PharmaCoNets of Pentaerythritol-tetranitrate (SPCN: 2.33 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pentaerythritol-tetranitratehsa00030Pentose phosphate pathway2.93E-022P60891, P37837PRPS1, TALDO1More
Pentaerythritol-tetranitratehsa00052Galactose metabolism2.00E-023P08237, P19367, Q14376PFKM, HK1, GALEMore
Pentaerythritol-tetranitratehsa00220Arginine biosynthesis2.93E-022P05089, P49448ARG1, GLUD2More
Pentaerythritol-tetranitratehsa00380Tryptophan metabolism2.05E-052Q16613, P46952AANAT, HAAOMore
Pentaerythritol-tetranitratehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate1.24E-031Q9Y2C2USTMore
Pentaerythritol-tetranitratehsa00565Ether lipid metabolism1.25E-022Q9Y6K0, Q8N661CEPT1, TMEM86BMore
Pentaerythritol-tetranitratehsa00785Lipoic acid metabolism1.84E-052O43766, Q9Y234LIAS, LIPT1More
Pentaerythritol-tetranitratehsa00830Retinol metabolism1.10E-032P11766, P00352ADH5, ALDH1A1More
Pentaerythritol-tetranitratehsa01100Metabolic pathways1.38E-0225O43766, Q9Y234, P35790, Q16772, P30041, P19367, Q14642, P20839, P00918, Q9Y6K0, Q14376, P48506, P08237, O95861, P21399, P07101, Q9UHK6, Q86VZ5, P48651, Q9H4F1, P34059, P35573, Q969G6, P14927, Q13029LIAS, LIPT1, CHKA, GSTA3, PRDX6, HK1, INPP5A, IMPDH1, CA2, CEPT1, GALE, GCLC, PFKM, BPNT1, ACO1, TH, AMACR, SGMS1, PTDSS1, ST6GALNAC4, GALNS, AGL, RFK, UQCRB, PRDM2More
Pentaerythritol-tetranitratehsa01200Carbon metabolism2.71E-024P37837, P60891, P11766, P49448TALDO1, PRPS1, ADH5, GLUD2More
Pentaerythritol-tetranitratehsa012102-Oxocarboxylic acid metabolism1.51E-022P21399, P50213ACO1, IDH3AMore
Pentaerythritol-tetranitratehsa01230Biosynthesis of amino acids3.05E-024P08237, P21399, P50213, P37837PFKM, ACO1, IDH3A, TALDO1More
Pentaerythritol-tetranitratehsa03013RNA transport1.85E-027P52298, P61326, Q7Z3B4, Q14152, O75822, Q14240, Q9Y6A5NCBP2, MAGOH, NUP54, EIF3A, EIF3J, EIF4A2, TACC3More
Pentaerythritol-tetranitratehsa04010MAPK signaling pathway1.15E-029Q02750, Q15283, P09619, Q8IZS8, P54284, Q9H2K8, O43283, Q12933, P51812MAP2K1, RASA2, PDGFRB, CACNA2D3, CACNB3, TAOK3, MAP3K13, TRAF2, RPS6KA3More
Pentaerythritol-tetranitratehsa04071Sphingolipid signaling pathway4.14E-024Q16537, Q9BX95, Q16539, P04637PPP2R5E, SGPP1, MAPK14, TP53More
Pentaerythritol-tetranitratehsa04216Ferroptosis1.51E-023P04637, Q9H1Y0, P33121TP53, ATG5, ACSL1More
Pentaerythritol-tetranitratehsa04260Cardiac muscle contraction1.81E-044Q8IZS8, P54284, P09493, P14927CACNA2D3, CACNB3, TPM1, UQCRBMore
Pentaerythritol-tetranitratehsa04520Adherens junction9.72E-035Q09472, P19784, P61586, P60709, P63261EP300, CSNK2A2, RHOA, ACTB, ACTG1More
Pentaerythritol-tetranitratehsa04610Complement and coagulation cascades5.02E-032P00734, P0C0L4F2, C4AMore
Pentaerythritol-tetranitratehsa04810Regulation of actin cytoskeleton2.84E-027P00734, P61586, Q02750, P23229, P26012, P60709, P63261F2, RHOA, MAP2K1, ITGA6, ITGB8, ACTB, ACTG1More
Pentaerythritol-tetranitratehsa04919Thyroid hormone signaling pathway2.73E-037Q02750, P26678, P60709, P63261, Q09472, P08237, P01106MAP2K1, PLN, ACTB, ACTG1, EP300, PFKM, MYCMore
Pentaerythritol-tetranitratehsa04921Oxytocin signaling pathway1.22E-026Q02750, P60660, P60709, P63261, P61586, P54284MAP2K1, MYL6, ACTB, ACTG1, RHOA, CACNB3More
Pentaerythritol-tetranitratehsa04931Insulin resistance3.18E-043Q9Y4H2, P36956, Q13133IRS2, SREBF1, NR1H3More
Pentaerythritol-tetranitratehsa04932Non-alcoholic fatty liver disease4.74E-043Q9Y4H2, P36956, Q13133IRS2, SREBF1, NR1H3More
Pentaerythritol-tetranitratehsa04966Collecting duct acid secretion3.44E-022P02730, P00918SLC4A1, CA2More
Pentaerythritol-tetranitratehsa05120Epithelial cell signaling in Helicobacter pylori infection1.35E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Pentaerythritol-tetranitratehsa05130Pathogenic Escherichia coli infection1.31E-028P61586, P19338, Q13885, P60709, P63261, Q12933, P00734, O95487RHOA, NCL, TUBB2A, ACTB, ACTG1, TRAF2, F2, SEC24BMore
Pentaerythritol-tetranitratehsa05133Pertussis1.96E-023P10145, P23528, P0C0L4IL8, CFL1, C4AMore
Pentaerythritol-tetranitratehsa05135Yersinia infection9.76E-037P60709, P63261, P61586, Q16513, P51812, Q12933, Q02750ACTB, ACTG1, RHOA, PKN2, RPS6KA3, TRAF2, MAP2K1More
Pentaerythritol-tetranitratehsa05140Leishmaniasis1.90E-036P13612, O75015, O60603, P49006, Q16539, Q15080ITGA4, FCGR3B, TLR2, MARCKSL1, MAPK14, NCF4More
Pentaerythritol-tetranitratehsa05164Influenza A8.79E-038Q09472, P48551, P29728, O15131, Q02750, P60709, P63261, Q9BUJ2EP300, IFNAR2, OAS2, KPNA5, MAP2K1, ACTB, ACTG1, HNRPUL1More
Pentaerythritol-tetranitratehsa05203Viral carcinogenesis2.61E-033Q12834, P62807, Q16778CDC20, HIST1H2BC, HIST2H2BEMore
Pentaerythritol-tetranitratehsa05219Bladder cancer2.72E-022P14780, P04637MMP9, TP53More
Pentaerythritol-tetranitratehsa05230Central carbon metabolism in cancer1.09E-035P01106, P09619, Q02750, P19367, P08237MYC, PDGFRB, MAP2K1, HK1, PFKMMore
Pentaerythritol-tetranitratehsa05231Choline metabolism in cancer2.71E-024Q02750, P09619, O15245, P35790MAP2K1, PDGFRB, SLC22A1, CHKAMore
Pentaerythritol-tetranitratehsa05322Systemic lupus erythematosus3.83E-032P62807, Q16778HIST1H2BC, HIST2H2BEMore
Pentaerythritol-tetranitratehsa05410Hypertrophic cardiomyopathy1.48E-069Q8IZS8, P54284, P23229, P13612, P26012, P09493, Q8WZ42, P60709, P63261CACNA2D3, CACNB3, ITGA6, ITGA4, ITGB8, TPM1, TTN, ACTB, ACTG1More
Pentaerythritol-tetranitratehsa05412Arrhythmogenic right ventricular cardiomyopathy1.08E-078Q8IZS8, P54284, P15924, P23229, P13612, P26012, P60709, P63261CACNA2D3, CACNB3, DSP, ITGA6, ITGA4, ITGB8, ACTB, ACTG1More
Pentaerythritol-tetranitratehsa05414Dilated cardiomyopathy6.73E-0710Q8IZS8, P54284, P23229, P13612, P26012, P09493, Q8WZ42, P26678, P60709, P63261CACNA2D3, CACNB3, ITGA6, ITGA4, ITGB8, TPM1, TTN, PLN, ACTB, ACTG1More

Community members of Pentaerythritol-tetranitrate (SDC: 0.53)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)