PharmaCoNets of Pexidartinib (SPCN: 272.16 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pexidartinibhsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Pexidartinibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Pexidartinibhsa00051Fructose and mannose metabolism3.92E-033P15121, P19367, P08237AKR1B1, HK1, PFKMMore
Pexidartinibhsa00052Galactose metabolism3.77E-045P06280, P08237, O43451, P15121, P19367GLA, PFKM, MGAM, AKR1B1, HK1More
Pexidartinibhsa00190Oxidative phosphorylation4.38E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Pexidartinibhsa00220Arginine biosynthesis5.61E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Pexidartinibhsa00230Purine metabolism4.93E-021P21589NT5EMore
Pexidartinibhsa00240Pyrimidine metabolism1.81E-021P21589NT5EMore
Pexidartinibhsa00310Lysine degradation2.60E-033Q8NEZ4, Q13029, Q02809MLL3, PRDM2, PLOD1More
Pexidartinibhsa00500Starch and sucrose metabolism1.91E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Pexidartinibhsa00520Amino sugar and nucleotide sugar metabolism7.84E-043Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Pexidartinibhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.01E-021Q14442PIGHMore
Pexidartinibhsa00564Glycerophospholipid metabolism3.56E-023P48651, Q9Y6K0, P35790PTDSS1, CEPT1, CHKAMore
Pexidartinibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Pexidartinibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Pexidartinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.02E-032P06865, O75752HEXA, B3GALNT1More
Pexidartinibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Pexidartinibhsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Pexidartinibhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Pexidartinibhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Pexidartinibhsa00760Nicotinate and nicotinamide metabolism9.09E-031P21589NT5EMore
Pexidartinibhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Pexidartinibhsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Pexidartinibhsa00860Porphyrin and chlorophyll metabolism1.66E-033P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Pexidartinibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Pexidartinibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Pexidartinibhsa01100Metabolic pathways2.92E-0339Q9NR34, Q9Y234, P35790, P05089, Q16772, P30041, P19367, P48426, P22557, P32320, P20839, P22748, P55809, P06280, Q16875, O43286, O43451, Q9Y6K0, P05186, P24666, P15121, P08237, O95861, Q9HCC0, P33121, Q86VZ5, P48651, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P14927MAN1C1, LIPT1, CHKA, ARG1, GSTA3, PRDX6, HK1, PIP4K2A, ALAS2, CDA, IMPDH1, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CEPT1, ALPL, ACP1, AKR1B1, PFKM, BPNT1, MCCC2, ACSL1, SGMS1, PTDSS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, UQCRBMore
Pexidartinibhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Pexidartinibhsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Pexidartinibhsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Pexidartinibhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Pexidartinibhsa01522Endocrine resistance2.16E-021P04049RAF1More
Pexidartinibhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Pexidartinibhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Pexidartinibhsa02010ABC transporters1.08E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Pexidartinibhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Pexidartinibhsa03010Ribosome7.34E-036P62753, P62829, P62888, P61927, P61513, P36578RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4More
Pexidartinibhsa03013RNA transport1.83E-0820P62826, O14980, P52298, O14893, P61326, P38919, Q9UBU9, P37198, Q7Z3B4, P35658, P63279, P68104, Q14152, P55884, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787RAN, XPO1, NCBP2, GEMIN2, MAGOH, EIF4A3, NXF1, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3B, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1More
Pexidartinibhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Pexidartinibhsa03020RNA polymerase5.39E-064P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Pexidartinibhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Pexidartinibhsa03050Proteasome4.83E-021P55036PSMD4More
Pexidartinibhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Pexidartinibhsa03460Fanconi anemia pathway2.71E-021O94782USP1More
Pexidartinibhsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Pexidartinibhsa04012ErbB signaling pathway1.36E-035Q13153, P16333, P19174, P01106, P04049PAK1, NCK1, PLCG1, MYC, RAF1More
Pexidartinibhsa04014Ras signaling pathway4.31E-043P04049, P31751, P0DP23RAF1, AKT2, CALM1More
Pexidartinibhsa04015Rap1 signaling pathway2.83E-043P04049, P31751, P0DP23RAF1, AKT2, CALM1More
Pexidartinibhsa04020Calcium signaling pathway4.83E-024Q08828, P0DP23, P05141, P51828ADCY1, CALM1, SLC25A5, ADCY7More
Pexidartinibhsa04022cGMP-PKG signaling pathway6.51E-057P04049, P18848, P31751, Q08828, P51828, P05141, P0DP23RAF1, ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Pexidartinibhsa04024cAMP signaling pathway1.08E-046Q08828, P51828, P31751, P0DP23, P04049, Q13153ADCY1, ADCY7, AKT2, CALM1, RAF1, PAK1More
Pexidartinibhsa04060Cytokine-cytokine receptor interaction8.46E-0414P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, P78552, P25024, Q9UBD3, P47992, P09341, P80075, P01730IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CCL8, CD4More
Pexidartinibhsa04061Viral protein interaction with cytokine and cytokine receptor1.83E-049Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Pexidartinibhsa04062Chemokine signaling pathway1.90E-0414P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, P04049CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RAF1More
Pexidartinibhsa04064NF-kappa B signaling pathway1.48E-0722P10415, Q13489, O00463, P14778, P01584, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, TRAF5, IL1R1, IL1B, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Pexidartinibhsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Pexidartinibhsa04070Phosphatidylinositol signaling system8.69E-059P0DP23, Q14643, O14986, P23743, Q86XP1, Q16760, P48426, Q96DU7, P17252CALM1, ITPR1, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKC, PRKCAMore
Pexidartinibhsa04071Sphingolipid signaling pathway6.63E-048P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Pexidartinibhsa04072Phospholipase D signaling pathway2.43E-0412P04049, P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Pexidartinibhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Pexidartinibhsa04110Cell cycle8.83E-058Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYCMore
Pexidartinibhsa04114Oocyte meiosis1.06E-0510Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Pexidartinibhsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Pexidartinibhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Pexidartinibhsa04140Autophagy - animal4.41E-036P31751, P04049, Q7L523, O75460, Q96GC9, Q8TEV9AKT2, RAF1, RRAGA, ERN1, TMEM49, SMCR8More
Pexidartinibhsa04145Phagosome1.59E-037Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Pexidartinibhsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Pexidartinibhsa04151PI3K-Akt signaling pathway7.38E-0311P25116, P49767, Q13362, P62873, P16144, P02452, P24821, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, COL1A1, TNC, TLR2, IFNA21, BCL2, PRKCAMore
Pexidartinibhsa04210Apoptosis2.16E-021P04049RAF1More
Pexidartinibhsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Pexidartinibhsa04213Longevity regulating pathway - multiple species4.29E-037P31751, P42338, Q9Y4H2, Q08828, P51828, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA8, HDAC1More
Pexidartinibhsa04217Necroptosis1.08E-0617P01375, P01568, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P15104, P01584, Q6FI13, Q99878, P10415, Q9H444, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, GLUL, IL1B, H2AC18; H2AC19, H2AC14, BCL2, CHMP4B, CHMP2A, PPIDMore
Pexidartinibhsa04218Cellular senescence1.43E-043P31751, P04049, P0DP23AKT2, RAF1, CALM1More
Pexidartinibhsa04261Adrenergic signaling in cardiomyocytes8.93E-0712P09493, P07550, Q08828, P51828, P22694, P31751, P18848, Q13362, Q14738, P0DP23, P17252, P10415TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, PRKCA, BCL2More
Pexidartinibhsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Pexidartinibhsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Pexidartinibhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Pexidartinibhsa04340Hedgehog signaling pathway1.71E-032P17612, Q9Y496PRKACA, KIF3AMore
Pexidartinibhsa04360Axon guidance2.49E-021P04049RAF1More
Pexidartinibhsa04370VEGF signaling pathway6.68E-075P16298, P31751, Q05397, Q02750, P04049PPP3CB, AKT2, PTK2, MAP2K1, RAF1More
Pexidartinibhsa04371Apelin signaling pathway6.08E-045P31751, P04049, Q08828, P51828, P0DP23AKT2, RAF1, ADCY1, ADCY7, CALM1More
Pexidartinibhsa04380Osteoclast differentiation2.07E-0510Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Pexidartinibhsa04390Hippo signaling pathway2.41E-022P04628, O43623WNT1, SNAI2More
Pexidartinibhsa04392Hippo signaling pathway - multiple species7.65E-042Q13153, Q6V0I7PAK1, FAT4More
Pexidartinibhsa04510Focal adhesion3.48E-021P04049RAF1More
Pexidartinibhsa04512ECM-receptor interaction3.33E-044P02452, P24821, P26012, P16070COL1A1, TNC, ITGB8, CD44More
Pexidartinibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Pexidartinibhsa04540Gap junction2.79E-035P17252, Q13509, P68371, P04049, Q14643PRKCA, TUBB3, TUBB2C, RAF1, ITPR1More
Pexidartinibhsa04550Signaling pathways regulating pluripotency of stem cells9.61E-034Q13873, P04049, Q02750, Q86SE9BMPR2, RAF1, MAP2K1, PCGF5More
Pexidartinibhsa04610Complement and coagulation cascades1.19E-062P00734, P0C0L4F2, C4AMore
Pexidartinibhsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Pexidartinibhsa04612Antigen processing and presentation2.51E-069P13765, P01730, Q14953, P26715, P26717, Q07444, Q13241, P01732, P01375HLA-DOB, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, TNFMore
Pexidartinibhsa04613Neutrophil extracellular trap formation3.41E-0515P17252, P04049, O60603, P08246, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539PRKCA, RAF1, TLR2, ELA2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14More
Pexidartinibhsa04620Toll-like receptor signaling pathway2.48E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Pexidartinibhsa04621NOD-like receptor signaling pathway2.92E-023P01584, P07900, P43490IL1B, HSP90AA1, PBEF1More
Pexidartinibhsa04622RIG-I-like receptor signaling pathway1.88E-043P01568, Q9NQC7, Q13546IFNA21, CYLD, RIPK1More
Pexidartinibhsa04623Cytosolic DNA-sensing pathway2.07E-075P01584, P01568, Q13546, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, POLR3H, CCL4L2More
Pexidartinibhsa04625C-type lectin receptor signaling pathway1.92E-0710Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Pexidartinibhsa04630JAK-STAT signaling pathway8.73E-034P31751, P23458, Q13651, P04049AKT2, JAK1, IL10RA, RAF1More
Pexidartinibhsa04640Hematopoietic cell lineage2.06E-0612P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOBMore
Pexidartinibhsa04650Natural killer cell mediated cytotoxicity2.82E-1418P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, P26717, Q07444, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KIR2DS5, KLRC1More
Pexidartinibhsa04657IL-17 signaling pathway1.01E-0510P07900, O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1BMore
Pexidartinibhsa04658Th1 and Th2 cell differentiation9.50E-1412Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Pexidartinibhsa04659Th17 cell differentiation3.03E-1012Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Pexidartinibhsa04660T cell receptor signaling pathway1.39E-1014Q04759, P42338, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1More
Pexidartinibhsa04662B cell receptor signaling pathway1.12E-032P31751, P04049AKT2, RAF1More
Pexidartinibhsa04664Fc epsilon RI signaling pathway1.50E-035P01375, P31751, Q16539, Q9UQC2, P04049TNF, AKT2, MAPK14, GAB2, RAF1More
Pexidartinibhsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Pexidartinibhsa04668TNF signaling pathway2.12E-037P01375, O00463, Q16539, P18848, P19875, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9More
Pexidartinibhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Pexidartinibhsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Pexidartinibhsa04713Circadian entrainment2.85E-036P0DP23, P17252, P62873, Q14643, Q08828, P51828CALM1, PRKCA, GNB1, ITPR1, ADCY1, ADCY7More
Pexidartinibhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Pexidartinibhsa04720Long-term potentiation1.71E-059P17252, P16298, P0DP23, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Pexidartinibhsa04722Neurotrophin signaling pathway2.01E-046P31751, P04049, P49841, O43524, P48023, P0DP23AKT2, RAF1, GSK3B, FOXO3, FASLG, CALM1More
Pexidartinibhsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Pexidartinibhsa04725Cholinergic synapse7.24E-048Q08828, P51828, Q14643, P17252, P62873, P18848, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, ATF4, AKT2, BCL2More
Pexidartinibhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Pexidartinibhsa04728Dopaminergic synapse7.82E-058Q14643, P17252, P62873, P31751, P18848, Q13362, Q14738, P0DP23ITPR1, PRKCA, GNB1, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Pexidartinibhsa04730Long-term depression1.16E-021P04049RAF1More
Pexidartinibhsa04740Olfactory transduction2.41E-021P0DP23CALM1More
Pexidartinibhsa04742Taste transduction3.91E-021P17612PRKACAMore
Pexidartinibhsa04744Phototransduction1.74E-032P62873, P0DP23GNB1, CALM1More
Pexidartinibhsa04750Inflammatory mediator regulation of TRP channels2.03E-049P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Pexidartinibhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Pexidartinibhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Pexidartinibhsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Pexidartinibhsa04912GnRH signaling pathway6.90E-047P17252, Q08828, P51828, P18848, Q14643, P0DP23, P04049PRKCA, ADCY1, ADCY7, ATF4, ITPR1, CALM1, RAF1More
Pexidartinibhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Pexidartinibhsa04914Progesterone-mediated oocyte maturation1.19E-045Q17RY0, Q9Y6D9, P51812, Q02750, P04049CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Pexidartinibhsa04915Estrogen signaling pathway3.57E-046P04049, P18848, Q08828, P51828, P31751, P0DP23RAF1, ATF4, ADCY1, ADCY7, AKT2, CALM1More
Pexidartinibhsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Pexidartinibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Pexidartinibhsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Pexidartinibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Pexidartinibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Pexidartinibhsa04922Glucagon signaling pathway3.10E-047P14618, P06737, Q12778, P31751, Q13370, P0DP23, Q14643PKM2, PYGL, FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Pexidartinibhsa04923Regulation of lipolysis in adipocytes5.39E-056Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Pexidartinibhsa04924Renin secretion1.57E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Pexidartinibhsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Pexidartinibhsa04926Relaxin signaling pathway4.96E-048P31751, P18848, P22694, P14780, Q08828, P51828, P04049, P30679AKT2, ATF4, PRKACB, MMP9, ADCY1, ADCY7, RAF1, GNA15More
Pexidartinibhsa04927Cortisol synthesis and secretion7.43E-044P18848, Q08828, P51828, P22694ATF4, ADCY1, ADCY7, PRKACBMore
Pexidartinibhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Pexidartinibhsa04929GnRH secretion1.87E-042P31751, P04049AKT2, RAF1More
Pexidartinibhsa04932Non-alcoholic fatty liver disease6.56E-0612P31751, P01375, P49841, P18848, P48023, O75460, P01584, P12074, O15239, Q16718, O95298, O14521AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Pexidartinibhsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Pexidartinibhsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Pexidartinibhsa04935Growth hormone synthesis, secretion and action5.00E-035Q08828, P51828, P04049, P18848, P31751ADCY1, ADCY7, RAF1, ATF4, AKT2More
Pexidartinibhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Pexidartinibhsa04960Aldosterone-regulated sodium reabsorption4.40E-021O00141SGKMore
Pexidartinibhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Pexidartinibhsa04966Collecting duct acid secretion1.95E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Pexidartinibhsa04970Salivary secretion1.35E-046P07550, Q08828, P51828, P22694, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMPMore
Pexidartinibhsa04971Gastric acid secretion4.91E-044Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Pexidartinibhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Pexidartinibhsa04974Protein digestion and absorption2.78E-021P02452COL1A1More
Pexidartinibhsa04976Bile secretion9.77E-045O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Pexidartinibhsa05010Alzheimer disease1.12E-0415Q16718, O95298, O14521, Q14643, Q00535, O75460, P0DP23, P01584, P18848, Q13509, P68371, P31751, P05141, Q08752, P28070NDUFA5, NDUFC2, SDHD, ITPR1, CDK5, ERN1, CALM1, IL1B, ATF4, TUBB3, TUBB2C, AKT2, SLC25A5, PPID, PSMB4More
Pexidartinibhsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Pexidartinibhsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Pexidartinibhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Pexidartinibhsa05020Prion disease1.31E-039Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14More
Pexidartinibhsa05022Pathways of neurodegeneration - multiple diseases3.19E-0622Q14643, Q13509, P68371, P49841, P10415, Q16718, O95298, O14521, Q06055, Q8TEV9, O75460, P18848, Q13561, P05141, P17252, Q16539, Q00535, P01584, Q08752, O15020, P0DP23, P28070ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, NDUFC2, SDHD, ATP5G2, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, MAPK14, CDK5, IL1B, PPID, SPTBN2, CALM1, PSMB4More
Pexidartinibhsa05030Cocaine addiction4.19E-021Q00535CDK5More
Pexidartinibhsa05031Amphetamine addiction6.98E-034P0DP23, P22694, P18848, Q13547CALM1, PRKACB, ATF4, HDAC1More
Pexidartinibhsa05034Alcoholism2.78E-045P04049, Q93077, P62807, O60814, P68431RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pexidartinibhsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Pexidartinibhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Pexidartinibhsa05120Epithelial cell signaling in Helicobacter pylori infection2.27E-057Q16539, Q13153, P09341, P19875, P19174, P25024, P25025MAPK14, PAK1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Pexidartinibhsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Pexidartinibhsa05132Salmonella infection7.93E-039P04049, Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371RAF1, LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Pexidartinibhsa05133Pertussis2.35E-032P0DP23, P0C0L4CALM1, C4AMore
Pexidartinibhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Pexidartinibhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Pexidartinibhsa05140Leishmaniasis2.04E-049O75015, P14598, P42224, P13765, O60603, P29350, P49006, Q16539, Q15080FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, PTPN6, MARCKSL1, MAPK14, NCF4More
Pexidartinibhsa05143African trypanosomiasis2.12E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Pexidartinibhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Pexidartinibhsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Pexidartinibhsa05146Amoebiasis1.52E-0813P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Pexidartinibhsa05150Staphylococcus aureus infection1.16E-036P0C0L4, P13646, Q14532, P59665, P59666, P49913C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Pexidartinibhsa05152Tuberculosis1.60E-0410P04049, Q13488, P0DP23, P42224, O60603, P31751, P10415, P13765, P01568, Q9UDY8RAF1, TCIRG1, CALM1, STAT1, TLR2, AKT2, BCL2, HLA-DOB, IFNA21, MALT1More
Pexidartinibhsa05160Hepatitis C1.31E-047Q13546, P01568, P60033, P04049, P49841, P01375, P48023RIPK1, IFNA21, CD81, RAF1, GSK3B, TNF, FASLGMore
Pexidartinibhsa05161Hepatitis B1.99E-021P04049RAF1More
Pexidartinibhsa05163Human cytomegalovirus infection1.49E-0618P31751, P04049, P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463AKT2, RAF1, TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5More
Pexidartinibhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Pexidartinibhsa05165Human papillomavirus infection9.67E-0411P16144, P02452, P24821, Q05086, P01568, P42224, Q13488, Q13362, Q12778, P04628, Q13315ITGB4, COL1A1, TNC, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, WNT1, ATMMore
Pexidartinibhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Pexidartinibhsa05167Kaposi sarcoma-associated herpesvirus infection1.26E-038P01568, P31751, P42224, P62873, Q14643, P04049, P0DP23, Q9UJU2IFNA21, AKT2, STAT1, GNB1, ITPR1, RAF1, CALM1, LEF1More
Pexidartinibhsa05168Herpes simplex virus 1 infection4.79E-028P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189More
Pexidartinibhsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Pexidartinibhsa05170Human immunodeficiency virus 1 infection5.51E-0511P31751, P04049, P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5AKT2, RAF1, GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Pexidartinibhsa05171Coronavirus disease - COVID-193.18E-037P01584, P62753, P36578, P62888, P61927, P61513, P62829IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23More
Pexidartinibhsa05200Pathways in cancer8.38E-0313P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P31751, P25116, P62873, P0DP23, P01568STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, AKT2, F2R, GNB1, CALM1, IFNA21More
Pexidartinibhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Pexidartinibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Pexidartinibhsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Pexidartinibhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Pexidartinibhsa05210Colorectal cancer2.55E-033Q9UKG1, P04049, P37173APPL1, RAF1, TGFBR2More
Pexidartinibhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Pexidartinibhsa05212Pancreatic cancer5.93E-044P31751, P04049, Q15311, P23458AKT2, RAF1, RALBP1, JAK1More
Pexidartinibhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Pexidartinibhsa05214Glioma8.46E-063P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Pexidartinibhsa05215Prostate cancer1.33E-021P04049RAF1More
Pexidartinibhsa05218Melanoma4.47E-042P31751, P04049AKT2, RAF1More
Pexidartinibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Pexidartinibhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Pexidartinibhsa05221Acute myeloid leukemia8.16E-042P31751, P04049AKT2, RAF1More
Pexidartinibhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Pexidartinibhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Pexidartinibhsa05224Breast cancer1.24E-025P04049, P49841, Q92837, P04637, P24522RAF1, GSK3B, FRAT1, TP53, GADD45AMore
Pexidartinibhsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Pexidartinibhsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Pexidartinibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Pexidartinibhsa05231Choline metabolism in cancer4.08E-047P04049, P31751, Q9Y259, P19174, P49619, Q16760, O14986RAF1, AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1BMore
Pexidartinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.33E-0712P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, PRKCQ, MAPK14, CD4More
Pexidartinibhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Pexidartinibhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Pexidartinibhsa05322Systemic lupus erythematosus3.04E-0713P08246, P08311, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814ELA2, CTSG, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Pexidartinibhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Pexidartinibhsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Pexidartinibhsa05332Graft-versus-host disease9.47E-055P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Pexidartinibhsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Pexidartinibhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Pexidartinibhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Pexidartinibhsa05415Diabetic cardiomyopathy2.54E-049P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P49841, P37173PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, TGFBR2More
Pexidartinibhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Pexidartinibhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Pexidartinib (SDC: 9.53)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09619PDGFRBPlateletNonederived growth factor receptor betaReported00.04960.94440.74082.6543
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P00441SOD1Superoxide dismutase [CuNoneZn]Predicted10.53850.07130.48710.8991
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
O94782USP1Ubiquitin carboxylNoneterminal hydrolase 1Predicted00.4410.08980.02130.4215
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
O14786NRP1NeuropilinNone1Predicted10.38340.20260.51531.1123
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)