PharmaCoNets of Pargyline (SPCN: 8.50 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pargylinehsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Pargylinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Pargylinehsa00190Oxidative phosphorylation4.36E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Pargylinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Pargylinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Pargylinehsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Pargylinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Pargylinehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Pargylinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Pargylinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Pargylinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Pargylinehsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Pargylinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Pargylinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Pargylinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Pargylinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Pargylinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Pargylinehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Pargylinehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Pargylinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Pargylinehsa05140Leishmaniasis4.50E-035P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Pargylinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Pargylinehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Pargylinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Pargylinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Pargylinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Pargylinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Pargyline (SDC: 2.99)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)