBX7	Chromobox protein homolog 7	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.771
O95931	CBX7	Chromobox protein homolog 7	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.702
O95931	CBX7	Chromobox protein homolog 7	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.726
O95931	CBX7	Chromobox protein homolog 7	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.798
O95931	CBX7	Chromobox protein homolog 7	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.762
O95931	CBX7	Chromobox protein homolog 7	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.731
O95931	CBX7	Chromobox protein homolog 7	P30041	PRDX6	Peroxiredoxin-6	0.72
O95931	CBX7	Chromobox protein homolog 7	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.771
O95931	CBX7	Chromobox protein homolog 7	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.702
O95931	CBX7	Chromobox protein homolog 7	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.726
O95931	CBX7	Chromobox protein homolog 7	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.798
O95931	CBX7	Chromobox protein homolog 7	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.762
O95931	CBX7	Chromobox protein homolog 7	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.731
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Brompheniramine

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Brompheniramine

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Brompheniramine

hsa03040

Spliceosome

6.28E-03

Q14562, O43143, O60508, Q07955, Q01130, Q13243

DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5

Brompheniramine

Proteasome

1.21E-02

P28074

PSMB5

Brompheniramine

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Brompheniramine

cAMP signaling pathway

4.38E-02

P42338, P0DP23, Q13370, Q13009

PIK3CB, CALM1, PDE3B, TIAM1

Brompheniramine

NF-kappa B signaling pathway

1.60E-02

P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341

BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7

Brompheniramine

hsa04070

Phosphatidylinositol signaling system

4.86E-02

P0DP23, P42338, P27987

CALM1, PIK3CB, ITPKB

Brompheniramine

Sphingolipid signaling pathway

2.96E-02

P21453, Q9H228, Q13362, Q9BX95, P10415

S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.773
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.799
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.917
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P21462	FPR1	fMet-Leu-Phe receptor	P17252	PRKCA	Protein kinase C alpha type	-0.731
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P21462	FPR1	fMet-Leu-Phe receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.716
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P21462	FPR1	fMet-Leu-Phe receptor	P01375	TNF	Tumor necrosis factor	0.77
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P21462	FPR1	fMet-Leu-Phe receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.878
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P21462	FPR1	fMet-Leu-Phe receptor	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.932
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P21462	FPR1	fMet-Leu-Phe receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.855

Brompheniramine

Neuroactive ligand-receptor interaction

3.22E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1

Brompheniramine

hsa04114

Oocyte meiosis

6.23E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Brompheniramine

p53 signaling pathway

3.98E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Brompheniramine

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Brompheniramine

Apoptosis

3.77E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1

Brompheniramine

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P02768	ALB	Albumin	P15104	GLUL	Glutamine synthetase	0.717
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P0C0S5	H2AFZ	Histone H2A.Z	0.756
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771

Brompheniramine

hsa04330

Notch signaling pathway

7.49E-03

Q92542, P49768

NCSTN, PSEN1

Brompheniramine

Axon guidance

1.71E-02

P20827, O95631, P42338, P23528

EFNA1, NTN1, PIK3CB, CFL1

Brompheniramine

VEGF signaling pathway

3.06E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Brompheniramine

Signaling pathways regulating pluripotency of stem cells

4.73E-02

Q13873, Q02750, Q86SE9

BMPR2, MAP2K1, PCGF5

Brompheniramine

Antigen processing and presentation

3.21E-02

P13765, P48382, P26715, P26717, Q13241, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755

Brompheniramine

Neutrophil extracellular trap formation

4.20E-02

P04908, Q93077, P68431, O43315, Q16539

H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Brompheniramine

Natural killer cell mediated cytotoxicity

3.73E-02

P16298, P50591, Q02750

PPP3CB, TNFSF10, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Brompheniramine

hsa04659

Th17 cell differentiation

4.38E-02

P42224, P14784, P40189, P08238

STAT1, IL2RB, IL6ST, HSP90AB1

Brompheniramine

Fc gamma R-mediated phagocytosis

3.08E-02

P42338, P23528, P14598

PIK3CB, CFL1, NCF1

Brompheniramine

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Brompheniramine

Long-term potentiation

2.85E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Brompheniramine

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Brompheniramine

Cholinergic synapse

4.83E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Brompheniramine

Progesterone-mediated oocyte maturation

9.70E-04

Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1

Brompheniramine

Estrogen signaling pathway

2.96E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Brompheniramine

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Brompheniramine

Thyroid hormone signaling pathway

3.71E-02

P26678, P08237

PLN, PFKM

Brompheniramine

Renin secretion

3.77E-02

Q13370, P0DP23

PDE3B, CALM1

Brompheniramine

Cortisol synthesis and secretion

8.60E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Brompheniramine

Parathyroid hormone synthesis, secretion and action

2.13E-02

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81

Brompheniramine

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Brompheniramine

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Brompheniramine

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Brompheniramine

Spinocerebellar ataxia

2.43E-02

P28074

PSMB5

Brompheniramine

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P02768	ALB	Albumin	P13591	NCAM1	Neural cell adhesion molecule 1	0.701
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.72
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Brompheniramine

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859

Brompheniramine

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Brompheniramine

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Brompheniramine

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Brompheniramine

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Brompheniramine

hsa05168

Herpes simplex virus 1 infection

1.15E-02

P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6

STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824

Brompheniramine

hsa05200

Pathways in cancer

3.92E-02

P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189

PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6ST

Brompheniramine

Transcriptional misregulation in cancer

1.77E-02

Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522

SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q12778	FOXO1	Forkhead box protein O1	0.777
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15532	SS18	Protein SSXT	0.763
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14923	JUP	Junction plakoglobin	0.845
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.754
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08246	ELA2	Neutrophil elastase	-0.896
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.787
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812

Brompheniramine

Pancreatic cancer

1.72E-02

P42338, P42224, O75293

PIK3CB, STAT1, GADD45B

Brompheniramine

Glioma

1.72E-02

P0DP23, P42338, O75293

CALM1, PIK3CB, GADD45B

Brompheniramine

Inflammatory bowel disease

2.29E-02

P13765, Q14765, P23771, Q9HBE5

HLA-DOB, STAT4, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P07550	ADRB2	Beta-2 adrenergic receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.826
P07550	ADRB2	Beta-2 adrenergic receptor	Q9UL17	TBX21	T-box transcription factor TBX21	0.758
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P07550	ADRB2	Beta-2 adrenergic receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.826
P07550	ADRB2	Beta-2 adrenergic receptor	Q9UL17	TBX21	T-box transcription factor TBX21	0.758
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718

Brompheniramine

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Brompheniramine

Graft-versus-host disease

7.94E-04

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838

Brompheniramine

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725

Brompheniramine

hsa05418

Fluid shear stress and atherosclerosis

3.73E-02

P42338, P14598, P0DP23, P08238

PIK3CB, NCF1, CALM1, HSP90AB1

Chlorpheniramine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Chlorpheniramine

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Chlorpheniramine

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Chlorpheniramine

hsa00500

Starch and sucrose metabolism

1.67E-02

O43451, P06737

MGAM, PYGL

Chlorpheniramine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Chlorpheniramine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Chlorpheniramine

hsa00600

Sphingolipid metabolism

4.77E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Chlorpheniramine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.87E-03

P06865, O15466, Q9H4F1

HEXA, ST8SIA5, ST6GALNAC4

Chlorpheniramine

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Chlorpheniramine

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Chlorpheniramine

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Chlorpheniramine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Chlorpheniramine

Drug metabolism - other enzymes

3.09E-04

P04183, P32320, P05164

TK1, CDA, MPO

Chlorpheniramine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Chlorpheniramine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Chlorpheniramine

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Chlorpheniramine

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P04049

RAF1

Chlorpheniramine

hsa01522

Endocrine resistance

2.16E-02

P04049

RAF1

Chlorpheniramine

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Chlorpheniramine

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Chlorpheniramine

hsa03013

RNA transport

2.12E-02

P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.956
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O14893	GEMIN2	Gem-associated protein 2	0.925
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P61326	MAGOH	Protein mago nashi homolog	0.761
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q7Z3B4	NUP54	Nucleoporin p54	0.854
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.79
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.715
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.793
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P78345	RPP38	Ribonuclease P protein subunit p38	0.819
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.891
P21462	FPR1	fMet-Leu-Phe receptor	O14980	XPO1	Exportin-1	-0.742
P21462	FPR1	fMet-Leu-Phe receptor	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.874
P21462	FPR1	fMet-Leu-Phe receptor	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.78
P21462	FPR1	fMet-Leu-Phe receptor	O14893	GEMIN2	Gem-associated protein 2	-0.87
P21462	FPR1	fMet-Leu-Phe receptor	P61326	MAGOH	Protein mago nashi homolog	-0.835
P21462	FPR1	fMet-Leu-Phe receptor	Q7Z3B4	NUP54	Nucleoporin p54	-0.903
P21462	FPR1	fMet-Leu-Phe receptor	P35658	NUP214	Nuclear pore complex protein Nup214	0.971
P21462	FPR1	fMet-Leu-Phe receptor	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.89
P21462	FPR1	fMet-Leu-Phe receptor	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.953
P21462	FPR1	fMet-Leu-Phe receptor	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	-0.721
P21462	FPR1	fMet-Leu-Phe receptor	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.904
P21462	FPR1	fMet-Leu-Phe receptor	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	-0.713

Chlorpheniramine

hsa03020

RNA polymerase

3.59E-02

P30876, P62487

POLR2B, POLR2G

Chlorpheniramine

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Chlorpheniramine

Proteasome

1.21E-02

P28074

PSMB5

Chlorpheniramine

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Chlorpheniramine

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Chlorpheniramine

hsa04010

MAPK signaling pathway

4.15E-02

P04049

RAF1

Chlorpheniramine

hsa04012

ErbB signaling pathway

1.82E-02

P04049

RAF1

Chlorpheniramine

hsa04014

Ras signaling pathway

3.65E-02

P04049

RAF1

Chlorpheniramine

hsa04015

Rap1 signaling pathway

2.99E-02

P04049

RAF1

Chlorpheniramine

hsa04022

cGMP-PKG signaling pathway

3.15E-02

P04049

RAF1

Chlorpheniramine

cAMP signaling pathway

2.49E-02

P04049

RAF1

Chlorpheniramine

hsa04062

Chemokine signaling pathway

3.98E-02

P04049

RAF1

Chlorpheniramine

NF-kappa B signaling pathway

1.60E-02

P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341

BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7

Chlorpheniramine

hsa04068

FoxO signaling pathway

1.99E-02

P04049

RAF1

Chlorpheniramine

Sphingolipid signaling pathway

8.30E-06

P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2

RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.773
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.799
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.917
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P21462	FPR1	fMet-Leu-Phe receptor	P17252	PRKCA	Protein kinase C alpha type	-0.731
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P21462	FPR1	fMet-Leu-Phe receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.716
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P21462	FPR1	fMet-Leu-Phe receptor	P01375	TNF	Tumor necrosis factor	0.77
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P21462	FPR1	fMet-Leu-Phe receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.878
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P21462	FPR1	fMet-Leu-Phe receptor	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.932
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P21462	FPR1	fMet-Leu-Phe receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.855

Chlorpheniramine

hsa04072

Phospholipase D signaling pathway

2.82E-02

P04049

RAF1

Chlorpheniramine

Neuroactive ligand-receptor interaction

2.16E-03

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1

Chlorpheniramine

hsa04114

Oocyte meiosis

6.23E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Chlorpheniramine

p53 signaling pathway

3.98E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Chlorpheniramine

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Chlorpheniramine

hsa04140

Autophagy - animal

2.82E-02

P04049

RAF1

Chlorpheniramine

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Chlorpheniramine

hsa04145

Phagosome

3.82E-03

Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4

Chlorpheniramine

hsa04150

mTOR signaling pathway

2.32E-02

P04049

RAF1

Chlorpheniramine

Apoptosis

5.97E-04

Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, P18848, Q14643, P04049

ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ATF4, ITPR1, RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1

Chlorpheniramine

hsa04213

Longevity regulating pathway - multiple species

2.85E-02

Q9Y4H2, Q13547

IRS2, HDAC1

Chlorpheniramine

Necroptosis

4.24E-05

P01375, P48023, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557

TNF, FASLG, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P02768	ALB	Albumin	P15104	GLUL	Glutamine synthetase	0.717
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P0C0S5	H2AFZ	Histone H2A.Z	0.756
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771

Chlorpheniramine

hsa04218

Cellular senescence

2.49E-02

P04049

RAF1

Chlorpheniramine

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Chlorpheniramine

hsa04270

Vascular smooth muscle contraction

2.32E-02

P04049

RAF1

Chlorpheniramine

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Chlorpheniramine

Axon guidance

2.49E-02

P04049

RAF1

Chlorpheniramine

VEGF signaling pathway

2.77E-04

P16298, Q05397, Q02750, P04049

PPP3CB, PTK2, MAP2K1, RAF1

Chlorpheniramine

hsa04371

Apelin signaling pathway

2.65E-02

P04049

RAF1

Chlorpheniramine

hsa04510

Focal adhesion

3.48E-02

P04049

RAF1

Chlorpheniramine

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Chlorpheniramine

hsa04540

Gap junction

1.33E-02

P04049

RAF1

Chlorpheniramine

Signaling pathways regulating pluripotency of stem cells

9.61E-03

Q13873, P04049, Q02750, Q86SE9

BMPR2, RAF1, MAP2K1, PCGF5

Chlorpheniramine

hsa04610

Complement and coagulation cascades

2.78E-03

P0C0L4

C4A

Chlorpheniramine

Antigen processing and presentation

2.09E-04

P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755

Chlorpheniramine

Neutrophil extracellular trap formation

1.62E-06

P04049, P11215, Q13547, P04908, Q93077, P58876, P62807, Q16778, O60814, P68431, O43315, Q16539

RAF1, ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Chlorpheniramine

hsa04625

C-type lectin receptor signaling pathway

1.49E-02

P04049

RAF1

Chlorpheniramine

hsa04630

JAK-STAT signaling pathway

1.49E-02

P04049

RAF1

Chlorpheniramine

Natural killer cell mediated cytotoxicity

5.84E-06

P16298, P50591, P01375, P20963, Q02750, P04049, Q13241, P26718, P26717, Q14953, P26715

PPP3CB, TNFSF10, TNF, CD247, MAP2K1, RAF1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Chlorpheniramine

hsa04657

IL-17 signaling pathway

2.73E-04

P07900, P49841, P19875, P14780, P80188, P01375, P01584

HSP90AA1, GSK3B, CXCL2, MMP9, LCN2, TNF, IL1B

Chlorpheniramine

hsa04660

T cell receptor signaling pathway

1.66E-02

P04049

RAF1

Chlorpheniramine

hsa04662

B cell receptor signaling pathway

9.95E-03

P04049

RAF1

Chlorpheniramine

hsa04664

Fc epsilon RI signaling pathway

1.16E-02

P04049

RAF1

Chlorpheniramine

Fc gamma R-mediated phagocytosis

2.32E-02

P04049

RAF1

Chlorpheniramine

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Chlorpheniramine

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Chlorpheniramine

Long-term potentiation

4.88E-03

P16298, P51812, Q02750, P04049

PPP3CB, RPS6KA3, MAP2K1, RAF1

Chlorpheniramine

Neurotrophin signaling pathway

7.10E-03

P04049, P49841, O43524, P48023

RAF1, GSK3B, FOXO3, FASLG

Chlorpheniramine

Cholinergic synapse

4.83E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Chlorpheniramine

hsa04726

Serotonergic synapse

1.33E-02

P04049

RAF1

Chlorpheniramine

hsa04730

Long-term depression

1.16E-02

P04049

RAF1

Chlorpheniramine

hsa04810

Regulation of actin cytoskeleton

3.81E-02

P04049

RAF1

Chlorpheniramine

hsa04910

Insulin signaling pathway

2.51E-03

P22694, P06737, P04049, P49841

PRKACB, PYGL, RAF1, GSK3B

Chlorpheniramine

hsa04912

GnRH signaling pathway

1.82E-02

P04049

RAF1

Chlorpheniramine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Chlorpheniramine

Progesterone-mediated oocyte maturation

1.91E-03

Q17RY0, Q9Y6D9, P51812, Q02750, P04049

CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1

Chlorpheniramine

Estrogen signaling pathway

3.15E-02

P14780, P22694, P04049, P18848, Q14643, P10415

MMP9, PRKACB, RAF1, ATF4, ITPR1, BCL2

Chlorpheniramine

hsa04916

Melanogenesis

1.33E-02

P04049

RAF1

Chlorpheniramine

hsa04917

Prolactin signaling pathway

6.63E-03

P04049

RAF1

Chlorpheniramine

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Chlorpheniramine

Thyroid hormone signaling pathway

6.83E-04

P49841, P04049, P22694, O60244, Q9NVC6

GSK3B, RAF1, PRKACB, MED14, MED17

Chlorpheniramine

hsa04921

Oxytocin signaling pathway

2.32E-02

P04049

RAF1

Chlorpheniramine

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Chlorpheniramine

hsa04926

Relaxin signaling pathway

6.24E-03

P18848, P22694, P14780, P04049, P30679

ATF4, PRKACB, MMP9, RAF1, GNA15

Chlorpheniramine

Cortisol synthesis and secretion

4.44E-04

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Chlorpheniramine

Parathyroid hormone synthesis, secretion and action

9.56E-03

Q14643, P22694, P23771, P04049, P18848, P10415

ITPR1, PRKACB, GATA3, RAF1, ATF4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81

Chlorpheniramine

hsa04929

GnRH secretion

4.98E-03

P04049

RAF1

Chlorpheniramine

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Chlorpheniramine

Non-alcoholic fatty liver disease

6.73E-05

P01375, P49841, P18848, P48023, P01584, P13073, O15239, Q16718, O14521

TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Chlorpheniramine

hsa04935

Growth hormone synthesis, secretion and action

2.16E-02

P04049

RAF1

Chlorpheniramine

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Chlorpheniramine

hsa04961

Endocrine and other factor-regulated calcium reabsorption

2.68E-02

P20020, Q9UEF7, P17252

ATP2B1, KL, PRKCA

Chlorpheniramine

hsa04966

Collecting duct acid secretion

1.68E-02

P02730, P00918

SLC4A1, CA2

Chlorpheniramine

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Chlorpheniramine

hsa04972

Pancreatic secretion

2.68E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Chlorpheniramine

Bile secretion

1.67E-03

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Chlorpheniramine

hsa05012

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Chlorpheniramine

hsa05016

Huntington disease

3.21E-02

O15239, P13073, P30876, P62487, P05141

NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5

Chlorpheniramine

Spinocerebellar ataxia

2.43E-02

P28074

PSMB5

Chlorpheniramine

Prion disease

3.73E-04

P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539

NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P02768	ALB	Albumin	P13591	NCAM1	Neural cell adhesion molecule 1	0.701
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.72
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Chlorpheniramine

Pathways of neurodegeneration - multiple diseases

1.47E-03

P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557

GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859

Chlorpheniramine

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Chlorpheniramine

hsa05034

Alcoholism

1.81E-06

Q13547, P04049, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, RAF1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Chlorpheniramine

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Chlorpheniramine

hsa05132

Salmonella infection

5.10E-03

P51617, P04049, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371

IRAK1, RAF1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.825
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75369	FLNB	Filamin-B	-0.746
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.924
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13561	DCTN2	Dynactin subunit 2	-0.809
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.846
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P68371	TUBB2C	Tubulin beta-4B chain	-0.783
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722

Chlorpheniramine

hsa05133

Pertussis

4.94E-02

P0C0L4

C4A

Chlorpheniramine

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Chlorpheniramine

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Chlorpheniramine

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Chlorpheniramine

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Chlorpheniramine

hsa05146

Amoebiasis

2.41E-02

P19875, P01375, P30679, P22694

CXCL2, TNF, GNA15, PRKACB

Chlorpheniramine

hsa05152

Tuberculosis

1.40E-02

P04049, Q13488, P48382, P25208, O60603, P10415, P01568, Q9UDY8, P51617

RAF1, TCIRG1, RFX5, NFYB, TLR2, BCL2, IFNA21, MALT1, IRAK1

Chlorpheniramine

Hepatitis C

1.40E-03

P60033, P04049, P49841, P01375, P48023

CD81, RAF1, GSK3B, TNF, FASLG

Chlorpheniramine

hsa05161

Hepatitis B

1.99E-02

P04049

RAF1

Chlorpheniramine

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Chlorpheniramine

hsa05163

Human cytomegalovirus infection

4.98E-02

P04049

RAF1

Chlorpheniramine

hsa05164

Influenza A

3.65E-02

P04049

RAF1

Chlorpheniramine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.15E-02

P04049

RAF1

Chlorpheniramine

hsa05170

Human immunodeficiency virus 1 infection

5.63E-03

P04049, P62873, P17252, Q13546, Q14643, P01568, P51617, O60603, Q13315, P10415, Q9Y6Q5

RAF1, GNB1, PRKCA, RIPK1, ITPR1, IFNA21, IRAK1, TLR2, ATM, BCL2, AP1M2

Chlorpheniramine

hsa05171

Coronavirus disease - COVID-19

9.72E-03

P01584, P62753, P25398, P36578, P32969, P18077, P62829

IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23

Chlorpheniramine

Transcriptional misregulation in cancer

1.12E-04

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q12778	FOXO1	Forkhead box protein O1	0.777
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15532	SS18	Protein SSXT	0.763
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14923	JUP	Junction plakoglobin	0.845
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.754
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08246	ELA2	Neutrophil elastase	-0.896
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.787
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812

Chlorpheniramine

hsa05203

Viral carcinogenesis

1.22E-03

Q13547, Q15283, P58876, P62807, Q16778, O60814

HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Chlorpheniramine

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Chlorpheniramine

hsa05205

Proteoglycans in cancer

8.14E-04

Q13009, Q14643, O75369, P04049, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962

TIAM1, ITPR1, FLNB, RAF1, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.711
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.823
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75369	FLNB	Filamin-B	-0.746
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.703
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P04628	WNT1	Proto-oncogene Wnt-1	0.829
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13635	PTCH1	Protein patched homolog 1	0.85
P07550	ADRB2	Beta-2 adrenergic receptor	Q13635	PTCH1	Protein patched homolog 1	0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08962	CD63	CD63 antigen	-0.782
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.703
P07550	ADRB2	Beta-2 adrenergic receptor	Q13635	PTCH1	Protein patched homolog 1	0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724

Chlorpheniramine

hsa05206

MicroRNAs in cancer

3.15E-02

P04049

RAF1

Chlorpheniramine

hsa05210

Colorectal cancer

1.66E-02

P04049

RAF1

Chlorpheniramine

hsa05211

Renal cell carcinoma

1.16E-02

P04049

RAF1

Chlorpheniramine

Pancreatic cancer

1.16E-02

P04049

RAF1

Chlorpheniramine

hsa05213

Endometrial cancer

9.95E-03

P04049

RAF1

Chlorpheniramine

Glioma

9.95E-03

P04049

RAF1

Chlorpheniramine

hsa05215

Prostate cancer

1.33E-02

P04049

RAF1

Chlorpheniramine

hsa05218

Melanoma

9.63E-04

P09619, Q9GZP0, Q02750, P04049

PDGFRB, PDGFD, MAP2K1, RAF1

Chlorpheniramine

hsa05219

Bladder cancer

4.98E-03

P04049

RAF1

Chlorpheniramine

hsa05220

Chronic myeloid leukemia

9.95E-03

P04049

RAF1

Chlorpheniramine

hsa05221

Acute myeloid leukemia

8.29E-03

P04049

RAF1

Chlorpheniramine

hsa05223

Non-small cell lung cancer

6.63E-03

P04049

RAF1

Chlorpheniramine

hsa05224

Breast cancer

1.49E-02

P04049

RAF1

Chlorpheniramine

hsa05225

Hepatocellular carcinoma

1.33E-02

P04049

RAF1

Chlorpheniramine

hsa05226

Gastric cancer

8.29E-03

P04049

RAF1

Chlorpheniramine

hsa05230

Central carbon metabolism in cancer

9.95E-03

P04049

RAF1

Chlorpheniramine

hsa05231

Choline metabolism in cancer

1.49E-03

Q02750, P04049, P09619, Q9GZP0, O15245

MAP2K1, RAF1, PDGFRB, PDGFD, SLC22A1

Chlorpheniramine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.66E-02

P04049

RAF1

Chlorpheniramine

Inflammatory bowel disease

1.19E-03

P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P07550	ADRB2	Beta-2 adrenergic receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.826
P07550	ADRB2	Beta-2 adrenergic receptor	Q9UL17	TBX21	T-box transcription factor TBX21	0.758
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P07550	ADRB2	Beta-2 adrenergic receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.826
P07550	ADRB2	Beta-2 adrenergic receptor	Q9UL17	TBX21	T-box transcription factor TBX21	0.758
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718

Chlorpheniramine

hsa05322

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Chlorpheniramine

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Chlorpheniramine

Graft-versus-host disease

1.91E-05

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838

Chlorpheniramine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

3.10E-02

Q8IZS8, P54284, P13612

CACNA2D3, CACNB3, ITGA4

Chlorpheniramine

hsa05414

Dilated cardiomyopathy

2.11E-02

Q8IZS8, P54284, P13612, P26678

CACNA2D3, CACNB3, ITGA4, PLN

Chlorpheniramine

Diabetic cardiomyopathy

1.02E-03

P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557

SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725

Dexbrompheniramine

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Dexbrompheniramine

hsa00630

Glyoxylate and dicarboxylate metabolism

4.29E-03

P40925, P15104

MDH1, GLUL

Dexbrompheniramine

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Dexbrompheniramine

Drug metabolism - other enzymes

3.50E-02

P04183, P32320, P05164

TK1, CDA, MPO

Dexbrompheniramine

hsa01100

Metabolic pathways

4.11E-02

P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6

PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95931	CBX7	Chromobox protein homolog 7	P30041	PRDX6	Peroxiredoxin-6	0.72
O95931	CBX7	Chromobox protein homolog 7	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.771
O95931	CBX7	Chromobox protein homolog 7	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.702
O95931	CBX7	Chromobox protein homolog 7	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.726
O95931	CBX7	Chromobox protein homolog 7	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.798
O95931	CBX7	Chromobox protein homolog 7	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.762
O95931	CBX7	Chromobox protein homolog 7	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.731
O95931	CBX7	Chromobox protein homolog 7	P30041	PRDX6	Peroxiredoxin-6	0.72
O95931	CBX7	Chromobox protein homolog 7	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.771
O95931	CBX7	Chromobox protein homolog 7	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.702
O95931	CBX7	Chromobox protein homolog 7	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.726
O95931	CBX7	Chromobox protein homolog 7	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.798
O95931	CBX7	Chromobox protein homolog 7	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.762
O95931	CBX7	Chromobox protein homolog 7	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.731
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Dexbrompheniramine

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Dexbrompheniramine

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Dexbrompheniramine

hsa03040

Spliceosome

6.28E-03

Q14562, O43143, O60508, Q07955, Q01130, Q13243

DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5

Dexbrompheniramine

Proteasome

1.21E-02

P28074

PSMB5

Dexbrompheniramine

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Dexbrompheniramine

cAMP signaling pathway

4.38E-02

P42338, P0DP23, Q13370, Q13009

PIK3CB, CALM1, PDE3B, TIAM1

Dexbrompheniramine

NF-kappa B signaling pathway

1.60E-02

P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341

BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7

Dexbrompheniramine

hsa04070

Phosphatidylinositol signaling system

4.86E-02

P0DP23, P42338, P27987

CALM1, PIK3CB, ITPKB

Dexbrompheniramine

Sphingolipid signaling pathway

2.96E-02

P21453, Q9H228, Q13362, Q9BX95, P10415

S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.773
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.799
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.917
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P21462	FPR1	fMet-Leu-Phe receptor	P17252	PRKCA	Protein kinase C alpha type	-0.731
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P21462	FPR1	fMet-Leu-Phe receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.716
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P21462	FPR1	fMet-Leu-Phe receptor	P01375	TNF	Tumor necrosis factor	0.77
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P21462	FPR1	fMet-Leu-Phe receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.878
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P21462	FPR1	fMet-Leu-Phe receptor	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.932
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P21462	FPR1	fMet-Leu-Phe receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.855

Dexbrompheniramine

Neuroactive ligand-receptor interaction

3.22E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1

Dexbrompheniramine

hsa04114

Oocyte meiosis

6.23E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Dexbrompheniramine

p53 signaling pathway

3.98E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Dexbrompheniramine

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Dexbrompheniramine

Apoptosis

3.77E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1

Dexbrompheniramine

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P02768	ALB	Albumin	P15104	GLUL	Glutamine synthetase	0.717
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P0C0S5	H2AFZ	Histone H2A.Z	0.756
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771

Dexbrompheniramine

hsa04330

Notch signaling pathway

7.49E-03

Q92542, P49768

NCSTN, PSEN1

Dexbrompheniramine

Axon guidance

1.71E-02

P20827, O95631, P42338, P23528

EFNA1, NTN1, PIK3CB, CFL1

Dexbrompheniramine

VEGF signaling pathway

3.06E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Dexbrompheniramine

Signaling pathways regulating pluripotency of stem cells

4.73E-02

Q13873, Q02750, Q86SE9

BMPR2, MAP2K1, PCGF5

Dexbrompheniramine

Antigen processing and presentation

3.21E-02

P13765, P48382, P26715, P26717, Q13241, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755

Dexbrompheniramine

Neutrophil extracellular trap formation

4.20E-02

P04908, Q93077, P68431, O43315, Q16539

H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Dexbrompheniramine

Natural killer cell mediated cytotoxicity

3.73E-02

P16298, P50591, Q02750

PPP3CB, TNFSF10, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Dexbrompheniramine

hsa04659

Th17 cell differentiation

4.38E-02

P42224, P14784, P40189, P08238

STAT1, IL2RB, IL6ST, HSP90AB1

Dexbrompheniramine

Fc gamma R-mediated phagocytosis

3.08E-02

P42338, P23528, P14598

PIK3CB, CFL1, NCF1

Dexbrompheniramine

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Dexbrompheniramine

Long-term potentiation

2.85E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Dexbrompheniramine

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Dexbrompheniramine

Cholinergic synapse

4.83E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Dexbrompheniramine

Progesterone-mediated oocyte maturation

9.70E-04

Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1

Dexbrompheniramine

Estrogen signaling pathway

2.96E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Dexbrompheniramine

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Dexbrompheniramine

Thyroid hormone signaling pathway

3.71E-02

P26678, P08237

PLN, PFKM

Dexbrompheniramine

Renin secretion

3.77E-02

Q13370, P0DP23

PDE3B, CALM1

Dexbrompheniramine

Cortisol synthesis and secretion

8.60E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Dexbrompheniramine

Parathyroid hormone synthesis, secretion and action

2.13E-02

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81

Dexbrompheniramine

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Dexbrompheniramine

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Dexbrompheniramine

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Dexbrompheniramine

Spinocerebellar ataxia

2.43E-02

P28074

PSMB5

Dexbrompheniramine

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P02768	ALB	Albumin	P13591	NCAM1	Neural cell adhesion molecule 1	0.701
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.72
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Dexbrompheniramine

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859

Dexbrompheniramine

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Dexbrompheniramine

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Dexbrompheniramine

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Dexbrompheniramine

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Dexbrompheniramine

hsa05168

Herpes simplex virus 1 infection

1.15E-02

P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6

STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824

Dexbrompheniramine

hsa05200

Pathways in cancer

3.92E-02

P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189

PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6ST

Dexbrompheniramine

Transcriptional misregulation in cancer

1.77E-02

Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522

SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q12778	FOXO1	Forkhead box protein O1	0.777
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15532	SS18	Protein SSXT	0.763
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14923	JUP	Junction plakoglobin	0.845
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.754
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08246	ELA2	Neutrophil elastase	-0.896
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.787
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812

Dexbrompheniramine

Pancreatic cancer

1.72E-02

P42338, P42224, O75293

PIK3CB, STAT1, GADD45B

Dexbrompheniramine

Glioma

1.72E-02

P0DP23, P42338, O75293

CALM1, PIK3CB, GADD45B

Dexbrompheniramine

Inflammatory bowel disease

2.29E-02

P13765, Q14765, P23771, Q9HBE5

HLA-DOB, STAT4, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P07550	ADRB2	Beta-2 adrenergic receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.826
P07550	ADRB2	Beta-2 adrenergic receptor	Q9UL17	TBX21	T-box transcription factor TBX21	0.758
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P07550	ADRB2	Beta-2 adrenergic receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.826
P07550	ADRB2	Beta-2 adrenergic receptor	Q9UL17	TBX21	T-box transcription factor TBX21	0.758
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718

Dexbrompheniramine

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Dexbrompheniramine

Graft-versus-host disease

7.94E-04

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838

Dexbrompheniramine

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725

Dexbrompheniramine

hsa05418

Fluid shear stress and atherosclerosis

3.73E-02

P42338, P14598, P0DP23, P08238

PIK3CB, NCF1, CALM1, HSP90AB1

Pheniramine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Pheniramine

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Pheniramine

Oxidative phosphorylation

5.12E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Pheniramine

hsa00500

Starch and sucrose metabolism

1.47E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Pheniramine

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Pheniramine

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Pheniramine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Pheniramine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Pheniramine

hsa00730

Thiamine metabolism

4.07E-02

P05186, P24666

ALPL, ACP1

Pheniramine

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Pheniramine

hsa00830

Retinol metabolism

3.15E-02

P00325

ADH1B

Pheniramine

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Pheniramine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Pheniramine

Drug metabolism - other enzymes

3.50E-02

P04183, P32320, P05164

TK1, CDA, MPO

Pheniramine

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95931	CBX7	Chromobox protein homolog 7	P30041	PRDX6	Peroxiredoxin-6	0.72
O95931	CBX7	Chromobox protein homolog 7	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.771
O95931	CBX7	Chromobox protein homolog 7	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.702
O95931	CBX7	Chromobox protein homolog 7	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.726
O95931	CBX7	Chromobox protein homolog 7	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.798
O95931	CBX7	Chromobox protein homolog 7	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.762
O95931	CBX7	Chromobox protein homolog 7	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.731
O95931	CBX7	Chromobox protein homolog 7	P30041	PRDX6	Peroxiredoxin-6	0.72
O95931	CBX7	Chromobox protein homolog 7	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.771
O95931	CBX7	Chromobox protein homolog 7	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.702
O95931	CBX7	Chromobox protein homolog 7	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.726
O95931	CBX7	Chromobox protein homolog 7	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.798
O95931	CBX7	Chromobox protein homolog 7	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.762
O95931	CBX7	Chromobox protein homolog 7	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.731
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Pheniramine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Pheniramine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Pheniramine

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Pheniramine

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P04049

RAF1

Pheniramine

hsa01522

Endocrine resistance

2.16E-02

P04049

RAF1

Pheniramine

hsa01523

Antifolate resistance

3.80E-02

Q92820, P04818

GGH, TYMS

Pheniramine

hsa01524

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Pheniramine

ABC transporters

2.17E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Pheniramine

hsa03013

RNA transport

7.27E-03

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, TACC3, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.956
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O14893	GEMIN2	Gem-associated protein 2	0.925
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P61326	MAGOH	Protein mago nashi homolog	0.761
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q7Z3B4	NUP54	Nucleoporin p54	0.854
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.79
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.715
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.793
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P78345	RPP38	Ribonuclease P protein subunit p38	0.819
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.891
P21462	FPR1	fMet-Leu-Phe receptor	O14980	XPO1	Exportin-1	-0.742
P21462	FPR1	fMet-Leu-Phe receptor	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.874
P21462	FPR1	fMet-Leu-Phe receptor	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.78
P21462	FPR1	fMet-Leu-Phe receptor	O14893	GEMIN2	Gem-associated protein 2	-0.87
P21462	FPR1	fMet-Leu-Phe receptor	P61326	MAGOH	Protein mago nashi homolog	-0.835
P21462	FPR1	fMet-Leu-Phe receptor	Q7Z3B4	NUP54	Nucleoporin p54	-0.903
P21462	FPR1	fMet-Leu-Phe receptor	P35658	NUP214	Nuclear pore complex protein Nup214	0.971
P21462	FPR1	fMet-Leu-Phe receptor	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.89
P21462	FPR1	fMet-Leu-Phe receptor	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.953
P21462	FPR1	fMet-Leu-Phe receptor	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	-0.721
P21462	FPR1	fMet-Leu-Phe receptor	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.904
P21462	FPR1	fMet-Leu-Phe receptor	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	-0.713

Pheniramine

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Pheniramine

hsa03020

RNA polymerase

1.31E-02

P24928, P62487

POLR2A, POLR2G

Pheniramine

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Pheniramine

hsa03030

DNA replication

5.00E-02

P27694

RPA1

Pheniramine

Proteasome

1.21E-02

P28074

PSMB5

Pheniramine

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Pheniramine

hsa04010

MAPK signaling pathway

4.15E-02

P04049

RAF1

Pheniramine

hsa04012

ErbB signaling pathway

1.82E-02

P04049

RAF1

Pheniramine

hsa04014

Ras signaling pathway

3.65E-02

P04049

RAF1

Pheniramine

hsa04015

Rap1 signaling pathway

2.99E-02

P04049

RAF1

Pheniramine

hsa04022

cGMP-PKG signaling pathway

3.15E-02

P04049

RAF1

Pheniramine

cAMP signaling pathway

2.49E-02

P04049

RAF1

Pheniramine

hsa04062

Chemokine signaling pathway

3.98E-02

P04049

RAF1

Pheniramine

NF-kappa B signaling pathway

1.44E-03

P10415, O00463, P14778, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P24522, P09341

BCL2, TRAF5, IL1R1, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, GADD45A, CXCL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7

Pheniramine

hsa04068

FoxO signaling pathway

1.99E-02

P04049

RAF1

Pheniramine

Sphingolipid signaling pathway

1.46E-04

P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.773
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.799
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.917
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P21462	FPR1	fMet-Leu-Phe receptor	P17252	PRKCA	Protein kinase C alpha type	-0.731
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P21462	FPR1	fMet-Leu-Phe receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.716
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P21462	FPR1	fMet-Leu-Phe receptor	P01375	TNF	Tumor necrosis factor	0.77
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P21462	FPR1	fMet-Leu-Phe receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.878
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P21462	FPR1	fMet-Leu-Phe receptor	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.932
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P21462	FPR1	fMet-Leu-Phe receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.855

Pheniramine

hsa04072

Phospholipase D signaling pathway

2.82E-02

P04049

RAF1

Pheniramine

Neuroactive ligand-receptor interaction

2.16E-03

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1

Pheniramine

hsa04110

Cell cycle

6.80E-03

P06493, O75293, P30304, P33981, P42773, P01106

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC

Pheniramine

p53 signaling pathway

3.98E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Pheniramine

Ubiquitin mediated proteolysis

4.81E-03

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Pheniramine

hsa04140

Autophagy - animal

2.82E-02

P04049

RAF1

Pheniramine

hsa04150

mTOR signaling pathway

2.32E-02

P04049

RAF1

Pheniramine

Apoptosis

4.14E-03

Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643, P04049

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1, RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1

Pheniramine

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Pheniramine

Necroptosis

2.24E-04

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P02768	ALB	Albumin	P15104	GLUL	Glutamine synthetase	0.717
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P0C0S5	H2AFZ	Histone H2A.Z	0.756
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771

Pheniramine

hsa04218

Cellular senescence

8.08E-03

P01106, P04049, O75293, P30304, P06493

MYC, RAF1, GADD45B, CDC25A, CDK1

Pheniramine

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Pheniramine

hsa04270

Vascular smooth muscle contraction

2.32E-02

P04049

RAF1

Pheniramine

Axon guidance

2.49E-02

P04049

RAF1

Pheniramine

VEGF signaling pathway

8.29E-03

P04049

RAF1

Pheniramine

hsa04371

Apelin signaling pathway

2.65E-02

P04049

RAF1

Pheniramine

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Pheniramine

hsa04510

Focal adhesion

3.48E-02

P04049

RAF1

Pheniramine

hsa04514

Cell adhesion molecules

1.22E-02

P23229, P30511

ITGA6, HLA-F

Pheniramine

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Pheniramine

hsa04540

Gap junction

1.33E-02

P04049

RAF1

Pheniramine

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P04049

RAF1

Pheniramine

hsa04610

Complement and coagulation cascades

6.23E-06

P0C0L4

C4A

Pheniramine

Antigen processing and presentation

2.09E-04

P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755

Pheniramine

Neutrophil extracellular trap formation

2.09E-04

P04049, P04908, Q93077, P62807, O60814, P68431, O43315, Q16539

RAF1, H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Pheniramine

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Pheniramine

hsa04625

C-type lectin receptor signaling pathway

1.49E-02

P04049

RAF1

Pheniramine

hsa04630

JAK-STAT signaling pathway

1.49E-02

P04049

RAF1

Pheniramine

hsa04640

Hematopoietic cell lineage

3.69E-02

P21926, P07766, P01730, P09564

CD9, CD3E, CD4, CD7

Pheniramine

Natural killer cell mediated cytotoxicity

2.93E-05

P01375, P20963, P04049, Q13241, P26718, P26717, Q14953, P26715

TNF, CD247, RAF1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Pheniramine

hsa04657

IL-17 signaling pathway

3.33E-03

O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF

Pheniramine

hsa04659

Th17 cell differentiation

3.17E-02

P25963, P84022, Q13485

NFKBIA, SMAD3, SMAD4

Pheniramine

hsa04660

T cell receptor signaling pathway

1.66E-02

P04049

RAF1

Pheniramine

hsa04662

B cell receptor signaling pathway

9.95E-03

P04049

RAF1

Pheniramine

hsa04664

Fc epsilon RI signaling pathway

1.16E-02

P04049

RAF1

Pheniramine

Fc gamma R-mediated phagocytosis

2.32E-02

P04049

RAF1

Pheniramine

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Pheniramine

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Pheniramine

Long-term potentiation

1.66E-02

P04049

RAF1

Pheniramine

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Pheniramine

Neurotrophin signaling pathway

7.10E-03

P04049, P49841, O43524, P48023

RAF1, GSK3B, FOXO3, FASLG

Pheniramine

Cholinergic synapse

4.83E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Pheniramine

hsa04726

Serotonergic synapse

1.33E-02

P04049

RAF1

Pheniramine

hsa04730

Long-term depression

3.01E-03

Q14344, P04049

GNA13, RAF1

Pheniramine

hsa04810

Regulation of actin cytoskeleton

4.09E-03

P04049, P23229, Q14344

RAF1, ITGA6, GNA13

Pheniramine

hsa04910

Insulin signaling pathway

1.49E-02

P04049

RAF1

Pheniramine

hsa04912

GnRH signaling pathway

1.82E-02

P04049

RAF1

Pheniramine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Pheniramine

Progesterone-mediated oocyte maturation

2.16E-02

P04049

RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1

Pheniramine

Estrogen signaling pathway

3.15E-02

P14780, P22694, P04049, P18848, Q14643, P10415

MMP9, PRKACB, RAF1, ATF4, ITPR1, BCL2

Pheniramine

hsa04916

Melanogenesis

1.33E-02

P04049

RAF1

Pheniramine

hsa04917

Prolactin signaling pathway

6.63E-03

P04049

RAF1

Pheniramine

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Pheniramine

Thyroid hormone signaling pathway

1.82E-02

P04049

RAF1

Pheniramine

hsa04921

Oxytocin signaling pathway

2.32E-02

P04049

RAF1

Pheniramine

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Pheniramine

hsa04926

Relaxin signaling pathway

6.24E-03

P18848, P22694, P14780, P04049, P30679

ATF4, PRKACB, MMP9, RAF1, GNA15

Pheniramine

Cortisol synthesis and secretion

4.44E-04

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Pheniramine

Parathyroid hormone synthesis, secretion and action

9.56E-03

Q14643, P22694, P23771, P04049, P18848, P10415

ITPR1, PRKACB, GATA3, RAF1, ATF4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81

Pheniramine

hsa04929

GnRH secretion

4.98E-03

P04049

RAF1

Pheniramine

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Pheniramine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Pheniramine

hsa04935

Growth hormone synthesis, secretion and action

2.16E-02

P04049

RAF1

Pheniramine

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Pheniramine

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Pheniramine

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Pheniramine

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Pheniramine

hsa04972

Pancreatic secretion

1.31E-02

Q08828, P62491

ADCY1, RAB11A

Pheniramine

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Pheniramine

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Pheniramine

Spinocerebellar ataxia

2.43E-02

P28074

PSMB5

Pheniramine

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P02768	ALB	Albumin	P13591	NCAM1	Neural cell adhesion molecule 1	0.701
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.72
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Pheniramine

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859

Pheniramine

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Pheniramine

hsa05034

Alcoholism

2.78E-04

P04049, Q93077, P62807, O60814, P68431

RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Pheniramine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.45E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Pheniramine

hsa05132

Salmonella infection

6.67E-03

P25963, P04049, Q13489, P10415, Q9BQS8

NFKBIA, RAF1, BIRC3, BCL2, FYCO1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.825
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75369	FLNB	Filamin-B	-0.746
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.924
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13561	DCTN2	Dynactin subunit 2	-0.809
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.846
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P68371	TUBB2C	Tubulin beta-4B chain	-0.783
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722

Pheniramine

hsa05133

Pertussis

4.24E-03

P0C0L4

C4A

Pheniramine

hsa05140

Leishmaniasis

1.16E-03

O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080

FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4

Pheniramine

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Pheniramine

hsa05144

Malaria

1.44E-03

P69905, P68871, P01375, P35443, P26718

HBA2, HBB, TNF, THBS4, KLRK1

Pheniramine

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Pheniramine

hsa05146

Amoebiasis

3.33E-03

P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB

Pheniramine

hsa05152

Tuberculosis

3.98E-02

P04049

RAF1

Pheniramine

Hepatitis C

1.40E-03

P60033, P04049, P49841, P01375, P48023

CD81, RAF1, GSK3B, TNF, FASLG

Pheniramine

hsa05161

Hepatitis B

6.38E-04

P04049, P25963, Q13485, P10415, P84022

RAF1, NFKBIA, SMAD4, BCL2, SMAD3

Pheniramine

hsa05163

Human cytomegalovirus infection

6.95E-03

P04049, P30511, Q14643, Q14344, P49841, P14778, P25025, Q16539, P04637, O00463

RAF1, HLA-F, ITPR1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Pheniramine

hsa05164

Influenza A

3.65E-02

P04049

RAF1

Pheniramine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.15E-02

P04049

RAF1

Pheniramine

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824

Pheniramine

hsa05170

Human immunodeficiency virus 1 infection

3.48E-02

P04049

RAF1

Pheniramine

Transcriptional misregulation in cancer

1.77E-02

Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522

SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q12778	FOXO1	Forkhead box protein O1	0.777
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15532	SS18	Protein SSXT	0.763
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14923	JUP	Junction plakoglobin	0.845
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.754
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08246	ELA2	Neutrophil elastase	-0.896
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.787
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812

Pheniramine

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Pheniramine

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Pheniramine

hsa05205

Proteoglycans in cancer

1.09E-02

P04049, P14780, P01375, P23588, Q13635, P22694

RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.711
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.823
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75369	FLNB	Filamin-B	-0.746
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.703
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P04628	WNT1	Proto-oncogene Wnt-1	0.829
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13635	PTCH1	Protein patched homolog 1	0.85
P07550	ADRB2	Beta-2 adrenergic receptor	Q13635	PTCH1	Protein patched homolog 1	0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08962	CD63	CD63 antigen	-0.782
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.703
P07550	ADRB2	Beta-2 adrenergic receptor	Q13635	PTCH1	Protein patched homolog 1	0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724

Pheniramine

hsa05206

MicroRNAs in cancer

3.15E-02

P04049

RAF1

Pheniramine

hsa05210

Colorectal cancer

1.68E-03

P84022, Q13485, P04049, P10415

SMAD3, SMAD4, RAF1, BCL2

Pheniramine

hsa05211

Renal cell carcinoma

1.16E-02

P04049

RAF1

Pheniramine

Pancreatic cancer

3.44E-03

P04049, P84022, Q13485

RAF1, SMAD3, SMAD4

Pheniramine

hsa05213

Endometrial cancer

9.95E-03

P04049

RAF1

Pheniramine

Glioma

9.95E-03

P04049

RAF1

Pheniramine

hsa05215

Prostate cancer

1.33E-02

P04049

RAF1

Pheniramine

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Pheniramine

hsa05218

Melanoma

6.63E-03

P04049

RAF1

Pheniramine

hsa05219

Bladder cancer

5.65E-03

P14780, P04637, P04049

MMP9, TP53, RAF1

Pheniramine

hsa05220

Chronic myeloid leukemia

6.24E-04

Q13485, P25963, P84022, P04049

SMAD4, NFKBIA, SMAD3, RAF1

Pheniramine

hsa05221

Acute myeloid leukemia

8.29E-03

P04049

RAF1

Pheniramine

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Pheniramine

hsa05223

Non-small cell lung cancer

6.95E-04

P10826, P04049, Q9HC35, O75293

RARB, RAF1, EML4, GADD45B

Pheniramine

hsa05224

Breast cancer

1.24E-02

P04049, P49841, Q92837, P04637, P24522

RAF1, GSK3B, FRAT1, TP53, GADD45A

Pheniramine

hsa05225

Hepatocellular carcinoma

1.33E-02

P04049

RAF1

Pheniramine

hsa05226

Gastric cancer

1.25E-03

P04049, P84022, Q13485, P10415

RAF1, SMAD3, SMAD4, BCL2

Pheniramine

hsa05230

Central carbon metabolism in cancer

9.95E-03

P04049

RAF1

Pheniramine

hsa05231

Choline metabolism in cancer

1.33E-02

P04049

RAF1

Pheniramine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

3.29E-04

O95267, P07766, P09693, P06239, P04049, O60603, Q16539, Q9HC35, P01730

RASGRP1, CD3E, CD3G, LCK, RAF1, TLR2, MAPK14, EML4, CD4

Pheniramine

Inflammatory bowel disease

1.19E-03

P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P07550	ADRB2	Beta-2 adrenergic receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.826
P07550	ADRB2	Beta-2 adrenergic receptor	Q9UL17	TBX21	T-box transcription factor TBX21	0.758
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P07550	ADRB2	Beta-2 adrenergic receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.826
P07550	ADRB2	Beta-2 adrenergic receptor	Q9UL17	TBX21	T-box transcription factor TBX21	0.758
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718

Pheniramine

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Pheniramine

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Pheniramine

Graft-versus-host disease

1.91E-05

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838

Pheniramine

hsa05340

Primary immunodeficiency

1.28E-03

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Pheniramine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Pheniramine