PharmaCoNets of Perampanel (SPCN: 313.15 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Perampanelhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Perampanelhsa00030Pentose phosphate pathway2.59E-054P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Perampanelhsa00040Pentose and glucuronate interconversions9.59E-032P15121, P14550AKR1B1, AKR1A1More
Perampanelhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Perampanelhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Perampanelhsa00071Fatty acid degradation3.65E-034O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Perampanelhsa00190Oxidative phosphorylation3.08E-084Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Perampanelhsa00220Arginine biosynthesis1.65E-063P15104, P05089, P49448GLUL, ARG1, GLUD2More
Perampanelhsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Perampanelhsa00240Pyrimidine metabolism3.59E-032P31350, P04818RRM2, TYMSMore
Perampanelhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Perampanelhsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Perampanelhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Perampanelhsa00500Starch and sucrose metabolism2.42E-093O43451, P46976, P06737MGAM, GYG1, PYGLMore
Perampanelhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Perampanelhsa00512Mucin type O-glycan biosynthesis1.03E-032O95395, Q8N4A0GCNT3, GALNT4More
Perampanelhsa00514Other types of O-glycan biosynthesis7.01E-032P15907, Q8N4A0ST6GAL1, GALNT4More
Perampanelhsa00520Amino sugar and nucleotide sugar metabolism1.59E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Perampanelhsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate3.68E-021Q9Y2C2USTMore
Perampanelhsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Perampanelhsa00561Glycerolipid metabolism7.94E-033P15121, P14550, Q86XP1AKR1B1, AKR1A1, DGKHMore
Perampanelhsa00565Ether lipid metabolism3.00E-031Q8N661TMEM86BMore
Perampanelhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Perampanelhsa00591Linoleic acid metabolism1.48E-031P11712CYP2C9More
Perampanelhsa00600Sphingolipid metabolism2.44E-022Q9BX95, Q06136SGPP1, FVT1More
Perampanelhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Perampanelhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.10E-032P06865, O75752HEXA, B3GALNT1More
Perampanelhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Perampanelhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Perampanelhsa00670One carbon pool by folate4.14E-021P04818TYMSMore
Perampanelhsa00730Thiamine metabolism1.51E-073Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Perampanelhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Perampanelhsa00770Pantothenate and CoA biosynthesis8.85E-063O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Perampanelhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Perampanelhsa00790Folate biosynthesis2.45E-022Q92820, P07101GGH, THMore
Perampanelhsa00830Retinol metabolism1.66E-045P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Perampanelhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Perampanelhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Perampanelhsa00970Aminoacyl-tRNA biosynthesis6.08E-094O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Perampanelhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Perampanelhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Perampanelhsa00983Drug metabolism - other enzymes3.32E-023P04183, P32320, P05164TK1, CDA, MPOMore
Perampanelhsa01100Metabolic pathways7.38E-0332Q9NR34, P05089, O95455, P21953, Q13572, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P43034, Q13423, P15907, Q8N4A0, P57054, Q9UNP4, O96024, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, O95395, P46976, P06737MAN1C1, ARG1, TGDS, BCKDHB, ITPK1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PAFAH1B1, NNT, ST6GAL1, GALNT4, PIGP, ST3GAL5, B3GALT4, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GCNT3, GYG1, PYGLMore
Perampanelhsa012102-Oxocarboxylic acid metabolism6.96E-041P50213IDH3AMore
Perampanelhsa01230Biosynthesis of amino acids3.05E-057P51854, P60891, Q99707, P50213, P05089, P15104, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, GLUL, TALDO1More
Perampanelhsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Perampanelhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Perampanelhsa01522Endocrine resistance4.47E-042P04049, P08069RAF1, IGF1RMore
Perampanelhsa01523Antifolate resistance1.09E-045P41440, Q92820, P04818, P01375, P18054SLC19A1, GGH, TYMS, TNF, ALOX12More
Perampanelhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Perampanelhsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Perampanelhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Perampanelhsa03010Ribosome1.41E-0617P62753, P30050, P40429, P62906, P62917, P62829, P46777, Q9H0U6, Q9UHA3, P62888, P61927, P61513, P36578, P50914, P05386, P62249, P23396RPS6, RPL12, RPL13A, RPL10A, RPL8, RPL23, RPL5, MRPL18, RSL24D1, RPL30, RPL37, RPL37A, RPL4, RPL14, RPLP1, RPS16, RPS3More
Perampanelhsa03013RNA transport1.24E-1227P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1, FXR1More
Perampanelhsa03020RNA polymerase2.49E-074P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Perampanelhsa03022Basal transcription factors2.97E-033P20226, O00268, Q15544TBP, TAF4, TAF11More
Perampanelhsa03030DNA replication1.48E-023P49005, P33993, P15927POLD2, MCM7, RPA2More
Perampanelhsa03040Spliceosome2.33E-0817Q14562, O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Perampanelhsa03050Proteasome1.79E-031P55036PSMD4More
Perampanelhsa03060Protein export1.20E-032P37108, Q15005SRP14, SPCS2More
Perampanelhsa03320PPAR signaling pathway4.55E-022O00767, Q02318SCD, CYP27A1More
Perampanelhsa03410Base excision repair7.59E-031P27695APEX1More
Perampanelhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Perampanelhsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Perampanelhsa04012ErbB signaling pathway1.12E-037P21860, P16333, Q13557, P19174, O14944, P01106, P04049ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC, RAF1More
Perampanelhsa04014Ras signaling pathway6.01E-0412P04049, P31751, P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P0DP23, P63218, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, CALM1, GNG5, GNG10, PLCG1More
Perampanelhsa04015Rap1 signaling pathway2.05E-0412P04049, P20827, P49767, P08069, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P31751, P0DP23, P19174RAF1, EFNA1, VEGFC, IGF1R, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, AKT2, CALM1, PLCG1More
Perampanelhsa04020Calcium signaling pathway5.03E-0813Q96DU7, Q08828, P45880, Q13557, P21860, P0DP24, P0DP23, P05141, P12236, P51828, P26678, P63092, P23634ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CALM2, CALM1, SLC25A5, SLC25A6, ADCY7, PLN, GNAS, ATP2B4More
Perampanelhsa04022cGMP-PKG signaling pathway6.41E-0713P61586, P26678, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P12236, P45880, P0DP23RHOA, PLN, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, SLC25A6, VDAC2, CALM1More
Perampanelhsa04024cAMP signaling pathway5.99E-057Q08828, P51828, P31751, P0DP24, P0DP23, P23634, P04049ADCY1, ADCY7, AKT2, CALM2, CALM1, ATP2B4, RAF1More
Perampanelhsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Perampanelhsa04061Viral protein interaction with cytokine and cytokine receptor2.55E-0611Q8NHW4, P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Perampanelhsa04062Chemokine signaling pathway1.27E-0720P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P04049, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, RAF1, GSK3B, PIK3R5More
Perampanelhsa04064NF-kappa B signaling pathway2.62E-1727P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Perampanelhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Perampanelhsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Perampanelhsa04070Phosphatidylinositol signaling system8.69E-059P0DP23, Q14643, O14986, P23743, Q86XP1, Q16760, P48426, Q96DU7, P17252CALM1, ITPR1, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKC, PRKCAMore
Perampanelhsa04071Sphingolipid signaling pathway4.44E-0510P04049, P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, P10415, Q9UQC2RAF1, PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, BCL2, GAB2More
Perampanelhsa04072Phospholipase D signaling pathway2.43E-0412P04049, P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Perampanelhsa04080Neuroactive ligand-receptor interaction3.11E-0410P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P14416, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, DRD2, ADMMore
Perampanelhsa04110Cell cycle7.05E-058P06493, O60566, O75293, P30304, P33981, P42773, P01106, Q13547CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Perampanelhsa04114Oocyte meiosis2.72E-0713Q9Y6D9, P51812, Q02750, P0DP24, P0DP23, P16298, Q17RY0, Q08828, P51828, P27348, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM2, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQ, PPP2R5C, PPP2R5D, IGF1RMore
Perampanelhsa04115p53 signaling pathway6.31E-048P24522, O15151, Q13315, P31350, Q53FA7, P06493, O95067, P10415GADD45A, MDM4, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2More
Perampanelhsa04120Ubiquitin mediated proteolysis7.75E-058Q9UBT2, Q14145, Q13042, P62837, Q15751, O95071, Q14669, P0CG47SAE2, KEAP1, CDC16, UBE2D2, HERC1, UBR5, TRIP12, UBBMore
Perampanelhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Perampanelhsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Perampanelhsa04140Autophagy - animal2.53E-0312P08069, P31751, P04049, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, AKT2, RAF1, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Perampanelhsa04141Protein processing in endoplasmic reticulum2.01E-038P07384, O95487, Q99941, O75460, P11142, Q9H3Z4, P07900, O95816CAPN1, SEC24B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, BAG2More
Perampanelhsa04142Lysosome1.46E-0511Q99437, P25774, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2More
Perampanelhsa04144Endocytosis2.00E-049P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q8WU79, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, SMAP1L, GIT2, SNX12More
Perampanelhsa04145Phagosome4.15E-0813O75015, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Perampanelhsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Perampanelhsa04150mTOR signaling pathway1.32E-035P08069, P04049, Q02750, Q9NQL2, P51812IGF1R, RAF1, MAP2K1, RRAGD, RPS6KA3More
Perampanelhsa04151PI3K-Akt signaling pathway3.23E-0429P42338, P21860, P43657, P25116, P27348, P20827, O14944, P49767, Q13362, P07900, P08238, Q15831, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, P22105, O60603, P14784, P01568, Q99941, P18848, P10415, P17252, P30281, O95988PIK3CB, ERBB3, P2RY5, F2R, YWHAQ, EFNA1, EREG, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, STK11, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TNXB, TLR2, IL2RB, IFNA21, CREBL1, ATF4, BCL2, PRKCA, CCND3, TCL1BMore
Perampanelhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Perampanelhsa04210Apoptosis2.84E-0310Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643, P04049ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1, RAF1More
Perampanelhsa04211Longevity regulating pathway1.96E-048Q12778, P31751, P08069, Q08828, P51828, P18848, Q9UEF7, Q96KQ7FOXO1, AKT2, IGF1R, ADCY1, ADCY7, ATF4, KL, EHMT2More
Perampanelhsa04213Longevity regulating pathway - multiple species1.91E-059P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Perampanelhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Perampanelhsa04217Necroptosis4.20E-0817P01375, P01568, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P15104, P01584, Q6FI13, Q99878, P10415, Q9H444, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, GLUL, IL1B, H2AC18; H2AC19, H2AC14, BCL2, CHMP4B, CHMP2A, PPIDMore
Perampanelhsa04218Cellular senescence1.43E-043P31751, P04049, P0DP23AKT2, RAF1, CALM1More
Perampanelhsa04261Adrenergic signaling in cardiomyocytes6.11E-0916P09493, P63092, Q08828, P51828, P31751, Q99941, P18848, P26678, Q13362, Q14738, P0DP24, P0DP23, Q13557, P17252, P10415, P23634TPM1, GNAS, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PLN, PPP2R5C, PPP2R5D, CALM2, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Perampanelhsa04270Vascular smooth muscle contraction1.06E-057P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Perampanelhsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Perampanelhsa04360Axon guidance9.77E-049P16333, P20827, O95631, P42338, P07332, P23528, P04049, P19174, Q06124NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, RAF1, PLCG1, PTPN11More
Perampanelhsa04370VEGF signaling pathway9.21E-075P16298, P31751, Q05397, Q02750, P04049PPP3CB, AKT2, PTK2, MAP2K1, RAF1More
Perampanelhsa04371Apelin signaling pathway4.24E-0512P63218, P50151, Q8WYR1, P31751, P04049, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P0DP23GNG5, GNG10, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CALM1More
Perampanelhsa04380Osteoclast differentiation3.07E-0714Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Perampanelhsa04390Hippo signaling pathway3.80E-058P63261, P84022, Q13485, O15105, P04628, Q9UJU2, O43623, Q13489ACTG1, SMAD3, SMAD4, SMAD7, WNT1, LEF1, SNAI2, BIRC3More
Perampanelhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Perampanelhsa04510Focal adhesion1.18E-032P04049, P08069RAF1, IGF1RMore
Perampanelhsa04520Adherens junction8.29E-031P08069IGF1RMore
Perampanelhsa04530Tight junction1.85E-059Q8TEU7, P63261, P16989, P56750, O00501, Q9Y478, Q92974, Q14247, P24844RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, PRKAB1, ARHGEF2, CTTN, MYL9More
Perampanelhsa04540Gap junction6.48E-056P17252, Q13509, P68371, P04049, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, RAF1, PDGFC, ITPR1More
Perampanelhsa04550Signaling pathways regulating pluripotency of stem cells3.80E-042P04049, P08069RAF1, IGF1RMore
Perampanelhsa04610Complement and coagulation cascades4.27E-061P0C0L4C4AMore
Perampanelhsa04612Antigen processing and presentation2.87E-0910P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Perampanelhsa04613Neutrophil extracellular trap formation4.66E-0925P17252, P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Perampanelhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Perampanelhsa04620Toll-like receptor signaling pathway6.42E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Perampanelhsa04621NOD-like receptor signaling pathway5.25E-0720P01584, P07900, Q14643, P01568, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838IL1B, HSP90AA1, ITPR1, IFNA21, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Perampanelhsa04622RIG-I-like receptor signaling pathway1.02E-033P01568, Q9NQC7, Q13546IFNA21, CYLD, RIPK1More
Perampanelhsa04623Cytosolic DNA-sensing pathway3.42E-105P01584, P01568, Q13546, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, POLR3H, CCL4L2More
Perampanelhsa04625C-type lectin receptor signaling pathway1.30E-0712Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Perampanelhsa04630JAK-STAT signaling pathway8.73E-034P31751, P23458, Q13651, P04049AKT2, JAK1, IL10RA, RAF1More
Perampanelhsa04640Hematopoietic cell lineage4.59E-1018P13612, P08514, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Perampanelhsa04650Natural killer cell mediated cytotoxicity6.37E-2018P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Perampanelhsa04657IL-17 signaling pathway7.24E-079P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Perampanelhsa04658Th1 and Th2 cell differentiation3.23E-2216Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Perampanelhsa04659Th17 cell differentiation4.00E-1921P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Perampanelhsa04660T cell receptor signaling pathway8.46E-1820P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Perampanelhsa04662B cell receptor signaling pathway7.02E-088P49841, P31751, P42338, P60033, P07948, P21854, Q8N149, P04049GSK3B, AKT2, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Perampanelhsa04664Fc epsilon RI signaling pathway5.80E-0710P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917, P20292TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5APMore
Perampanelhsa04666Fc gamma R-mediated phagocytosis2.64E-026P04049, P23528, P06396, O14494, P14598, P17252RAF1, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Perampanelhsa04668TNF signaling pathway2.41E-0411P01375, O00463, Q13489, Q16539, P25963, Q99941, P01584, P20749, Q13077, P14780, O95429TNF, TRAF5, BIRC3, MAPK14, NFKBIA, CREBL1, IL1B, BCL3, TRAF1, MMP9, BAG4More
Perampanelhsa04670Leukocyte transendothelial migration6.23E-0311P14780, P11215, P60709, Q96A32, P17252, P14598, Q15080, Q08881, P42681, P19174, P12814MMP9, ITGAM, ACTB, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK, PLCG1, ACTN1More
Perampanelhsa04672Intestinal immune network for IgA production1.24E-043P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Perampanelhsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Perampanelhsa04713Circadian entrainment2.85E-036P0DP23, P17252, P62873, Q14643, Q08828, P51828CALM1, PRKCA, GNB1, ITPR1, ADCY1, ADCY7More
Perampanelhsa04714Thermogenesis1.73E-047Q16539, P15336, P63261, P33121, Q9Y478, Q16718, O14521MAPK14, ATF2, ACTG1, ACSL1, PRKAB1, NDUFA5, SDHDMore
Perampanelhsa04720Long-term potentiation1.08E-059P17252, P16298, P0DP23, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Perampanelhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Perampanelhsa04722Neurotrophin signaling pathway7.07E-068Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P0DP23PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, CALM1More
Perampanelhsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Perampanelhsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Perampanelhsa04725Cholinergic synapse7.72E-0511Q08828, P51828, Q14643, P17252, P62873, P63218, P50151, P18848, P42338, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, PIK3CB, AKT2, BCL2More
Perampanelhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Perampanelhsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Perampanelhsa04728Dopaminergic synapse2.31E-0715Q14643, P17252, P14416, P62873, P63218, P50151, P31751, P49841, P18848, Q16539, P49407, Q13362, Q14738, P0DP23, O00327ITPR1, PRKCA, DRD2, GNB1, GNG5, GNG10, AKT2, GSK3B, ATF4, MAPK14, ARRB1, PPP2R5C, PPP2R5D, CALM1, ARNTLMore
Perampanelhsa04730Long-term depression1.25E-042P08069, P04049IGF1R, RAF1More
Perampanelhsa04740Olfactory transduction2.41E-021P0DP23CALM1More
Perampanelhsa04744Phototransduction1.45E-042P62873, P0DP23GNB1, CALM1More
Perampanelhsa04750Inflammatory mediator regulation of TRP channels1.99E-0714P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Perampanelhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Perampanelhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Perampanelhsa04911Insulin secretion1.04E-056Q08828, P51828, P63092, Q99941, P18848, Q13557ADCY1, ADCY7, GNAS, CREBL1, ATF4, CAMK2DMore
Perampanelhsa04912GnRH signaling pathway2.22E-0511P17252, Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049PRKCA, ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1More
Perampanelhsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Perampanelhsa04914Progesterone-mediated oocyte maturation9.18E-056P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Perampanelhsa04915Estrogen signaling pathway2.15E-0711P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1More
Perampanelhsa04916Melanogenesis3.38E-047P0DP23, Q9UJU2, Q08828, P51828, P17252, P04628, P04049CALM1, LEF1, ADCY1, ADCY7, PRKCA, WNT1, RAF1More
Perampanelhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Perampanelhsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Perampanelhsa04920Adipocytokine signaling pathway1.16E-037P25963, Q06124, P33121, Q9Y478, Q04759, P31751, P01375NFKBIA, PTPN11, ACSL1, PRKAB1, PRKCQ, AKT2, TNFMore
Perampanelhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Perampanelhsa04922Glucagon signaling pathway2.33E-035Q12778, P31751, Q13370, P0DP23, Q14643FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Perampanelhsa04923Regulation of lipolysis in adipocytes5.39E-056Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Perampanelhsa04924Renin secretion2.05E-044P07550, Q14643, Q13370, P0DP23ADRB2, ITPR1, PDE3B, CALM1More
Perampanelhsa04925Aldosterone synthesis and secretion3.04E-079Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, P63092, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, GNAS, CAMK2D, ATP2B4More
Perampanelhsa04926Relaxin signaling pathway1.26E-0410P31751, P42338, P63218, P50151, P18848, P49767, Q08828, P51828, P04049, P49407AKT2, PIK3CB, GNG5, GNG10, ATF4, VEGFC, ADCY1, ADCY7, RAF1, ARRB1More
Perampanelhsa04927Cortisol synthesis and secretion8.61E-045Q99941, P18848, Q08828, P51828, P63092CREBL1, ATF4, ADCY1, ADCY7, GNASMore
Perampanelhsa04928Parathyroid hormone synthesis, secretion and action6.58E-035P63092, P04049, P61586, Q99941, P18848GNAS, RAF1, RHOA, CREBL1, ATF4More
Perampanelhsa04929GnRH secretion2.28E-044P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Perampanelhsa04930Type II diabetes mellitus2.68E-021Q05655PRKCDMore
Perampanelhsa04932Non-alcoholic fatty liver disease2.89E-0714P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Perampanelhsa04933AGE-RAGE signaling pathway in diabetic complications8.03E-059P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Perampanelhsa04934Cushing syndrome2.16E-067Q99941, P18848, Q08828, P51828, P63092, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, GNAS, AXIN1, CAMK2DMore
Perampanelhsa04935Growth hormone synthesis, secretion and action5.00E-035Q08828, P51828, P04049, P18848, P31751ADCY1, ADCY7, RAF1, ATF4, AKT2More
Perampanelhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Perampanelhsa04960Aldosterone-regulated sodium reabsorption4.40E-021O00141SGKMore
Perampanelhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Perampanelhsa04962Vasopressin-regulated water reabsorption7.22E-032P52566, P62491ARHGDIB, RAB11AMore
Perampanelhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Perampanelhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Perampanelhsa04970Salivary secretion8.93E-0810P07550, Q08828, P51828, P22694, Q14643, P23634, P17252, P0DP24, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CALM1, CAMPMore
Perampanelhsa04971Gastric acid secretion2.02E-055Q08828, P51828, P15311, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM1, CAMK2DMore
Perampanelhsa04972Pancreatic secretion1.35E-044P23634, Q08828, P51828, P62491ATP2B4, ADCY1, ADCY7, RAB11AMore
Perampanelhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Perampanelhsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Perampanelhsa04976Bile secretion1.67E-056O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Perampanelhsa05010Alzheimer disease1.85E-0828Q92542, O15239, Q16718, O95298, O14521, P05496, P12074, Q14643, O15399, Q00535, Q9NZJ5, O75460, P0DP23, P49841, P01584, P18848, Q13509, P68371, O15169, P31751, P05141, P12236, P21796, P45880, Q08752, P28070, P43686, P62195NCSTN, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX6A1, ITPR1, GRIN2D, CDK5, EIF2AK3, ERN1, CALM1, GSK3B, IL1B, ATF4, TUBB3, TUBB2C, AXIN1, AKT2, SLC25A5, SLC25A6, VDAC1, VDAC2, PPID, PSMB4, PSMC4, PSMC5More
Perampanelhsa05012Parkinson disease1.77E-0518O15239, Q16718, O14521, P05496, P05141, P12236, P21796, P14416, P63092, Q9NZJ5, P18848, P43686, P62195, Q14643, P0DP23, Q13557, Q13509, P68371NDUFA1, NDUFA5, SDHD, ATP5G1, SLC25A5, SLC25A6, VDAC1, DRD2, GNAS, EIF2AK3, ATF4, PSMC4, PSMC5, ITPR1, CALM1, CAMK2D, TUBB3, TUBB2CMore
Perampanelhsa05014Amyotrophic lateral sclerosis2.05E-0422O15399, P01375, P20333, O15239, Q16718, O14521, P36542, P05496, Q9NZJ5, P18848, P43686, P62195, Q13148, P21796, P51991, P09651, Q7Z3B4, P35658, P43243, P20073, Q09161, Q16629GRIN2D, TNF, TNFRSF1B, NDUFA1, NDUFA5, SDHD, ATP5C1, ATP5G1, EIF2AK3, ATF4, PSMC4, PSMC5, TARDBP, VDAC1, HNRPA3, HNRNPA1, NUP54, NUP214, MATR3, ANXA7, NCBP1, SFRS7More
Perampanelhsa05016Huntington disease1.76E-0310O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Perampanelhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Perampanelhsa05020Prion disease8.77E-0825P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P12074, Q14643, O15399, Q9NZJ5, P18848, P05141, P12236, P21796, P45880, P43686, P62195, Q13509, P68371, P49841, Q99941, P14598, Q15080, Q16539IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, GRIN2D, EIF2AK3, ATF4, SLC25A5, SLC25A6, VDAC1, VDAC2, PSMC4, PSMC5, TUBB3, TUBB2C, GSK3B, CREBL1, NCF1, NCF4, MAPK14More
Perampanelhsa05022Pathways of neurodegeneration - multiple diseases5.53E-0934Q14643, O15399, Q13509, P68371, P49841, P10415, O15239, Q16718, O95298, O14521, P05496, Q06055, Q8TEV9, P21796, Q13148, Q9NZJ5, O75460, P18848, Q13561, P05141, P12236, P17252, P20333, Q16539, Q00535, O15169, P01584, Q08752, O15020, P0DP23, Q13557, P28070, P43686, P62195ITPR1, GRIN2D, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, ATP5G2, SMCR8, VDAC1, TARDBP, EIF2AK3, ERN1, ATF4, DCTN2, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, MAPK14, CDK5, AXIN1, IL1B, PPID, SPTBN2, CALM1, CAMK2D, PSMB4, PSMC4, PSMC5More
Perampanelhsa05030Cocaine addiction1.88E-046P14416, P63092, Q00535, Q99941, P18848, O15399DRD2, GNAS, CDK5, CREBL1, ATF4, GRIN2DMore
Perampanelhsa05031Amphetamine addiction9.47E-045P0DP23, Q13557, P63092, Q99941, P18848CALM1, CAMK2D, GNAS, CREBL1, ATF4More
Perampanelhsa05034Alcoholism2.25E-057Q96RR4, P04049, Q93077, P62807, O60814, P84243, P68431CAMKK2, RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Perampanelhsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Perampanelhsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Perampanelhsa05120Epithelial cell signaling in Helicobacter pylori infection2.22E-067Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Perampanelhsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Perampanelhsa05131Shigellosis5.65E-0622P01375, P25963, O00463, Q13546, P68431, Q05655, Q04759, Q9UDY8, Q9NQL2, Q9H1Y0, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32, P07737TNF, NFKBIA, TRAF5, RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCQ, MALT1, RRAGD, ATG5, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPF, PFN1More
Perampanelhsa05132Salmonella infection1.94E-0918P51617, P25963, P01375, P04049, Q9UJU2, P84095, Q13546, Q13489, P10415, O75369, P07737, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, NFKBIA, TNF, RAF1, LEF1, RHOG, RIPK1, BIRC3, BCL2, FLNB, PFN1, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Perampanelhsa05133Pertussis3.02E-031P0C0L4C4AMore
Perampanelhsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Perampanelhsa05135Yersinia infection2.78E-038P60709, P13612, P06239, P19174, Q16539, P01375, P49841, P01730ACTB, ITGA4, LCK, PLCG1, MAPK14, TNF, GSK3B, CD4More
Perampanelhsa05140Leishmaniasis6.29E-1015P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Perampanelhsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Perampanelhsa05144Malaria5.97E-098P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Perampanelhsa05145Toxoplasmosis1.55E-049P51617, P25963, P01375, P10415, Q13489, P42224, P13765, O60603, P29965IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Perampanelhsa05146Amoebiasis5.31E-1313P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Perampanelhsa05150Staphylococcus aureus infection1.20E-0710P0C0L4, P21730, P21462, O75015, P13646, Q14532, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Perampanelhsa05152Tuberculosis1.36E-0718P04049, Q13488, Q99437, Q15075, P0DP23, P42224, P48382, O60603, P01375, P31751, P10415, P13765, P25774, Q13651, P01568, P49913, Q9UDY8, P51617RAF1, TCIRG1, ATP6V0B, EEA1, CALM1, STAT1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CTSS, IL10RA, IFNA21, CAMP, MALT1, IRAK1More
Perampanelhsa05160Hepatitis C2.03E-059P60033, O00501, P29728, Q9NZJ5, P04049, P49841, P01375, P48023, P01106CD81, CLDN5, OAS2, EIF2AK3, RAF1, GSK3B, TNF, FASLG, MYCMore
Perampanelhsa05161Hepatitis B2.67E-0411P17252, P04049, P14780, P25963, Q13485, P01375, P10415, P84022, P51617, O60603, Q14765PRKCA, RAF1, MMP9, NFKBIA, SMAD4, TNF, BCL2, SMAD3, IRAK1, TLR2, STAT4More
Perampanelhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Perampanelhsa05163Human cytomegalovirus infection2.20E-0820P31751, P04049, P01375, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463AKT2, RAF1, TNF, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5More
Perampanelhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Perampanelhsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Perampanelhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Perampanelhsa05167Kaposi sarcoma-associated herpesvirus infection8.06E-0512P01568, P31751, P42224, P62873, P62879, P16298, Q14643, P04049, Q02750, P0DP23, P0CG47, Q9UJU2IFNA21, AKT2, STAT1, GNB1, GNB2, PPP3CB, ITPR1, RAF1, MAP2K1, CALM1, UBB, LEF1More
Perampanelhsa05168Herpes simplex virus 1 infection4.79E-028P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189More
Perampanelhsa05169Epstein-Barr virus infection7.34E-0514P13765, P01106, Q13547, O00463, P42338, P07948, Q13761, P24522, O75293, P01375, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TNF, OAS2, CD3E, CD3G, CD247More
Perampanelhsa05170Human immunodeficiency virus 1 infection3.67E-1124P31751, P04049, Q02750, P62873, P62879, P16298, P0DP23, P01375, Q05397, P17252, O00463, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P23528, P10415, Q13619, Q93034, Q9Y6Q5, P20333AKT2, RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, CFL1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Perampanelhsa05171Coronavirus disease - COVID-193.18E-037P01584, P62753, P36578, P62888, P61927, P61513, P62829IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23More
Perampanelhsa05200Pathways in cancer2.98E-0429Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P31751, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, AKT2, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RBMore
Perampanelhsa05202Transcriptional misregulation in cancer1.11E-0922Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Perampanelhsa05203Viral carcinogenesis3.27E-049Q99941, P18848, P27348, Q15283, P61586, P61978, P62807, P33778, O60814CREBL1, ATF4, YWHAQ, RASA2, RHOA, HNRPK, HIST1H2BC, H2BC3, H2BC12More
Perampanelhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Perampanelhsa05205Proteoglycans in cancer1.89E-0312Q13009, Q12955, Q14643, O75369, P04049, P14780, P17252, O60603, P08069, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, RAF1, MMP9, PRKCA, TLR2, IGF1R, WNT1, PTCH1, CD63More
Perampanelhsa05206MicroRNAs in cancer4.38E-058P15311, P21860, P61978, P46531, P63279, P22105, P61586, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RHOA, RAF1More
Perampanelhsa05210Colorectal cancer1.68E-034P84022, Q13485, P04049, P10415SMAD3, SMAD4, RAF1, BCL2More
Perampanelhsa05211Renal cell carcinoma1.99E-044Q06124, Q99814, P31751, P04049PTPN11, EPAS1, AKT2, RAF1More
Perampanelhsa05212Pancreatic cancer1.45E-058P42338, P31751, P04049, Q15311, P23458, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, SMAD3, SMAD4, GADD45BMore
Perampanelhsa05213Endometrial cancer4.41E-044O15169, P31751, Q02750, P04049AXIN1, AKT2, MAP2K1, RAF1More
Perampanelhsa05214Glioma1.14E-074P08069, P0DP23, P04049, P31751IGF1R, CALM1, RAF1, AKT2More
Perampanelhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Perampanelhsa05217Basal cell carcinoma7.91E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Perampanelhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Perampanelhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Perampanelhsa05220Chronic myeloid leukemia2.22E-058Q13547, Q13485, P25963, P84022, P31751, P42338, P04049, O75293HDAC1, SMAD4, NFKBIA, SMAD3, AKT2, PIK3CB, RAF1, GADD45BMore
Perampanelhsa05221Acute myeloid leukemia8.16E-042P31751, P04049AKT2, RAF1More
Perampanelhsa05222Small cell lung cancer3.73E-047P31751, Q13489, P10415, P25963, Q13077, O00463, P24522AKT2, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Perampanelhsa05223Non-small cell lung cancer2.44E-045P31751, P19174, P04049, Q9HC35, O75293AKT2, PLCG1, RAF1, EML4, GADD45BMore
Perampanelhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Perampanelhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Perampanelhsa05226Gastric cancer2.61E-057P04049, Q02750, P31751, O15169, P84022, Q13485, P10415RAF1, MAP2K1, AKT2, AXIN1, SMAD3, SMAD4, BCL2More
Perampanelhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Perampanelhsa05231Choline metabolism in cancer7.30E-047P04049, P31751, Q9Y259, P19174, P49619, Q16760, O14986RAF1, AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1BMore
Perampanelhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.01E-1215P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, P42224, O60603, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, STAT1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Perampanelhsa05310Asthma4.97E-053P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Perampanelhsa05320Autoimmune thyroid disease2.92E-054P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Perampanelhsa05321Inflammatory bowel disease1.31E-098O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Perampanelhsa05322Systemic lupus erythematosus2.79E-0816P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, P33778, Q16778, O60814, P68431, P12814, P05455ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Perampanelhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Perampanelhsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Perampanelhsa05332Graft-versus-host disease1.87E-076P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Perampanelhsa05340Primary immunodeficiency1.32E-066P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Perampanelhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Perampanelhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Perampanelhsa05415Diabetic cardiomyopathy7.90E-0513P17252, P05141, P12236, P14598, Q15080, O15239, Q16718, O14521, P05496, Q16539, P49841, Q13557, P26678PRKCA, SLC25A5, SLC25A6, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, ATP5G1, MAPK14, GSK3B, CAMK2D, PLNMore
Perampanelhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Perampanelhsa05418Fluid shear stress and atherosclerosis4.89E-0710Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Perampanel (SDC: 11.49)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P01106MYCMyc protoNoneoncogene proteinPredicted00.12370.02911.1198
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P49281SLC11A2Natural resistanceNoneassociated macrophage protein 2Predicted10.33250.05050.26620.5334
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
Q9GZR1SENP6SentrinNonespecific protease 6Predicted00.38440.078400.349
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
Q06609RAD51DNA repair protein RAD51 homolog 1Predicted00.10220.09540.27250.5144
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P40926MDH2Malate dehydrogenase, mitochondrialPredicted00.47210.16110.24740.8055
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
Q92499DDX1ATPNonedependent RNA helicase DDX1Predicted00.05070.010700.0467
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
O15164TRIM24Transcription intermediary factor 1NonealphaPredicted00.28070.105500.3514
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P48058GRIA4Glutamate receptor 4Predicted00.40370.12090.37480.8184
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)