| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Phenindione | hsa00010 | Glycolysis / Gluconeogenesis | 4.41E-02 | 4 | P04075, P06733, P04406, P60174 | ALDOA, ENO1, GAPDH, TPI1 | More | | | Phenindione | hsa00051 | Fructose and mannose metabolism | 2.08E-03 | 4 | P15121, O14772, P60174, P04075 | AKR1B1, FPGT, TPI1, ALDOA | More | | | Phenindione | hsa00071 | Fatty acid degradation | 4.66E-02 | 3 | O75521, P11766, P33121 | ECI2, ADH5, ACSL1 | More | | | Phenindione | hsa00120 | Primary bile acid biosynthesis | 3.72E-02 | 2 | P22680, P22307 | CYP7A1, SCP2 | More | | | Phenindione | hsa00190 | Oxidative phosphorylation | 8.71E-03 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Phenindione | hsa00220 | Arginine biosynthesis | 3.38E-05 | 3 | P15104, P05089, P49448 | GLUL, ARG1, GLUD2 | More | | | Phenindione | hsa00230 | Purine metabolism | 1.45E-03 | 5 | Q7LG56, P31350, P51828, P21589, Q9Y227 | RRM2B, RRM2, ADCY7, NT5E, ENTPD4 | More | | | Phenindione | hsa00240 | Pyrimidine metabolism | 1.38E-05 | 5 | Q7LG56, P31350, Q9Y227, P21589, P04818 | RRM2B, RRM2, ENTPD4, NT5E, TYMS | More | | | Phenindione | hsa00250 | Alanine, aspartate and glutamate metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Phenindione | hsa00280 | Valine, leucine and isoleucine degradation | 3.41E-03 | 4 | P55809, Q9HCC0, Q02252, P11310 | OXCT1, MCCC2, ALDH6A1, ACADM | More | | | Phenindione | hsa00310 | Lysine degradation | 2.59E-02 | 2 | Q96KQ7, P51648 | EHMT2, ALDH3A2 | More | | | Phenindione | hsa00330 | Arginine and proline metabolism | 4.86E-02 | 1 | P17707 | AMD1 | More | | | Phenindione | hsa00500 | Starch and sucrose metabolism | 1.51E-04 | 4 | O43451, P46976, P35573, P06737 | MGAM, GYG1, AGL, PYGL | More | | | Phenindione | hsa00512 | Mucin type O-glycan biosynthesis | 3.19E-03 | 3 | O95395, Q8N4A0, Q9NY28 | GCNT3, GALNT4, GALNT8 | More | | | Phenindione | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Phenindione | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Phenindione | hsa00600 | Sphingolipid metabolism | 1.10E-02 | 4 | Q9BX95, O14494, P06280, P15289 | SGPP1, PLPP1, GLA, ARSA | More | | | Phenindione | hsa00630 | Glyoxylate and dicarboxylate metabolism | 6.37E-05 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Phenindione | hsa00730 | Thiamine metabolism | 4.07E-02 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Phenindione | hsa00830 | Retinol metabolism | 3.93E-02 | 3 | P00352, Q9BPW9, O75911 | ALDH1A1, DHRS9, DHRS3 | More | | | Phenindione | hsa00910 | Nitrogen metabolism | 2.66E-03 | 3 | P22748, P15104, P49448 | CA4, GLUL, GLUD2 | More | | | Phenindione | hsa00920 | Sulfur metabolism | 3.18E-02 | 1 | Q16762 | TST | More | | | Phenindione | hsa00970 | Aminoacyl-tRNA biosynthesis | 6.28E-04 | 3 | O95363, P14868, Q15046 | FARS2, DARS, KARS | More | | | Phenindione | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Phenindione | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Phenindione | hsa00983 | Drug metabolism - other enzymes | 3.54E-03 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Phenindione | hsa01100 | Metabolic pathways | 4.43E-02 | 23 | Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737 | MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL | More | | | Phenindione | hsa01200 | Carbon metabolism | 5.71E-03 | 7 | P04075, P04406, P60174, P06733, O14521, Q9P2R7, Q02252 | ALDOA, GAPDH, TPI1, ENO1, SDHD, SUCLA2, ALDH6A1 | More | | | Phenindione | hsa01230 | Biosynthesis of amino acids | 6.95E-04 | 7 | P60174, P04406, P06733, P04075, Q99707, P15104, P37837 | TPI1, GAPDH, ENO1, ALDOA, MTR, GLUL, TALDO1 | More | | | Phenindione | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1.82E-02 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa01522 | Endocrine resistance | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa01523 | Antifolate resistance | 6.06E-03 | 2 | Q92820, P04818 | GGH, TYMS | More | | | Phenindione | hsa01524 | Platinum drug resistance | 4.67E-02 | 4 | Q13489, P98170, P78417, P43246 | BIRC3, BIRC4, GSTO1, MSH2 | More | | | Phenindione | hsa02010 | ABC transporters | 4.48E-02 | 1 | Q8IZY2 | ABCA7 | More | | | Phenindione | hsa03010 | Ribosome | 4.92E-05 | 11 | P42677, P30050, P40429, P46776, Q9H0U6, Q07020, P62910, P36578, P05386, P62249, P23396 | RPS27, RPL12, RPL13A, RPL27A, MRPL18, RPL18, RPL32, RPL4, RPLP1, RPS16, RPS3 | More | | | Phenindione | hsa03013 | RNA transport | 3.96E-04 | 12 | P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q9Y6A5, P51114 | NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, TACC3, FXR1 | More | | | Phenindione | hsa03040 | Spliceosome | 1.25E-08 | 14 | Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643 | DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.775 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.871 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.809 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.716 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.811 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.702 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.879 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.827 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.806 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.783 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.703 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.943 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.731 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.876 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
| | Phenindione | hsa03050 | Proteasome | 3.93E-02 | 1 | P62195 | PSMC5 | More | | | Phenindione | hsa03320 | PPAR signaling pathway | 4.33E-02 | 2 | Q6PCB7, Q9UNU6 | SLC27A1, CYP8B1 | More | | | Phenindione | hsa03410 | Base excision repair | 4.17E-02 | 2 | P49005, P29372 | POLD2, MPG | More | | | Phenindione | hsa03430 | Mismatch repair | 4.38E-02 | 1 | P20585 | MSH3 | More | | | Phenindione | hsa04010 | MAPK signaling pathway | 4.15E-02 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa04012 | ErbB signaling pathway | 3.15E-02 | 3 | P16333, P19174, P01106 | NCK1, PLCG1, MYC | More | | | Phenindione | hsa04014 | Ras signaling pathway | 3.86E-04 | 12 | P42338, P20827, Q9NRA1, P49767, P08069, Q13009, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174 | PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1 | More | | | Phenindione | hsa04015 | Rap1 signaling pathway | 9.79E-05 | 14 | P20827, P49767, P08069, P06213, Q96FS4, P11215, P25116, Q8TEU7, Q13009, O00522, Q7LDG7, P42338, P08514, P19174 | EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, KRIT1, RASGRP2, PIK3CB, ITGA2B, PLCG1 | More | | | Phenindione | hsa04020 | Calcium signaling pathway | 4.45E-02 | 3 | P0DP24, P51828, P23634 | CALM2, ADCY7, ATP2B4 | More | | | Phenindione | hsa04022 | cGMP-PKG signaling pathway | 4.79E-02 | 3 | P21796, Q14344, P01042 | VDAC1, GNA13, KNG1 | More | | | Phenindione | hsa04024 | cAMP signaling pathway | 3.79E-02 | 3 | P51828, P0DP24, P23634 | ADCY7, CALM2, ATP2B4 | More | | | Phenindione | hsa04060 | Cytokine-cytokine receptor interaction | 7.03E-05 | 16 | P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P01375, P09341, P18510, P01730, Q93038 | IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNF, CXCL1, IL1RN, CD4, TNFRSF25 | More | | | Phenindione | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 1.57E-03 | 7 | P09341, P25024, P47992, Q9UBD3, Q13651, P14784, P01375 | CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB, TNF | More | | | Phenindione | hsa04062 | Chemokine signaling pathway | 2.53E-07 | 19 | P25024, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P14598, P42224, P25963, Q8WYR1 | CXCR1, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, PIK3R5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06239 | LCK | Tyrosine-protein kinase Lck | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.779 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | | P06239 | LCK | Tyrosine-protein kinase Lck | P47992 | XCL1 | Lymphotactin | 0.715 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UBD3 | XCL2 | Cytokine SCM-1 beta | 0.715 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.782 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.767 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.709 | | P06239 | LCK | Tyrosine-protein kinase Lck | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.728 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.759 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P06239 | LCK | Tyrosine-protein kinase Lck | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.71 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.744 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P06239 | LCK | Tyrosine-protein kinase Lck | P43250 | GRK6 | G protein-coupled receptor kinase 6 | -0.702 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.815 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.746 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.771 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.785 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 |
| | Phenindione | hsa04064 | NF-kappa B signaling pathway | 2.19E-09 | 19 | P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P29965, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, Q06643 | BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, CD40LG, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, LTB | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P06239 | LCK | Tyrosine-protein kinase Lck | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.718 | | P08246 | ELA2 | Neutrophil elastase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.814 | | P08311 | CTSG | Cathepsin G | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.853 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P08311 | CTSG | Cathepsin G | P01375 | TNF | Tumor necrosis factor | 0.733 | | P17252 | PRKCA | Protein kinase C alpha type | P29965 | CD40LG | CD40 ligand | 0.788 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | | P08311 | CTSG | Cathepsin G | Q04759 | PRKCQ | Protein kinase C theta type | -0.913 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.769 | | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.73 | | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.875 | | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | | P08311 | CTSG | Cathepsin G | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.79 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P08311 | CTSG | Cathepsin G | P06239 | LCK | Tyrosine-protein kinase Lck | -0.816 | | P17252 | PRKCA | Protein kinase C alpha type | Q8WV28 | BLNK | B-cell linker protein | 0.838 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q8WV28 | BLNK | B-cell linker protein | -0.816 | | P17252 | PRKCA | Protein kinase C alpha type | Q13315 | ATM | Serine-protein kinase ATM | 0.739 | | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | | P08311 | CTSG | Cathepsin G | Q13315 | ATM | Serine-protein kinase ATM | -0.709 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | | P06239 | LCK | Tyrosine-protein kinase Lck | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.724 | | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 | | P08311 | CTSG | Cathepsin G | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.799 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | | P08311 | CTSG | Cathepsin G | P09341 | CXCL1 | Growth-regulated alpha protein | 0.877 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q06643 | LTB | Lymphotoxin-beta | 0.846 |
| | Phenindione | hsa04066 | HIF-1 signaling pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa04070 | Phosphatidylinositol signaling system | 2.57E-03 | 6 | P19174, P0DP23, Q14643, P23743, P27987, P17252 | PLCG1, CALM1, ITPR1, DGKA, ITPKB, PRKCA | More | | | Phenindione | hsa04071 | Sphingolipid signaling pathway | 1.42E-06 | 9 | P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, P10415, Q9UQC2 | PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, BCL2, GAB2 | More | | | Phenindione | hsa04080 | Neuroactive ligand-receptor interaction | 1.18E-02 | 7 | P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1 | More | | | Phenindione | hsa04110 | Cell cycle | 5.59E-04 | 8 | P06493, O60566, O75293, P30304, P33981, P42773, P01106, Q13547 | CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1 | More | | | Phenindione | hsa04114 | Oocyte meiosis | 1.75E-06 | 10 | Q9Y6D9, P51812, Q02750, P0DP24, P16298, Q17RY0, P51828, P27348, Q13362, P08069 | MAD1L1, RPS6KA3, MAP2K1, CALM2, PPP3CB, CPEB4, ADCY7, YWHAQ, PPP2R5C, IGF1R | More | | | Phenindione | hsa04115 | p53 signaling pathway | 5.07E-03 | 7 | P24522, Q13315, P31350, Q53FA7, P06493, O95067, P10415 | GADD45A, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2 | More | | | Phenindione | hsa04122 | Sulfur relay system | 3.18E-02 | 1 | Q16762 | TST | More | | | Phenindione | hsa04137 | Mitophagy - animal | 1.41E-03 | 3 | P67870, P19532, P18848 | CSNK2B, TFE3, ATF4 | More | | | Phenindione | hsa04140 | Autophagy - animal | 5.31E-02 | 6 | P08069, P22694, Q14643, P10415, Q9H1Y0, Q04759 | IGF1R, PRKACB, ITPR1, BCL2, ATG5, PRKCQ | More | | | Phenindione | hsa04141 | Protein processing in endoplasmic reticulum | 8.60E-03 | 6 | P30101, P60604, P11142, P08238, Q9H173, Q9UNL2 | PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3 | More | | | Phenindione | hsa04142 | Lysosome | 2.08E-03 | 6 | Q99437, P25774, P22304, Q13510, Q04900, Q9Y227 | ATP6V0B, CTSS, IDS, ASAH1, CD164, ENTPD4 | More | | | Phenindione | hsa04144 | Endocytosis | 2.25E-02 | 5 | O75351, P42566, Q15438, Q14161, Q9UNH7 | VPS4B, EPS15, PSCD1, GIT2, SNX6 | More | | | Phenindione | hsa04145 | Phagosome | 6.28E-08 | 13 | P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, Q99437, P05164, O60603, P35443, P13765, P25774 | ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, TLR2, THBS4, HLA-DOB, CTSS | More | | | Phenindione | hsa04150 | mTOR signaling pathway | 7.74E-03 | 4 | P08069, Q02750, Q9NQL2, P51812 | IGF1R, MAP2K1, RRAGD, RPS6KA3 | More | | | Phenindione | hsa04151 | PI3K-Akt signaling pathway | 5.33E-03 | 20 | P42338, P43657, P25116, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252, P30281 | PIK3CB, P2RY5, F2R, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA, CCND3 | More | | | Phenindione | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa04210 | Apoptosis | 1.52E-02 | 9 | Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643 | ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1 | More | | | Phenindione | hsa04211 | Longevity regulating pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa04213 | Longevity regulating pathway - multiple species | 1.66E-02 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa04217 | Necroptosis | 3.82E-04 | 11 | P01568, Q13489, P98170, P42224, P08238, P15104, Q6FI13, P10415, O43633, P21796, Q08752 | IFNA21, BIRC3, BIRC4, STAT1, HSP90AB1, GLUL, H2AC18; H2AC19, BCL2, CHMP2A, VDAC1, PPID | More | | | Phenindione | hsa04261 | Adrenergic signaling in cardiomyocytes | 1.43E-03 | 8 | P09493, P51828, Q13362, P0DP24, P0DP23, P17252, P10415, P23634 | TPM1, ADCY7, PPP2R5C, CALM2, CALM1, PRKCA, BCL2, ATP2B4 | More | | | Phenindione | hsa04360 | Axon guidance | 4.04E-02 | 6 | P16333, P20827, O95631, P42338, P07332, P19174 | NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1 | More | | | Phenindione | hsa04370 | VEGF signaling pathway | 1.79E-05 | 3 | P16298, Q05397, Q02750 | PPP3CB, PTK2, MAP2K1 | More | | | Phenindione | hsa04371 | Apelin signaling pathway | 1.80E-09 | 11 | P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23 | GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.711 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.709 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.759 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.744 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | -0.826 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14814 | MEF2D | Myocyte-specific enhancer factor 2D | 0.767 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.735 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.756 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.832 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.899 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 1 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.847 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | 0.708 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P0DP23 | CALM1 | Calmodulin-1 | -0.724 |
| | Phenindione | hsa04510 | Focal adhesion | 3.48E-02 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa04512 | ECM-receptor interaction | 3.73E-02 | 2 | P07359, P08514 | GP1BA, ITGA2B | More | | | Phenindione | hsa04514 | Cell adhesion molecules | 8.19E-03 | 3 | P16109, P56750, O00501 | SELP, CLDN17, CLDN5 | More | | | Phenindione | hsa04520 | Adherens junction | 8.29E-03 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa04530 | Tight junction | 2.47E-05 | 5 | Q8TEU7, P16989, P56750, O00501, Q14247 | RAPGEF6, CSDA, CLDN17, CLDN5, CTTN | More | | | Phenindione | hsa04540 | Gap junction | 3.48E-04 | 6 | P17252, Q13509, P68371, Q71U36, Q9NRA1, Q14643 | PRKCA, TUBB3, TUBB2C, TUBA1A, PDGFC, ITPR1 | More | | | Phenindione | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 9.61E-03 | 4 | Q13873, Q02750, P08069, Q86SE9 | BMPR2, MAP2K1, IGF1R, PCGF5 | More | | | Phenindione | hsa04610 | Complement and coagulation cascades | 8.72E-04 | 3 | P25116, P09871, P0C0L4 | F2R, C1S, C4A | More | | | Phenindione | hsa04611 | Platelet activation | 5.18E-05 | 5 | P25116, P08514, Q15746, Q8WYR1, P07359 | F2R, ITGA2B, MYLK, PIK3R5, GP1BA | More | | | Phenindione | hsa04612 | Antigen processing and presentation | 3.74E-07 | 13 | P04233, P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732, P01889, P10321, Q06323, P01375 | CD74, HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HLA-B, HLA-C, PSME1, TNF | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| Q9BQB6 | VKORC1 | Vitamin K epoxide reductase complex subunit 1 | P04233 | CD74 | HLA class II histocompatibility antigen gamma chain | 0.7 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.757 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.7 | | P08311 | CTSG | Cathepsin G | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.863 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P48382 | RFX5 | DNA-binding protein RFX5 | -0.782 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P48382 | RFX5 | DNA-binding protein RFX5 | -0.743 | | P08311 | CTSG | Cathepsin G | P48382 | RFX5 | DNA-binding protein RFX5 | -0.794 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.874 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.756 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.714 | | P08311 | CTSG | Cathepsin G | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.867 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.874 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.756 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.714 | | P08311 | CTSG | Cathepsin G | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.867 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.906 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.758 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.715 | | P08311 | CTSG | Cathepsin G | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.812 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O43908 | KLRC4 | NKG2-F type II integral membrane protein | -0.721 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.839 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.722 | | P08311 | CTSG | Cathepsin G | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.826 | | Q9BQB6 | VKORC1 | Vitamin K epoxide reductase complex subunit 1 | P01889 | HLA-B | HLA class I histocompatibility antigen, B alpha chain | 0.706 | | Q9BQB6 | VKORC1 | Vitamin K epoxide reductase complex subunit 1 | P10321 | HLA-C | HLA class I histocompatibility antigen, C alpha chain | 0.706 | | Q9BQB6 | VKORC1 | Vitamin K epoxide reductase complex subunit 1 | Q06323 | PSME1 | Proteasome activator complex subunit 1 | 0.708 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P01375 | TNF | Tumor necrosis factor | 0.788 | | P08311 | CTSG | Cathepsin G | P01375 | TNF | Tumor necrosis factor | 0.733 |
| | Phenindione | hsa04613 | Neutrophil extracellular trap formation | 8.03E-07 | 20 | P17252, P16109, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, P21730, P08514, P21462, P07359 | PRKCA, SELP, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, ITGA2B, FPR1, GP1BA | More | | | Phenindione | hsa04621 | NOD-like receptor signaling pathway | 5.12E-04 | 14 | P08238, Q14643, P21796, P25963, Q13489, P98170, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838 | HSP90AB1, ITPR1, VDAC1, NFKBIA, BIRC3, BIRC4, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4 | More | | | Phenindione | hsa04623 | Cytosolic DNA-sensing pathway | 2.59E-02 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Phenindione | hsa04640 | Hematopoietic cell lineage | 8.64E-06 | 12 | P13612, P14778, P27930, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375 | ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF | More | | | Phenindione | hsa04650 | Natural killer cell mediated cytotoxicity | 9.22E-09 | 14 | P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715 | PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1 | More | | | Phenindione | hsa04657 | IL-17 signaling pathway | 2.40E-03 | 7 | O00463, Q16539, P49841, P09341, P14780, P80188, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF | More | | | Phenindione | hsa04658 | Th1 and Th2 cell differentiation | 1.06E-12 | 14 | Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q04759 | PRKCQ | Protein kinase C theta type | -0.91 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | P08311 | CTSG | Cathepsin G | Q04759 | PRKCQ | Protein kinase C theta type | -0.913 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.761 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.828 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P08311 | CTSG | Cathepsin G | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.888 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.793 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P08311 | CTSG | Cathepsin G | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.706 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.762 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.708 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P08311 | CTSG | Cathepsin G | P06239 | LCK | Tyrosine-protein kinase Lck | -0.816 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.767 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.75 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.815 | | P08311 | CTSG | Cathepsin G | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.81 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.905 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | P08311 | CTSG | Cathepsin G | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.866 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.788 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | P08311 | CTSG | Cathepsin G | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.795 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.795 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.757 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P08311 | CTSG | Cathepsin G | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.863 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.721 |
| | Phenindione | hsa04659 | Th17 cell differentiation | 8.38E-13 | 18 | P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963 | NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.705 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | P08311 | CTSG | Cathepsin G | Q04759 | PRKCQ | Protein kinase C theta type | -0.913 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.762 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.708 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P08311 | CTSG | Cathepsin G | P06239 | LCK | Tyrosine-protein kinase Lck | -0.816 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.767 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.75 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.795 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P08311 | CTSG | Cathepsin G | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.863 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.764 | | P08311 | CTSG | Cathepsin G | Q9HBE5 | IL21R | Interleukin-21 receptor | -0.763 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | P08311 | CTSG | Cathepsin G | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.795 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | P08311 | CTSG | Cathepsin G | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.866 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 1 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.832 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.77 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.761 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.838 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P08311 | CTSG | Cathepsin G | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.706 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P08311 | CTSG | Cathepsin G | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.888 |
| | Phenindione | hsa04660 | T cell receptor signaling pathway | 2.55E-10 | 18 | P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841 | TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P01375 | TNF | Tumor necrosis factor | 0.788 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P08311 | CTSG | Cathepsin G | P01375 | TNF | Tumor necrosis factor | 0.733 | | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.779 | | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q04759 | PRKCQ | Protein kinase C theta type | -0.91 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | | P08311 | CTSG | Cathepsin G | Q04759 | PRKCQ | Protein kinase C theta type | -0.913 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | -0.735 | | P08246 | ELA2 | Neutrophil elastase | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | -0.854 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.799 | | P08246 | ELA2 | Neutrophil elastase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.724 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | | P08311 | CTSG | Cathepsin G | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.705 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.855 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | P08246 | ELA2 | Neutrophil elastase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.782 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.746 | | P08311 | CTSG | Cathepsin G | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.866 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.762 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P16333 | NCK1 | Cytoplasmic protein NCK1 | -0.781 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.761 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.828 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.722 | | P08311 | CTSG | Cathepsin G | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.888 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.793 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.77 | | P08311 | CTSG | Cathepsin G | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.706 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.708 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.839 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.722 | | P08311 | CTSG | Cathepsin G | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.826 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.796 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.714 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P08311 | CTSG | Cathepsin G | P06239 | LCK | Tyrosine-protein kinase Lck | -0.816 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.767 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.889 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.861 |
| | Phenindione | hsa04662 | B cell receptor signaling pathway | 1.74E-02 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Phenindione | hsa04664 | Fc epsilon RI signaling pathway | 5.14E-04 | 5 | P04141, P42338, P07948, P19174, P09917 | CSF2, PIK3CB, LYN, PLCG1, ALOX5 | More | | | Phenindione | hsa04668 | TNF signaling pathway | 2.59E-02 | 7 | P01375, O00463, Q13489, P25963, P20749, Q13077, P14780 | TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9 | More | | | Phenindione | hsa04670 | Leukocyte transendothelial migration | 4.20E-02 | 7 | P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681 | MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK | More | | | Phenindione | hsa04672 | Intestinal immune network for IgA production | 1.27E-04 | 4 | P29965, P10747, P13765, P13612 | CD40LG, CD28, HLA-DOB, ITGA4 | More | | | Phenindione | hsa04713 | Circadian entrainment | 1.03E-05 | 7 | O15399, P0DP23, P17252, P62873, P63218, P50151, Q14643 | GRIN2D, CALM1, PRKCA, GNB1, GNG5, GNG10, ITPR1 | More | | | Phenindione | hsa04720 | Long-term potentiation | 1.59E-06 | 10 | P17252, Q16566, P16298, P0DP23, Q15418, P51812, P18848, O15399, Q02750, Q14643 | PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA1, RPS6KA3, ATF4, GRIN2D, MAP2K1, ITPR1 | More | | | Phenindione | hsa04723 | Retrograde endocannabinoid signaling | 1.88E-02 | 4 | Q14643, P17252, P62873, Q16718 | ITPR1, PRKCA, GNB1, NDUFA5 | More | | | Phenindione | hsa04724 | Glutamatergic synapse | 5.54E-05 | 5 | O15399, P62873, P63218, P50151, P15104 | GRIN2D, GNB1, GNG5, GNG10, GLUL | More | | | Phenindione | hsa04725 | Cholinergic synapse | 4.70E-04 | 7 | Q14643, P17252, P62873, P63218, P50151, Q16566, P10415 | ITPR1, PRKCA, GNB1, GNG5, GNG10, CAMK4, BCL2 | More | | | Phenindione | hsa04726 | Serotonergic synapse | 2.36E-03 | 4 | P62873, P63218, P50151, P09917 | GNB1, GNG5, GNG10, ALOX5 | More | | | Phenindione | hsa04727 | GABAergic synapse | 2.50E-05 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Phenindione | hsa04728 | Dopaminergic synapse | 3.55E-02 | 5 | Q14643, P17252, P62873, Q13362, P0DP23 | ITPR1, PRKCA, GNB1, PPP2R5C, CALM1 | More | | | Phenindione | hsa04730 | Long-term depression | 1.95E-02 | 3 | Q14344, P08069, P07948 | GNA13, IGF1R, LYN | More | | | Phenindione | hsa04744 | Phototransduction | 6.50E-07 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Phenindione | hsa04810 | Regulation of actin cytoskeleton | 2.58E-02 | 3 | Q15746, P08514, P25116 | MYLK, ITGA2B, F2R | More | | | Phenindione | hsa04912 | GnRH signaling pathway | 3.26E-03 | 6 | P17252, P51828, Q14643, P0DP24, P0DP23, P45985 | PRKCA, ADCY7, ITPR1, CALM2, CALM1, MAP2K4 | More | | | Phenindione | hsa04913 | Ovarian steroidogenesis | 8.40E-04 | 2 | P06213, P08069 | INSR, IGF1R | More | | | Phenindione | hsa04914 | Progesterone-mediated oocyte maturation | 1.68E-04 | 5 | P08069, Q17RY0, Q9Y6D9, P51812, Q02750 | IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1 | More | | | Phenindione | hsa04918 | Thyroid hormone synthesis | 4.48E-02 | 2 | P18848, P05543 | ATF4, SERPINA7 | More | | | Phenindione | hsa04920 | Adipocytokine signaling pathway | 4.49E-02 | 4 | P25963, P33121, Q04759, P01375 | NFKBIA, ACSL1, PRKCQ, TNF | More | | | Phenindione | hsa04922 | Glucagon signaling pathway | 3.47E-02 | 4 | Q12778, Q13370, P0DP23, Q14643 | FOXO1, PDE3B, CALM1, ITPR1 | More | | | Phenindione | hsa04923 | Regulation of lipolysis in adipocytes | 3.76E-02 | 1 | P06213 | INSR | More | | | Phenindione | hsa04924 | Renin secretion | 7.51E-04 | 5 | P22694, P07550, Q14643, Q13370, P0DP23 | PRKACB, ADRB2, ITPR1, PDE3B, CALM1 | More | | | Phenindione | hsa04925 | Aldosterone synthesis and secretion | 1.32E-02 | 3 | P51828, P0DP24, P23634 | ADCY7, CALM2, ATP2B4 | More | | | Phenindione | hsa04927 | Cortisol synthesis and secretion | 1.66E-02 | 3 | Q14643, P18848, P22694 | ITPR1, ATF4, PRKACB | More | | | Phenindione | hsa04930 | Type II diabetes mellitus | 3.14E-02 | 1 | P06213 | INSR | More | | | Phenindione | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.19E-03 | 9 | P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174 | SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1 | More | | | Phenindione | hsa04940 | Type I diabetes mellitus | 3.64E-02 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | | | Phenindione | hsa04960 | Aldosterone-regulated sodium reabsorption | 3.14E-02 | 1 | P06213 | INSR | More | | | Phenindione | hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 1.90E-03 | 5 | P20020, P23634, P62491, Q9UEF7, P17252 | ATP2B1, ATP2B4, RAB11A, KL, PRKCA | More | | | Phenindione | hsa04964 | Proximal tubule bicarbonate reclamation | 2.61E-03 | 3 | P22748, P00918, P49448 | CA4, CA2, GLUD2 | More | | | Phenindione | hsa04966 | Collecting duct acid secretion | 1.95E-03 | 3 | Q13488, P00918, Q9Y666 | TCIRG1, CA2, SLC12A7 | More | | | Phenindione | hsa04970 | Salivary secretion | 2.22E-05 | 8 | P07550, P51828, P22694, Q14643, P23634, P17252, P0DP24, P49913 | ADRB2, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CAMP | More | | | Phenindione | hsa04972 | Pancreatic secretion | 1.08E-03 | 6 | Q14643, P20020, P23634, P17252, P51828, P62491 | ITPR1, ATP2B1, ATP2B4, PRKCA, ADCY7, RAB11A | More | | | Phenindione | hsa04979 | Cholesterol metabolism | 1.77E-02 | 2 | P21796, P22680 | VDAC1, CYP7A1 | More | | | Phenindione | hsa05010 | Alzheimer disease | 3.76E-03 | 13 | Q16718, O14521, P13073, Q14643, P0DP23, P18848, Q13509, P68371, P67870, P05141, Q08752, P17861, P62195 | NDUFA5, SDHD, COX4I1, ITPR1, CALM1, ATF4, TUBB3, TUBB2C, CSNK2B, SLC25A5, PPID, XBP1, PSMC5 | More | | | Phenindione | hsa05012 | Parkinson disease | 1.01E-03 | 11 | Q16718, O14521, P60604, P17861, P62195, Q14643, P19174, P0DP23, Q71U36, Q13509, P68371 | NDUFA5, SDHD, UBE2G2, XBP1, PSMC5, ITPR1, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C | More | | | Phenindione | hsa05014 | Amyotrophic lateral sclerosis | 2.32E-04 | 3 | P17861, P62195, Q53GS7 | XBP1, PSMC5, GLE1 | More | | | Phenindione | hsa05017 | Spinocerebellar ataxia | 1.95E-03 | 2 | P17861, P62195 | XBP1, PSMC5 | More | | | Phenindione | hsa05020 | Prion disease | 4.67E-03 | 11 | Q16718, O14521, P13073, Q14643, P18848, P05141, Q13509, P68371, P67870, P14598, Q15080 | NDUFA5, SDHD, COX4I1, ITPR1, ATF4, SLC25A5, TUBB3, TUBB2C, CSNK2B, NCF1, NCF4 | More | | | Phenindione | hsa05022 | Pathways of neurodegeneration - multiple diseases | 3.73E-03 | 12 | Q14643, Q13509, P68371, P10415, Q16718, O14521, P17861, Q13561, P17252, Q08752, P0DP23, P62195 | ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, XBP1, DCTN2, PRKCA, PPID, CALM1, PSMC5 | More | | | Phenindione | hsa05032 | Morphine addiction | 7.62E-04 | 5 | P62873, P63218, P50151, Q13370, P43250 | GNB1, GNG5, GNG10, PDE3B, GRK6 | More | | | Phenindione | hsa05034 | Alcoholism | 4.45E-05 | 11 | O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431 | GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Phenindione | hsa05100 | Bacterial invasion of epithelial cells | 2.85E-02 | 3 | Q14141, Q05397, Q96JJ3 | SEPT6, PTK2, ELMO2 | More | | | Phenindione | hsa05110 | Vibrio cholerae infection | 4.78E-02 | 1 | Q99437 | ATP6V0B | More | | | Phenindione | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 6.88E-04 | 8 | Q16539, P25963, Q13488, P09341, P19174, P25024, P25025, P07948 | MAPK14, NFKBIA, TCIRG1, CXCL1, PLCG1, CXCR1, CXCR2, LYN | More | | | Phenindione | hsa05130 | Pathogenic Escherichia coli infection | 1.89E-04 | 13 | Q71U36, Q14247, P56750, O00501, P16333, Q13509, P68371, P25116, Q14344, P25963, Q15438, P35579, P55061 | TUBA1A, CTTN, CLDN17, CLDN5, NCK1, TUBB3, TUBB2C, F2R, GNA13, NFKBIA, PSCD1, MYH9, TEGT | More | | | Phenindione | hsa05131 | Shigellosis | 2.65E-03 | 14 | P01375, P25963, O00463, P68431, Q04759, Q9UDY8, Q9H1Y0, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32 | TNF, NFKBIA, TRAF5, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCQ, MALT1, ATG5, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPF | More | | | Phenindione | hsa05132 | Salmonella infection | 3.06E-06 | 17 | P51617, P25963, P01375, P08238, Q9UJU2, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754 | IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.741 | | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.881 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.825 | | P08246 | ELA2 | Neutrophil elastase | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | -0.771 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.769 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.794 | | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O75369 | FLNB | Filamin-B | -0.746 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O75369 | FLNB | Filamin-B | 0.706 | | P08246 | ELA2 | Neutrophil elastase | Q96A32 | MYLPF | Myosin regulatory light chain 2, skeletal muscle isoform | 0.724 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | | P17252 | PRKCA | Protein kinase C alpha type | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.701 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.924 | | P08246 | ELA2 | Neutrophil elastase | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | -0.949 | | P17252 | PRKCA | Protein kinase C alpha type | Q13561 | DCTN2 | Dynactin subunit 2 | -0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13561 | DCTN2 | Dynactin subunit 2 | -0.809 | | P08246 | ELA2 | Neutrophil elastase | Q13561 | DCTN2 | Dynactin subunit 2 | 0.78 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q71U36 | TUBA1A | Tubulin alpha-1A chain | -0.866 | | P17252 | PRKCA | Protein kinase C alpha type | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.756 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.846 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13509 | TUBB3 | Tubulin beta-3 chain | 0.789 | | P08246 | ELA2 | Neutrophil elastase | Q13509 | TUBB3 | Tubulin beta-3 chain | 0.724 | | P17252 | PRKCA | Protein kinase C alpha type | P68371 | TUBB2C | Tubulin beta-4B chain | -0.842 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P68371 | TUBB2C | Tubulin beta-4B chain | 0.741 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P49754 | VPS41 | Vacuolar protein sorting-associated protein 41 homolog | 0.728 |
| | Phenindione | hsa05133 | Pertussis | 1.58E-03 | 3 | P09871, P0C0L4, Q02556 | C1S, C4A, IRF8 | More | | | Phenindione | hsa05134 | Legionellosis | 4.75E-02 | 3 | P25963, P11215, P11142 | NFKBIA, ITGAM, HSPA8 | More | | | Phenindione | hsa05135 | Yersinia infection | 3.29E-02 | 4 | Q05397, P51812, Q02750, Q96JJ3 | PTK2, RPS6KA3, MAP2K1, ELMO2 | More | | | Phenindione | hsa05140 | Leishmaniasis | 1.49E-06 | 13 | O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, P51617, Q15080 | FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4 | More | | | Phenindione | hsa05144 | Malaria | 3.82E-03 | 5 | P60033, O60603, P01375, P35443, P26718 | CD81, TLR2, TNF, THBS4, KLRK1 | More | | | Phenindione | hsa05145 | Toxoplasmosis | 1.19E-03 | 9 | P51617, P25963, P01375, P10415, Q13489, P42224, P13765, O60603, P29965 | IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG | More | | | Phenindione | hsa05146 | Amoebiasis | 2.40E-06 | 9 | P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311 | CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG | More | | | Phenindione | hsa05150 | Staphylococcus aureus infection | 1.62E-03 | 6 | P0C0L4, P21462, P13646, Q14532, P59665, P59666 | C4A, FPR1, KRT13, KRT32, DEFA1; DEFA1B, DEFA3 | More | | | Phenindione | hsa05152 | Tuberculosis | 5.29E-06 | 15 | Q13488, Q99437, P0DP23, P42224, P48382, P25208, O60603, P01375, P10415, P13765, P25774, P01568, P49913, Q9UDY8, P51617 | TCIRG1, ATP6V0B, CALM1, STAT1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, CTSS, IFNA21, CAMP, MALT1, IRAK1 | More | | | Phenindione | hsa05161 | Hepatitis B | 2.33E-02 | 8 | P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765 | PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4 | More | | | Phenindione | hsa05163 | Human cytomegalovirus infection | 2.66E-05 | 15 | P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, P49841, P14778, P25025, Q16539, P04637, O00463, P30101, P01568 | NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21 | More | | | Phenindione | hsa05165 | Human papillomavirus infection | 3.10E-02 | 8 | P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315 | ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM | More | | | Phenindione | hsa05166 | Human T-cell leukemia virus 1 infection | 3.22E-03 | 7 | P27824, P21796, P84022, Q13485, O95067, P25963, P98170 | CANX, VDAC1, SMAD3, SMAD4, CCNB2, NFKBIA, BIRC4 | More | | | Phenindione | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 1.36E-07 | 16 | P01568, P42224, P25963, P62873, P62879, P63218, P50151, P19174, P16298, Q14643, Q02750, P07948, P04141, P0DP23, P0CG47, Q9UJU2 | IFNA21, STAT1, NFKBIA, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, ITPR1, MAP2K1, LYN, CSF2, CALM1, UBB, LEF1 | More | | | Phenindione | hsa05168 | Herpes simplex virus 1 infection | 5.00E-03 | 12 | P25963, P01568, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P30101, Q13398, O75820, Q9NZL3 | NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF189, ZNF224 | More | | | Phenindione | hsa05169 | Epstein-Barr virus infection | 4.84E-03 | 10 | P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963 | HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247 | More | | | Phenindione | hsa05170 | Human immunodeficiency virus 1 infection | 1.78E-10 | 27 | Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, Q13546, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P10415, Q13619, Q93034, Q9Y6Q5, P20333 | MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, RIPK1, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P11511 | CYP19A1 | Aromatase | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 0.783 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.701 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.709 | | P11511 | CYP19A1 | Aromatase | P62879 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | 0.704 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.759 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.744 | | P11511 | CYP19A1 | Aromatase | P16298 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.706 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P0DP23 | CALM1 | Calmodulin-1 | -0.724 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P11511 | CYP19A1 | Aromatase | Q05397 | PTK2 | Focal adhesion kinase 1 | 0.75 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P17252 | PRKCA | Protein kinase C alpha type | 0.769 | | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.769 | | P08246 | ELA2 | Neutrophil elastase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.814 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.83 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P30101 | PDIA3 | Protein disulfide-isomerase A3 | -0.825 | | P17252 | PRKCA | Protein kinase C alpha type | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.786 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.823 | | P08246 | ELA2 | Neutrophil elastase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.816 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P01568 | IFNA21 | Interferon alpha-21 | 0.716 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P01568 | IFNA21 | Interferon alpha-21 | 0.703 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.741 | | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | | P17252 | PRKCA | Protein kinase C alpha type | Q13315 | ATM | Serine-protein kinase ATM | 0.739 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13315 | ATM | Serine-protein kinase ATM | 0.758 | | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | | P08246 | ELA2 | Neutrophil elastase | O95067 | CCNB2 | G2/mitotic-specific cyclin-B2 | 0.711 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P23528 | CFL1 | Cofilin-1 | 0.738 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | | P08246 | ELA2 | Neutrophil elastase | Q13619 | CUL4A | Cullin-4A | -0.707 | | P08246 | ELA2 | Neutrophil elastase | Q93034 | CUL5 | Cullin-5 | -0.744 | | P17252 | PRKCA | Protein kinase C alpha type | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.829 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.946 | | P08246 | ELA2 | Neutrophil elastase | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | 0.811 | | P11511 | CYP19A1 | Aromatase | P20333 | TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B | -0.75 |
| | Phenindione | hsa05171 | Coronavirus disease - COVID-19 | 9.07E-04 | 10 | P23396, P62249, P42677, P40429, P36578, P30050, Q07020, P46776, P62910, P05386 | RPS3, RPS16, RPS27, RPL13A, RPL4, RPL12, RPL18, RPL27A, RPL32, RPLP1 | More | | | Phenindione | hsa05200 | Pathways in cancer | 1.45E-09 | 33 | Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, Q13547, P14923, P30281, P10415, Q13489, P98170, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P01042 | LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND3, BCL2, BIRC3, BIRC4, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.868 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.77 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.724 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P17252 | PRKCA | Protein kinase C alpha type | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.706 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.705 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.881 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.816 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.742 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 1 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.847 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.832 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.899 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | P20585 | MSH3 | DNA mismatch repair protein Msh3 | -0.766 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P20585 | MSH3 | DNA mismatch repair protein Msh3 | 0.825 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | | P17252 | PRKCA | Protein kinase C alpha type | P14923 | JUP | Junction plakoglobin | 0.761 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.715 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | P98170 | BIRC4 | E3 ubiquitin-protein ligase XIAP | 0.792 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P98170 | BIRC4 | E3 ubiquitin-protein ligase XIAP | 0.716 | | P17252 | PRKCA | Protein kinase C alpha type | P49767 | VEGFC | Vascular endothelial growth factor C | 0.719 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P17252 | PRKCA | Protein kinase C alpha type | Q12778 | FOXO1 | Forkhead box protein O1 | 0.863 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | P17252 | PRKCA | Protein kinase C alpha type | P25116 | F2R | Proteinase-activated receptor 1 | 0.857 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.711 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.709 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.759 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.744 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.735 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.756 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | 0.754 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.742 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.708 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P0DP23 | CALM1 | Calmodulin-1 | -0.724 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P01568 | IFNA21 | Interferon alpha-21 | 0.703 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | P01042 | KNG1 | Kininogen-1 | 0.752 | | Q96KQ7 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | P01042 | KNG1 | Kininogen-1 | 0.708 |
| | Phenindione | hsa05202 | Transcriptional misregulation in cancer | 2.57E-09 | 18 | Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P12980, P24522 | FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, LYL1, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.777 | | P08246 | ELA2 | Neutrophil elastase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.75 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q15532 | SS18 | Protein SSXT | 0.763 | | P08246 | ELA2 | Neutrophil elastase | Q15532 | SS18 | Protein SSXT | -0.806 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13315 | ATM | Serine-protein kinase ATM | 0.758 | | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | | P08311 | CTSG | Cathepsin G | Q13315 | ATM | Serine-protein kinase ATM | -0.709 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.9 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.767 | | P08246 | ELA2 | Neutrophil elastase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.859 | | P08311 | CTSG | Cathepsin G | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.79 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.721 | | P08311 | CTSG | Cathepsin G | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.726 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P14923 | JUP | Junction plakoglobin | 0.845 | | P08246 | ELA2 | Neutrophil elastase | P14923 | JUP | Junction plakoglobin | -0.811 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.772 | | P08311 | CTSG | Cathepsin G | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.909 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.776 | | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | | P08311 | CTSG | Cathepsin G | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.79 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.794 | | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.754 | | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.805 | | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.805 | | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P05164 | MPO | Myeloperoxidase | 0.909 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P05164 | MPO | Myeloperoxidase | -0.758 | | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | | P08311 | CTSG | Cathepsin G | P05164 | MPO | Myeloperoxidase | 0.956 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.882 | | P08246 | ELA2 | Neutrophil elastase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.709 | | P08311 | CTSG | Cathepsin G | P12838 | DEFA4 | Neutrophil defensin 4 | 0.817 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P08246 | ELA2 | Neutrophil elastase | 0.889 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P08246 | ELA2 | Neutrophil elastase | -0.896 | | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | | P08311 | CTSG | Cathepsin G | P08246 | ELA2 | Neutrophil elastase | 0.792 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.85 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.787 | | P08246 | ELA2 | Neutrophil elastase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.75 | | P08311 | CTSG | Cathepsin G | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.853 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P12980 | LYL1 | Protein lyl-1 | 0.702 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.859 | | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 | | P08311 | CTSG | Cathepsin G | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.799 |
| | Phenindione | hsa05203 | Viral carcinogenesis | 6.87E-03 | 6 | Q15283, P06396, P01889, P10321, P62807, O60814 | RASA2, GSN, HLA-B, HLA-C, HIST1H2BC, H2BC12 | More | | | Phenindione | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Phenindione | hsa05205 | Proteoglycans in cancer | 7.11E-03 | 10 | Q13009, Q14643, O75369, P14780, P17252, O60603, P08069, P04628, Q13635, P08962 | TIAM1, ITPR1, FLNB, MMP9, PRKCA, TLR2, IGF1R, WNT1, PTCH1, CD63 | More | | | Phenindione | hsa05210 | Colorectal cancer | 4.64E-03 | 5 | P84022, Q13485, P43246, P20585, O75293 | SMAD3, SMAD4, MSH2, MSH3, GADD45B | More | | | Phenindione | hsa05212 | Pancreatic cancer | 4.38E-04 | 5 | P42338, P42224, P84022, Q13485, O75293 | PIK3CB, STAT1, SMAD3, SMAD4, GADD45B | More | | | Phenindione | hsa05213 | Endometrial cancer | 3.79E-02 | 2 | O15169, Q02750 | AXIN1, MAP2K1 | More | | | Phenindione | hsa05214 | Glioma | 6.12E-04 | 5 | P08069, P0DP23, Q16566, P19174, O75293 | IGF1R, CALM1, CAMK4, PLCG1, GADD45B | More | | | Phenindione | hsa05215 | Prostate cancer | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa05218 | Melanoma | 6.63E-03 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa05219 | Bladder cancer | 4.07E-02 | 2 | P14780, P04637 | MMP9, TP53 | More | | | Phenindione | hsa05220 | Chronic myeloid leukemia | 2.08E-03 | 6 | Q13547, Q13485, P25963, P84022, P42338, O75293 | HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B | More | | | Phenindione | hsa05222 | Small cell lung cancer | 3.10E-03 | 9 | Q13751, Q13489, P98170, P10415, P25963, Q13077, O00463, P24522, O75293 | LAMB3, BIRC3, BIRC4, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A, GADD45B | More | | | Phenindione | hsa05223 | Non-small cell lung cancer | 4.24E-02 | 3 | P19174, Q9HC35, O75293 | PLCG1, EML4, GADD45B | More | | | Phenindione | hsa05224 | Breast cancer | 1.24E-02 | 5 | P08069, P49841, Q92837, P04637, P24522 | IGF1R, GSK3B, FRAT1, TP53, GADD45A | More | | | Phenindione | hsa05225 | Hepatocellular carcinoma | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Phenindione | hsa05226 | Gastric cancer | 3.79E-02 | 2 | Q02750, O15169 | MAP2K1, AXIN1 | More | | | Phenindione | hsa05231 | Choline metabolism in cancer | 4.24E-02 | 3 | Q9Y259, P19174, P49619 | CHKB, PLCG1, DGKG | More | | | Phenindione | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 1.72E-06 | 12 | O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, Q04759, Q16539, Q9HC35, P01730 | RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, PRKCQ, MAPK14, EML4, CD4 | More | | | Phenindione | hsa05310 | Asthma | 2.15E-04 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Phenindione | hsa05320 | Autoimmune thyroid disease | 1.27E-03 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | | Phenindione | hsa05321 | Inflammatory bowel disease | 3.90E-07 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R | More | | | Phenindione | hsa05322 | Systemic lupus erythematosus | 5.50E-07 | 15 | P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455 | ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSB | More | | | Phenindione | hsa05323 | Rheumatoid arthritis | 5.62E-04 | 6 | P01375, P13765, Q13488, P10747, P09341, O60603 | TNF, HLA-DOB, TCIRG1, CD28, CXCL1, TLR2 | More | | | Phenindione | hsa05330 | Allograft rejection | 1.62E-02 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | | | Phenindione | hsa05332 | Graft-versus-host disease | 1.21E-06 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Phenindione | hsa05340 | Primary immunodeficiency | 2.26E-03 | 4 | P01730, P01732, P07766, P06239 | CD4, CD8A, CD3E, LCK | More | | | Phenindione | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.48E-02 | 1 | P54284 | CACNB3 | More | | | Phenindione | hsa05414 | Dilated cardiomyopathy | 4.55E-02 | 2 | P54284, P26678 | CACNB3, PLN | More | | | Phenindione | hsa05415 | Diabetic cardiomyopathy | 3.55E-02 | 5 | P17252, P14598, Q15080, Q16718, O14521 | PRKCA, NCF1, NCF4, NDUFA5, SDHD | More | | | Phenindione | hsa05416 | Viral myocarditis | 2.62E-02 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | | | Phenindione | hsa05418 | Fluid shear stress and atherosclerosis | 2.62E-02 | 6 | Q16539, P10599, P14780, P04637, P14778, P27930 | MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2 | More | |
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