PharmaCoNets of Phenelzine (SPCN: 28.36 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Phenelzinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Phenelzinehsa00410beta-Alanine metabolism4.50E-021Q6ZQY3GADL1More
Phenelzinehsa00471D-Glutamine and D-glutamate metabolism2.28E-021Q7Z3D6C14orf159More
Phenelzinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Phenelzinehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Phenelzinehsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis4.50E-021Q14442PIGHMore
Phenelzinehsa00565Ether lipid metabolism4.50E-021Q8N661TMEM86BMore
Phenelzinehsa00590Arachidonic acid metabolism2.95E-033P11712, P18054, P09960CYP2C9, ALOX12, LTA4HMore
Phenelzinehsa00591Linoleic acid metabolism1.58E-031P11712CYP2C9More
Phenelzinehsa00600Sphingolipid metabolism4.56E-023Q9BX95, Q06136, P06280SGPP1, FVT1, GLAMore
Phenelzinehsa00770Pantothenate and CoA biosynthesis2.28E-021Q6ZQY3GADL1More
Phenelzinehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Phenelzinehsa00980Metabolism of xenobiotics by cytochrome P4501.45E-042P78417, P11712GSTO1, CYP2C9More
Phenelzinehsa00982Drug metabolism - cytochrome P4501.45E-042P11712, P78417CYP2C9, GSTO1More
Phenelzinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Phenelzinehsa03013RNA transport1.91E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Phenelzinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Phenelzinehsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Phenelzinehsa04014Ras signaling pathway1.72E-0311P42338, P20827, P49767, Q13009, P17252, Q7LDG7, Q14644, P0DP23, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, PRKCA, RASGRP2, RASA3, CALM1, GNG5, GNG10, PLCG1More
Phenelzinehsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Phenelzinehsa04020Calcium signaling pathway8.12E-056P17252, Q93086, Q15746, P0DP23, P23634, P49767PRKCA, P2RX5, MYLK, CALM1, ATP2B4, VEGFCMore
Phenelzinehsa04022cGMP-PKG signaling pathway3.50E-023P23634, Q15746, P0DP23ATP2B4, MYLK, CALM1More
Phenelzinehsa04062Chemokine signaling pathway9.51E-0411P10145, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1IL8, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Phenelzinehsa04064NF-kappa B signaling pathway2.83E-028P10415, Q13489, O00463, Q13546, Q9UDY8, Q13077, Q16548, P24522BCL2, BIRC3, TRAF5, RIPK1, MALT1, TRAF1, BCL2A1, GADD45AMore
Phenelzinehsa04071Sphingolipid signaling pathway1.03E-026P21453, Q9H228, Q16537, Q9BX95, Q16539, P10415S1PR1, EDG8, PPP2R5E, SGPP1, MAPK14, BCL2More
Phenelzinehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Phenelzinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Phenelzinehsa04261Adrenergic signaling in cardiomyocytes3.02E-023P0DP23, P17252, P23634CALM1, PRKCA, ATP2B4More
Phenelzinehsa04270Vascular smooth muscle contraction1.50E-023Q15746, P17252, P0DP23MYLK, PRKCA, CALM1More
Phenelzinehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Phenelzinehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Phenelzinehsa04510Focal adhesion2.35E-024Q15746, P17252, Q13489, P49767MYLK, PRKCA, BIRC3, VEGFCMore
Phenelzinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Phenelzinehsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Phenelzinehsa04613Neutrophil extracellular trap formation1.78E-0621P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, O75015, P21730, P21462, O43315, Q16539ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Phenelzinehsa04659Th17 cell differentiation1.70E-027P19174, P14784, P14778, P84022, Q13485, P08238, P07766PLCG1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Phenelzinehsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Phenelzinehsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Phenelzinehsa04668TNF signaling pathway4.96E-026O00463, Q13546, Q13489, Q16539, Q13077, P14780TRAF5, RIPK1, BIRC3, MAPK14, TRAF1, MMP9More
Phenelzinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Phenelzinehsa04720Long-term potentiation3.63E-022P17252, P0DP23PRKCA, CALM1More
Phenelzinehsa04726Serotonergic synapse1.50E-023P17252, P11712, P18054PRKCA, CYP2C9, ALOX12More
Phenelzinehsa04750Inflammatory mediator regulation of TRP channels9.58E-033P18054, P17252, P0DP23ALOX12, PRKCA, CALM1More
Phenelzinehsa04912GnRH signaling pathway3.63E-022P17252, P0DP23PRKCA, CALM1More
Phenelzinehsa04916Melanogenesis3.97E-033P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Phenelzinehsa04921Oxytocin signaling pathway2.19E-023Q15746, P0DP23, P17252MYLK, CALM1, PRKCAMore
Phenelzinehsa04925Aldosterone synthesis and secretion5.51E-033P0DP23, P17252, P23634CALM1, PRKCA, ATP2B4More
Phenelzinehsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Phenelzinehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Phenelzinehsa04961Endocrine and other factor-regulated calcium reabsorption1.40E-022P23634, P17252ATP2B4, PRKCAMore
Phenelzinehsa04970Salivary secretion3.97E-033P23634, P17252, P0DP23ATP2B4, PRKCA, CALM1More
Phenelzinehsa04971Gastric acid secretion5.51E-033P17252, P0DP23, Q15746PRKCA, CALM1, MYLKMore
Phenelzinehsa04972Pancreatic secretion1.40E-022P23634, P17252ATP2B4, PRKCAMore
Phenelzinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Phenelzinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Phenelzinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Phenelzinehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Phenelzinehsa05120Epithelial cell signaling in Helicobacter pylori infection6.89E-032Q99437, P10145ATP6V0B, IL8More
Phenelzinehsa05133Pertussis1.73E-033P0DP23, P09871, P0C0L4CALM1, C1S, C4AMore
Phenelzinehsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Phenelzinehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Phenelzinehsa05202Transcriptional misregulation in cancer1.45E-0416Q15532, P41732, P14780, P27930, Q16548, P11215, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, Q13547, Q92769, P12980, P24522SS18, TSPAN7, MMP9, IL1R2, BCL2A1, ITGAM, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, HDAC1, HDAC2, LYL1, GADD45AMore
Phenelzinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Phenelzinehsa05204Chemical carcinogenesis4.09E-042P78417, P11712GSTO1, CYP2C9More
Phenelzinehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Phenelzinehsa05214Glioma4.55E-022P0DP23, P17252CALM1, PRKCAMore
Phenelzinehsa05217Basal cell carcinoma2.01E-024Q13635, P04628, Q9UJU2, P24522PTCH1, WNT1, LEF1, GADD45AMore
Phenelzinehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Phenelzinehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Phenelzinehsa05323Rheumatoid arthritis4.28E-022Q99437, P10145ATP6V0B, IL8More
Phenelzinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Phenelzine (SDC: 3.51)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P09958FURINFurinPredicted10.15690.07500.2286
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P09871C1SComplement C1s subcomponentPredicted10.09720.02820.54030.6452
Q6ZQY3GADL1Acidic amino acid decarboxylase GADL1Predicted00.17670.01760.16780.2912
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)