PharmaCoNets of Paroxetine (SPCN: 177.41 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Paroxetinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Paroxetinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Paroxetinehsa00190Oxidative phosphorylation1.03E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Paroxetinehsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Paroxetinehsa00500Starch and sucrose metabolism6.40E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Paroxetinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Paroxetinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Paroxetinehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Paroxetinehsa00730Thiamine metabolism5.86E-042P05186, P24666ALPL, ACP1More
Paroxetinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Paroxetinehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Paroxetinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Paroxetinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Paroxetinehsa00983Drug metabolism - other enzymes2.46E-033P04183, P32320, P05164TK1, CDA, MPOMore
Paroxetinehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Paroxetinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Paroxetinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Paroxetinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Paroxetinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Paroxetinehsa01522Endocrine resistance2.16E-021P04049RAF1More
Paroxetinehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Paroxetinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Paroxetinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Paroxetinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Paroxetinehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Paroxetinehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Paroxetinehsa04014Ras signaling pathway3.65E-021P04049RAF1More
Paroxetinehsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Paroxetinehsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Paroxetinehsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Paroxetinehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Paroxetinehsa04061Viral protein interaction with cytokine and cytokine receptor1.32E-026P09341, P25024, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Paroxetinehsa04062Chemokine signaling pathway2.83E-0310P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881, P04049CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITK, RAF1More
Paroxetinehsa04064NF-kappa B signaling pathway5.42E-0616P10415, Q13489, O00463, P14778, P29965, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, Q06643BCL2, BIRC3, TRAF5, IL1R1, CD40LG, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, LTBMore
Paroxetinehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Paroxetinehsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Paroxetinehsa04071Sphingolipid signaling pathway5.70E-069P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Paroxetinehsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Paroxetinehsa04080Neuroactive ligand-receptor interaction2.16E-039P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2More
Paroxetinehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Paroxetinehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Paroxetinehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Paroxetinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Paroxetinehsa04140Autophagy - animal2.82E-021P04049RAF1More
Paroxetinehsa04145Phagosome1.59E-037Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Paroxetinehsa04150mTOR signaling pathway7.74E-034P04049, Q02750, Q9NQL2, P51812RAF1, MAP2K1, RRAGD, RPS6KA3More
Paroxetinehsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Paroxetinehsa04210Apoptosis5.97E-0411Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, P18848, Q14643, P04049ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ATF4, ITPR1, RAF1More
Paroxetinehsa04217Necroptosis7.46E-0613P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, P10415, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP2A, PPIDMore
Paroxetinehsa04218Cellular senescence2.49E-021P04049RAF1More
Paroxetinehsa04261Adrenergic signaling in cardiomyocytes2.31E-038P09493, P07550, P22694, P18848, Q13362, P0DP23, P17252, P10415TPM1, ADRB2, PRKACB, ATF4, PPP2R5C, CALM1, PRKCA, BCL2More
Paroxetinehsa04270Vascular smooth muscle contraction2.75E-033P04049, P35579, P35318RAF1, MYH9, ADMMore
Paroxetinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Paroxetinehsa04360Axon guidance2.49E-021P04049RAF1More
Paroxetinehsa04370VEGF signaling pathway1.79E-044P16298, Q05397, Q02750, P04049PPP3CB, PTK2, MAP2K1, RAF1More
Paroxetinehsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Paroxetinehsa04510Focal adhesion3.48E-021P04049RAF1More
Paroxetinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Paroxetinehsa04540Gap junction2.79E-035P17252, Q13509, P68371, P04049, Q14643PRKCA, TUBB3, TUBB2C, RAF1, ITPR1More
Paroxetinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Paroxetinehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Paroxetinehsa04612Antigen processing and presentation1.25E-059P13765, P48382, P01730, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Paroxetinehsa04613Neutrophil extracellular trap formation3.41E-0515P17252, P04049, O60603, P08246, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539PRKCA, RAF1, TLR2, ELA2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14More
Paroxetinehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Paroxetinehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Paroxetinehsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Paroxetinehsa04640Hematopoietic cell lineage3.30E-0511P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOBMore
Paroxetinehsa04650Natural killer cell mediated cytotoxicity3.69E-0814P16298, P50591, P01375, P06239, O60880, P20963, Q02750, P04049, Q13241, P26718, O14931, P26717, Q14953, P26715PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Paroxetinehsa04657IL-17 signaling pathway3.73E-048O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Paroxetinehsa04658Th1 and Th2 cell differentiation2.44E-0711Q04759, P07766, P20963, P09693, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Paroxetinehsa04659Th17 cell differentiation4.63E-0611Q04759, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Paroxetinehsa04660T cell receptor signaling pathway4.20E-0510Q04759, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049PRKCQ, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1More
Paroxetinehsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Paroxetinehsa04664Fc epsilon RI signaling pathway3.33E-043Q9UQC2, P04049, P20292GAB2, RAF1, ALOX5APMore
Paroxetinehsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Paroxetinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Paroxetinehsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Paroxetinehsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Paroxetinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Paroxetinehsa04720Long-term potentiation7.18E-047P17252, P16298, P0DP23, P51812, Q02750, P04049, Q14643PRKCA, PPP3CB, CALM1, RPS6KA3, MAP2K1, RAF1, ITPR1More
Paroxetinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Paroxetinehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Paroxetinehsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Paroxetinehsa04725Cholinergic synapse2.42E-036P22694, Q14643, P17252, P62873, P18848, P10415PRKACB, ITPR1, PRKCA, GNB1, ATF4, BCL2More
Paroxetinehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Paroxetinehsa04728Dopaminergic synapse3.55E-025Q14643, P17252, P62873, Q13362, P0DP23ITPR1, PRKCA, GNB1, PPP2R5C, CALM1More
Paroxetinehsa04730Long-term depression1.16E-021P04049RAF1More
Paroxetinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Paroxetinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Paroxetinehsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Paroxetinehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Paroxetinehsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Paroxetinehsa04912GnRH signaling pathway2.12E-024P17252, Q14643, P0DP23, P04049PRKCA, ITPR1, CALM1, RAF1More
Paroxetinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Paroxetinehsa04914Progesterone-mediated oocyte maturation5.89E-034Q17RY0, P51812, Q02750, P04049CPEB4, RPS6KA3, MAP2K1, RAF1More
Paroxetinehsa04915Estrogen signaling pathway3.15E-026P14780, P22694, P04049, P18848, Q14643, P10415MMP9, PRKACB, RAF1, ATF4, ITPR1, BCL2More
Paroxetinehsa04916Melanogenesis1.33E-021P04049RAF1More
Paroxetinehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Paroxetinehsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Paroxetinehsa04919Thyroid hormone signaling pathway6.83E-045P49841, P04049, P22694, O60244, Q9NVC6GSK3B, RAF1, PRKACB, MED14, MED17More
Paroxetinehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Paroxetinehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Paroxetinehsa04924Renin secretion7.38E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Paroxetinehsa04926Relaxin signaling pathway6.24E-035P18848, P22694, P14780, P04049, P30679ATF4, PRKACB, MMP9, RAF1, GNA15More
Paroxetinehsa04927Cortisol synthesis and secretion4.44E-043Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Paroxetinehsa04928Parathyroid hormone synthesis, secretion and action9.56E-036Q14643, P22694, P23771, P04049, P18848, P10415ITPR1, PRKACB, GATA3, RAF1, ATF4, BCL2More
Paroxetinehsa04929GnRH secretion4.98E-031P04049RAF1More
Paroxetinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Paroxetinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Paroxetinehsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Paroxetinehsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Paroxetinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Paroxetinehsa04962Vasopressin-regulated water reabsorption7.22E-032P52566, P62491ARHGDIB, RAB11AMore
Paroxetinehsa04966Collecting duct acid secretion8.41E-044Q13488, P02730, P00918, Q9Y666TCIRG1, SLC4A1, CA2, SLC12A7More
Paroxetinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Paroxetinehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Paroxetinehsa05010Alzheimer disease3.55E-027Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPIDMore
Paroxetinehsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Paroxetinehsa05020Prion disease1.31E-039Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14More
Paroxetinehsa05022Pathways of neurodegeneration - multiple diseases2.00E-0412Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, P17252, Q16539, Q08752, P0DP23ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, MAPK14, PPID, CALM1More
Paroxetinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Paroxetinehsa05034Alcoholism2.25E-057Q96RR4, P04049, Q93077, P62807, O60814, P84243, P68431CAMKK2, RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Paroxetinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Paroxetinehsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Paroxetinehsa05132Salmonella infection7.93E-039P04049, Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371RAF1, LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Paroxetinehsa05133Pertussis4.94E-021P0C0L4C4AMore
Paroxetinehsa05140Leishmaniasis1.00E-0510O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4More
Paroxetinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Paroxetinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Paroxetinehsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Paroxetinehsa05146Amoebiasis1.06E-0411P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Paroxetinehsa05152Tuberculosis9.31E-049P04049, Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8RAF1, TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Paroxetinehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Paroxetinehsa05161Hepatitis B1.99E-021P04049RAF1More
Paroxetinehsa05163Human cytomegalovirus infection4.00E-028P04049, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463RAF1, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Paroxetinehsa05164Influenza A3.65E-021P04049RAF1More
Paroxetinehsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Paroxetinehsa05167Kaposi sarcoma-associated herpesvirus infection9.70E-0411P01568, P42224, P62873, P62879, P16298, Q14643, P04049, Q02750, P0DP23, P0CG47, Q9UJU2IFNA21, STAT1, GNB1, GNB2, PPP3CB, ITPR1, RAF1, MAP2K1, CALM1, UBB, LEF1More
Paroxetinehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Paroxetinehsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Paroxetinehsa05170Human immunodeficiency virus 1 infection1.90E-0515P04049, Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1BMore
Paroxetinehsa05200Pathways in cancer4.99E-0212P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21More
Paroxetinehsa05202Transcriptional misregulation in cancer1.77E-0211Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Paroxetinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Paroxetinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Paroxetinehsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Paroxetinehsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Paroxetinehsa05210Colorectal cancer1.66E-021P04049RAF1More
Paroxetinehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Paroxetinehsa05212Pancreatic cancer1.16E-021P04049RAF1More
Paroxetinehsa05213Endometrial cancer4.26E-033O15169, Q02750, P04049AXIN1, MAP2K1, RAF1More
Paroxetinehsa05214Glioma9.95E-031P04049RAF1More
Paroxetinehsa05215Prostate cancer1.33E-021P04049RAF1More
Paroxetinehsa05218Melanoma9.63E-044P09619, Q9GZP0, Q02750, P04049PDGFRB, PDGFD, MAP2K1, RAF1More
Paroxetinehsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Paroxetinehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Paroxetinehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Paroxetinehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Paroxetinehsa05224Breast cancer1.24E-025P04049, P49841, Q92837, P04637, P24522RAF1, GSK3B, FRAT1, TP53, GADD45AMore
Paroxetinehsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Paroxetinehsa05226Gastric cancer3.26E-033P04049, Q02750, O15169RAF1, MAP2K1, AXIN1More
Paroxetinehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Paroxetinehsa05231Choline metabolism in cancer1.49E-035Q02750, P04049, P09619, Q9GZP0, O15245MAP2K1, RAF1, PDGFRB, PDGFD, SLC22A1More
Paroxetinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.40E-0410O95267, P07766, P20963, P09693, P06239, P04049, O60603, Q04759, Q16539, P01730RASGRP1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, PRKCQ, MAPK14, CD4More
Paroxetinehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Paroxetinehsa05321Inflammatory bowel disease1.19E-036P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Paroxetinehsa05322Systemic lupus erythematosus4.80E-0610P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Paroxetinehsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Paroxetinehsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Paroxetinehsa05332Graft-versus-host disease2.27E-066P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Paroxetinehsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Paroxetinehsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Paroxetinehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Paroxetinehsa05415Diabetic cardiomyopathy5.60E-058P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Paroxetinehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Paroxetinehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Paroxetine (SDC: 7.37)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FReported00.000910.01982.0202
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
SLC6A4P31645IC500.2
SLC6A4P31645IC500.56
SLC6A4P31645IC502
SLC6A4P31645Ki0.04
SLC6A4P31645Ki0.06
SLC6A4P31645Ki0.077
SLC6A4P31645Kd0.13
DRD2P14416Ki>10000