PharmaCoNets of Penbutolol (SPCN: 51.45 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Penbutololhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Penbutololhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Penbutololhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Penbutololhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Penbutololhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Penbutololhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Penbutololhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Penbutololhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Penbutololhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Penbutololhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Penbutololhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Penbutololhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Penbutololhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Penbutololhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Penbutololhsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Penbutololhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Penbutololhsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Penbutololhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Penbutololhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Penbutololhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Penbutololhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Penbutololhsa04217Necroptosis4.24E-0510P01375, P48023, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557TNF, FASLG, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2DMore
Penbutololhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Penbutololhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Penbutololhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Penbutololhsa04613Neutrophil extracellular trap formation3.76E-0410P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Penbutololhsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Penbutololhsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Penbutololhsa04657IL-17 signaling pathway2.73E-047P07900, P49841, P19875, P14780, P80188, P01375, P01584HSP90AA1, GSK3B, CXCL2, MMP9, LCN2, TNF, IL1BMore
Penbutololhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Penbutololhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Penbutololhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Penbutololhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Penbutololhsa04742Taste transduction1.01E-021P30939HTR1FMore
Penbutololhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Penbutololhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Penbutololhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Penbutololhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Penbutololhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Penbutololhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Penbutololhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Penbutololhsa04932Non-alcoholic fatty liver disease6.73E-059P01375, P49841, P18848, P48023, P01584, P13073, O15239, Q16718, O14521TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Penbutololhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Penbutololhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Penbutololhsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Penbutololhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Penbutololhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Penbutololhsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Penbutololhsa05022Pathways of neurodegeneration - multiple diseases1.47E-0312P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2DMore
Penbutololhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Penbutololhsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Penbutololhsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Penbutololhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Penbutololhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Penbutololhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Penbutololhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Penbutololhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Penbutololhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Penbutololhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Penbutololhsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Penbutololhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Penbutololhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Penbutololhsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Penbutololhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Penbutololhsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Penbutololhsa05415Diabetic cardiomyopathy1.02E-038P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2DMore

Community members of Penbutolol (SDC: 5.53)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)