PharmaCoNets of Pentagastrin (SPCN: 63.77 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pentagastrinhsa00052Galactose metabolism3.41E-022O43451, Q14376MGAM, GALEMore
Pentagastrinhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Pentagastrinhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Pentagastrinhsa00531Glycosaminoglycan degradation3.53E-021P15586GNSMore
Pentagastrinhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Pentagastrinhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Pentagastrinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Pentagastrinhsa00970Aminoacyl-tRNA biosynthesis2.43E-032O95363, Q15046FARS2, KARSMore
Pentagastrinhsa01100Metabolic pathways4.11E-027P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHEMore
Pentagastrinhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Pentagastrinhsa01524Platinum drug resistance2.64E-033P04637, Q14790, P48023TP53, CASP8, FASLGMore
Pentagastrinhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Pentagastrinhsa03010Ribosome3.41E-022P46777, P50914RPL5, RPL14More
Pentagastrinhsa03013RNA transport1.14E-0313O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Pentagastrinhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Pentagastrinhsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Pentagastrinhsa03060Protein export1.90E-022Q15070, O76094OXA1L, SRP72More
Pentagastrinhsa04010MAPK signaling pathway3.58E-026Q8IZS8, Q16539, P24522, P14778, P49407, P01106CACNA2D3, MAPK14, GADD45A, IL1R1, ARRB1, MYCMore
Pentagastrinhsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Pentagastrinhsa04015Rap1 signaling pathway1.98E-0311P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P19174EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PLCG1More
Pentagastrinhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Pentagastrinhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Pentagastrinhsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Pentagastrinhsa04064NF-kappa B signaling pathway1.91E-0412P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45AMore
Pentagastrinhsa04068FoxO signaling pathway1.02E-022P48023, Q96BR1FASLG, SGK3More
Pentagastrinhsa04071Sphingolipid signaling pathway1.63E-037P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Pentagastrinhsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Pentagastrinhsa04110Cell cycle1.21E-027P06493, O60566, P24522, P49918, P30304, P42773, P01106CDK1, BUB1B, GADD45A, CDKN1C, CDC25A, CDKN2C, MYCMore
Pentagastrinhsa04115p53 signaling pathway7.60E-037P24522, Q13315, Q53FA7, Q14790, P04637, O95067, P10415GADD45A, ATM, TP53I3, CASP8, TP53, CCNB2, BCL2More
Pentagastrinhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Pentagastrinhsa04145Phagosome1.98E-028Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Pentagastrinhsa04151PI3K-Akt signaling pathway3.32E-0315P42338, P43657, P48023, P04637, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, Q96BR1, P30281PIK3CB, P2RY5, FASLG, TP53, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, SGK3, CCND3More
Pentagastrinhsa04210Apoptosis8.06E-0413Q13315, P04637, P10415, Q13489, P25963, Q14790, P01375, P48023, P24522, Q16548, Q13077, Q14643, P42575ATM, TP53, BCL2, BIRC3, NFKBIA, CASP8, TNF, FASLG, GADD45A, BCL2A1, TRAF1, ITPR1, CASP2More
Pentagastrinhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Pentagastrinhsa04218Cellular senescence1.33E-026P01106, Q9H422, Q16539, P24522, P30304, P06493MYC, HIPK3, MAPK14, GADD45A, CDC25A, CDK1More
Pentagastrinhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Pentagastrinhsa04330Notch signaling pathway7.49E-032Q92542, P49768NCSTN, PSEN1More
Pentagastrinhsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Pentagastrinhsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Pentagastrinhsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Pentagastrinhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Pentagastrinhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Pentagastrinhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Pentagastrinhsa04530Tight junction9.34E-056Q8TEU7, P63261, O00501, Q92974, Q14247, P24844RAPGEF6, ACTG1, CLDN5, ARHGEF2, CTTN, MYL9More
Pentagastrinhsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Pentagastrinhsa04611Platelet activation1.59E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Pentagastrinhsa04613Neutrophil extracellular trap formation2.81E-0418P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P68431, P14598, Q15080, P20160, P08311, P49913, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1, AQP9, MAPK14More
Pentagastrinhsa04621NOD-like receptor signaling pathway3.10E-0311Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Pentagastrinhsa04650Natural killer cell mediated cytotoxicity2.95E-027P06239, P20963, Q13241, P26718, O14931, P26717, P26715LCK, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Pentagastrinhsa04658Th1 and Th2 cell differentiation1.26E-049P07766, P20963, P09693, Q16539, P01730, P06239, P23771, Q9UL17, Q13761CD3E, CD247, CD3G, MAPK14, CD4, LCK, GATA3, TBX21, RUNX3More
Pentagastrinhsa04659Th17 cell differentiation2.95E-0411Q16539, P19174, P01730, P06239, P14784, P14778, P23771, P84022, Q13485, P08238, P07766MAPK14, PLCG1, CD4, LCK, IL2RB, IL1R1, GATA3, SMAD3, SMAD4, HSP90AB1, CD3EMore
Pentagastrinhsa04660T cell receptor signaling pathway1.37E-0313P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Pentagastrinhsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Pentagastrinhsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Pentagastrinhsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Pentagastrinhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Pentagastrinhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Pentagastrinhsa04722Neurotrophin signaling pathway2.78E-034P49841, O43524, P48023, P04637GSK3B, FOXO3, FASLG, TP53More
Pentagastrinhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Pentagastrinhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Pentagastrinhsa04919Thyroid hormone signaling pathway3.71E-022P26678, P08237PLN, PFKMMore
Pentagastrinhsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Pentagastrinhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Pentagastrinhsa04932Non-alcoholic fatty liver disease2.21E-046P01375, P49841, Q14790, P48023, Q16718, O14521TNF, GSK3B, CASP8, FASLG, NDUFA5, SDHDMore
Pentagastrinhsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Pentagastrinhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Pentagastrinhsa04970Salivary secretion4.49E-024P22694, Q14643, P17252, P49913PRKACB, ITPR1, PRKCA, CAMPMore
Pentagastrinhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Pentagastrinhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Pentagastrinhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Pentagastrinhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Pentagastrinhsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Pentagastrinhsa05132Salmonella infection2.98E-0211P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3More
Pentagastrinhsa05140Leishmaniasis1.18E-027P14598, P13765, O60603, P25963, P01375, P51617, Q15080NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4More
Pentagastrinhsa05142Chagas disease2.37E-022P48023, Q14790FASLG, CASP8More
Pentagastrinhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Pentagastrinhsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Pentagastrinhsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Pentagastrinhsa05160Hepatitis C2.45E-046P60033, P49841, P04637, P01375, P48023, Q14790CD81, GSK3B, TP53, TNF, FASLG, CASP8More
Pentagastrinhsa05161Hepatitis B2.63E-0311P17252, P14780, P25963, P01375, P10415, P48023, Q14790, P04637, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, FASLG, CASP8, TP53, IRAK1, TLR2, STAT4More
Pentagastrinhsa05162Measles8.19E-033P48023, P04637, Q14790FASLG, TP53, CASP8More
Pentagastrinhsa05163Human cytomegalovirus infection1.02E-023P48023, Q14790, P04637FASLG, CASP8, TP53More
Pentagastrinhsa05164Influenza A4.65E-022P48023, Q14790FASLG, CASP8More
Pentagastrinhsa05165Human papillomavirus infection2.62E-023P48023, P04637, Q14790FASLG, TP53, CASP8More
Pentagastrinhsa05170Human immunodeficiency virus 1 infection1.06E-0313P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2More
Pentagastrinhsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Pentagastrinhsa05202Transcriptional misregulation in cancer1.51E-0414Q12778, Q15532, Q13315, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Pentagastrinhsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Pentagastrinhsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Pentagastrinhsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Pentagastrinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.02E-024P07766, P06239, Q16539, P01730CD3E, LCK, MAPK14, CD4More
Pentagastrinhsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Pentagastrinhsa05321Inflammatory bowel disease1.28E-025O60603, P01375, P13765, Q14765, P23771TLR2, TNF, HLA-DOB, STAT4, GATA3More
Pentagastrinhsa05322Systemic lupus erythematosus4.20E-027P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Pentagastrinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Pentagastrinhsa05332Graft-versus-host disease8.44E-046P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Pentagastrinhsa05340Primary immunodeficiency5.29E-045P01730, P11912, P16871, P07766, P06239CD4, CD79A, IL7R, CD3E, LCKMore
Pentagastrinhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Pentagastrin (SDC: 4.21)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q14790CASP8CaspaseNone8Predicted10.150.055811.1867
P42575CASP2CaspaseNone2Predicted00.18770.0080.22630.3363
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P13612ITGA4Integrin alphaNone4Predicted00.11650.23860.68621.2217
O95931CBX7Chromobox protein homolog 7Predicted00.41860.181600.5726
P01730CD4TNonecell surface glycoprotein CD4Predicted10.04750.00540.81550.8501
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)