PharmaCoNets of Pemigatinib (SPCN: 280.22 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pemigatinibhsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Pemigatinibhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Pemigatinibhsa00030Pentose phosphate pathway1.80E-094P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Pemigatinibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Pemigatinibhsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Pemigatinibhsa00052Galactose metabolism4.25E-056P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Pemigatinibhsa00071Fatty acid degradation2.38E-023P11310, O75521, P33121ACADM, ECI2, ACSL1More
Pemigatinibhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Pemigatinibhsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Pemigatinibhsa00190Oxidative phosphorylation9.21E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Pemigatinibhsa00220Arginine biosynthesis8.15E-073P15104, P05089, P49448GLUL, ARG1, GLUD2More
Pemigatinibhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Pemigatinibhsa00250Alanine, aspartate and glutamate metabolism3.77E-063Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Pemigatinibhsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Pemigatinibhsa00280Valine, leucine and isoleucine degradation1.93E-066P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Pemigatinibhsa00310Lysine degradation2.14E-057Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Pemigatinibhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Pemigatinibhsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Pemigatinibhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Pemigatinibhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Pemigatinibhsa00500Starch and sucrose metabolism6.81E-074O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Pemigatinibhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Pemigatinibhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Pemigatinibhsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Pemigatinibhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Pemigatinibhsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Pemigatinibhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Pemigatinibhsa00564Glycerophospholipid metabolism1.25E-046P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Pemigatinibhsa00590Arachidonic acid metabolism2.97E-021P09917ALOX5More
Pemigatinibhsa00600Sphingolipid metabolism2.67E-044Q9BX95, Q8TCT0, Q06136, P15289SGPP1, CERK, FVT1, ARSAMore
Pemigatinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Pemigatinibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Pemigatinibhsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Pemigatinibhsa00630Glyoxylate and dicarboxylate metabolism6.16E-104P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Pemigatinibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Pemigatinibhsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Pemigatinibhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Pemigatinibhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Pemigatinibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Pemigatinibhsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Pemigatinibhsa00770Pantothenate and CoA biosynthesis3.98E-021Q6ZQY3GADL1More
Pemigatinibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Pemigatinibhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Pemigatinibhsa00830Retinol metabolism3.35E-045P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Pemigatinibhsa00860Porphyrin and chlorophyll metabolism2.26E-033P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Pemigatinibhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Pemigatinibhsa00910Nitrogen metabolism1.75E-042P15104, P49448GLUL, GLUD2More
Pemigatinibhsa00970Aminoacyl-tRNA biosynthesis3.83E-022P54136, P14868RARS1, DARSMore
Pemigatinibhsa00983Drug metabolism - other enzymes6.25E-085P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Pemigatinibhsa01040Biosynthesis of unsaturated fatty acids2.60E-032P22307, Q9H5J4SCP2, ELOVL6More
Pemigatinibhsa01100Metabolic pathways8.01E-0769Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q96RQ9, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, IL4I1, MCCC2, ACSL1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Pemigatinibhsa01200Carbon metabolism2.13E-022P52209, P37837PGD, TALDO1More
Pemigatinibhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Pemigatinibhsa01230Biosynthesis of amino acids2.13E-057P51854, P60891, Q99707, P50213, P05089, P15104, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, GLUL, TALDO1More
Pemigatinibhsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Pemigatinibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Pemigatinibhsa01522Endocrine resistance3.25E-0510P22694, P04049, Q02750, Q9UM47, P04637, P42773, P46527, P08069, P10415, Q13323PRKACB, RAF1, MAP2K1, NOTCH3, TP53, CDKN2C, CDKN1B, IGF1R, BCL2, BIKMore
Pemigatinibhsa01523Antifolate resistance2.88E-033P41440, Q92820, P01375SLC19A1, GGH, TNFMore
Pemigatinibhsa01524Platinum drug resistance5.43E-0610Q13489, P98170, Q14790, P48023, P78417, P40692, P23025, P43246, P52701, P31751BIRC3, BIRC4, CASP8, FASLG, GSTO1, MLH1, XPA, MSH2, MSH6, AKT2More
Pemigatinibhsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Pemigatinibhsa03010Ribosome2.33E-1118P26373, P62753, P42677, P25398, P32969, P62917, P46776, Q9H0U6, Q07020, P62899, P62910, P18077, P61927, Q02878, P36578, P27635, P05386, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL27A, MRPL18, RPL18, RPL31, RPL32, RPL35A, RPL37, RPL6, RPL4, RPL10, RPLP1, RPS3More
Pemigatinibhsa03013RNA transport1.97E-1829P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Pemigatinibhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Pemigatinibhsa03020RNA polymerase7.29E-084P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Pemigatinibhsa03040Spliceosome1.48E-0815Q14562, O43143, O60508, P08579, P26368, O75940, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Pemigatinibhsa03060Protein export3.67E-094Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Pemigatinibhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Pemigatinibhsa03430Mismatch repair4.38E-021P20585MSH3More
Pemigatinibhsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Pemigatinibhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Pemigatinibhsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Pemigatinibhsa04012ErbB signaling pathway3.61E-057Q13153, P16333, Q13191, P19174, P42338, P01106, P04049PAK1, NCK1, CBLB, PLCG1, PIK3CB, MYC, RAF1More
Pemigatinibhsa04014Ras signaling pathway5.89E-0410Q02750, P04049, P31751, Q15389, P08069, P17252, P21359, P0DP23, P62879, P22694MAP2K1, RAF1, AKT2, ANGPT1, IGF1R, PRKCA, NF1, CALM1, GNB2, PRKACBMore
Pemigatinibhsa04015Rap1 signaling pathway3.20E-076P04049, P08069, P06213, O00522, P31751, P0DP23RAF1, IGF1R, INSR, KRIT1, AKT2, CALM1More
Pemigatinibhsa04020Calcium signaling pathway2.78E-0612Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P30679, P0DP24, P0DP23, P05141, P51828, P23634ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, GNA15, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4More
Pemigatinibhsa04022cGMP-PKG signaling pathway1.32E-0712Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Pemigatinibhsa04024cAMP signaling pathway1.08E-046Q08828, P51828, P31751, P0DP23, P04049, Q13153ADCY1, ADCY7, AKT2, CALM1, RAF1, PAK1More
Pemigatinibhsa04060Cytokine-cytokine receptor interaction1.60E-0518P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, O75509, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, TNFRSF21, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Pemigatinibhsa04061Viral protein interaction with cytokine and cytokine receptor1.92E-0510Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Pemigatinibhsa04062Chemokine signaling pathway4.16E-0720P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIAMore
Pemigatinibhsa04064NF-kappa B signaling pathway5.48E-1623P10415, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Pemigatinibhsa04066HIF-1 signaling pathway1.49E-025P08069, P17252, Q15389, Q02750, P46527IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Pemigatinibhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Pemigatinibhsa04070Phosphatidylinositol signaling system5.07E-059P19174, P0DP23, O14986, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7PLCG1, CALM1, PIP5K1B, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKCMore
Pemigatinibhsa04071Sphingolipid signaling pathway7.65E-059P04049, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, Q12933, Q02156RAF1, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, TRAF2, PRKCEMore
Pemigatinibhsa04072Phospholipase D signaling pathway9.04E-0715P04049, P31751, P42338, Q92529, Q9UQC2, P43657, P25024, P25025, P19174, O14986, Q14344, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, SHC3, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNA13, PSCD1, ADCY1, ADCY7, DGKDMore
Pemigatinibhsa04080Neuroactive ligand-receptor interaction1.97E-0411P08311, P78334, Q15722, P21453, Q9H228, P43657, P21462, P21730, P30939, P07550, P35318CTSG, GABRE, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, HTR1F, ADRB2, ADMMore
Pemigatinibhsa04110Cell cycle9.34E-0511Q9UBD5, P30260, P06493, Q14683, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, SMC1A, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Pemigatinibhsa04114Oocyte meiosis5.73E-1011Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Pemigatinibhsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Pemigatinibhsa04136Autophagy - other7.59E-032O94817, Q9H1Y0ATG12, ATG5More
Pemigatinibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Pemigatinibhsa04140Autophagy - animal3.90E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Pemigatinibhsa04141Protein processing in endoplasmic reticulum1.13E-0412P18848, Q12933, P30101, Q15436, P60604, Q99941, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SSR3More
Pemigatinibhsa04142Lysosome1.89E-0613Q99437, P25774, O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900ATP6V0B, CTSS, TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Pemigatinibhsa04144Endocytosis8.76E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Pemigatinibhsa04145Phagosome3.20E-0412O75015, Q15080, P14598, Q13509, P68371, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Pemigatinibhsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Pemigatinibhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Pemigatinibhsa04151PI3K-Akt signaling pathway1.09E-0621P62753, P21860, O43521, P04637, P27348, Q13362, P07900, P62873, P61952, P02452, P24821, Q16363, P22105, P23458, P01568, Q99941, P18848, Q96BR1, O00141, Q6ZUJ8, P56279RPS6, ERBB3, BCL2L11, TP53, YWHAQ, PPP2R5C, HSP90AA1, GNB1, GNG11, COL1A1, TNC, LAMA4, TNXB, JAK1, IFNA21, CREBL1, ATF4, SGK3, SGK, PIK3AP1, TCL1AMore
Pemigatinibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Pemigatinibhsa04210Apoptosis1.10E-034Q14790, P48023, P42575, P04049CASP8, FASLG, CASP2, RAF1More
Pemigatinibhsa04211Longevity regulating pathway2.60E-046P31751, P08069, Q08828, P51828, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, ATF4, CAMKK2More
Pemigatinibhsa04213Longevity regulating pathway - multiple species1.70E-089P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Pemigatinibhsa04217Necroptosis2.28E-1223Q12933, P01568, P23458, Q13489, P98170, Q9NQC7, Q13546, P42224, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q93077, Q13557, Q9H444, O43633, O75351, P21796, P45880, Q08752TRAF2, IFNA21, JAK1, BIRC3, BIRC4, CYLD, RIPK1, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, HIST1H2AC, CAMK2D, CHMP4B, CHMP2A, VPS4B, VDAC1, VDAC2, PPIDMore
Pemigatinibhsa04218Cellular senescence1.96E-047P31751, P04049, P30281, P0DP23, P01889, P10321, P12236AKT2, RAF1, CCND3, CALM1, HLA-B, HLA-C, SLC25A6More
Pemigatinibhsa04260Cardiac muscle contraction4.20E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Pemigatinibhsa04261Adrenergic signaling in cardiomyocytes4.78E-0812P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP24, P0DP23, Q13557, P23634TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, CAMK2D, ATP2B4More
Pemigatinibhsa04270Vascular smooth muscle contraction1.71E-0611P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Pemigatinibhsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Pemigatinibhsa04330Notch signaling pathway4.54E-044Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Pemigatinibhsa04340Hedgehog signaling pathway2.58E-034P17612, P22694, Q13635, P10415PRKACA, PRKACB, PTCH1, BCL2More
Pemigatinibhsa04360Axon guidance4.12E-047P16298, Q05397, Q13873, P42338, P04049, O14639, P24844PPP3CB, PTK2, BMPR2, PIK3CB, RAF1, ABLIM1, MYL9More
Pemigatinibhsa04370VEGF signaling pathway6.18E-137P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Pemigatinibhsa04371Apelin signaling pathway3.11E-0714P62873, P63218, P50151, P61952, P31751, P04049, Q08828, P51828, Q13485, P84022, P62753, Q16566, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, AKT2, RAF1, ADCY1, ADCY7, SMAD4, SMAD3, RPS6, CAMK4, CALM1, CALM2More
Pemigatinibhsa04380Osteoclast differentiation2.25E-0710Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Pemigatinibhsa04390Hippo signaling pathway3.37E-055O95835, P04628, Q9UJU2, O43623, Q13489LATS1, WNT1, LEF1, SNAI2, BIRC3More
Pemigatinibhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Pemigatinibhsa04510Focal adhesion1.63E-035Q15942, P51636, P30281, P04049, P08069ZYX, CAV2, CCND3, RAF1, IGF1RMore
Pemigatinibhsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Pemigatinibhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Pemigatinibhsa04540Gap junction9.74E-057P17252, P22694, Q13509, P68371, Q02750, P04049, Q9NRA1PRKCA, PRKACB, TUBB3, TUBB2C, MAP2K1, RAF1, PDGFCMore
Pemigatinibhsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Pemigatinibhsa04610Complement and coagulation cascades1.45E-084P09871, P0C0L4, P20023, P05107C1S, C4A, CR2, ITGB2More
Pemigatinibhsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Pemigatinibhsa04612Antigen processing and presentation1.36E-0811P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNFMore
Pemigatinibhsa04613Neutrophil extracellular trap formation7.65E-0620P19174, P04049, P16109, P11215, P05164, P08246, Q9UM07, Q13547, Q99878, P62807, Q16778, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359PLCG1, RAF1, SELP, ITGAM, MPO, ELA2, PADI4, HDAC1, H2AC14, HIST1H2BC, HIST2H2BE, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BAMore
Pemigatinibhsa04620Toll-like receptor signaling pathway2.48E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Pemigatinibhsa04621NOD-like receptor signaling pathway2.55E-0312P01584, P07900, Q14643, P23458, P45880, P10599, P43490, O00463, P29728, P01375, P09341, P12838IL1B, HSP90AA1, ITPR1, JAK1, VDAC2, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Pemigatinibhsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Pemigatinibhsa04623Cytosolic DNA-sensing pathway2.36E-116P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Pemigatinibhsa04625C-type lectin receptor signaling pathway4.61E-0810Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Pemigatinibhsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Pemigatinibhsa04640Hematopoietic cell lineage1.89E-1016P13612, P07359, P08514, P14778, P27930, P11215, P15144, P20023, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNFMore
Pemigatinibhsa04650Natural killer cell mediated cytotoxicity3.36E-2018P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Pemigatinibhsa04657IL-17 signaling pathway3.80E-0613P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, P80188, P01375, P06702NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, S100A9More
Pemigatinibhsa04658Th1 and Th2 cell differentiation3.18E-3217P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, RUNX3More
Pemigatinibhsa04659Th17 cell differentiation1.63E-2318P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Pemigatinibhsa04660T cell receptor signaling pathway9.95E-2219P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Pemigatinibhsa04662B cell receptor signaling pathway3.04E-1213P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Pemigatinibhsa04664Fc epsilon RI signaling pathway1.57E-068P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P04049, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, RAF1, ALOX5More
Pemigatinibhsa04666Fc gamma R-mediated phagocytosis4.61E-034P08637, O75015, P04049, P06396FCGR3A, FCGR3B, RAF1, GSNMore
Pemigatinibhsa04668TNF signaling pathway4.51E-0511P01375, Q12933, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Pemigatinibhsa04710Circadian rhythm4.86E-021O15516CLOCKMore
Pemigatinibhsa04713Circadian entrainment1.16E-0811O15399, P0DP23, P0DP24, Q13557, Q02153, P62873, P63218, P50151, P61952, Q08828, P51828GRIN2D, CALM1, CALM2, CAMK2D, GUCY1B3, GNB1, GNG5, GNG10, GNG11, ADCY1, ADCY7More
Pemigatinibhsa04714Thermogenesis4.42E-024Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Pemigatinibhsa04720Long-term potentiation1.50E-1214P17252, Q16566, Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, O15399, P22694, Q08828, Q02750, P04049PRKCA, CAMK4, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, GRIN2D, PRKACB, ADCY1, MAP2K1, RAF1More
Pemigatinibhsa04721Synaptic vesicle cycle9.45E-042Q13488, P31645TCIRG1, SLC6A4More
Pemigatinibhsa04722Neurotrophin signaling pathway9.79E-067Q05655, P31751, P04049, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, ARHGDIB, IRAK1, BCL2, CALM1More
Pemigatinibhsa04723Retrograde endocannabinoid signaling3.71E-024P62873, P61952, Q08828, O15239GNB1, GNG11, ADCY1, NDUFA1More
Pemigatinibhsa04724Glutamatergic synapse1.33E-077O15399, Q08828, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLULMore
Pemigatinibhsa04725Cholinergic synapse1.28E-0815Q08828, P51828, P22694, P17252, P62873, P62879, P63218, P50151, P61952, P18848, Q16566, Q13557, P42338, P31751, Q02750ADCY1, ADCY7, PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, GNG11, ATF4, CAMK4, CAMK2D, PIK3CB, AKT2, MAP2K1More
Pemigatinibhsa04726Serotonergic synapse2.49E-049P22694, P17252, P62873, P62879, P63218, P50151, P09917, P04049, Q02750PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, ALOX5, RAF1, MAP2K1More
Pemigatinibhsa04727GABAergic synapse6.10E-1113Q08828, P51828, P62873, P62879, P63218, P50151, P61952, P15104, P22694, P46459, O60296, Q15111, P17252ADCY1, ADCY7, GNB1, GNB2, GNG5, GNG10, GNG11, GLUL, PRKACB, NSF, TRAK2, PLCL1, PRKCAMore
Pemigatinibhsa04728Dopaminergic synapse9.23E-0916P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP24, P0DP23, O15516, P48058GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM2, CALM1, CLOCK, GRIA4More
Pemigatinibhsa04730Long-term depression5.03E-053Q14344, P08069, P04049GNA13, IGF1R, RAF1More
Pemigatinibhsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Pemigatinibhsa04742Taste transduction1.18E-032P30939, P17612HTR1F, PRKACAMore
Pemigatinibhsa04744Phototransduction6.33E-093P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Pemigatinibhsa04750Inflammatory mediator regulation of TRP channels2.01E-1011P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM2, CALM1More
Pemigatinibhsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Pemigatinibhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Pemigatinibhsa04911Insulin secretion1.04E-065Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Pemigatinibhsa04912GnRH signaling pathway5.04E-067Q08828, P51828, P18848, Q9Y6R4, P0DP23, P04049, P45985ADCY1, ADCY7, ATF4, MAP3K4, CALM1, RAF1, MAP2K4More
Pemigatinibhsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Pemigatinibhsa04914Progesterone-mediated oocyte maturation1.58E-086P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Pemigatinibhsa04915Estrogen signaling pathway8.54E-1012P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Pemigatinibhsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Pemigatinibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Pemigatinibhsa04918Thyroid hormone synthesis2.47E-045Q08828, Q99941, P18848, P02768, P05543ADCY1, CREBL1, ATF4, ALB, SERPINA7More
Pemigatinibhsa04919Thyroid hormone signaling pathway1.07E-0511P17252, P19174, P04049, Q02750, P42224, P22694, P60709, Q13547, Q12778, Q9UM47, P01106PRKCA, PLCG1, RAF1, MAP2K1, STAT1, PRKACB, ACTB, HDAC1, FOXO1, NOTCH3, MYCMore
Pemigatinibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Pemigatinibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Pemigatinibhsa04922Glucagon signaling pathway4.86E-044P14618, P06737, P31751, P0DP23PKM2, PYGL, AKT2, CALM1More
Pemigatinibhsa04923Regulation of lipolysis in adipocytes4.29E-077Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2More
Pemigatinibhsa04924Renin secretion3.14E-054P22694, P07550, Q14643, P0DP23PRKACB, ADRB2, ITPR1, CALM1More
Pemigatinibhsa04925Aldosterone synthesis and secretion1.79E-088Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Pemigatinibhsa04926Relaxin signaling pathway1.62E-0714P31751, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P30679, P49407AKT2, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Pemigatinibhsa04927Cortisol synthesis and secretion2.32E-054Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Pemigatinibhsa04928Parathyroid hormone synthesis, secretion and action1.33E-025P22694, P04049, Q02750, P17252, Q9Y5Q3PRKACB, RAF1, MAP2K1, PRKCA, MAFBMore
Pemigatinibhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Pemigatinibhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Pemigatinibhsa04932Non-alcoholic fatty liver disease3.31E-1112P31751, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298, P19404AKT2, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2, NDUFV2More
Pemigatinibhsa04934Cushing syndrome5.10E-076Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Pemigatinibhsa04935Growth hormone synthesis, secretion and action5.87E-046Q08828, P51828, P04049, P18848, P31751, P45985ADCY1, ADCY7, RAF1, ATF4, AKT2, MAP2K4More
Pemigatinibhsa04940Type I diabetes mellitus1.55E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Pemigatinibhsa04960Aldosterone-regulated sodium reabsorption2.32E-032P06213, P48048INSR, KCNJ1More
Pemigatinibhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Pemigatinibhsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Pemigatinibhsa04970Salivary secretion2.93E-1011P07550, Q08828, P51828, P22694, Q14643, P23634, P17252, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CALM1, GUCY1B3, CAMPMore
Pemigatinibhsa04971Gastric acid secretion3.36E-076Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Pemigatinibhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Pemigatinibhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Pemigatinibhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Pemigatinibhsa04976Bile secretion1.97E-043Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Pemigatinibhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Pemigatinibhsa05010Alzheimer disease3.85E-0920P49768, Q92542, O15239, O95298, P19404, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, Q12933, P18848, O15169, P67870, P31751, P05141, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFC2, NDUFV2, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, AXIN1, CSNK2B, AKT2, SLC25A5, PSMB4, PSMC4More
Pemigatinibhsa05012Parkinson disease5.92E-0414O15239, O95298, P13073, P12074, P05496, P05141, P12236, O75460, P18848, P28070, P43686, P0DP23, P0DP24, Q13557NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, ERN1, ATF4, PSMB4, PSMC4, CALM1, CALM2, CAMK2DMore
Pemigatinibhsa05014Amyotrophic lateral sclerosis4.18E-025P19404, P12074, O75460, P28070, Q8TEV9NDUFV2, COX6A1, ERN1, PSMB4, SMCR8More
Pemigatinibhsa05016Huntington disease1.51E-0612O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Pemigatinibhsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Pemigatinibhsa05020Prion disease1.31E-0516P01584, P46531, P0DMV8, P11142, O15239, O95298, P05496, P13073, P12074, P18848, P05141, P12236, P28070, P43686, P67870, Q99941IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFC2, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, CSNK2B, CREBL1More
Pemigatinibhsa05022Pathways of neurodegeneration - multiple diseases1.42E-0826P67870, O15239, O95298, P19404, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, P05141, P45880, Q15078, Q00535, O15169, P01584, P49768, O15020, P0DP24, P0DP23, Q13557, P62987, P28070, P43686CSNK2B, NDUFA1, NDUFC2, NDUFV2, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, SLC25A5, VDAC2, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, SPTBN2, CALM2, CALM1, CAMK2D, UBA52, PSMB4, PSMC4More
Pemigatinibhsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Pemigatinibhsa05031Amphetamine addiction4.45E-055P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Pemigatinibhsa05032Morphine addiction6.04E-046P62873, P63218, P50151, P78334, P32298, P43250GNB1, GNG5, GNG10, GABRE, GRK4, GRK6More
Pemigatinibhsa05033Nicotine addiction4.01E-021P78334GABREMore
Pemigatinibhsa05034Alcoholism5.03E-0616O15399, Q99941, P18848, Q16566, Q13547, P0DP23, P0DP24, P62873, P63218, P50151, P61952, P04049, P0C0S5, P62807, Q93079, Q16778GRIN2D, CREBL1, ATF4, CAMK4, HDAC1, CALM1, CALM2, GNB1, GNG5, GNG10, GNG11, RAF1, H2AFZ, HIST1H2BC, H2BC9, HIST2H2BEMore
Pemigatinibhsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Pemigatinibhsa05110Vibrio cholerae infection1.86E-042Q99437, P17612ATP6V0B, PRKACAMore
Pemigatinibhsa05120Epithelial cell signaling in Helicobacter pylori infection2.10E-1210Q16539, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240MAPK14, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSKMore
Pemigatinibhsa05130Pathogenic Escherichia coli infection2.77E-039P16333, Q13509, P60709, P25963, P04406, P29350, Q15438, P35579, P55061NCK1, TUBB3, ACTB, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Pemigatinibhsa05131Shigellosis2.79E-0514Q12933, Q13546, Q05655, Q02156, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q12778, Q13315, P10415, P07737TRAF2, RIPK1, PRKCD, PRKCE, MALT1, RRAGD, UBB, SEPT6, ELMO2, PTK2, FOXO1, ATM, BCL2, PFN1More
Pemigatinibhsa05132Salmonella infection1.34E-0819P51617, P25963, P08238, P04049, Q9UJU2, P01106, P84095, P60709, Q13546, Q13489, P10415, P04406, O75369, P07737, Q9BQS8, Q13561, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41More
Pemigatinibhsa05133Pertussis1.43E-053P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Pemigatinibhsa05134Legionellosis1.05E-099P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Pemigatinibhsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Pemigatinibhsa05140Leishmaniasis7.67E-0813P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Pemigatinibhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Pemigatinibhsa05143African trypanosomiasis2.11E-032P69905, P68871HBA2, HBBMore
Pemigatinibhsa05144Malaria6.72E-059P60033, P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Pemigatinibhsa05146Amoebiasis1.85E-1712P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Pemigatinibhsa05150Staphylococcus aureus infection4.78E-0915P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Pemigatinibhsa05152Tuberculosis1.30E-059P04049, Q99437, P0DP23, P48382, P31751, P10415, P25774, Q9UDY8, P51617RAF1, ATP6V0B, CALM1, RFX5, AKT2, BCL2, CTSS, MALT1, IRAK1More
Pemigatinibhsa05160Hepatitis C2.32E-033Q13546, P01568, P04049RIPK1, IFNA21, RAF1More
Pemigatinibhsa05161Hepatitis B4.32E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Pemigatinibhsa05162Measles5.20E-046P23458, P31751, P0DMV8, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9BMore
Pemigatinibhsa05163Human cytomegalovirus infection9.44E-1227P31751, P04049, P01375, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769, P01568AKT2, RAF1, TNF, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2M, IFNA21More
Pemigatinibhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Pemigatinibhsa05165Human papillomavirus infection6.89E-0619P46527, Q02750, P02452, P24821, Q16363, P35443, Q92796, Q05086, P30281, Q9UM47, P01568, P01889, P10321, Q99437, P22694, Q13362, Q12778, P04628, Q13315CDKN1B, MAP2K1, COL1A1, TNC, LAMA4, THBS4, DLG3, UBE3A, CCND3, NOTCH3, IFNA21, HLA-B, HLA-C, ATP6V0B, PRKACB, PPP2R5C, FOXO1, WNT1, ATMMore
Pemigatinibhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Pemigatinibhsa05167Kaposi sarcoma-associated herpesvirus infection2.83E-0512P01568, P31751, P42224, P25963, P62873, P63218, P50151, P19174, P04049, P07948, P01106, P0DP23IFNA21, AKT2, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, RAF1, LYN, MYC, CALM1More
Pemigatinibhsa05168Herpes simplex virus 1 infection1.14E-0526O00463, O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, P84103, Q13243, Q16629, Q13489, P30101, Q9Y2A4, Q13398, P51522, Q9NR11, Q9HCX3, P17097, P17038, Q03923, P52738, O75820, Q9NZL3, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, SFRS7, BIRC3, PDIA3, ZNF443, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF224, ZNF212, BCL2More
Pemigatinibhsa05169Epstein-Barr virus infection1.72E-0617P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Pemigatinibhsa05170Human immunodeficiency virus 1 infection1.98E-0717P31751, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P51617, Q13315, P23528, P10415, Q9Y6Q5AKT2, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, IRAK1, ATM, CFL1, BCL2, AP1M2More
Pemigatinibhsa05171Coronavirus disease - COVID-193.96E-0917P23396, P62753, P25398, P42677, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P46776, P62899, P62910, P18077, P61927, P05386RPS3, RPS6, RPS12, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPLP1More
Pemigatinibhsa05200Pathways in cancer4.15E-0930Q13751, P08238, P42224, P25963, P19174, P01106, Q9UJU2, P43246, P84022, Q13485, P20585, P52701, P14923, P30279, P10415, Q13489, P98170, Q13077, P14921, P31751, P62873, P63218, P50151, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P01042LAMB3, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, MSH2, SMAD3, SMAD4, MSH3, MSH6, JUP, CCND2, BCL2, BIRC3, BIRC4, TRAF1, ETS1, AKT2, GNB1, GNG5, GNG10, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Pemigatinibhsa05202Transcriptional misregulation in cancer4.45E-0919Q12778, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P46527, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522FOXO1, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Pemigatinibhsa05203Viral carcinogenesis4.16E-0513Q12933, Q99941, P18848, P30281, P27348, Q13547, P06396, P12814, P01889, P10321, P06493, P62807, Q16778TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, GSN, ACTN1, HLA-B, HLA-C, CDK1, HIST1H2BC, HIST2H2BEMore
Pemigatinibhsa05205Proteoglycans in cancer6.79E-0510Q13009, Q12955, O75369, P60709, P04049, P01106, P08069, P19174, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MYC, IGF1R, PLCG1, PTPN6, CD63More
Pemigatinibhsa05206MicroRNAs in cancer1.19E-027P46527, Q9UM47, P16070, Q13315, P17252, P04049, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, RAF1, MAP2K1More
Pemigatinibhsa05210Colorectal cancer2.62E-0510Q9UKG1, P84022, Q13485, P43246, P04049, P01106, P52701, P20585, P37173, O75293APPL1, SMAD3, SMAD4, MSH2, RAF1, MYC, MSH6, MSH3, TGFBR2, GADD45BMore
Pemigatinibhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Pemigatinibhsa05212Pancreatic cancer7.63E-057P31751, P04049, Q15311, P23458, P84022, Q13485, O75293AKT2, RAF1, RALBP1, JAK1, SMAD3, SMAD4, GADD45BMore
Pemigatinibhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Pemigatinibhsa05214Glioma1.15E-067P08069, P0DP23, Q16566, P04049, P31751, P19174, O75293IGF1R, CALM1, CAMK4, RAF1, AKT2, PLCG1, GADD45BMore
Pemigatinibhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Pemigatinibhsa05217Basal cell carcinoma4.31E-022P04628, Q9UJU2WNT1, LEF1More
Pemigatinibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Pemigatinibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Pemigatinibhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Pemigatinibhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Pemigatinibhsa05222Small cell lung cancer4.77E-035P31751, Q13751, Q13489, P98170, O75293AKT2, LAMB3, BIRC3, BIRC4, GADD45BMore
Pemigatinibhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Pemigatinibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Pemigatinibhsa05225Hepatocellular carcinoma1.81E-054P04049, Q92529, P08069, P51531RAF1, SHC3, IGF1R, SMARCA2More
Pemigatinibhsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Pemigatinibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Pemigatinibhsa05231Choline metabolism in cancer2.51E-069P04049, P31751, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494RAF1, AKT2, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1More
Pemigatinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-1517P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Pemigatinibhsa05310Asthma7.64E-083P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Pemigatinibhsa05321Inflammatory bowel disease6.18E-147O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Pemigatinibhsa05322Systemic lupus erythematosus3.82E-0511P08637, O75015, P08246, P08311, P01375, P10747, P13765, P62807, Q16778, P14678, P12814FCGR3A, FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, HIST1H2BC, HIST2H2BE, SNRPB, ACTN1More
Pemigatinibhsa05323Rheumatoid arthritis1.89E-047P01375, Q06643, P13765, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, CD28, CXCL1, CXCL2, TLR2More
Pemigatinibhsa05330Allograft rejection2.83E-023P13765, P10747, P01375HLA-DOB, CD28, TNFMore
Pemigatinibhsa05332Graft-versus-host disease3.29E-115P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Pemigatinibhsa05340Primary immunodeficiency2.96E-046P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Pemigatinibhsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Pemigatinibhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Pemigatinibhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Pemigatinibhsa05415Diabetic cardiomyopathy1.49E-0410P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P14780, P37173, P04406PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9, TGFBR2, GAPDHMore
Pemigatinibhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Pemigatinib (SDC: 10.87)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
P26358DNMT1DNAPredicted00.34040.28090.26590.998
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)