PharmaCoNets of Pentobarbital (SPCN: 21.58 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pentobarbitalhsa00310Lysine degradation1.53E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Pentobarbitalhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Pentobarbitalhsa00500Starch and sucrose metabolism2.86E-022O43451, P46976MGAM, GYG1More
Pentobarbitalhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Pentobarbitalhsa00562Inositol phosphate metabolism2.54E-034P27987, Q13572, Q96PE3, P42338ITPKB, ITPK1, INPP4A, PIK3CBMore
Pentobarbitalhsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Pentobarbitalhsa00770Pantothenate and CoA biosynthesis1.78E-022O95498, O95497VNN2, VNN1More
Pentobarbitalhsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Pentobarbitalhsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Pentobarbitalhsa03040Spliceosome3.94E-048Q14562, O43143, O60508, P08579, P26368, Q13595, Q01130, O43447DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, PPIHMore
Pentobarbitalhsa03050Proteasome1.40E-021P55036PSMD4More
Pentobarbitalhsa04014Ras signaling pathway3.62E-025P42338, P49767, P0DP23, P63218, P50151PIK3CB, VEGFC, CALM1, GNG5, GNG10More
Pentobarbitalhsa04020Calcium signaling pathway5.15E-058P27987, P21796, Q16566, P30679, O15399, P0DP23, P23634, P49767ITPKB, VDAC1, CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Pentobarbitalhsa04024cAMP signaling pathway1.46E-038P63092, P42338, P26678, P0DP23, P23634, P61586, Q16566, O15399GNAS, PIK3CB, PLN, CALM1, ATP2B4, RHOA, CAMK4, GRIN2DMore
Pentobarbitalhsa04070Phosphatidylinositol signaling system1.49E-035P0DP23, P42338, Q96PE3, Q13572, P27987CALM1, PIK3CB, INPP4A, ITPK1, ITPKBMore
Pentobarbitalhsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Pentobarbitalhsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Pentobarbitalhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Pentobarbitalhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Pentobarbitalhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Pentobarbitalhsa04371Apelin signaling pathway7.45E-035P63218, P50151, Q13485, Q16566, P0DP23GNG5, GNG10, SMAD4, CAMK4, CALM1More
Pentobarbitalhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Pentobarbitalhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Pentobarbitalhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Pentobarbitalhsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Pentobarbitalhsa04640Hematopoietic cell lineage4.27E-024P08514, P14778, P01730, P13765ITGA2B, IL1R1, CD4, HLA-DOBMore
Pentobarbitalhsa04659Th17 cell differentiation2.33E-037P25963, Q16539, P01730, P13765, P14778, P84022, Q13485NFKBIA, MAPK14, CD4, HLA-DOB, IL1R1, SMAD3, SMAD4More
Pentobarbitalhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Pentobarbitalhsa04666Fc gamma R-mediated phagocytosis4.10E-023P07948, P42338, P23528LYN, PIK3CB, CFL1More
Pentobarbitalhsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Pentobarbitalhsa04713Circadian entrainment9.72E-046O15399, P0DP23, P62873, P63218, P50151, P63092GRIN2D, CALM1, GNB1, GNG5, GNG10, GNASMore
Pentobarbitalhsa04720Long-term potentiation1.63E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Pentobarbitalhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Pentobarbitalhsa04724Glutamatergic synapse3.78E-035O15399, P63092, P62873, P63218, P50151GRIN2D, GNAS, GNB1, GNG5, GNG10More
Pentobarbitalhsa04725Cholinergic synapse5.94E-034P63218, P50151, Q16566, P42338GNG5, GNG10, CAMK4, PIK3CBMore
Pentobarbitalhsa04726Serotonergic synapse9.72E-046P63092, P62873, P63218, P50151, P33260, P09917GNAS, GNB1, GNG5, GNG10, CYP2C18, ALOX5More
Pentobarbitalhsa04728Dopaminergic synapse4.47E-024P63218, P50151, P0DP23, O00327GNG5, GNG10, CALM1, ARNTLMore
Pentobarbitalhsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Pentobarbitalhsa04925Aldosterone synthesis and secretion3.14E-023P0DP23, Q16566, P23634CALM1, CAMK4, ATP2B4More
Pentobarbitalhsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P30679PIK3CB, GNG5, GNG10, VEGFC, GNA15More
Pentobarbitalhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Pentobarbitalhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Pentobarbitalhsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Pentobarbitalhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Pentobarbitalhsa05017Spinocerebellar ataxia5.94E-034Q8TB72, O15399, P42338, P21796PUM2, GRIN2D, PIK3CB, VDAC1More
Pentobarbitalhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Pentobarbitalhsa05034Alcoholism3.62E-025O15399, Q16566, P0DP23, P63218, P50151GRIN2D, CAMK4, CALM1, GNG5, GNG10More
Pentobarbitalhsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Pentobarbitalhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Pentobarbitalhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Pentobarbitalhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Pentobarbitalhsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Pentobarbitalhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Pentobarbitalhsa05163Human cytomegalovirus infection3.23E-039P42338, P62873, P63218, P50151, P0DP23, P61586, P63092, P30101, P61769PIK3CB, GNB1, GNG5, GNG10, CALM1, RHOA, GNAS, PDIA3, B2MMore
Pentobarbitalhsa05167Kaposi sarcoma-associated herpesvirus infection4.19E-025P42338, P63218, P50151, P07948, P0DP23PIK3CB, GNG5, GNG10, LYN, CALM1More
Pentobarbitalhsa05170Human immunodeficiency virus 1 infection3.27E-026P42338, P63218, P50151, P0DP23, P30101, P23528PIK3CB, GNG5, GNG10, CALM1, PDIA3, CFL1More
Pentobarbitalhsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Pentobarbitalhsa05204Chemical carcinogenesis4.62E-022P78417, P33260GSTO1, CYP2C18More
Pentobarbitalhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Pentobarbitalhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Pentobarbitalhsa05214Glioma2.32E-023P0DP23, Q16566, P42338CALM1, CAMK4, PIK3CBMore
Pentobarbitalhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Pentobarbitalhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Pentobarbitalhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Pentobarbitalhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Pentobarbitalhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Pentobarbitalhsa05340Primary immunodeficiency1.58E-023P01730, P11912, Q8WV28CD4, CD79A, BLNKMore

Community members of Pentobarbital (SDC: 2.71)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
O15399GRIN2DGlutamate receptor ionotropic, NMDA 2DReported00.10350.15650.64481.0095
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Reported10.03150.949301.9143
P48058GRIA4Glutamate receptor 4Predicted00.40370.12090.37480.8184
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
GABRB3P28472IC5088000