PharmaCoNets of Pentostatin (SPCN: 9.28 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pentostatinhsa00220Arginine biosynthesis2.66E-022P05089, P49448ARG1, GLUD2More
Pentostatinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Pentostatinhsa04012ErbB signaling pathway4.91E-023P49841, Q13191, P42338GSK3B, CBLB, PIK3CBMore
Pentostatinhsa04060Cytokine-cytokine receptor interaction3.84E-028P14784, P27930, Q13651, Q9HBE5, P25024, P01375, P09341, Q93038IL2RB, IL1R2, IL10RA, IL21R, CXCR1, TNF, CXCL1, TNFRSF25More
Pentostatinhsa04061Viral protein interaction with cytokine and cytokine receptor2.44E-025P09341, P25024, Q13651, P14784, P01375CXCL1, CXCR1, IL10RA, IL2RB, TNFMore
Pentostatinhsa04064NF-kappa B signaling pathway3.38E-026O00463, P01375, Q04759, Q16548, P06239, P09341TRAF5, TNF, PRKCQ, BCL2A1, LCK, CXCL1More
Pentostatinhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Pentostatinhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Pentostatinhsa04612Antigen processing and presentation3.06E-025P13765, P26715, P26717, P01732, P01375HLA-DOB, KLRC1, KLRC2, CD8A, TNFMore
Pentostatinhsa04640Hematopoietic cell lineage5.76E-037P27930, P25063, P07766, P01732, P09564, P13765, P01375IL1R2, CD24, CD3E, CD8A, CD7, HLA-DOB, TNFMore
Pentostatinhsa04650Natural killer cell mediated cytotoxicity8.56E-048P01375, P06239, O60880, P20963, P42338, P26718, P26717, P26715TNF, LCK, SH2D1A, CD247, PIK3CB, KLRK1, KLRC2, KLRC1More
Pentostatinhsa04658Th1 and Th2 cell differentiation6.68E-069Q04759, P07766, P20963, P06239, Q14765, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, LCK, STAT4, TBX21, IL2RB, HLA-DOB, RUNX3More
Pentostatinhsa04659Th17 cell differentiation4.19E-048Q04759, P06239, P14784, P13765, Q9HBE5, Q9UL17, P07766, P20963PRKCQ, LCK, IL2RB, HLA-DOB, IL21R, TBX21, CD3E, CD247More
Pentostatinhsa04660T cell receptor signaling pathway2.88E-0510P01375, Q04759, P42338, Q08881, P07766, P20963, P01732, Q13191, P06239, P49841TNF, PRKCQ, PIK3CB, ITK, CD3E, CD247, CD8A, CBLB, LCK, GSK3BMore
Pentostatinhsa04668TNF signaling pathway3.06E-025P01375, O00463, P09341, P20749, P42338TNF, TRAF5, CXCL1, BCL3, PIK3CBMore
Pentostatinhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Pentostatinhsa04750Inflammatory mediator regulation of TRP channels2.28E-024P22694, P42338, P24723, Q04759PRKACB, PIK3CB, PRKCH, PRKCQMore
Pentostatinhsa04910Insulin signaling pathway1.08E-025P22694, P06737, P42338, P49841, Q13191PRKACB, PYGL, PIK3CB, GSK3B, CBLBMore
Pentostatinhsa04931Insulin resistance7.80E-035P01375, P42338, P49841, Q04759, P06737TNF, PIK3CB, GSK3B, PRKCQ, PYGLMore
Pentostatinhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Pentostatinhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Pentostatinhsa05135Yersinia infection1.45E-025P06239, P01375, P42338, P49841, P01732LCK, TNF, PIK3CB, GSK3B, CD8AMore
Pentostatinhsa05142Chagas disease3.97E-024P01375, P42338, P07766, P20963TNF, PIK3CB, CD3E, CD247More
Pentostatinhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Pentostatinhsa05144Malaria7.31E-034P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Pentostatinhsa05146Amoebiasis6.94E-058P09341, P27930, P01375, P42338, P05089, P22694, P12814, P08311CXCL1, IL1R2, TNF, PIK3CB, ARG1, PRKACB, ACTN1, CTSGMore
Pentostatinhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Pentostatinhsa05163Human cytomegalovirus infection4.01E-026P42338, P01375, P22694, P49841, Q13651, O00463PIK3CB, TNF, PRKACB, GSK3B, IL10RA, TRAF5More
Pentostatinhsa05169Epstein-Barr virus infection1.54E-028P13765, Q13547, O00463, P42338, Q13761, P01375, P07766, P20963HLA-DOB, HDAC1, TRAF5, PIK3CB, RUNX3, TNF, CD3E, CD247More
Pentostatinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.90E-025P42338, P07766, P20963, P06239, Q04759PIK3CB, CD3E, CD247, LCK, PRKCQMore
Pentostatinhsa05310Asthma3.36E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Pentostatinhsa05321Inflammatory bowel disease7.29E-045P01375, P13765, Q14765, Q9UL17, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, IL21RMore
Pentostatinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Pentostatinhsa05332Graft-versus-host disease2.07E-034P13765, P48023, P01375, P26715HLA-DOB, FASLG, TNF, KLRC1More
Pentostatinhsa05418Fluid shear stress and atherosclerosis3.77E-025P42338, Q14145, P10599, P01375, P27930PIK3CB, KEAP1, TXN, TNF, IL1R2More

Community members of Pentostatin (SDC: 1.51)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P10153RNASE2NonNonesecretory ribonucleasePredicted10.24880.012100.1487
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)