PharmaCoNets of Perphenazine (SPCN: 61.28 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Perphenazinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Perphenazinehsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Perphenazinehsa00230Purine metabolism4.60E-024Q13370, P36959, Q13956, P27707PDE3B, GMPR, PDE6H, DCKMore
Perphenazinehsa00240Pyrimidine metabolism4.50E-022P32320, P27707CDA, DCKMore
Perphenazinehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Perphenazinehsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin4.77E-021Q7LGA3HS2ST1More
Perphenazinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Perphenazinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Perphenazinehsa00670One carbon pool by folate3.99E-022O95954, Q99707FTCD, MTRMore
Perphenazinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Perphenazinehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Perphenazinehsa00920Sulfur metabolism3.01E-021O95571ETHE1More
Perphenazinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Perphenazinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Perphenazinehsa01100Metabolic pathways3.95E-0223Q9Y234, Q99707, P29218, P11310, P27707, Q13370, P36959, Q13956, P30043, Q02252, O60701, O14772, O95954, Q02318, P04406, O15466, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809LIPT1, MTR, IMPA1, ACADM, DCK, PDE3B, GMPR, PDE6H, BLVRB, ALDH6A1, UGDH, FPGT, FTCD, CYP27A1, GAPDH, ST8SIA5, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1More
Perphenazinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Perphenazinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Perphenazinehsa01524Platinum drug resistance4.45E-024P10415, Q13489, P78417, P43246BCL2, BIRC3, GSTO1, MSH2More
Perphenazinehsa02010ABC transporters4.89E-021Q99758ABCA3More
Perphenazinehsa03013RNA transport4.79E-022P62826, P63279RAN, UBE2IMore
Perphenazinehsa03015mRNA surveillance pathway3.62E-023O43148, P61326, P52298RNMT, MAGOH, NCBP2More
Perphenazinehsa03040Spliceosome1.11E-0718Q14562, O43143, O60508, P17844, O14776, P08579, O75940, P52298, P09651, Q15365, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, P61326DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, MAGOHMore
Perphenazinehsa03050Proteasome5.53E-032P43686, P28070PSMC4, PSMB4More
Perphenazinehsa03060Protein export4.22E-022P37108, Q15005SRP14, SPCS2More
Perphenazinehsa03320PPAR signaling pathway2.18E-022O00767, Q02318SCD, CYP27A1More
Perphenazinehsa03460Fanconi anemia pathway3.70E-033Q9NPI8, O60673, Q9UNA4FANCF, REV3L, POLIMore
Perphenazinehsa04014Ras signaling pathway2.65E-039P31751, P20827, P49767, Q13009, P17252, Q15311, P0DP23, P62873, P19174AKT2, EFNA1, VEGFC, TIAM1, PRKCA, RALBP1, CALM1, GNB1, PLCG1More
Perphenazinehsa04015Rap1 signaling pathway5.41E-039P20827, P49767, Q13009, Q08828, P51828, P31751, P0DP23, P17252, P19174EFNA1, VEGFC, TIAM1, ADCY1, ADCY7, AKT2, CALM1, PRKCA, PLCG1More
Perphenazinehsa04020Calcium signaling pathway1.04E-0611P27987, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P51828, P23634, P49767ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, VEGFCMore
Perphenazinehsa04024cAMP signaling pathway3.01E-039Q08828, P51828, P31751, P0DP23, P23634, Q13557, Q13370, O15399, Q13009ADCY1, ADCY7, AKT2, CALM1, ATP2B4, CAMK2D, PDE3B, GRIN2D, TIAM1More
Perphenazinehsa04061Viral protein interaction with cytokine and cytokine receptor2.60E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Perphenazinehsa04062Chemokine signaling pathway2.04E-0210P51684, Q8NHW4, P19174, P62873, Q08828, P51828, Q13009, P14598, P42224, P31751CCR6, CCL4L2, PLCG1, GNB1, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2More
Perphenazinehsa04064NF-kappa B signaling pathway9.06E-0611P10415, Q13489, P51617, P01584, P29965, P19174, P67870, P63279, O75293, Q8NHW4, Q9NQC7BCL2, BIRC3, IRAK1, IL1B, CD40LG, PLCG1, CSNK2B, UBE2I, GADD45B, CCL4L2, CYLDMore
Perphenazinehsa04070Phosphatidylinositol signaling system5.66E-046P19174, P0DP23, P23743, P48426, P27987, P17252PLCG1, CALM1, DGKA, PIP4K2A, ITPKB, PRKCAMore
Perphenazinehsa04071Sphingolipid signaling pathway1.60E-039P17252, P21453, Q9H228, P01375, Q13510, Q13362, P10415, Q9UQC2, P01042PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, BCL2, GAB2, KNG1More
Perphenazinehsa04072Phospholipase D signaling pathway2.03E-028P31751, P19174, P17252, Q15438, Q08828, P51828, P23743, P00734AKT2, PLCG1, PRKCA, PSCD1, ADCY1, ADCY7, DGKA, F2More
Perphenazinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Perphenazinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Perphenazinehsa04140Autophagy - animal2.58E-027P31751, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9AKT2, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8More
Perphenazinehsa04144Endocytosis8.99E-0312P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6More
Perphenazinehsa04145Phagosome5.56E-038P60709, P63261, Q15075, Q15080, P14598, Q13509, Q13488, O60603ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TCIRG1, TLR2More
Perphenazinehsa04151PI3K-Akt signaling pathway6.57E-0426P43657, O43521, P27348, P09603, P20827, P49767, Q9GZP0, Q13362, P08238, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, Q6ZUJ8P2RY5, BCL2L11, YWHAQ, CSF1, EFNA1, VEGFC, PDGFD, PPP2R5C, HSP90AB1, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, PIK3AP1More
Perphenazinehsa04210Apoptosis6.18E-033P07384, P60709, P63261CAPN1, ACTB, ACTG1More
Perphenazinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Perphenazinehsa04217Necroptosis2.92E-0919P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P08238, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4BMore
Perphenazinehsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Perphenazinehsa04261Adrenergic signaling in cardiomyocytes4.46E-0713P09493, P07550, Q08828, P51828, P22694, P31751, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Perphenazinehsa04360Axon guidance8.44E-048P61073, P16333, P20827, O95631, P17252, Q13557, P23528, P19174CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, CFL1, PLCG1More
Perphenazinehsa04371Apelin signaling pathway3.08E-027P62873, P31751, Q08828, P51828, Q13370, Q13485, P0DP23GNB1, AKT2, ADCY1, ADCY7, PDE3B, SMAD4, CALM1More
Perphenazinehsa04380Osteoclast differentiation4.18E-027Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1More
Perphenazinehsa04390Hippo signaling pathway2.80E-022P60709, P63261ACTB, ACTG1More
Perphenazinehsa04510Focal adhesion3.76E-027P16144, O75369, Q15942, P17252, Q13489, P10415, P49767ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, VEGFCMore
Perphenazinehsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Perphenazinehsa04520Adherens junction1.58E-022P60709, P63261ACTB, ACTG1More
Perphenazinehsa04530Tight junction6.83E-046P60709, P63261, P16989, P56750, Q14247, P60660ACTB, ACTG1, CSDA, CLDN17, CTTN, MYL6More
Perphenazinehsa04540Gap junction4.08E-025P17252, Q13509, P68371, Q08828, P51828PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7More
Perphenazinehsa04611Platelet activation2.61E-022P60709, P63261ACTB, ACTG1More
Perphenazinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Perphenazinehsa04613Neutrophil extracellular trap formation1.02E-048P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Perphenazinehsa04620Toll-like receptor signaling pathway1.33E-025P51617, P01568, P31751, P42224, Q8NHW4IRAK1, IFNA21, AKT2, STAT1, CCL4L2More
Perphenazinehsa04621NOD-like receptor signaling pathway3.16E-029P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, P43490, P10415IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, PBEF1, BCL2More
Perphenazinehsa04623Cytosolic DNA-sensing pathway1.55E-033P01584, P01568, Q8NHW4IL1B, IFNA21, CCL4L2More
Perphenazinehsa04630JAK-STAT signaling pathway1.16E-028P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21More
Perphenazinehsa04640Hematopoietic cell lineage2.82E-034P08514, P21926, P07766, P09564ITGA2B, CD9, CD3E, CD7More
Perphenazinehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Perphenazinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Perphenazinehsa04662B cell receptor signaling pathway3.68E-022P25963, P20023NFKBIA, CR2More
Perphenazinehsa04666Fc gamma R-mediated phagocytosis2.78E-026P08575, P19174, P23528, Q9UQC2, P14598, P17252PTPRC, PLCG1, CFL1, GAB2, NCF1, PRKCAMore
Perphenazinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Perphenazinehsa04670Leukocyte transendothelial migration4.07E-022P60709, P63261ACTB, ACTG1More
Perphenazinehsa04713Circadian entrainment5.61E-057O15399, P0DP23, Q13557, P17252, P62873, Q08828, P51828GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, ADCY1, ADCY7More
Perphenazinehsa04714Thermogenesis3.64E-044P15336, P60709, P63261, P36542ATF2, ACTB, ACTG1, ATP5C1More
Perphenazinehsa04720Long-term potentiation3.26E-036P17252, Q13557, P0DP23, P18848, O15399, Q08828PRKCA, CAMK2D, CALM1, ATF4, GRIN2D, ADCY1More
Perphenazinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Perphenazinehsa04724Glutamatergic synapse2.02E-049P48058, O15399, Q08828, P51828, P17252, P62873, P63218, P50151, P15104GRIA4, GRIN2D, ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, GLULMore
Perphenazinehsa04725Cholinergic synapse4.42E-048Q08828, P51828, P17252, P62873, P18848, Q13557, P31751, P10415ADCY1, ADCY7, PRKCA, GNB1, ATF4, CAMK2D, AKT2, BCL2More
Perphenazinehsa04727GABAergic synapse3.01E-038Q08828, P51828, P62873, P63218, P50151, P15104, P46459, P17252ADCY1, ADCY7, GNB1, GNG5, GNG10, GLUL, NSF, PRKCAMore
Perphenazinehsa04730Long-term depression3.72E-022Q14344, P07948GNA13, LYNMore
Perphenazinehsa04740Olfactory transduction5.88E-034P62873, Q9H255, Q13557, P0DP23GNB1, OR51E2, CAMK2D, CALM1More
Perphenazinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Perphenazinehsa04744Phototransduction1.30E-052P62873, P0DP23GNB1, CALM1More
Perphenazinehsa04750Inflammatory mediator regulation of TRP channels4.32E-058P01584, Q08828, P51828, Q13557, P19174, P17252, P0DP23, P01042IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PRKCA, CALM1, KNG1More
Perphenazinehsa04911Insulin secretion3.47E-024Q08828, P17252, P18848, Q13557ADCY1, PRKCA, ATF4, CAMK2DMore
Perphenazinehsa04912GnRH signaling pathway2.85E-025P17252, Q08828, P18848, Q13557, P0DP23PRKCA, ADCY1, ATF4, CAMK2D, CALM1More
Perphenazinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Perphenazinehsa04914Progesterone-mediated oocyte maturation3.26E-026Q08828, P51828, P31751, Q13370, Q9UJX4, P08238ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, HSP90AB1More
Perphenazinehsa04915Estrogen signaling pathway3.28E-039P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2More
Perphenazinehsa04919Thyroid hormone signaling pathway3.20E-022P60709, P63261ACTB, ACTG1More
Perphenazinehsa04921Oxytocin signaling pathway1.77E-033P60660, P60709, P63261MYL6, ACTB, ACTG1More
Perphenazinehsa04923Regulation of lipolysis in adipocytes2.12E-024Q08828, P51828, Q13370, P31751ADCY1, ADCY7, PDE3B, AKT2More
Perphenazinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Perphenazinehsa04925Aldosterone synthesis and secretion6.45E-047P18848, Q08828, P51828, P0DP23, P17252, Q13557, P23634ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B4More
Perphenazinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Perphenazinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Perphenazinehsa04932Non-alcoholic fatty liver disease6.66E-049P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, O15239TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1More
Perphenazinehsa04933AGE-RAGE signaling pathway in diabetic complications2.04E-068Q13485, P01584, P42224, P10415, P31751, P49767, P17252, P19174SMAD4, IL1B, STAT1, BCL2, AKT2, VEGFC, PRKCA, PLCG1More
Perphenazinehsa04935Growth hormone synthesis, secretion and action3.93E-026P19174, Q08828, P51828, P17252, P31751, P42224PLCG1, ADCY1, ADCY7, PRKCA, AKT2, STAT1More
Perphenazinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Perphenazinehsa04970Salivary secretion9.40E-058P07550, Q08828, P51828, P22694, P23634, P17252, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ATP2B4, PRKCA, CALM1, CAMPMore
Perphenazinehsa04971Gastric acid secretion1.02E-022P60709, P63261ACTB, ACTG1More
Perphenazinehsa04972Pancreatic secretion1.92E-035P23634, P17252, Q08828, P51828, P62491ATP2B4, PRKCA, ADCY1, ADCY7, RAB11AMore
Perphenazinehsa05010Alzheimer disease1.94E-0316O15239, P13073, P12074, O15399, Q00535, Q9NZJ5, O75460, P0DP23, Q13564, P01584, O95197, Q71U36, P67870, P09603, P21796, P28070NDUFA1, COX4I1, COX6A1, GRIN2D, CDK5, EIF2AK3, ERN1, CALM1, APPBP1, IL1B, RTN3, TUBA1A, CSNK2B, CSF1, VDAC1, PSMB4More
Perphenazinehsa05014Amyotrophic lateral sclerosis2.98E-023P36542, P60709, P63261ATP5C1, ACTB, ACTG1More
Perphenazinehsa05017Spinocerebellar ataxia3.80E-038P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12More
Perphenazinehsa05031Amphetamine addiction3.62E-037O15399, P0DP23, Q13557, P22694, P18848, P17252, Q13547GRIN2D, CALM1, CAMK2D, PRKACB, ATF4, PRKCA, HDAC1More
Perphenazinehsa05032Morphine addiction1.94E-039Q08828, P51828, P62873, P63218, P50151, Q13370, Q07343, P17252, P43250ADCY1, ADCY7, GNB1, GNG5, GNG10, PDE3B, PDE4B, PRKCA, GRK6More
Perphenazinehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Perphenazinehsa05100Bacterial invasion of epithelial cells1.02E-022P60709, P63261ACTB, ACTG1More
Perphenazinehsa05110Vibrio cholerae infection3.95E-032P60709, P63261ACTB, ACTG1More
Perphenazinehsa05131Shigellosis1.91E-023P60709, P63261, P07384ACTB, ACTG1, CAPN1More
Perphenazinehsa05132Salmonella infection3.99E-0413P51617, P01584, P08238, Q96RF0, Q13489, P10415, P08575, O75369, Q13561, Q13509, P68371, P49754, Q9NP90IRAK1, IL1B, HSP90AB1, SNAG1, BIRC3, BCL2, PTPRC, FLNB, DCTN2, TUBB3, TUBB2C, VPS41, RAB9BMore
Perphenazinehsa05133Pertussis3.94E-045P0DP23, P01584, P23528, P09871, P51617CALM1, IL1B, CFL1, C1S, IRAK1More
Perphenazinehsa05135Yersinia infection3.88E-033P60709, P63261, Q16513ACTB, ACTG1, PKN2More
Perphenazinehsa05140Leishmaniasis2.58E-025P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Perphenazinehsa05143African trypanosomiasis3.56E-035P01375, P01584, P48023, P17252, P01042TNF, IL1B, FASLG, PRKCA, KNG1More
Perphenazinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Perphenazinehsa05145Toxoplasmosis5.28E-059P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RAMore
Perphenazinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Perphenazinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Perphenazinehsa05161Hepatitis B1.31E-0410P17252, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617PRKCA, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1More
Perphenazinehsa05162Measles1.74E-0410P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2More
Perphenazinehsa05163Human cytomegalovirus infection2.48E-0414P31751, P62873, P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, P17252, Q13651, P18848, P61769, P01568AKT2, GNB1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, PRKCA, IL10RA, ATF4, B2M, IFNA21More
Perphenazinehsa05164Influenza A7.10E-033P48551, P60709, P63261IFNAR2, ACTB, ACTG1More
Perphenazinehsa05168Herpes simplex virus 1 infection2.45E-0518P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P61769, P31751, Q13398, Q6P280, Q03923, Q9UDV6, P10415, Q14232IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, B2M, AKT2, ZNF211, ZNF529, ZNF85, ZNF212, BCL2, EIF2B1More
Perphenazinehsa05170Human immunodeficiency virus 1 infection4.12E-0512P31751, P62873, P0DP23, P61073, P17252, P61769, P01568, P51617, P19174, P23528, P10415, Q9Y6Q5AKT2, GNB1, CALM1, CXCR4, PRKCA, B2M, IFNA21, IRAK1, PLCG1, CFL1, BCL2, AP1M2More
Perphenazinehsa05200Pathways in cancer4.30E-0928P23458, P08238, P42224, P19174, Q15311, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P31751, Q08828, P51828, P62873, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042JAK1, HSP90AB1, STAT1, PLCG1, RALBP1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, AKT2, ADCY1, ADCY7, GNB1, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1More
Perphenazinehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Perphenazinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Perphenazinehsa05204Chemical carcinogenesis2.59E-044P00325, P78417, P11712, P33260ADH1B, GSTO1, CYP2C9, CYP2C18More
Perphenazinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Perphenazinehsa05206MicroRNAs in cancer4.07E-022P15311, P63279VIL2, UBE2IMore
Perphenazinehsa05212Pancreatic cancer5.55E-036P31751, Q15311, P23458, P42224, Q13485, O75293AKT2, RALBP1, JAK1, STAT1, SMAD4, GADD45BMore
Perphenazinehsa05214Glioma1.87E-056P0DP23, Q13557, P17252, P31751, P19174, O75293CALM1, CAMK2D, PRKCA, AKT2, PLCG1, GADD45BMore
Perphenazinehsa05225Hepatocellular carcinoma4.07E-022P60709, P63261ACTB, ACTG1More
Perphenazinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Perphenazinehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Perphenazinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Perphenazinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Perphenazinehsa05340Primary immunodeficiency2.68E-022P11912, P07766CD79A, CD3EMore
Perphenazinehsa05410Hypertrophic cardiomyopathy1.02E-022P60709, P63261ACTB, ACTG1More
Perphenazinehsa05412Arrhythmogenic right ventricular cardiomyopathy8.96E-032P60709, P63261ACTB, ACTG1More
Perphenazinehsa05414Dilated cardiomyopathy1.73E-022P60709, P63261ACTB, ACTG1More
Perphenazinehsa05416Viral myocarditis8.96E-032P60709, P63261ACTB, ACTG1More
Perphenazinehsa05418Fluid shear stress and atherosclerosis3.64E-038P14598, P78417, P60709, P63261, P10415, P0DP23, P08238, Q92974NCF1, GSTO1, ACTB, ACTG1, BCL2, CALM1, HSP90AB1, ARHGEF2More

Community members of Perphenazine (SDC: 3.11)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P0DP23CALM1CalmodulinNone1Reported00.45520.147911.5235
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
P0DP25CALM3CalmodulinNone3Predicted00.56610.147900.5789
P0DP24CALM2CalmodulinNone2Predicted00.43760.147900.5147
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P60660MYL6Myosin light polypeptide 6Predicted00.55950.06870.21750.6346
P24844MYL9Myosin regulatory light polypeptide 9Predicted00.00640.0630.60260.7318
P14649MYL6BMyosin light chain 6BPredicted00.04770.06530.21750.3719
P05976MYL1Myosin light chain 1/3, skeletal muscle isoformPredicted00.25810.061900.2528
O15182CETN3CentrinNone3Predicted00.18720.059400.2123
Q96A32MYLPFMyosin regulatory light chain 2, skeletal muscle isoformPredicted00.01350.04730.54120.6425
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416IC500.3
DRD2P14416Ki0.16
DRD2P14416Ki1.4