PharmaCoNets of Perhexiline (SPCN: 49.67 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Perhexilinehsa00190Oxidative phosphorylation1.03E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Perhexilinehsa00270Cysteine and methionine metabolism4.56E-023Q99707, P26358, Q9UHY7MTR, DNMT1, ENOPH1More
Perhexilinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Perhexilinehsa00591Linoleic acid metabolism8.00E-041P11712CYP2C9More
Perhexilinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Perhexilinehsa00920Sulfur metabolism1.65E-021Q16762TSTMore
Perhexilinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Perhexilinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Perhexilinehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Perhexilinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Perhexilinehsa03013RNA transport2.89E-027O14980, Q09161, Q7Z3B4, P47813, Q14152, O75822, Q14240XPO1, NCBP1, NUP54, EIF1AX, EIF3A, EIF3J, EIF4A2More
Perhexilinehsa03022Basal transcription factors1.47E-033P20226, O00268, Q15544TBP, TAF4, TAF11More
Perhexilinehsa04010MAPK signaling pathway1.53E-022Q9H2K8, Q12933TAOK3, TRAF2More
Perhexilinehsa04064NF-kappa B signaling pathway3.99E-026P10415, Q13489, P29965, Q9UDY8, Q8WV28, Q13315BCL2, BIRC3, CD40LG, MALT1, BLNK, ATMMore
Perhexilinehsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Perhexilinehsa04071Sphingolipid signaling pathway4.58E-036P17252, Q13362, Q9BX95, P10415, Q12933, Q02156PRKCA, PPP2R5C, SGPP1, BCL2, TRAF2, PRKCEMore
Perhexilinehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Perhexilinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Perhexilinehsa04122Sulfur relay system1.65E-021Q16762TSTMore
Perhexilinehsa04142Lysosome2.98E-022P10619, P49281CTSA, SLC11A2More
Perhexilinehsa04145Phagosome1.59E-037Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Perhexilinehsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Perhexilinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Perhexilinehsa04217Necroptosis7.46E-0613P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, P10415, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP2A, PPIDMore
Perhexilinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Perhexilinehsa04261Adrenergic signaling in cardiomyocytes2.84E-025P09493, Q13362, P0DP23, P17252, P10415TPM1, PPP2R5C, CALM1, PRKCA, BCL2More
Perhexilinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Perhexilinehsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Perhexilinehsa04613Neutrophil extracellular trap formation6.17E-0618P17252, P11215, O60603, P08246, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539PRKCA, ITGAM, TLR2, ELA2, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14More
Perhexilinehsa04622RIG-I-like receptor signaling pathway2.47E-021Q12933TRAF2More
Perhexilinehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Perhexilinehsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Perhexilinehsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Perhexilinehsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Perhexilinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Perhexilinehsa04720Long-term potentiation3.89E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Perhexilinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Perhexilinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Perhexilinehsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Perhexilinehsa04725Cholinergic synapse1.88E-024Q14643, P17252, P62873, P10415ITPR1, PRKCA, GNB1, BCL2More
Perhexilinehsa04728Dopaminergic synapse3.55E-025Q14643, P17252, P62873, Q13362, P0DP23ITPR1, PRKCA, GNB1, PPP2R5C, CALM1More
Perhexilinehsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Perhexilinehsa04912GnRH signaling pathway3.89E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Perhexilinehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Perhexilinehsa04924Renin secretion8.71E-033Q14643, Q13370, P0DP23ITPR1, PDE3B, CALM1More
Perhexilinehsa04930Type II diabetes mellitus2.47E-021Q02156PRKCEMore
Perhexilinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Perhexilinehsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Perhexilinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Perhexilinehsa04966Collecting duct acid secretion2.86E-022Q13488, Q9Y666TCIRG1, SLC12A7More
Perhexilinehsa04974Protein digestion and absorption2.47E-021Q7Z2H8SLC36A1More
Perhexilinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Perhexilinehsa05010Alzheimer disease3.55E-027Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPIDMore
Perhexilinehsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Perhexilinehsa05020Prion disease1.31E-039Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14More
Perhexilinehsa05022Pathways of neurodegeneration - multiple diseases2.00E-0412Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, P17252, Q16539, Q08752, P0DP23ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, MAPK14, PPID, CALM1More
Perhexilinehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Perhexilinehsa05131Shigellosis3.33E-0310Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Perhexilinehsa05132Salmonella infection1.11E-028Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Perhexilinehsa05140Leishmaniasis1.06E-047P14598, P42224, P13765, O60603, P25963, P29350, Q15080NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, NCF4More
Perhexilinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Perhexilinehsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Perhexilinehsa05150Staphylococcus aureus infection8.37E-035P21462, O75015, Q14532, P59665, P59666FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3More
Perhexilinehsa05152Tuberculosis7.93E-048Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Perhexilinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Perhexilinehsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Perhexilinehsa05167Kaposi sarcoma-associated herpesvirus infection4.73E-026P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1More
Perhexilinehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Perhexilinehsa05170Human immunodeficiency virus 1 infection4.67E-039P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Perhexilinehsa05200Pathways in cancer4.99E-0212P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21More
Perhexilinehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Perhexilinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Perhexilinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Perhexilinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Perhexilinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Perhexilinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Perhexilinehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Perhexilinehsa05322Systemic lupus erythematosus2.33E-0712P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Perhexilinehsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Perhexilinehsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Perhexilinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Perhexilinehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Perhexilinehsa05415Diabetic cardiomyopathy5.60E-058P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Perhexilinehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More

Community members of Perhexiline (SDC: 4.49)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P43155CRATCarnitine ONoneacetyltransferasePredicted00.06810.019200.0724
Q9UKG9CROTPeroxisomal carnitine ONoneoctanoyltransferasePredicted00.13110.01270.10970.2007
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)