| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Pentoxifylline | hsa00030 | Pentose phosphate pathway | 3.06E-04 | 3 | P60891, P51854, P37837 | PRPS1, TKTL1, TALDO1 | More | | | Pentoxifylline | hsa00190 | Oxidative phosphorylation | 1.94E-02 | 3 | Q16718, P36542, O14521 | NDUFA5, ATP5C1, SDHD | More | | | Pentoxifylline | hsa00230 | Purine metabolism | 2.11E-02 | 3 | Q7LG56, P31350, P21589 | RRM2B, RRM2, NT5E | More | | | Pentoxifylline | hsa00240 | Pyrimidine metabolism | 1.86E-06 | 5 | Q7LG56, P31350, P21589, P04183, P04818 | RRM2B, RRM2, NT5E, TK1, TYMS | More | | | Pentoxifylline | hsa00480 | Glutathione metabolism | 3.85E-02 | 2 | Q7LG56, P31350 | RRM2B, RRM2 | More | | | Pentoxifylline | hsa00983 | Drug metabolism - other enzymes | 1.05E-06 | 4 | P04183, Q7LG56, P31350, P05164 | TK1, RRM2B, RRM2, MPO | More | | | Pentoxifylline | hsa01200 | Carbon metabolism | 4.32E-02 | 3 | P51854, P37837, P60891 | TKTL1, TALDO1, PRPS1 | More | | | Pentoxifylline | hsa01230 | Biosynthesis of amino acids | 2.60E-02 | 3 | P51854, P60891, P37837 | TKTL1, PRPS1, TALDO1 | More | | | Pentoxifylline | hsa03008 | Ribosome biogenesis in eukaryotes | 8.16E-03 | 3 | Q9NYH9, P78345, Q9GZY0 | UTP6, RPP38, NXF2; NXF2B | More | | | Pentoxifylline | hsa03013 | RNA transport | 1.39E-04 | 12 | O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114 | XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1 | More | | | Pentoxifylline | hsa03015 | mRNA surveillance pathway | 3.37E-02 | 3 | O43148, Q9GZY0, P52298 | RNMT, NXF2; NXF2B, NCBP2 | More | | | Pentoxifylline | hsa03022 | Basal transcription factors | 3.50E-02 | 3 | P20226, O00268, Q15544 | TBP, TAF4, TAF11 | More | | | Pentoxifylline | hsa03050 | Proteasome | 4.83E-02 | 1 | P55036 | PSMD4 | More | | | Pentoxifylline | hsa04071 | Sphingolipid signaling pathway | 1.19E-02 | 4 | P21453, Q9H228, P01375, Q13362 | S1PR1, EDG8, TNF, PPP2R5C | More | | | Pentoxifylline | hsa04080 | Neuroactive ligand-receptor interaction | 1.97E-02 | 5 | P28472, P21453, Q9H228, P21730, P07550 | GABRB3, S1PR1, EDG8, C5AR1, ADRB2 | More | | | Pentoxifylline | hsa04115 | p53 signaling pathway | 1.74E-03 | 4 | Q7LG56, P31350, Q9HA38, P04637 | RRM2B, RRM2, ZMAT3, TP53 | More | | | Pentoxifylline | hsa04142 | Lysosome | 4.94E-02 | 2 | P08311, Q9UPM8 | CTSG, AP4E1 | More | | | Pentoxifylline | hsa04146 | Peroxisome | 4.83E-02 | 4 | O96011, P56589, Q9UKG9, O75521 | PEX11B, PEX3, CROT, ECI2 | More | | | Pentoxifylline | hsa04261 | Adrenergic signaling in cardiomyocytes | 2.95E-02 | 4 | P07550, P22694, P18848, Q13362 | ADRB2, PRKACB, ATF4, PPP2R5C | More | | | Pentoxifylline | hsa04612 | Antigen processing and presentation | 3.75E-04 | 8 | P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375 | RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Pentoxifylline | hsa04613 | Neutrophil extracellular trap formation | 4.72E-02 | 3 | P05164, P20160, P08311 | MPO, AZU1, CTSG | More | | | Pentoxifylline | hsa04621 | NOD-like receptor signaling pathway | 2.27E-02 | 9 | Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838 | ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4 | More | | | Pentoxifylline | hsa04650 | Natural killer cell mediated cytotoxicity | 4.40E-05 | 9 | P01375, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715 | TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1 | More | | | Pentoxifylline | hsa04657 | IL-17 signaling pathway | 2.41E-02 | 4 | P19875, P14780, P80188, P01375 | CXCL2, MMP9, LCN2, TNF | More | | | Pentoxifylline | hsa04659 | Th17 cell differentiation | 8.77E-03 | 3 | Q04759, Q9HBE5, P84022 | PRKCQ, IL21R, SMAD3 | More | | | Pentoxifylline | hsa04668 | TNF signaling pathway | 3.55E-02 | 4 | P01375, P18848, P19875, P14780 | TNF, ATF4, CXCL2, MMP9 | More | | | Pentoxifylline | hsa04913 | Ovarian steroidogenesis | 2.54E-02 | 2 | P42330, P22694 | AKR1C3, PRKACB | More | | | Pentoxifylline | hsa04924 | Renin secretion | 4.04E-02 | 2 | P22694, P07550 | PRKACB, ADRB2 | More | | | Pentoxifylline | hsa04926 | Relaxin signaling pathway | 2.41E-02 | 4 | P18848, P22694, P14780, P30679 | ATF4, PRKACB, MMP9, GNA15 | More | | | Pentoxifylline | hsa04927 | Cortisol synthesis and secretion | 2.54E-02 | 2 | P18848, P22694 | ATF4, PRKACB | More | | | Pentoxifylline | hsa04970 | Salivary secretion | 1.91E-02 | 3 | P07550, P22694, P49913 | ADRB2, PRKACB, CAMP | More | | | Pentoxifylline | hsa05014 | Amyotrophic lateral sclerosis | 2.72E-02 | 10 | P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629 | TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7 | More | | | Pentoxifylline | hsa05031 | Amphetamine addiction | 4.32E-02 | 3 | P22694, P18848, Q13547 | PRKACB, ATF4, HDAC1 | More | | | Pentoxifylline | hsa05144 | Malaria | 1.72E-03 | 4 | P60033, P01375, P35443, P26718 | CD81, TNF, THBS4, KLRK1 | More | | | Pentoxifylline | hsa05146 | Amoebiasis | 2.41E-02 | 4 | P19875, P01375, P30679, P22694 | CXCL2, TNF, GNA15, PRKACB | More | | | Pentoxifylline | hsa05150 | Staphylococcus aureus infection | 1.19E-05 | 8 | P21730, P21462, O75015, Q14532, P59665, P59666, P12838, P49913 | C5AR1, FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP | More | | | Pentoxifylline | hsa05202 | Transcriptional misregulation in cancer | 1.79E-02 | 5 | Q15532, P14923, O15550, P04637, P05164 | SS18, JUP, UTX, TP53, MPO | More | | | Pentoxifylline | hsa05205 | Proteoglycans in cancer | 3.68E-02 | 5 | P14780, P01375, P23588, Q13635, P22694 | MMP9, TNF, EIF4B, PTCH1, PRKACB | More | | | Pentoxifylline | hsa05321 | Inflammatory bowel disease | 8.78E-04 | 5 | P01375, Q14765, Q9UL17, P84022, Q9HBE5 | TNF, STAT4, TBX21, SMAD3, IL21R | More | | | Pentoxifylline | hsa05332 | Graft-versus-host disease | 8.79E-03 | 3 | P01375, P26715, Q13241 | TNF, KLRC1, KLRD1 | More | |
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