PharmaCoNets of Pazopanib (SPCN: 275.49 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pazopanibhsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Pazopanibhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Pazopanibhsa00030Pentose phosphate pathway1.32E-134P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Pazopanibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Pazopanibhsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Pazopanibhsa00052Galactose metabolism4.25E-056P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Pazopanibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Pazopanibhsa00071Fatty acid degradation2.38E-023P11310, O75521, P33121ACADM, ECI2, ACSL1More
Pazopanibhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Pazopanibhsa00190Oxidative phosphorylation4.56E-064Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Pazopanibhsa00220Arginine biosynthesis1.55E-063P15104, P05089, P49448GLUL, ARG1, GLUD2More
Pazopanibhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Pazopanibhsa00250Alanine, aspartate and glutamate metabolism6.84E-053Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Pazopanibhsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Pazopanibhsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Pazopanibhsa00310Lysine degradation2.14E-057Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Pazopanibhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Pazopanibhsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Pazopanibhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Pazopanibhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Pazopanibhsa00500Starch and sucrose metabolism6.81E-074O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Pazopanibhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Pazopanibhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Pazopanibhsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Pazopanibhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Pazopanibhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Pazopanibhsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Pazopanibhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Pazopanibhsa00564Glycerophospholipid metabolism1.25E-046P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Pazopanibhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Pazopanibhsa00590Arachidonic acid metabolism2.48E-033P11712, P09917, P09960CYP2C9, ALOX5, LTA4HMore
Pazopanibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Pazopanibhsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Pazopanibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Pazopanibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Pazopanibhsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Pazopanibhsa00630Glyoxylate and dicarboxylate metabolism1.40E-094P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Pazopanibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Pazopanibhsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Pazopanibhsa00730Thiamine metabolism1.38E-053Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Pazopanibhsa00740Riboflavin metabolism2.80E-032P30043, P24666BLVRB, ACP1More
Pazopanibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Pazopanibhsa00770Pantothenate and CoA biosynthesis7.20E-043O95498, Q6ZQY3, Q9NRN7VNN2, GADL1, AASDHPPTMore
Pazopanibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Pazopanibhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Pazopanibhsa00830Retinol metabolism3.35E-045P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Pazopanibhsa00860Porphyrin and chlorophyll metabolism7.35E-053P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Pazopanibhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Pazopanibhsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Pazopanibhsa00970Aminoacyl-tRNA biosynthesis3.83E-022P54136, P14868RARS1, DARSMore
Pazopanibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Pazopanibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Pazopanibhsa00983Drug metabolism - other enzymes1.07E-065P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Pazopanibhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Pazopanibhsa01100Metabolic pathways8.01E-0769Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q96RQ9, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, IL4I1, MCCC2, ACSL1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Pazopanibhsa01200Carbon metabolism7.14E-034P51854, P52209, P37837, P60891TKTL1, PGD, TALDO1, PRPS1More
Pazopanibhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Pazopanibhsa01230Biosynthesis of amino acids1.59E-066P51854, P60891, Q99707, P50213, P05089, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, TALDO1More
Pazopanibhsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Pazopanibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Pazopanibhsa01522Endocrine resistance1.02E-047P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Pazopanibhsa01523Antifolate resistance2.08E-044P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Pazopanibhsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Pazopanibhsa02010ABC transporters2.17E-031Q8IZY2ABCA7More
Pazopanibhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Pazopanibhsa03010Ribosome7.89E-1321P26373, P62753, P42677, P25398, P32969, P62917, P62829, P46776, Q9H0U6, Q07020, P62888, P62899, P62910, P18077, P61927, P61513, Q02878, P36578, P27635, P05386, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL23, RPL27A, MRPL18, RPL18, RPL30, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPL6, RPL4, RPL10, RPLP1, RPS3More
Pazopanibhsa03013RNA transport1.51E-2732P62826, O14980, P52298, Q09161, O14893, P61326, P38919, Q15287, Q9UBU9, Q9H307, P37198, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, RNPS1, NXF1, PNN, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1, FXR1More
Pazopanibhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Pazopanibhsa03020RNA polymerase5.44E-094P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Pazopanibhsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Pazopanibhsa03040Spliceosome1.77E-1018Q14562, O43143, O60508, P08579, Q15427, P26368, O75940, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, SMNDC1, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Pazopanibhsa03050Proteasome4.83E-021P55036PSMD4More
Pazopanibhsa03060Protein export1.16E-104Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Pazopanibhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Pazopanibhsa03430Mismatch repair4.38E-021P20585MSH3More
Pazopanibhsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Pazopanibhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Pazopanibhsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Pazopanibhsa04012ErbB signaling pathway2.36E-0710P21860, Q13153, P16333, Q13191, Q13557, P19174, O14944, P42338, P01106, P04049ERBB3, PAK1, NCK1, CBLB, CAMK2D, PLCG1, EREG, PIK3CB, MYC, RAF1More
Pazopanibhsa04014Ras signaling pathway4.67E-0613P04049, P31751, P42338, P20827, Q9NRA1, P49767, P08069, Q13009, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Pazopanibhsa04015Rap1 signaling pathway2.31E-0613P04049, P20827, Q9NRA1, P49767, P08069, P06213, P11215, Q13009, O00522, P42338, P31751, P0DP23, P19174RAF1, EFNA1, PDGFC, VEGFC, IGF1R, INSR, ITGAM, TIAM1, KRIT1, PIK3CB, AKT2, CALM1, PLCG1More
Pazopanibhsa04020Calcium signaling pathway1.39E-0916P27987, Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P30679, P19174, P0DP24, P0DP23, P05141, P51828, P23634, Q9NRA1, P49767ITPKB, ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, GNA15, PLCG1, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4, PDGFC, VEGFCMore
Pazopanibhsa04022cGMP-PKG signaling pathway2.03E-0812Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Pazopanibhsa04024cAMP signaling pathway1.08E-046Q08828, P51828, P31751, P0DP23, P04049, Q13153ADCY1, ADCY7, AKT2, CALM1, RAF1, PAK1More
Pazopanibhsa04060Cytokine-cytokine receptor interaction6.46E-0517P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Pazopanibhsa04061Viral protein interaction with cytokine and cytokine receptor1.92E-0510Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Pazopanibhsa04062Chemokine signaling pathway6.99E-0920P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIAMore
Pazopanibhsa04064NF-kappa B signaling pathway5.48E-1623P10415, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Pazopanibhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Pazopanibhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Pazopanibhsa04070Phosphatidylinositol signaling system2.43E-0611P19174, P0DP23, P42338, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKCMore
Pazopanibhsa04071Sphingolipid signaling pathway3.20E-069P04049, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, Q12933, Q02156RAF1, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, TRAF2, PRKCEMore
Pazopanibhsa04072Phospholipase D signaling pathway2.30E-0616P04049, P31751, P42338, Q9UQC2, P43657, P25024, P25025, P19174, O14986, Q14344, Q15438, Q08828, P51828, P23743, Q16760, Q9NRA1RAF1, AKT2, PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNA13, PSCD1, ADCY1, ADCY7, DGKA, DGKD, PDGFCMore
Pazopanibhsa04080Neuroactive ligand-receptor interaction1.38E-0512P08311, P28472, P78334, Q15722, P21453, Q9H228, P43657, P21462, P21730, P30939, P07550, P35318CTSG, GABRB3, GABRE, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, HTR1F, ADRB2, ADMMore
Pazopanibhsa04110Cell cycle1.63E-0812Q9UBD5, P30260, P06493, O60566, Q14683, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Pazopanibhsa04114Oocyte meiosis5.73E-1011Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Pazopanibhsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Pazopanibhsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Pazopanibhsa04136Autophagy - other4.46E-052O94817, Q9H1Y0ATG12, ATG5More
Pazopanibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Pazopanibhsa04140Autophagy - animal3.90E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Pazopanibhsa04141Protein processing in endoplasmic reticulum1.48E-0513P18848, Q12933, P30101, Q15436, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SSR3More
Pazopanibhsa04142Lysosome1.11E-0511O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Pazopanibhsa04144Endocytosis8.76E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Pazopanibhsa04145Phagosome4.61E-0410O75015, Q15080, P14598, Q13509, P68371, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Pazopanibhsa04146Peroxisome1.95E-036O00623, O96011, P56589, Q9UKG9, O75521, P33121PEX12, PEX11B, PEX3, CROT, ECI2, ACSL1More
Pazopanibhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Pazopanibhsa04151PI3K-Akt signaling pathway3.15E-0831P62753, P42338, P21860, P01106, O43521, P04637, P27348, P20827, Q9NRA1, P49767, Q13362, P07900, P08238, P62873, P63218, P50151, P61952, O15335, P02452, P24821, Q16363, P22105, P14784, P23458, P01568, Q99941, P18848, Q96BR1, O00141, Q6ZUJ8, P56279RPS6, PIK3CB, ERBB3, MYC, BCL2L11, TP53, YWHAQ, EFNA1, PDGFC, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, GNB1, GNG5, GNG10, GNG11, CHAD, COL1A1, TNC, LAMA4, TNXB, IL2RB, JAK1, IFNA21, CREBL1, ATF4, SGK3, SGK, PIK3AP1, TCL1AMore
Pazopanibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Pazopanibhsa04210Apoptosis1.10E-034Q14790, P48023, P42575, P04049CASP8, FASLG, CASP2, RAF1More
Pazopanibhsa04211Longevity regulating pathway2.60E-046P31751, P08069, Q08828, P51828, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, ATF4, CAMKK2More
Pazopanibhsa04213Longevity regulating pathway - multiple species1.70E-089P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Pazopanibhsa04215Apoptosis - multiple species2.30E-022O15392, Q14790BIRC5, CASP8More
Pazopanibhsa04217Necroptosis3.78E-1425P01375, Q12933, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q13557, Q9H444, O43633, O75351, P45880, Q08752TNF, TRAF2, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CAMK2D, CHMP4B, CHMP2A, VPS4B, VDAC2, PPIDMore
Pazopanibhsa04218Cellular senescence1.96E-047P31751, P04049, P30281, P0DP23, P01889, P10321, P12236AKT2, RAF1, CCND3, CALM1, HLA-B, HLA-C, SLC25A6More
Pazopanibhsa04260Cardiac muscle contraction4.20E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Pazopanibhsa04261Adrenergic signaling in cardiomyocytes6.22E-1014P67936, P07550, Q08828, P51828, P22694, P31751, Q99941, P18848, Q13362, Q14738, P0DP24, P0DP23, Q13557, P23634TPM4, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, CAMK2D, ATP2B4More
Pazopanibhsa04270Vascular smooth muscle contraction1.71E-0611P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Pazopanibhsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Pazopanibhsa04330Notch signaling pathway3.00E-064Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Pazopanibhsa04340Hedgehog signaling pathway2.58E-034P17612, P22694, Q13635, P10415PRKACA, PRKACB, PTCH1, BCL2More
Pazopanibhsa04360Axon guidance9.87E-0511P16298, Q05397, P16333, P20827, O95631, Q13873, P42338, P04049, P19174, O14639, P24844PPP3CB, PTK2, NCK1, EFNA1, NTN1, BMPR2, PIK3CB, RAF1, PLCG1, ABLIM1, MYL9More
Pazopanibhsa04370VEGF signaling pathway6.18E-137P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Pazopanibhsa04371Apelin signaling pathway1.82E-0614P62873, P63218, P50151, P61952, P31751, P04049, Q08828, P51828, Q13370, Q14814, Q14344, P62753, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, AKT2, RAF1, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, RPS6, CALM1, CALM2More
Pazopanibhsa04380Osteoclast differentiation2.25E-0710Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Pazopanibhsa04390Hippo signaling pathway3.37E-055O95835, P04628, Q9UJU2, O43623, Q13489LATS1, WNT1, LEF1, SNAI2, BIRC3More
Pazopanibhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Pazopanibhsa04510Focal adhesion1.63E-035Q15942, P51636, P30281, P04049, P08069ZYX, CAV2, CCND3, RAF1, IGF1RMore
Pazopanibhsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Pazopanibhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Pazopanibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Pazopanibhsa04540Gap junction8.97E-044Q13509, P68371, P04049, Q9NRA1TUBB3, TUBB2C, RAF1, PDGFCMore
Pazopanibhsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Pazopanibhsa04610Complement and coagulation cascades1.51E-104P09871, P0C0L4, P20023, P05107C1S, C4A, CR2, ITGB2More
Pazopanibhsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Pazopanibhsa04612Antigen processing and presentation1.34E-1012P13765, P48382, P01730, Q14953, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNFMore
Pazopanibhsa04613Neutrophil extracellular trap formation7.13E-0827P42338, P19174, P04049, P16109, P11215, P05164, P08246, Q9UM07, Q13547, Q99878, Q93077, P62807, Q93079, Q16778, O60814, P68431, P21796, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359PIK3CB, PLCG1, RAF1, SELP, ITGAM, MPO, ELA2, PADI4, HDAC1, H2AC14, HIST1H2AC, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BAMore
Pazopanibhsa04620Toll-like receptor signaling pathway6.81E-068Q13546, P01568, P01584, P31751, P42224, P25963, P42338, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, STAT1, NFKBIA, PIK3CB, CCL4L2More
Pazopanibhsa04621NOD-like receptor signaling pathway1.92E-0412P01584, P07900, Q14643, P23458, P45880, P10599, P43490, O00463, P29728, P01375, P09341, P12838IL1B, HSP90AA1, ITPR1, JAK1, VDAC2, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Pazopanibhsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Pazopanibhsa04623Cytosolic DNA-sensing pathway3.02E-126P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Pazopanibhsa04625C-type lectin receptor signaling pathway4.18E-0913Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P42224, P20749, P25963, P01375, P42338, P31751, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, STAT1, BCL3, NFKBIA, TNF, PIK3CB, AKT2, CALM1, MAPK14More
Pazopanibhsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Pazopanibhsa04640Hematopoietic cell lineage3.05E-1218P13612, P07359, P08514, P21926, P14778, P27930, P11215, P15144, P20023, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375ITGA4, GP1BA, ITGA2B, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CR2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNFMore
Pazopanibhsa04650Natural killer cell mediated cytotoxicity1.25E-2219P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1More
Pazopanibhsa04657IL-17 signaling pathway2.67E-0815P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, S100A9, IL1BMore
Pazopanibhsa04658Th1 and Th2 cell differentiation1.39E-3317P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, RUNX3More
Pazopanibhsa04659Th17 cell differentiation2.11E-2418P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Pazopanibhsa04660T cell receptor signaling pathway9.95E-2219P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Pazopanibhsa04662B cell receptor signaling pathway7.41E-1514P25963, P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049NFKBIA, AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Pazopanibhsa04664Fc epsilon RI signaling pathway9.21E-089P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5More
Pazopanibhsa04666Fc gamma R-mediated phagocytosis2.40E-038P08637, O75015, P07948, P42338, P19174, P04049, P06396, P14598FCGR3A, FCGR3B, LYN, PIK3CB, PLCG1, RAF1, GSN, NCF1More
Pazopanibhsa04668TNF signaling pathway7.83E-0712P01375, Q12933, O00463, Q16539, Q99941, P18848, P19875, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, CXCL2, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Pazopanibhsa04710Circadian rhythm2.11E-031O15516CLOCKMore
Pazopanibhsa04713Circadian entrainment3.32E-0710P0DP23, P0DP24, Q13557, Q02153, P62873, P63218, P50151, P61952, Q08828, P51828CALM1, CALM2, CAMK2D, GUCY1B3, GNB1, GNG5, GNG10, GNG11, ADCY1, ADCY7More
Pazopanibhsa04714Thermogenesis4.42E-024Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Pazopanibhsa04720Long-term potentiation5.72E-1010Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1More
Pazopanibhsa04721Synaptic vesicle cycle9.45E-042Q13488, P31645TCIRG1, SLC6A4More
Pazopanibhsa04722Neurotrophin signaling pathway1.76E-0610Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, IRAK1, BCL2, CALM1More
Pazopanibhsa04723Retrograde endocannabinoid signaling3.71E-024P62873, P61952, Q08828, O15239GNB1, GNG11, ADCY1, NDUFA1More
Pazopanibhsa04724Glutamatergic synapse2.59E-067O15399, Q08828, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLULMore
Pazopanibhsa04725Cholinergic synapse5.31E-0710Q08828, P51828, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2More
Pazopanibhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Pazopanibhsa04727GABAergic synapse2.45E-099Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1More
Pazopanibhsa04728Dopaminergic synapse9.23E-0916P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP24, P0DP23, O15516, P48058GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM2, CALM1, CLOCK, GRIA4More
Pazopanibhsa04730Long-term depression1.25E-042P08069, P04049IGF1R, RAF1More
Pazopanibhsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Pazopanibhsa04742Taste transduction1.18E-032P30939, P17612HTR1F, PRKACAMore
Pazopanibhsa04744Phototransduction1.45E-083P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Pazopanibhsa04750Inflammatory mediator regulation of TRP channels3.52E-1211P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM2, CALM1More
Pazopanibhsa04810Regulation of actin cytoskeleton2.03E-0310P12814, Q13009, P04049, P42338, P11215, P16144, Q14344, Q9NRA1, P60709, P01042ACTN1, TIAM1, RAF1, PIK3CB, ITGAM, ITGB4, GNA13, PDGFC, ACTB, KNG1More
Pazopanibhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Pazopanibhsa04911Insulin secretion4.38E-085Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Pazopanibhsa04912GnRH signaling pathway5.04E-067Q08828, P51828, P18848, Q9Y6R4, P0DP23, P04049, P45985ADCY1, ADCY7, ATF4, MAP3K4, CALM1, RAF1, MAP2K4More
Pazopanibhsa04913Ovarian steroidogenesis5.67E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Pazopanibhsa04914Progesterone-mediated oocyte maturation5.29E-0910P08069, Q17RY0, P42338, Q13370, Q9Y6D9, P30304, P08238, P51812, Q02750, P04049IGF1R, CPEB4, PIK3CB, PDE3B, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Pazopanibhsa04915Estrogen signaling pathway1.37E-1012P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Pazopanibhsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Pazopanibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Pazopanibhsa04918Thyroid hormone synthesis2.47E-045Q08828, Q99941, P18848, P02768, P05543ADCY1, CREBL1, ATF4, ALB, SERPINA7More
Pazopanibhsa04919Thyroid hormone signaling pathway1.21E-047P19174, P04049, P42224, P60709, Q13547, Q9UM47, P01106PLCG1, RAF1, STAT1, ACTB, HDAC1, NOTCH3, MYCMore
Pazopanibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Pazopanibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Pazopanibhsa04922Glucagon signaling pathway4.86E-044P14618, P06737, P31751, P0DP23PKM2, PYGL, AKT2, CALM1More
Pazopanibhsa04923Regulation of lipolysis in adipocytes4.29E-077Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2More
Pazopanibhsa04924Renin secretion3.10E-064P22694, P07550, Q14643, P0DP23PRKACB, ADRB2, ITPR1, CALM1More
Pazopanibhsa04925Aldosterone synthesis and secretion3.39E-108Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Pazopanibhsa04926Relaxin signaling pathway5.04E-1017P31751, P25963, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P22694, P49767, P14780, Q08828, P51828, P04049, P30679, P49407AKT2, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, PRKACB, VEGFC, MMP9, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Pazopanibhsa04927Cortisol synthesis and secretion1.27E-065Q99941, P18848, Q08828, P51828, P22694CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Pazopanibhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Pazopanibhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Pazopanibhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Pazopanibhsa04932Non-alcoholic fatty liver disease2.82E-1314P31751, P01375, P49841, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298, P19404AKT2, TNF, GSK3B, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2, NDUFV2More
Pazopanibhsa04934Cushing syndrome6.22E-096Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Pazopanibhsa04935Growth hormone synthesis, secretion and action5.87E-046Q08828, P51828, P04049, P18848, P31751, P45985ADCY1, ADCY7, RAF1, ATF4, AKT2, MAP2K4More
Pazopanibhsa04940Type I diabetes mellitus7.38E-044P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Pazopanibhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Pazopanibhsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Pazopanibhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Pazopanibhsa04966Collecting duct acid secretion2.17E-031P00918CA2More
Pazopanibhsa04970Salivary secretion1.31E-1010P07550, Q08828, P51828, P22694, Q14643, P23634, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, CALM2, CALM1, GUCY1B3, CAMPMore
Pazopanibhsa04971Gastric acid secretion1.49E-086Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Pazopanibhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Pazopanibhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Pazopanibhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Pazopanibhsa04976Bile secretion1.97E-043Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Pazopanibhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Pazopanibhsa05010Alzheimer disease3.15E-1021P49768, Q92542, O15239, O95298, P19404, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, Q12933, P18848, O15169, P67870, P31751, P05141, P45880, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFC2, NDUFV2, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, AXIN1, CSNK2B, AKT2, SLC25A5, VDAC2, PSMB4, PSMC4More
Pazopanibhsa05012Parkinson disease9.83E-0519O15239, O95298, P13073, P12074, P05496, P05141, P12236, P21796, P60604, O75460, P18848, P28070, P43686, P19174, P0DP23, P0DP24, Q13557, Q71U36, Q13509NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, VDAC1, UBE2G2, ERN1, ATF4, PSMB4, PSMC4, PLCG1, CALM1, CALM2, CAMK2D, TUBA1A, TUBB3More
Pazopanibhsa05014Amyotrophic lateral sclerosis6.58E-0315P01375, Q16718, P19404, O14521, P12074, P36542, O75460, P28070, Q8TEV9, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, NDUFV2, SDHD, COX6A1, ATP5C1, ERN1, PSMB4, SMCR8, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Pazopanibhsa05016Huntington disease1.51E-0612O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Pazopanibhsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Pazopanibhsa05020Prion disease9.03E-0717P01584, P46531, P0DMV8, P11142, O15239, O95298, P05496, P13073, P12074, P18848, P05141, P12236, P45880, P28070, P43686, P67870, Q99941IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFC2, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, SLC25A6, VDAC2, PSMB4, PSMC4, CSNK2B, CREBL1More
Pazopanibhsa05022Pathways of neurodegeneration - multiple diseases1.42E-0826P67870, O15239, O95298, P19404, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, P05141, P45880, Q15078, Q00535, O15169, P01584, P49768, O15020, P0DP24, P0DP23, Q13557, P62987, P28070, P43686CSNK2B, NDUFA1, NDUFC2, NDUFV2, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, SLC25A5, VDAC2, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, SPTBN2, CALM2, CALM1, CAMK2D, UBA52, PSMB4, PSMC4More
Pazopanibhsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Pazopanibhsa05031Amphetamine addiction6.41E-067P0DP24, P0DP23, Q13557, P22694, Q99941, P18848, Q13547CALM2, CALM1, CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Pazopanibhsa05032Morphine addiction4.50E-047P62873, P63218, P50151, Q13370, P78334, P32298, P43250GNB1, GNG5, GNG10, PDE3B, GABRE, GRK4, GRK6More
Pazopanibhsa05033Nicotine addiction4.01E-021P78334GABREMore
Pazopanibhsa05034Alcoholism1.46E-0717Q99941, P18848, Q13547, P0DP23, P0DP24, P62873, P63218, P50151, P61952, P04049, P0C0S5, Q93077, P62807, Q93079, Q16778, O60814, P68431CREBL1, ATF4, HDAC1, CALM1, CALM2, GNB1, GNG5, GNG10, GNG11, RAF1, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pazopanibhsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Pazopanibhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Pazopanibhsa05120Epithelial cell signaling in Helicobacter pylori infection2.10E-1210Q16539, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240MAPK14, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSKMore
Pazopanibhsa05130Pathogenic Escherichia coli infection2.77E-039P16333, Q13509, P60709, P25963, P04406, P29350, Q15438, P35579, P55061NCK1, TUBB3, ACTB, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Pazopanibhsa05131Shigellosis2.79E-0514Q12933, Q13546, Q05655, Q02156, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q12778, Q13315, P10415, P07737TRAF2, RIPK1, PRKCD, PRKCE, MALT1, RRAGD, UBB, SEPT6, ELMO2, PTK2, FOXO1, ATM, BCL2, PFN1More
Pazopanibhsa05132Salmonella infection3.88E-0921P51617, P25963, P08238, P04049, Q9UJU2, P01106, P84095, P60709, P42338, Q13546, Q13489, P10415, P04406, O75369, P07737, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, PIK3CB, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41More
Pazopanibhsa05133Pertussis1.55E-063P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Pazopanibhsa05134Legionellosis1.05E-099P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Pazopanibhsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Pazopanibhsa05140Leishmaniasis7.67E-0813P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Pazopanibhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Pazopanibhsa05143African trypanosomiasis5.79E-064P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Pazopanibhsa05144Malaria4.74E-079P60033, P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Pazopanibhsa05146Amoebiasis1.78E-1813P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Pazopanibhsa05150Staphylococcus aureus infection1.11E-0915P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Pazopanibhsa05152Tuberculosis1.04E-047P04049, P0DP23, P48382, P31751, P10415, Q9UDY8, P51617RAF1, CALM1, RFX5, AKT2, BCL2, MALT1, IRAK1More
Pazopanibhsa05160Hepatitis C1.31E-047Q13546, P01568, P60033, P04049, P49841, P01375, P48023RIPK1, IFNA21, CD81, RAF1, GSK3B, TNF, FASLGMore
Pazopanibhsa05161Hepatitis B4.32E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Pazopanibhsa05162Measles3.90E-0513P01568, P25963, P23458, P42224, P14784, P07766, P42338, P31751, P0DMV8, P11142, P01584, P67870, Q9NP90IFNA21, NFKBIA, JAK1, STAT1, IL2RB, CD3E, PIK3CB, AKT2, HSPA1A, HSPA8, IL1B, CSNK2B, RAB9BMore
Pazopanibhsa05163Human cytomegalovirus infection5.97E-1331P31751, P42338, P04049, P01375, P25963, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P01106, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769, P01568AKT2, PIK3CB, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, MYC, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2M, IFNA21More
Pazopanibhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Pazopanibhsa05165Human papillomavirus infection2.80E-0410P02452, P24821, Q16363, P30281, Q9UM47, P01568, P01889, P10321, Q99437, P04628COL1A1, TNC, LAMA4, CCND3, NOTCH3, IFNA21, HLA-B, HLA-C, ATP6V0B, WNT1More
Pazopanibhsa05166Human T-cell leukemia virus 1 infection4.88E-0312P23458, P01106, P05141, P62826, Q08828, P51828, P18848, P30260, O60566, P31751, P42773, P01730JAK1, MYC, SLC25A5, RAN, ADCY1, ADCY7, ATF4, CDC27, BUB1B, AKT2, CDKN2C, CD4More
Pazopanibhsa05167Kaposi sarcoma-associated herpesvirus infection1.36E-0713P01568, P31751, P42224, P25963, P42338, P62873, P63218, P50151, P19174, P04049, P07948, P01106, P0DP23IFNA21, AKT2, STAT1, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, PLCG1, RAF1, LYN, MYC, CALM1More
Pazopanibhsa05168Herpes simplex virus 1 infection1.30E-0525O00463, O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q16629, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, Q9NR11, Q9HCX3, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, SFRS7, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Pazopanibhsa05169Epstein-Barr virus infection1.16E-0820P13765, P01106, Q13547, O00463, P25963, P10415, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, NFKBIA, BCL2, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Pazopanibhsa05170Human immunodeficiency virus 1 infection3.24E-0820P31751, P42338, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P51617, P25963, Q13315, P19174, P07766, P10415, Q9Y6Q5AKT2, PIK3CB, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, IRAK1, NFKBIA, ATM, PLCG1, CD3E, BCL2, AP1M2More
Pazopanibhsa05171Coronavirus disease - COVID-194.96E-1121P01584, P23396, P62753, P25398, P42677, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P62888, P46776, P62899, P62910, P18077, P61927, P61513, P05386, P62829IL1B, RPS3, RPS6, RPS12, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL30, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPLP1, RPL23More
Pazopanibhsa05200Pathways in cancer2.26E-0830P42338, P08238, P42224, P25963, P19174, P01106, Q9UJU2, P43246, Q13485, P20585, P52701, Q13547, P14923, P30279, P10415, Q13077, P49767, P14921, P31751, P62873, P63218, P50151, Q14344, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P01042PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, MSH2, SMAD4, MSH3, MSH6, HDAC1, JUP, CCND2, BCL2, TRAF1, VEGFC, ETS1, AKT2, GNB1, GNG5, GNG10, GNA13, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Pazopanibhsa05202Transcriptional misregulation in cancer5.74E-0818Q12778, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522FOXO1, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Pazopanibhsa05203Viral carcinogenesis1.04E-0721Q12933, Q99941, P18848, P42338, P06746, P07948, P30281, P27348, P29083, Q13547, Q15283, P06396, P12814, P25963, P01889, P10321, P06493, P62807, Q93079, Q16778, O60814TRAF2, CREBL1, ATF4, PIK3CB, POLB, LYN, CCND3, YWHAQ, GTF2E1, HDAC1, RASA2, GSN, ACTN1, NFKBIA, HLA-B, HLA-C, CDK1, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12More
Pazopanibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Pazopanibhsa05205Proteoglycans in cancer9.53E-0615Q13009, Q12955, O75369, P60709, P04049, P14780, P01106, P01375, P08069, P23588, P19174, Q13635, P22694, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MMP9, MYC, TNF, IGF1R, EIF4B, PLCG1, PTCH1, PRKACB, PTPN6, CD63More
Pazopanibhsa05206MicroRNAs in cancer1.17E-0414P30304, P09493, P15311, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P20827, P19174, P04049CDC25A, TPM1, VIL2, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, EFNA1, PLCG1, RAF1More
Pazopanibhsa05210Colorectal cancer1.47E-049Q9UKG1, Q13485, P43246, P04049, P01106, P52701, P20585, P37173, O75293APPL1, SMAD4, MSH2, RAF1, MYC, MSH6, MSH3, TGFBR2, GADD45BMore
Pazopanibhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Pazopanibhsa05212Pancreatic cancer5.93E-044P31751, P04049, Q15311, P23458AKT2, RAF1, RALBP1, JAK1More
Pazopanibhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Pazopanibhsa05214Glioma6.04E-077P08069, P0DP23, P04049, P42338, P31751, P19174, O75293IGF1R, CALM1, RAF1, PIK3CB, AKT2, PLCG1, GADD45BMore
Pazopanibhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Pazopanibhsa05217Basal cell carcinoma4.31E-022P04628, Q9UJU2WNT1, LEF1More
Pazopanibhsa05218Melanoma3.78E-056P08069, Q9NRA1, P31751, P42338, P04049, O75293IGF1R, PDGFC, AKT2, PIK3CB, RAF1, GADD45BMore
Pazopanibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Pazopanibhsa05220Chronic myeloid leukemia2.10E-047Q13547, P01106, P25963, P31751, P42338, P04049, O75293HDAC1, MYC, NFKBIA, AKT2, PIK3CB, RAF1, GADD45BMore
Pazopanibhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Pazopanibhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Pazopanibhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Pazopanibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Pazopanibhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Pazopanibhsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Pazopanibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Pazopanibhsa05231Choline metabolism in cancer2.98E-0811P04049, P31751, P42338, Q9NRA1, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494RAF1, AKT2, PIK3CB, PDGFC, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1More
Pazopanibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.67E-1617P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Pazopanibhsa05310Asthma7.64E-083P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Pazopanibhsa05321Inflammatory bowel disease5.66E-157O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Pazopanibhsa05322Systemic lupus erythematosus1.44E-0715P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q93077, P62807, Q16778, O60814, P68431, P14678, P12814FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SNRPB, ACTN1More
Pazopanibhsa05323Rheumatoid arthritis1.89E-047P01375, Q06643, P13765, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, CD28, CXCL1, CXCL2, TLR2More
Pazopanibhsa05330Allograft rejection2.02E-034P13765, P48023, P10747, P01375HLA-DOB, FASLG, CD28, TNFMore
Pazopanibhsa05332Graft-versus-host disease1.54E-136P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Pazopanibhsa05340Primary immunodeficiency2.96E-046P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Pazopanibhsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Pazopanibhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Pazopanibhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Pazopanibhsa05415Diabetic cardiomyopathy1.49E-0410P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P14780, P37173, P04406PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9, TGFBR2, GAPDHMore
Pazopanibhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Pazopanib (SDC: 12.15)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09619PDGFRBPlateletNonederived growth factor receptor betaReported00.04960.94440.74082.6543
Q08881ITKTyrosineNoneprotein kinase ITK/TSKReported10.16350.55450.4221.6127
Q9UQQ2SH2B3SH2B adapter protein 3Reported00.43760.00670.16830.4005
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P40925MDH1Malate dehydrogenase, cytoplasmicPredicted00.35660.27460.24260.97
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
PDGFRBP09619IC5083
PDGFRBP09619Kd2
PDGFRBP09619Kd2
ITKQ08881Kd>10000