PharmaCoNets of Pentamidine (SPCN: 10.48 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pentamidinehsa00500Starch and sucrose metabolism2.15E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Pentamidinehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Pentamidinehsa00590Arachidonic acid metabolism3.63E-022P11712, P18054CYP2C9, ALOX12More
Pentamidinehsa00591Linoleic acid metabolism3.94E-021P11712CYP2C9More
Pentamidinehsa00970Aminoacyl-tRNA biosynthesis9.57E-033O95363, P54136, P14868FARS2, RARS1, DARSMore
Pentamidinehsa00980Metabolism of xenobiotics by cytochrome P4508.58E-032P78417, P11712GSTO1, CYP2C9More
Pentamidinehsa00982Drug metabolism - cytochrome P4508.58E-032P11712, P78417CYP2C9, GSTO1More
Pentamidinehsa04014Ras signaling pathway1.60E-024P49767, P17252, Q14644, P0DP23VEGFC, PRKCA, RASA3, CALM1More
Pentamidinehsa04020Calcium signaling pathway8.12E-056P17252, Q93086, Q15746, P0DP23, P23634, P49767PRKCA, P2RX5, MYLK, CALM1, ATP2B4, VEGFCMore
Pentamidinehsa04022cGMP-PKG signaling pathway3.50E-023P23634, Q15746, P0DP23ATP2B4, MYLK, CALM1More
Pentamidinehsa04061Viral protein interaction with cytokine and cytokine receptor2.91E-026P09341, P25024, P25025, P47992, Q9UBD3, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNFMore
Pentamidinehsa04080Neuroactive ligand-receptor interaction1.20E-028P08311, Q15722, Q9H228, P43657, P21462, P21730, P14416, P35318CTSG, LTB4R, EDG8, P2RY5, FPR1, C5AR1, DRD2, ADMMore
Pentamidinehsa04261Adrenergic signaling in cardiomyocytes3.02E-023P0DP23, P17252, P23634CALM1, PRKCA, ATP2B4More
Pentamidinehsa04270Vascular smooth muscle contraction1.50E-023Q15746, P17252, P0DP23MYLK, PRKCA, CALM1More
Pentamidinehsa04510Focal adhesion2.35E-024Q15746, P17252, Q13489, P49767MYLK, PRKCA, BIRC3, VEGFCMore
Pentamidinehsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Pentamidinehsa04612Antigen processing and presentation5.26E-048P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Pentamidinehsa04613Neutrophil extracellular trap formation9.93E-0413O60603, P05164, P08246, Q9UM07, Q13547, Q92769, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Pentamidinehsa04625C-type lectin receptor signaling pathway4.80E-026Q9ULY5, P20749, Q14643, P01375, Q13191, Q16539CLEC4E, BCL3, ITPR1, TNF, CBLB, MAPK14More
Pentamidinehsa04640Hematopoietic cell lineage2.52E-029P13612, P14778, P27930, P15144, P11836, P09693, P01732, P13765, P01375ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, HLA-DOB, TNFMore
Pentamidinehsa04650Natural killer cell mediated cytotoxicity5.58E-049P01375, P78314, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Pentamidinehsa04657IL-17 signaling pathway1.77E-037O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Pentamidinehsa04658Th1 and Th2 cell differentiation7.47E-038Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Pentamidinehsa04659Th17 cell differentiation3.13E-028Q04759, Q16539, P13765, P14778, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, HLA-DOB, IL1R1, TBX21, GATA3, CD3G, CD247More
Pentamidinehsa04660T cell receptor signaling pathway8.00E-0310P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Pentamidinehsa04720Long-term potentiation3.63E-022P17252, P0DP23PRKCA, CALM1More
Pentamidinehsa04726Serotonergic synapse1.50E-023P17252, P11712, P18054PRKCA, CYP2C9, ALOX12More
Pentamidinehsa04750Inflammatory mediator regulation of TRP channels9.58E-033P18054, P17252, P0DP23ALOX12, PRKCA, CALM1More
Pentamidinehsa04912GnRH signaling pathway6.34E-036P17252, Q16539, Q9Y6R4, Q14643, P0DP23, P22694PRKCA, MAPK14, MAP3K4, ITPR1, CALM1, PRKACBMore
Pentamidinehsa04916Melanogenesis3.97E-033P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Pentamidinehsa04920Adipocytokine signaling pathway4.72E-024P33121, Q04759, Q9Y4H2, P01375ACSL1, PRKCQ, IRS2, TNFMore
Pentamidinehsa04921Oxytocin signaling pathway2.19E-023Q15746, P0DP23, P17252MYLK, CALM1, PRKCAMore
Pentamidinehsa04925Aldosterone synthesis and secretion5.51E-033P0DP23, P17252, P23634CALM1, PRKCA, ATP2B4More
Pentamidinehsa04961Endocrine and other factor-regulated calcium reabsorption1.40E-022P23634, P17252ATP2B4, PRKCAMore
Pentamidinehsa04970Salivary secretion3.97E-033P23634, P17252, P0DP23ATP2B4, PRKCA, CALM1More
Pentamidinehsa04971Gastric acid secretion5.51E-033P17252, P0DP23, Q15746PRKCA, CALM1, MYLKMore
Pentamidinehsa04972Pancreatic secretion1.40E-022P23634, P17252ATP2B4, PRKCAMore
Pentamidinehsa04976Bile secretion3.87E-023O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Pentamidinehsa05120Epithelial cell signaling in Helicobacter pylori infection3.87E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Pentamidinehsa05133Pertussis1.73E-033P0DP23, P09871, P0C0L4CALM1, C1S, C4AMore
Pentamidinehsa05140Leishmaniasis1.69E-037P13612, O75015, P13765, O60603, P01375, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4More
Pentamidinehsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Pentamidinehsa05144Malaria9.81E-045P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Pentamidinehsa05146Amoebiasis2.59E-058P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Pentamidinehsa05202Transcriptional misregulation in cancer2.41E-0315P41732, P14780, P27930, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522TSPAN7, MMP9, IL1R2, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Pentamidinehsa05204Chemical carcinogenesis1.40E-022P78417, P11712GSTO1, CYP2C9More
Pentamidinehsa05214Glioma4.55E-022P0DP23, P17252CALM1, PRKCAMore
Pentamidinehsa05321Inflammatory bowel disease2.22E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Pentamidinehsa05332Graft-versus-host disease2.76E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Pentamidinehsa05418Fluid shear stress and atherosclerosis4.81E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Pentamidine (SDC: 1.65)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
P09871C1SComplement C1s subcomponentPredicted10.09720.02820.54030.6452
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)