PharmaCoNets of Pergolide (SPCN: 76.09 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pergolidehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Pergolidehsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Pergolidehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Pergolidehsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Pergolidehsa00340Histidine metabolism4.52E-021O95954FTCDMore
Pergolidehsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Pergolidehsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Pergolidehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Pergolidehsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Pergolidehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Pergolidehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Pergolidehsa00980Metabolism of xenobiotics by cytochrome P4504.00E-021P09211GSTP1More
Pergolidehsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Pergolidehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Pergolidehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Pergolidehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Pergolidehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Pergolidehsa03010Ribosome2.25E-045P40429, Q07020, P27635, P05386, P62249RPL13A, RPL18, RPL10, RPLP1, RPS16More
Pergolidehsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Pergolidehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Pergolidehsa03050Proteasome4.83E-021P55036PSMD4More
Pergolidehsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Pergolidehsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Pergolidehsa03410Base excision repair7.59E-031P27695APEX1More
Pergolidehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Pergolidehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Pergolidehsa04061Viral protein interaction with cytokine and cytokine receptor1.32E-026P09341, P25024, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Pergolidehsa04062Chemokine signaling pathway6.73E-039P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITKMore
Pergolidehsa04064NF-kappa B signaling pathway4.18E-0618P10415, O00463, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7BCL2, TRAF5, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLDMore
Pergolidehsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Pergolidehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Pergolidehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Pergolidehsa04110Cell cycle7.04E-047Q9UBD5, P06493, O75293, P30304, P33981, P42773, P01106ORC3, CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Pergolidehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Pergolidehsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Pergolidehsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Pergolidehsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Pergolidehsa04145Phagosome3.69E-027O75015, Q15080, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Pergolidehsa04213Longevity regulating pathway - multiple species2.82E-023Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Pergolidehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Pergolidehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Pergolidehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Pergolidehsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Pergolidehsa04612Antigen processing and presentation1.91E-059P13765, P48382, P01730, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Pergolidehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Pergolidehsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Pergolidehsa04640Hematopoietic cell lineage1.06E-0513P13612, P21926, P14778, P27930, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375ITGA4, CD9, IL1R1, IL1R2, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNFMore
Pergolidehsa04650Natural killer cell mediated cytotoxicity5.96E-0711P01375, P06239, O60880, P20963, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Pergolidehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Pergolidehsa04658Th1 and Th2 cell differentiation2.05E-0812Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Pergolidehsa04659Th17 cell differentiation1.60E-0612Q04759, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247More
Pergolidehsa04660T cell receptor signaling pathway1.78E-0512P01375, Q9UDY8, Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239TNF, MALT1, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Pergolidehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Pergolidehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Pergolidehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Pergolidehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Pergolidehsa04742Taste transduction1.01E-021P30939HTR1FMore
Pergolidehsa04750Inflammatory mediator regulation of TRP channels4.01E-024P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Pergolidehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Pergolidehsa04915Estrogen signaling pathway3.17E-025Q08828, P51828, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Pergolidehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Pergolidehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Pergolidehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Pergolidehsa04932Non-alcoholic fatty liver disease7.01E-0511P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Pergolidehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Pergolidehsa04970Salivary secretion2.43E-036P07550, Q08828, P51828, P22694, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMPMore
Pergolidehsa04976Bile secretion3.14E-035O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Pergolidehsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Pergolidehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Pergolidehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Pergolidehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Pergolidehsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Pergolidehsa05140Leishmaniasis3.53E-026P13612, O75015, P13765, O60603, P01375, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, NCF4More
Pergolidehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Pergolidehsa05144Malaria6.75E-045P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Pergolidehsa05146Amoebiasis5.33E-0511P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Pergolidehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Pergolidehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Pergolidehsa05163Human cytomegalovirus infection3.31E-027P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RAMore
Pergolidehsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Pergolidehsa05171Coronavirus disease - COVID-193.87E-045P62249, P40429, P27635, Q07020, P05386RPS16, RPL13A, RPL10, RPL18, RPLP1More
Pergolidehsa05202Transcriptional misregulation in cancer2.35E-0212Q13315, P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522ATM, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Pergolidehsa05204Chemical carcinogenesis4.00E-021P09211GSTP1More
Pergolidehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Pergolidehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Pergolidehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Pergolidehsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Pergolidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.61E-047P07766, P20963, P09693, P06239, Q04759, Q9HC35, P01730CD3E, CD247, CD3G, LCK, PRKCQ, EML4, CD4More
Pergolidehsa05310Asthma1.92E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Pergolidehsa05321Inflammatory bowel disease1.17E-057O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Pergolidehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Pergolidehsa05332Graft-versus-host disease7.43E-065P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Pergolidehsa05340Primary immunodeficiency1.31E-045P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Pergolidehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Pergolide (SDC: 6.47)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416Ki4
DRD2P14416Ki19
DRD2P14416Ki25.7