PharmaCoNets of Pentazocine (SPCN: 33.90 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pentazocinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Pentazocinehsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Pentazocinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Pentazocinehsa00500Starch and sucrose metabolism9.22E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Pentazocinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Pentazocinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Pentazocinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Pentazocinehsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Pentazocinehsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Pentazocinehsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Pentazocinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Pentazocinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Pentazocinehsa01524Platinum drug resistance1.13E-025P10415, Q13489, P78417, P23025, P43246BCL2, BIRC3, GSTO1, XPA, MSH2More
Pentazocinehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Pentazocinehsa03008Ribosome biogenesis in eukaryotes2.60E-035Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0UTP6, RPP38, GNL3, NVL, NXF2; NXF2BMore
Pentazocinehsa03013RNA transport2.29E-0413O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Pentazocinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Pentazocinehsa03040Spliceosome5.79E-037Q14562, O43143, O60508, Q99633, Q13595, Q01130, Q9UMS4DHX8, DHX15, CDC40, PRPF18, TRA2A, SFRS2, PRPF19More
Pentazocinehsa04015Rap1 signaling pathway1.58E-026P20827, P49767, P63261, P25116, P0DP23, P17252EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCAMore
Pentazocinehsa04020Calcium signaling pathway1.16E-037Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFCMore
Pentazocinehsa04024cAMP signaling pathway2.84E-025P0DP23, P23634, Q16566, O15399, P25116CALM1, ATP2B4, CAMK4, GRIN2D, F2RMore
Pentazocinehsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Pentazocinehsa04064NF-kappa B signaling pathway4.92E-026P10415, P51617, Q13546, Q9UDY8, Q13077, P24522BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45AMore
Pentazocinehsa04070Phosphatidylinositol signaling system4.07E-024P0DP23, Q14643, O14732, P17252CALM1, ITPR1, IMPA2, PRKCAMore
Pentazocinehsa04071Sphingolipid signaling pathway1.90E-038P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Pentazocinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Pentazocinehsa04145Phagosome1.86E-025P63261, Q15080, Q13509, P68371, P27824ACTG1, NCF4, TUBB3, TUBB2C, CANXMore
Pentazocinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Pentazocinehsa04261Adrenergic signaling in cardiomyocytes3.44E-025Q16537, P0DP23, P17252, P10415, P20020PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Pentazocinehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Pentazocinehsa04390Hippo signaling pathway1.47E-025P63261, Q13485, Q9UJU2, O43623, Q13489ACTG1, SMAD4, LEF1, SNAI2, BIRC3More
Pentazocinehsa04510Focal adhesion3.21E-026Q15942, P17252, Q13489, P10415, P49767, P63261ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1More
Pentazocinehsa04520Adherens junction3.36E-024Q13485, Q9UJU2, O43623, P63261SMAD4, LEF1, SNAI2, ACTG1More
Pentazocinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Pentazocinehsa04540Gap junction4.76E-023P17252, Q13509, P68371PRKCA, TUBB3, TUBB2CMore
Pentazocinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Pentazocinehsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Pentazocinehsa04613Neutrophil extracellular trap formation1.57E-0416P17252, O60603, P08246, Q92769, P04908, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539PRKCA, TLR2, ELA2, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14More
Pentazocinehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Pentazocinehsa04650Natural killer cell mediated cytotoxicity7.01E-0510P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Pentazocinehsa04660T cell receptor signaling pathway1.49E-0310P01375, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Pentazocinehsa04666Fc gamma R-mediated phagocytosis2.22E-024P49006, P06396, P14598, P17252MARCKSL1, GSN, NCF1, PRKCAMore
Pentazocinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Pentazocinehsa04720Long-term potentiation3.70E-045P17252, Q16566, P0DP23, O15399, Q14643PRKCA, CAMK4, CALM1, GRIN2D, ITPR1More
Pentazocinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Pentazocinehsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Pentazocinehsa04912GnRH signaling pathway4.42E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Pentazocinehsa04916Melanogenesis3.55E-023P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Pentazocinehsa04921Oxytocin signaling pathway4.19E-024P0DP23, P17252, Q16566, P63261CALM1, PRKCA, CAMK4, ACTG1More
Pentazocinehsa04925Aldosterone synthesis and secretion2.90E-046Q14643, P0DP23, P17252, Q16566, P20020, P23634ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4More
Pentazocinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Pentazocinehsa04933AGE-RAGE signaling pathway in diabetic complications3.36E-024Q13485, P10415, P49767, P17252SMAD4, BCL2, VEGFC, PRKCAMore
Pentazocinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Pentazocinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Pentazocinehsa04966Collecting duct acid secretion2.32E-033P02730, P00918, Q9Y666SLC4A1, CA2, SLC12A7More
Pentazocinehsa04970Salivary secretion8.71E-045Q14643, P20020, P23634, P17252, P0DP23ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1More
Pentazocinehsa04971Gastric acid secretion4.76E-023P17252, P63261, P0DP23PRKCA, ACTG1, CALM1More
Pentazocinehsa04972Pancreatic secretion1.00E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Pentazocinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Pentazocinehsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Pentazocinehsa05014Amyotrophic lateral sclerosis4.31E-027O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2BMore
Pentazocinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Pentazocinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Pentazocinehsa05031Amphetamine addiction1.49E-024O15399, P0DP23, Q16566, P17252GRIN2D, CALM1, CAMK4, PRKCAMore
Pentazocinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pentazocinehsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Pentazocinehsa05132Salmonella infection2.12E-0413P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2CMore
Pentazocinehsa05133Pertussis3.10E-034P0DP23, P23528, P09871, P0C0L4CALM1, CFL1, C1S, C4AMore
Pentazocinehsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Pentazocinehsa05140Leishmaniasis1.56E-025P14598, O60603, P49006, P51617, Q15080NCF1, TLR2, MARCKSL1, IRAK1, NCF4More
Pentazocinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Pentazocinehsa05144Malaria2.23E-047P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Pentazocinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Pentazocinehsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Pentazocinehsa05168Herpes simplex virus 1 infection1.94E-029Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2More
Pentazocinehsa05169Epstein-Barr virus infection2.54E-028Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3GMore
Pentazocinehsa05170Human immunodeficiency virus 1 infection6.54E-039P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2More
Pentazocinehsa05200Pathways in cancer1.51E-0212Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P25116, P78417, P0DP23, P01568LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, F2R, GSTO1, CALM1, IFNA21More
Pentazocinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Pentazocinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Pentazocinehsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Pentazocinehsa05214Glioma8.71E-045P0DP23, Q16566, P17252, P04637, P24522CALM1, CAMK4, PRKCA, TP53, GADD45AMore
Pentazocinehsa05216Thyroid cancer1.85E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Pentazocinehsa05217Basal cell carcinoma4.42E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Pentazocinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pentazocinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Pentazocinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Pentazocinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Pentazocinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Pentazocinehsa05418Fluid shear stress and atherosclerosis2.49E-0311Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2More

Community members of Pentazocine (SDC: 2.98)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P46091GPR1ChemerinNonelike receptor 2Predicted00.24760.137200.3982
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)