PharmaCoNets of Pemetrexed (SPCN: 109.99 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pemetrexedhsa00030Pentose phosphate pathway1.03E-044P60891, P52209, P11413, P37837PRPS1, PGD, G6PD, TALDO1More
Pemetrexedhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Pemetrexedhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Pemetrexedhsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Pemetrexedhsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Pemetrexedhsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Pemetrexedhsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Pemetrexedhsa00500Starch and sucrose metabolism1.54E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Pemetrexedhsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Pemetrexedhsa00531Glycosaminoglycan degradation4.51E-022P22304, P06865IDS, HEXAMore
Pemetrexedhsa00600Sphingolipid metabolism4.56E-023Q9BX95, Q06136, P06280SGPP1, FVT1, GLAMore
Pemetrexedhsa00630Glyoxylate and dicarboxylate metabolism9.62E-043P40925, P40926, P15104MDH1, MDH2, GLULMore
Pemetrexedhsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Pemetrexedhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Pemetrexedhsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Pemetrexedhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Pemetrexedhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Pemetrexedhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Pemetrexedhsa01200Carbon metabolism2.91E-021P11413G6PDMore
Pemetrexedhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Pemetrexedhsa01523Antifolate resistance6.06E-032Q92820, P04818GGH, TYMSMore
Pemetrexedhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Pemetrexedhsa03010Ribosome1.53E-058P62753, P62906, P46776, Q07020, P61513, P27635, P62249, P23396RPS6, RPL10A, RPL27A, RPL18, RPL37A, RPL10, RPS16, RPS3More
Pemetrexedhsa03013RNA transport7.33E-0612O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3More
Pemetrexedhsa03040Spliceosome4.48E-0410Q14562, O43143, O60508, P17844, P51991, P61978, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, DDX5, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8More
Pemetrexedhsa03060Protein export2.43E-022Q15070, O76094OXA1L, SRP72More
Pemetrexedhsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Pemetrexedhsa04015Rap1 signaling pathway2.26E-023P25116, Q8TEU7, P08514F2R, RAPGEF6, ITGA2BMore
Pemetrexedhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Pemetrexedhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Pemetrexedhsa04061Viral protein interaction with cytokine and cytokine receptor5.82E-038P09341, P19875, P25024, P25025, P47992, Q9UBD3, P14784, P09603CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL2RB, CSF1More
Pemetrexedhsa04062Chemokine signaling pathway7.46E-0618P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, Q08881, Q13009, P14598, P42224, P25963, P49841CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, ITK, TIAM1, NCF1, STAT1, NFKBIA, GSK3BMore
Pemetrexedhsa04064NF-kappa B signaling pathway7.38E-0519P10415, Q13489, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CXCL2, LTB, CYLDMore
Pemetrexedhsa04070Phosphatidylinositol signaling system2.93E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Pemetrexedhsa04071Sphingolipid signaling pathway5.28E-059P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, BCL2, GAB2More
Pemetrexedhsa04072Phospholipase D signaling pathway5.05E-039P42338, Q9UQC2, P43657, P25024, P25025, P19174, Q8WYR1, Q15438, P51828PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIK3R5, PSCD1, ADCY7More
Pemetrexedhsa04110Cell cycle2.34E-023P06493, O60566, P33981CDK1, BUB1B, TTKMore
Pemetrexedhsa04115p53 signaling pathway3.34E-022P31350, P06493RRM2, CDK1More
Pemetrexedhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Pemetrexedhsa04140Autophagy - animal3.72E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Pemetrexedhsa04141Protein processing in endoplasmic reticulum3.12E-0513P18848, P30101, Q15437, Q15436, P60604, Q99941, P11142, P07900, P08238, Q9NR31, P14625, Q9H173, Q9UNL2ATF4, PDIA3, SEC23B, SEC23A, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, HSP90B1, SIL1, SSR3More
Pemetrexedhsa04142Lysosome3.32E-036P06865, P22304, Q13510, P07602, P61916, Q04900HEXA, IDS, ASAH1, PSAP, NPC2, CD164More
Pemetrexedhsa04145Phagosome6.51E-036P11215, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Pemetrexedhsa04151PI3K-Akt signaling pathway4.12E-049P62753, P27348, P07900, P14625, Q16363, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, HSP90B1, LAMA4, TNXB, CREBL1, ATF4, SGKMore
Pemetrexedhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Pemetrexedhsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Pemetrexedhsa04213Longevity regulating pathway - multiple species3.10E-036P42338, Q9Y4H2, P51828, P0DMV8, P11142, Q13547PIK3CB, IRS2, ADCY7, HSPA1A, HSPA8, HDAC1More
Pemetrexedhsa04261Adrenergic signaling in cardiomyocytes3.65E-048P67936, P51828, Q8WYR1, Q99941, P18848, Q13362, P0DP24, Q13557TPM4, ADCY7, PIK3R5, CREBL1, ATF4, PPP2R5C, CALM2, CAMK2DMore
Pemetrexedhsa04270Vascular smooth muscle contraction1.75E-036Q15746, P24844, P0DP24, P51828, P35579, P35749MYLK, MYL9, CALM2, ADCY7, MYH9, MYH11More
Pemetrexedhsa04330Notch signaling pathway2.93E-023Q13547, Q92769, Q92830HDAC1, HDAC2, KAT2AMore
Pemetrexedhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Pemetrexedhsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Pemetrexedhsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Pemetrexedhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Pemetrexedhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Pemetrexedhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Pemetrexedhsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Pemetrexedhsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Pemetrexedhsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Pemetrexedhsa04611Platelet activation1.59E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Pemetrexedhsa04612Antigen processing and presentation3.74E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Pemetrexedhsa04613Neutrophil extracellular trap formation9.38E-0517O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Pemetrexedhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Pemetrexedhsa04621NOD-like receptor signaling pathway2.24E-0315Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Pemetrexedhsa04623Cytosolic DNA-sensing pathway2.59E-022P01568, P25963IFNA21, NFKBIAMore
Pemetrexedhsa04625C-type lectin receptor signaling pathway8.11E-039Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Pemetrexedhsa04640Hematopoietic cell lineage8.88E-0615P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P09603, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, CSF1, IL1BMore
Pemetrexedhsa04650Natural killer cell mediated cytotoxicity1.32E-0613P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Pemetrexedhsa04657IL-17 signaling pathway3.31E-038O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Pemetrexedhsa04658Th1 and Th2 cell differentiation5.37E-0814Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Pemetrexedhsa04659Th17 cell differentiation6.17E-0718P25963, Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Pemetrexedhsa04660T cell receptor signaling pathway1.72E-0816P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Pemetrexedhsa04664Fc epsilon RI signaling pathway4.48E-045P04141, P07948, P19174, P09917, P20292CSF2, LYN, PLCG1, ALOX5, ALOX5APMore
Pemetrexedhsa04668TNF signaling pathway4.96E-026O00463, Q13546, Q13489, Q16539, Q13077, P14780TRAF5, RIPK1, BIRC3, MAPK14, TRAF1, MMP9More
Pemetrexedhsa04672Intestinal immune network for IgA production1.66E-023P10747, P13765, P13612CD28, HLA-DOB, ITGA4More
Pemetrexedhsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Pemetrexedhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Pemetrexedhsa04724Glutamatergic synapse1.48E-036P48058, P62873, P63218, P50151, P15104, Q9NSB8GRIA4, GNB1, GNG5, GNG10, GLUL, HOMER2More
Pemetrexedhsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Pemetrexedhsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Pemetrexedhsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Pemetrexedhsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Pemetrexedhsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Pemetrexedhsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Pemetrexedhsa04750Inflammatory mediator regulation of TRP channels3.14E-0411P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Pemetrexedhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Pemetrexedhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Pemetrexedhsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Pemetrexedhsa04912GnRH signaling pathway6.39E-038P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Pemetrexedhsa04915Estrogen signaling pathway1.02E-048Q99941, P18848, P51828, P07900, P0DMV8, P11142, P0DP24, Q15788CREBL1, ATF4, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM2, NCOA1More
Pemetrexedhsa04918Thyroid hormone synthesis1.98E-045P51828, Q99941, P18848, P14625, P02768ADCY7, CREBL1, ATF4, HSP90B1, ALBMore
Pemetrexedhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Pemetrexedhsa04921Oxytocin signaling pathway6.00E-046Q15746, P0DP24, P51828, P24844, Q96RR4, Q8WYR1MYLK, CALM2, ADCY7, MYL9, CAMKK2, PIK3R5More
Pemetrexedhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Pemetrexedhsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Pemetrexedhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Pemetrexedhsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Pemetrexedhsa04927Cortisol synthesis and secretion6.33E-045Q14643, Q99941, P18848, P51828, P22694ITPR1, CREBL1, ATF4, ADCY7, PRKACBMore
Pemetrexedhsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Pemetrexedhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Pemetrexedhsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Pemetrexedhsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Pemetrexedhsa04940Type I diabetes mellitus3.64E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Pemetrexedhsa04962Vasopressin-regulated water reabsorption2.18E-022P52566, P62491ARHGDIB, RAB11AMore
Pemetrexedhsa04970Salivary secretion4.92E-024P07550, P22694, Q14643, P49913ADRB2, PRKACB, ITPR1, CAMPMore
Pemetrexedhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Pemetrexedhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Pemetrexedhsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Pemetrexedhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Pemetrexedhsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Pemetrexedhsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Pemetrexedhsa05034Alcoholism2.79E-022P62879, Q9BTM1GNB2, H2AFJMore
Pemetrexedhsa05120Epithelial cell signaling in Helicobacter pylori infection2.93E-069Q16539, P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Pemetrexedhsa05130Pathogenic Escherichia coli infection3.29E-039Q71U36, Q14247, O00501, P16333, Q13509, P68371, P25116, Q14344, P25963TUBA1A, CTTN, CLDN5, NCK1, TUBB3, TUBB2C, F2R, GNA13, NFKBIAMore
Pemetrexedhsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Pemetrexedhsa05134Legionellosis1.49E-035P25963, P11215, P11142, P09341, P19875NFKBIA, ITGAM, HSPA8, CXCL1, CXCL2More
Pemetrexedhsa05140Leishmaniasis3.10E-0313P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, MAPK14, NCF4More
Pemetrexedhsa05144Malaria2.71E-046P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Pemetrexedhsa05145Toxoplasmosis3.55E-023P23458, Q8WYR1, P0DMV8JAK1, PIK3R5, HSPA1AMore
Pemetrexedhsa05146Amoebiasis8.07E-0613P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Pemetrexedhsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Pemetrexedhsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Pemetrexedhsa05163Human cytomegalovirus infection1.79E-0414P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, P49841, P14778, P25025, Q16539, O00463, P30101, P01568NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21More
Pemetrexedhsa05167Kaposi sarcoma-associated herpesvirus infection4.85E-0515P01568, P42224, P25963, P49841, P62873, P63218, P50151, P09341, P19174, Q14643, O15123, P07948, Q16539, P04141, P0DP23IFNA21, STAT1, NFKBIA, GSK3B, GNB1, GNG5, GNG10, CXCL1, PLCG1, ITPR1, ANGPT2, LYN, MAPK14, CSF2, CALM1More
Pemetrexedhsa05168Herpes simplex virus 1 infection3.79E-029P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189More
Pemetrexedhsa05169Epstein-Barr virus infection1.24E-0313Q13547, Q92769, O00463, Q16539, P07948, P30101, Q13761, P24522, P30279, P29728, P07766, P09693, P20963HDAC1, HDAC2, TRAF5, MAPK14, LYN, PDIA3, RUNX3, GADD45A, CCND2, OAS2, CD3E, CD3G, CD247More
Pemetrexedhsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Pemetrexedhsa05171Coronavirus disease - COVID-194.36E-058P23396, P62753, P62249, P62906, P27635, Q07020, P46776, P61513RPS3, RPS6, RPS16, RPL10A, RPL10, RPL18, RPL27A, RPL37AMore
Pemetrexedhsa05200Pathways in cancer2.14E-0417P17301, P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P62879, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784ITGA2, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNB2, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Pemetrexedhsa05202Transcriptional misregulation in cancer7.36E-0619Q15532, P41732, P17844, P14780, P27930, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522SS18, TSPAN7, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Pemetrexedhsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Pemetrexedhsa05212Pancreatic cancer4.75E-023P42224, P84022, O75293STAT1, SMAD3, GADD45BMore
Pemetrexedhsa05214Glioma4.75E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Pemetrexedhsa05215Prostate cancer4.48E-022P18848, P14625ATF4, HSP90B1More
Pemetrexedhsa05217Basal cell carcinoma1.72E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Pemetrexedhsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Pemetrexedhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.76E-0411P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14More
Pemetrexedhsa05310Asthma1.66E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Pemetrexedhsa05321Inflammatory bowel disease7.58E-057O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Pemetrexedhsa05323Rheumatoid arthritis1.58E-025P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Pemetrexedhsa05332Graft-versus-host disease2.03E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Pemetrexedhsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore

Community members of Pemetrexed (SDC: 5.18)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P04818TYMSThymidylate synthaseReported10.45530.27060.18930.9582
P00374DHFRDihydrofolate reductaseReported00.3380.18680.22630.7688
P41440SLC19A1Reduced folate transporterPredicted00.14250.0380.09850.2457
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P14625HSP90B1EndoplasminPredicted00.23360.14970.53840.9546
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q15788NCOA1Nuclear receptor coactivator 1Predicted00.43680.08280.31140.6954
P52209PGD6Nonephosphogluconate dehydrogenase, decarboxylatingPredicted00.1950.14540.26420.6525
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
Q9UM07PADI4ProteinNonearginine deiminase typeNone4Predicted10.14880.27780.42671.0567
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
P09958FURINFurinPredicted10.15690.07500.2286
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
TYMSP04818IC5070
TYMSP04818IC505700
TYMSP04818IC509500
TYMSP04818Ki1.3
TYMSP04818Ki340
DHFRP00374IC501400
DHFRP00374IC501500
DHFRP00374IC502300
DHFRP00374Ki7
DHFRP00374Ki7.2