PharmaCoNets of Phenformin (SPCN: 24.86 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Phenforminhsa00030Pentose phosphate pathway4.23E-022P51854, P37837TKTL1, TALDO1More
Phenforminhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Phenforminhsa00071Fatty acid degradation2.52E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Phenforminhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Phenforminhsa00220Arginine biosynthesis4.40E-032P15104, P49448GLUL, GLUD2More
Phenforminhsa00250Alanine, aspartate and glutamate metabolism4.40E-032P49448, P15104GLUD2, GLULMore
Phenforminhsa00471D-Glutamine and D-glutamate metabolism3.94E-021P49448GLUD2More
Phenforminhsa00500Starch and sucrose metabolism3.59E-053O43451, P46976, P06737MGAM, GYG1, PYGLMore
Phenforminhsa00562Inositol phosphate metabolism4.55E-022P27987, P42338ITPKB, PIK3CBMore
Phenforminhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Phenforminhsa00630Glyoxylate and dicarboxylate metabolism4.12E-032P40925, P15104MDH1, GLULMore
Phenforminhsa00730Thiamine metabolism6.87E-053Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Phenforminhsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Phenforminhsa00770Pantothenate and CoA biosynthesis2.27E-022O95498, O95497VNN2, VNN1More
Phenforminhsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Phenforminhsa00970Aminoacyl-tRNA biosynthesis2.77E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Phenforminhsa00983Drug metabolism - other enzymes2.83E-023P20839, P32320, P05164IMPDH1, CDA, MPOMore
Phenforminhsa01100Metabolic pathways4.28E-0435Q9NR34, P05089, O95455, P21953, P15104, P42338, P27987, P32320, P22748, P11766, P55809, P06280, Q16875, O43286, O43451, P53004, P05186, P24666, Q9HCC0, P33121, Q08477, P09917, P15907, P57054, Q9UNP4, Q9BX95, P37837, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, TGDS, BCKDHB, GLUL, PIK3CB, ITPKB, CDA, CA4, ADH5, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, BLVRA, ALPL, ACP1, MCCC2, ACSL1, CYP4F3, ALOX5, ST6GAL1, PIGP, ST3GAL5, SGPP1, TALDO1, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Phenforminhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Phenforminhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Phenforminhsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Phenforminhsa04062Chemokine signaling pathway2.94E-024P07948, P42338, P50151, P49407LYN, PIK3CB, GNG10, ARRB1More
Phenforminhsa04064NF-kappa B signaling pathway2.99E-027O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Phenforminhsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Phenforminhsa04071Sphingolipid signaling pathway2.16E-025P21453, Q9H228, P01375, Q13362, Q9BX95S1PR1, EDG8, TNF, PPP2R5C, SGPP1More
Phenforminhsa04072Phospholipase D signaling pathway9.70E-032Q92529, Q14344SHC3, GNA13More
Phenforminhsa04080Neuroactive ligand-receptor interaction2.16E-027P08311, Q15722, P21453, Q9H228, P21462, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, FPR1, C5AR1, ADRB2More
Phenforminhsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Phenforminhsa04145Phagosome2.24E-026O75015, Q15080, P05164, P78380, P35443, P13765FCGR3B, NCF4, MPO, OLR1, THBS4, HLA-DOBMore
Phenforminhsa04150mTOR signaling pathway2.23E-023P42338, Q13322, P49841PIK3CB, GRB10, GSK3BMore
Phenforminhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Phenforminhsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Phenforminhsa04340Hedgehog signaling pathway3.91E-021P17612PRKACAMore
Phenforminhsa04360Axon guidance2.19E-023P42338, O14639, P24844PIK3CB, ABLIM1, MYL9More
Phenforminhsa04380Osteoclast differentiation4.80E-024P06239, P42338, P14778, Q8N149LCK, PIK3CB, IL1R1, LILRA2More
Phenforminhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Phenforminhsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Phenforminhsa04612Antigen processing and presentation5.33E-037P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Phenforminhsa04613Neutrophil extracellular trap formation3.47E-0415P11215, P05164, P08246, Q9UM07, Q13547, P58876, Q16778, O60814, Q15080, P20160, P08311, P49913, O75015, P21730, P21462ITGAM, MPO, ELA2, PADI4, HDAC1, H2BC5, HIST2H2BE, H2BC12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1More
Phenforminhsa04621NOD-like receptor signaling pathway1.93E-028Q16539, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838MAPK14, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4More
Phenforminhsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Phenforminhsa04650Natural killer cell mediated cytotoxicity4.34E-038P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Phenforminhsa04657IL-17 signaling pathway2.09E-047O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Phenforminhsa04658Th1 and Th2 cell differentiation1.26E-026Q04759, P20963, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, STAT4, GATA3, TBX21, HLA-DOBMore
Phenforminhsa04659Th17 cell differentiation4.12E-024P06239, P14784, P14778, P07766LCK, IL2RB, IL1R1, CD3EMore
Phenforminhsa04660T cell receptor signaling pathway5.84E-038P01375, Q04759, P10747, O95267, Q08881, P20963, P01732, Q13191TNF, PRKCQ, CD28, RASGRP1, ITK, CD247, CD8A, CBLBMore
Phenforminhsa04662B cell receptor signaling pathway2.37E-046P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Phenforminhsa04664Fc epsilon RI signaling pathway3.97E-033P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Phenforminhsa04727GABAergic synapse3.63E-022P50151, P15104GNG10, GLULMore
Phenforminhsa04730Long-term depression3.52E-021Q14344GNA13More
Phenforminhsa04742Taste transduction3.91E-021P17612PRKACAMore
Phenforminhsa04750Inflammatory mediator regulation of TRP channels3.72E-023P14778, P42338, P24723IL1R1, PIK3CB, PRKCHMore
Phenforminhsa04924Renin secretion1.55E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Phenforminhsa04926Relaxin signaling pathway2.59E-023P42338, P50151, P49407PIK3CB, GNG10, ARRB1More
Phenforminhsa04929GnRH secretion1.13E-032P42338, P49407PIK3CB, ARRB1More
Phenforminhsa04940Type I diabetes mellitus1.55E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Phenforminhsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Phenforminhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Phenforminhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Phenforminhsa04970Salivary secretion1.74E-024P07550, P22694, Q14643, P49913ADRB2, PRKACB, ITPR1, CAMPMore
Phenforminhsa04973Carbohydrate digestion and absorption4.12E-032O43451, P42338MGAM, PIK3CBMore
Phenforminhsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Phenforminhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Phenforminhsa05120Epithelial cell signaling in Helicobacter pylori infection1.36E-034Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Phenforminhsa05133Pertussis4.20E-021P0C0L4C4AMore
Phenforminhsa05140Leishmaniasis1.77E-037P13612, O75015, P13765, O60603, P01375, P49006, Q16539ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MARCKSL1, MAPK14More
Phenforminhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Phenforminhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Phenforminhsa05146Amoebiasis7.18E-048P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Phenforminhsa05150Staphylococcus aureus infection2.66E-036P21730, P21462, O75015, P13765, P12838, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4, CAMPMore
Phenforminhsa05163Human cytomegalovirus infection3.44E-039P01375, P50151, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463TNF, GNG10, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Phenforminhsa05202Transcriptional misregulation in cancer2.43E-0415Q12778, Q13315, P41732, P14780, P27930, Q15744, Q16548, P11215, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980FOXO1, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1More
Phenforminhsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Phenforminhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Phenforminhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Phenforminhsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Phenforminhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Phenforminhsa05310Asthma6.83E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Phenforminhsa05321Inflammatory bowel disease2.27E-035P01375, P13765, Q14765, Q9UL17, P23771TNF, HLA-DOB, STAT4, TBX21, GATA3More
Phenforminhsa05322Systemic lupus erythematosus3.69E-039O75015, P08246, P08311, P01375, P10747, P13765, P58876, Q16778, O60814FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2BC5, HIST2H2BE, H2BC12More
Phenforminhsa05323Rheumatoid arthritis2.62E-024P01375, P13765, P10747, P09341TNF, HLA-DOB, CD28, CXCL1More
Phenforminhsa05330Allograft rejection2.83E-023P13765, P10747, P01375HLA-DOB, CD28, TNFMore
Phenforminhsa05332Graft-versus-host disease4.66E-045P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Phenforminhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Phenforminhsa05418Fluid shear stress and atherosclerosis2.04E-048Q16539, P42338, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, PIK3CB, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Phenformin (SDC: 2.51)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Predicted00.07310.08780.20670.4189
Q99712KCNJ15ATPNonesensitive inward rectifier potassium channel 15Predicted00.15870.07790.12670.3619
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)