PharmaCoNets of Parecoxib (SPCN: 229.27 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Parecoxibhsa00020Citrate cycle (TCA cycle)4.06E-044Q9P2R7, P50213, P40925, O14521SUCLA2, IDH3A, MDH1, SDHDMore
Parecoxibhsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Parecoxibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Parecoxibhsa00071Fatty acid degradation3.65E-034O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Parecoxibhsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Parecoxibhsa00190Oxidative phosphorylation3.78E-073Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Parecoxibhsa00220Arginine biosynthesis4.62E-043P15104, P05089, P49448GLUL, ARG1, GLUD2More
Parecoxibhsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Parecoxibhsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Parecoxibhsa00310Lysine degradation3.15E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Parecoxibhsa00380Tryptophan metabolism1.33E-022P46952, P51648HAAO, ALDH3A2More
Parecoxibhsa00500Starch and sucrose metabolism2.32E-053O43451, P46976, P06737MGAM, GYG1, PYGLMore
Parecoxibhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Parecoxibhsa00520Amino sugar and nucleotide sugar metabolism1.04E-033Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Parecoxibhsa00531Glycosaminoglycan degradation1.05E-032P15586, P34059GNS, GALNSMore
Parecoxibhsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate3.30E-021Q9Y2C2USTMore
Parecoxibhsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Parecoxibhsa00562Inositol phosphate metabolism1.91E-023P27987, Q13572, Q96PE3ITPKB, ITPK1, INPP4AMore
Parecoxibhsa00565Ether lipid metabolism3.52E-042Q9Y6K0, Q8N661CEPT1, TMEM86BMore
Parecoxibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Parecoxibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Parecoxibhsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Parecoxibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Parecoxibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Parecoxibhsa00630Glyoxylate and dicarboxylate metabolism6.08E-092P40925, P15104MDH1, GLULMore
Parecoxibhsa00730Thiamine metabolism2.49E-032P05186, P24666ALPL, ACP1More
Parecoxibhsa00750Vitamin B6 metabolism3.56E-021O00764PDXKMore
Parecoxibhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Parecoxibhsa00830Retinol metabolism1.64E-034P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Parecoxibhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Parecoxibhsa00910Nitrogen metabolism1.01E-033P22748, P15104, P49448CA4, GLUL, GLUD2More
Parecoxibhsa00970Aminoacyl-tRNA biosynthesis1.18E-064O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Parecoxibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Parecoxibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Parecoxibhsa00983Drug metabolism - other enzymes2.67E-045P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Parecoxibhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Parecoxibhsa01200Carbon metabolism1.01E-038P51854, P04406, P37837, P40925, O14521, Q9P2R7, P60891, Q02252TKTL1, GAPDH, TALDO1, MDH1, SDHD, SUCLA2, PRPS1, ALDH6A1More
Parecoxibhsa012102-Oxocarboxylic acid metabolism1.20E-031P50213IDH3AMore
Parecoxibhsa01230Biosynthesis of amino acids2.30E-045P51854, P60891, Q99707, P50213, P37837TKTL1, PRPS1, MTR, IDH3A, TALDO1More
Parecoxibhsa01240Biosynthesis of cofactors2.95E-022P13716, P14618ALAD, PKM2More
Parecoxibhsa01522Endocrine resistance6.77E-046P14780, P22694, Q9UM47, P46527, P10415, Q13323MMP9, PRKACB, NOTCH3, CDKN1B, BCL2, BIKMore
Parecoxibhsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Parecoxibhsa01524Platinum drug resistance4.67E-024Q13489, P98170, P78417, P43246BIRC3, BIRC4, GSTO1, MSH2More
Parecoxibhsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Parecoxibhsa03008Ribosome biogenesis in eukaryotes6.80E-056Q9NYH9, O14980, O60832, P78345, Q9BVP2, Q9GZY0UTP6, XPO1, DKC1, RPP38, GNL3, NXF2; NXF2BMore
Parecoxibhsa03013RNA transport3.68E-0818O14980, P52298, Q09161, O14893, P61326, Q9GZY0, P37198, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, Q06787, P51114, Q53GS7XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NXF2; NXF2B, NUP62, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FMR1, FXR1, GLE1More
Parecoxibhsa03015mRNA surveillance pathway1.64E-0411O60942, O43148, Q13362, Q16537, O94913, Q12996, P61326, Q9GZY0, Q09161, P52298, Q53GS7RNGTT, RNMT, PPP2R5C, PPP2R5E, PCF11, CSTF3, MAGOH, NXF2; NXF2B, NCBP1, NCBP2, GLE1More
Parecoxibhsa03020RNA polymerase6.47E-085P30876, P24928, P62487, Q9GZM3, P52435POLR2B, POLR2A, POLR2G, POLR2J2, POLR2JMore
Parecoxibhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Parecoxibhsa03040Spliceosome2.44E-1518Q14562, O43143, O60508, P08579, P26368, O75940, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O95777, O43447, O43395, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, LSM8, PPIH, PRPF3, ASCC3L1More
Parecoxibhsa03050Proteasome4.83E-021P55036PSMD4More
Parecoxibhsa03060Protein export2.97E-032P37108, Q15005SRP14, SPCS2More
Parecoxibhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Parecoxibhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Parecoxibhsa04012ErbB signaling pathway1.34E-024P16333, P19174, P42338, P01106NCK1, PLCG1, PIK3CB, MYCMore
Parecoxibhsa04014Ras signaling pathway2.92E-0612P42338, P20827, Q9NRA1, P49767, Q13009, P17252, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, PRKCA, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Parecoxibhsa04015Rap1 signaling pathway5.02E-0511P20827, Q9NRA1, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P0DP23, P17252, P19174EFNA1, PDGFC, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, CALM1, PRKCA, PLCG1More
Parecoxibhsa04020Calcium signaling pathway1.63E-0512P27987, P21796, Q16566, P17252, P30679, O15399, P19174, P0DP23, P20020, P23634, Q9NRA1, P49767ITPKB, VDAC1, CAMK4, PRKCA, GNA15, GRIN2D, PLCG1, CALM1, ATP2B1, ATP2B4, PDGFC, VEGFCMore
Parecoxibhsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Parecoxibhsa04060Cytokine-cytokine receptor interaction5.39E-0310P27930, P08476, Q13651, Q9HBE5, Q9UBD3, P47992, P01375, P09341, P18510, Q93038IL1R2, INHBA, IL10RA, IL21R, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25More
Parecoxibhsa04061Viral protein interaction with cytokine and cytokine receptor1.91E-0512Q8NHW4, P09341, P19875, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P14784, P09603, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, IL2RB, CSF1, TNFMore
Parecoxibhsa04062Chemokine signaling pathway2.79E-0823P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P14598, P22694, P42224, P25963, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, NCF1, PRKACB, STAT1, NFKBIA, GSK3B, PIK3R5More
Parecoxibhsa04064NF-kappa B signaling pathway6.54E-1426P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, P67870, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, CSNK2B, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Parecoxibhsa04070Phosphatidylinositol signaling system1.34E-036P19174, P0DP23, P42338, P23743, P27987, P17252PLCG1, CALM1, PIK3CB, DGKA, ITPKB, PRKCAMore
Parecoxibhsa04071Sphingolipid signaling pathway2.33E-0910P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2More
Parecoxibhsa04072Phospholipase D signaling pathway5.49E-038P42338, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFCMore
Parecoxibhsa04080Neuroactive ligand-receptor interaction3.69E-0610P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2More
Parecoxibhsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Parecoxibhsa04114Oocyte meiosis1.75E-055Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Parecoxibhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Parecoxibhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Parecoxibhsa04137Mitophagy - animal3.24E-024Q96CV9, Q9H1Y0, P18848, O43524OPTN, ATG5, ATF4, FOXO3More
Parecoxibhsa04140Autophagy - animal3.10E-057Q9Y4H2, Q9NQL2, P22694, Q14643, P10415, Q9H1Y0, Q04759IRS2, RRAGD, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Parecoxibhsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Parecoxibhsa04142Lysosome8.21E-0511P43234, P06865, P15586, P22304, P34059, P38571, Q13510, P07602, Q9NRA2, P49281, P61916CTSO, HEXA, GNS, IDS, GALNS, LIPA, ASAH1, PSAP, SLC17A5, SLC11A2, NPC2More
Parecoxibhsa04144Endocytosis1.13E-0314Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5More
Parecoxibhsa04145Phagosome7.09E-0913O75015, P60709, P63261, Q15075, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765FCGR3B, ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Parecoxibhsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Parecoxibhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Parecoxibhsa04151PI3K-Akt signaling pathway5.97E-0625P62753, P42338, P43657, P01106, O43521, P27348, P09603, P20827, Q9NRA1, P49767, Q9GZP0, P08238, Q8WYR1, P62873, P63218, P50151, P13612, O15335, Q13751, P14784, P01568, P18848, O00141, Q6ZUJ8, P30281RPS6, PIK3CB, P2RY5, MYC, BCL2L11, YWHAQ, CSF1, EFNA1, PDGFC, VEGFC, PDGFD, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGA4, CHAD, LAMB3, IL2RB, IFNA21, ATF4, SGK, PIK3AP1, CCND3More
Parecoxibhsa04210Apoptosis2.40E-0412Q13315, P04637, P10415, O76075, O75460, P24522, Q16548, O43521, P43234, P18848, Q14643, P63261ATM, TP53, BCL2, DFFB, ERN1, GADD45A, BCL2A1, BCL2L11, CTSO, ATF4, ITPR1, ACTG1More
Parecoxibhsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Parecoxibhsa04213Longevity regulating pathway - multiple species2.70E-037P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Parecoxibhsa04216Ferroptosis1.45E-022P04637, P49281TP53, SLC11A2More
Parecoxibhsa04217Necroptosis3.30E-0922P01375, P01568, P48023, Q13489, P98170, Q13546, P42224, Q14765, P08238, P15104, P05141, P01584, P07384, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q9H444, O43633, P21796, Q08752TNF, IFNA21, FASLG, BIRC3, BIRC4, RIPK1, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, CAPN1, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP4B, CHMP2A, VDAC1, PPIDMore
Parecoxibhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Parecoxibhsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Parecoxibhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Parecoxibhsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Parecoxibhsa04340Hedgehog signaling pathway9.48E-054P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Parecoxibhsa04360Axon guidance1.75E-069P16333, P20827, O95631, P17252, P42338, P07332, P23528, P19174, Q06124NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, CFL1, PLCG1, PTPN11More
Parecoxibhsa04370VEGF signaling pathway7.07E-073P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Parecoxibhsa04371Apelin signaling pathway1.88E-0811P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Parecoxibhsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Parecoxibhsa04390Hippo signaling pathway2.30E-023P63261, P04628, O43623ACTG1, WNT1, SNAI2More
Parecoxibhsa04510Focal adhesion4.64E-026O75369, Q15942, Q13489, P10415, P49767, P63261FLNB, ZYX, BIRC3, BCL2, VEGFC, ACTG1More
Parecoxibhsa04512ECM-receptor interaction3.11E-035Q13751, P13612, P26012, O15335, P16070LAMB3, ITGA4, ITGB8, CHAD, CD44More
Parecoxibhsa04530Tight junction1.74E-036P63261, P16989, P56750, Q9Y478, Q92974, Q14247ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTNMore
Parecoxibhsa04540Gap junction1.27E-046P17252, P22694, Q13509, P68371, Q9NRA1, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, PDGFC, ITPR1More
Parecoxibhsa04550Signaling pathways regulating pluripotency of stem cells2.68E-036P04628, P40189, Q13873, Q02750, P14653, Q86SE9WNT1, IL6ST, BMPR2, MAP2K1, HOXB1, PCGF5More
Parecoxibhsa04610Complement and coagulation cascades3.71E-082P00734, P0C0L4F2, C4AMore
Parecoxibhsa04612Antigen processing and presentation1.12E-099P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Parecoxibhsa04613Neutrophil extracellular trap formation1.14E-1230P42338, P19174, P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, Q93079, O60814, P68431, P21796, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, P63261, O43315, Q16539PIK3CB, PLCG1, PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, ACTG1, AQP9, MAPK14More
Parecoxibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Parecoxibhsa04620Toll-like receptor signaling pathway5.54E-035Q13546, P01568, P42224, P25963, P42338RIPK1, IFNA21, STAT1, NFKBIA, PIK3CBMore
Parecoxibhsa04621NOD-like receptor signaling pathway1.05E-0620Q16539, Q14643, P01568, P21796, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838MAPK14, ITPR1, IFNA21, VDAC1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Parecoxibhsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Parecoxibhsa04623Cytosolic DNA-sensing pathway9.87E-105P01584, P01568, Q13546, P25963, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2More
Parecoxibhsa04625C-type lectin receptor signaling pathway8.55E-0513Q9ULY5, P01584, Q9NQC7, P42224, P20749, P25963, Q14643, P01375, Q13191, P42338, P0DP24, P0DP23, Q16539CLEC4E, IL1B, CYLD, STAT1, BCL3, NFKBIA, ITPR1, TNF, CBLB, PIK3CB, CALM2, CALM1, MAPK14More
Parecoxibhsa04630JAK-STAT signaling pathway4.43E-023P48551, P40189, Q06124IFNAR2, IL6ST, PTPN11More
Parecoxibhsa04640Hematopoietic cell lineage2.98E-0817P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P09603, P01584ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, CSF1, IL1BMore
Parecoxibhsa04650Natural killer cell mediated cytotoxicity2.46E-1717P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Parecoxibhsa04657IL-17 signaling pathway2.41E-1115P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P19875, P14780, Q9UJX4, P04141, P80188, P01375, P06702, P01584NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, ANAPC5, CSF2, LCN2, TNF, S100A9, IL1BMore
Parecoxibhsa04658Th1 and Th2 cell differentiation1.39E-1916P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Parecoxibhsa04659Th17 cell differentiation1.06E-1520P25963, Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Parecoxibhsa04660T cell receptor signaling pathway1.44E-1520P01375, P04141, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01732, Q13191, P06239, P29350, Q16539, P49841TNF, CSF2, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, PTPN6, MAPK14, GSK3BMore
Parecoxibhsa04662B cell receptor signaling pathway5.44E-076P25963, P42338, P60033, P07948, P21854, Q8N149NFKBIA, PIK3CB, CD81, LYN, CD72, LILRA2More
Parecoxibhsa04664Fc epsilon RI signaling pathway5.90E-054P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Parecoxibhsa04666Fc gamma R-mediated phagocytosis7.22E-0510O75015, P07948, P42338, P19174, P23528, P49006, P06396, O14494, P14598, P17252FCGR3B, LYN, PIK3CB, PLCG1, CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCAMore
Parecoxibhsa04668TNF signaling pathway2.67E-036P01375, P18848, P19875, P01584, P14780, P20333TNF, ATF4, CXCL2, IL1B, MMP9, TNFRSF1BMore
Parecoxibhsa04713Circadian entrainment2.81E-057O15399, P0DP23, P17252, P62873, P63218, P50151, O15055GRIN2D, CALM1, PRKCA, GNB1, GNG5, GNG10, PER2More
Parecoxibhsa04714Thermogenesis1.73E-047Q16539, P15336, P63261, P33121, Q9Y478, Q16718, O14521MAPK14, ATF2, ACTG1, ACSL1, PRKAB1, NDUFA5, SDHDMore
Parecoxibhsa04720Long-term potentiation7.52E-056Q16566, P16298, P0DP23, P51812, O15399, Q02750CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1More
Parecoxibhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Parecoxibhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Parecoxibhsa04723Retrograde endocannabinoid signaling4.40E-025Q14643, P63218, P50151, P22694, Q16539ITPR1, GNG5, GNG10, PRKACB, MAPK14More
Parecoxibhsa04724Glutamatergic synapse5.58E-106O15399, P62873, P63218, P50151, P15104, Q9NSB8GRIN2D, GNB1, GNG5, GNG10, GLUL, HOMER2More
Parecoxibhsa04725Cholinergic synapse9.51E-068P22694, Q14643, P62873, P63218, P50151, Q16566, P42338, P10415PRKACB, ITPR1, GNB1, GNG5, GNG10, CAMK4, PIK3CB, BCL2More
Parecoxibhsa04726Serotonergic synapse2.38E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Parecoxibhsa04727GABAergic synapse2.34E-084P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Parecoxibhsa04730Long-term depression1.77E-032Q14344, P07948GNA13, LYNMore
Parecoxibhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Parecoxibhsa04742Taste transduction1.01E-021P30939HTR1FMore
Parecoxibhsa04744Phototransduction1.12E-062P62873, P0DP23GNB1, CALM1More
Parecoxibhsa04750Inflammatory mediator regulation of TRP channels2.56E-0713P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Parecoxibhsa04810Regulation of actin cytoskeleton2.61E-026P12814, Q13009, P42338, P11215, Q14344, Q9NRA1ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFCMore
Parecoxibhsa04912GnRH signaling pathway6.12E-036P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Parecoxibhsa04913Ovarian steroidogenesis1.27E-032P42330, P22694AKR1C3, PRKACBMore
Parecoxibhsa04914Progesterone-mediated oocyte maturation1.21E-058Q17RY0, P42338, Q13370, Q9Y6D9, P30304, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1More
Parecoxibhsa04915Estrogen signaling pathway3.17E-025Q08828, P51828, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Parecoxibhsa04920Adipocytokine signaling pathway5.67E-036Q06124, P33121, Q9Y478, Q04759, Q9Y4H2, P01375PTPN11, ACSL1, PRKAB1, PRKCQ, IRS2, TNFMore
Parecoxibhsa04922Glucagon signaling pathway7.57E-035P14618, P22694, P06737, Q12778, Q14643PKM2, PRKACB, PYGL, FOXO1, ITPR1More
Parecoxibhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Parecoxibhsa04924Renin secretion7.31E-063P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Parecoxibhsa04926Relaxin signaling pathway1.22E-0511P25963, P42338, P62873, P63218, P50151, P18848, P22694, P49767, P14780, P30679, P49407NFKBIA, PIK3CB, GNB1, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15, ARRB1More
Parecoxibhsa04927Cortisol synthesis and secretion1.27E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Parecoxibhsa04928Parathyroid hormone synthesis, secretion and action1.32E-034Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Parecoxibhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Parecoxibhsa04932Non-alcoholic fatty liver disease2.72E-0813P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Parecoxibhsa04933AGE-RAGE signaling pathway in diabetic complications1.52E-038P84022, Q13485, P42224, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Parecoxibhsa04934Cushing syndrome4.74E-023Q14643, P22694, P04628ITPR1, PRKACB, WNT1More
Parecoxibhsa04940Type I diabetes mellitus2.61E-034P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Parecoxibhsa04964Proximal tubule bicarbonate reclamation2.08E-043P22748, P00918, P49448CA4, CA2, GLUD2More
Parecoxibhsa04966Collecting duct acid secretion2.17E-031P00918CA2More
Parecoxibhsa04970Salivary secretion1.40E-047P07550, Q08828, P51828, P22694, Q14643, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM1, CAMPMore
Parecoxibhsa04972Pancreatic secretion1.67E-035Q14643, P20020, P17252, Q08828, P62491ITPR1, ATP2B1, PRKCA, ADCY1, RAB11AMore
Parecoxibhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Parecoxibhsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Parecoxibhsa04976Bile secretion3.14E-035O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Parecoxibhsa05010Alzheimer disease2.70E-0419O15239, P13073, P12074, O15399, Q00535, Q9NZJ5, O75460, P0DP23, P0DP24, Q13564, P01584, O95197, P18848, Q71U36, P67870, P09603, P05141, P21796, P28070NDUFA1, COX4I1, COX6A1, GRIN2D, CDK5, EIF2AK3, ERN1, CALM1, CALM2, APPBP1, IL1B, RTN3, ATF4, TUBA1A, CSNK2B, CSF1, SLC25A5, VDAC1, PSMB4More
Parecoxibhsa05012Parkinson disease1.03E-0314Q16718, O14521, P13073, P05141, P21796, P60604, O75460, P18848, P19174, P0DP23, P0DP24, Q71U36, Q13509, P68371NDUFA5, SDHD, COX4I1, SLC25A5, VDAC1, UBE2G2, ERN1, ATF4, PLCG1, CALM1, CALM2, TUBA1A, TUBB3, TUBB2CMore
Parecoxibhsa05016Huntington disease1.94E-0513O95298, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, P05141, Q9NYC9, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1, PSMB4, PSMD12More
Parecoxibhsa05017Spinocerebellar ataxia2.22E-024Q92915, O15399, P42338, P21796FGF14, GRIN2D, PIK3CB, VDAC1More
Parecoxibhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Parecoxibhsa05022Pathways of neurodegeneration - multiple diseases1.30E-0522O15399, Q13509, P68371, P49841, P10415, Q16718, O14521, P13073, O75460, P18848, Q13561, P19174, P05141, P17252, P20333, Q16539, P07384, P04628, P01584, Q08752, P0DP23, P0DP24GRIN2D, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, PLCG1, SLC25A5, PRKCA, TNFRSF1B, MAPK14, CAPN1, WNT1, IL1B, PPID, CALM1, CALM2More
Parecoxibhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Parecoxibhsa05032Morphine addiction1.09E-056P62873, P63218, P50151, Q13370, Q07343, P43250GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6More
Parecoxibhsa05033Nicotine addiction2.54E-022P28472, O15399GABRB3, GRIN2DMore
Parecoxibhsa05034Alcoholism1.38E-0612O15399, Q16566, Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431GRIN2D, CAMK4, HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Parecoxibhsa05100Bacterial invasion of epithelial cells1.82E-034Q14141, Q05397, Q92529, Q96JJ3SEPT6, PTK2, SHC3, ELMO2More
Parecoxibhsa05110Vibrio cholerae infection1.98E-044Q13488, P17252, P19174, P60709TCIRG1, PRKCA, PLCG1, ACTBMore
Parecoxibhsa05120Epithelial cell signaling in Helicobacter pylori infection2.00E-057Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Parecoxibhsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Parecoxibhsa05131Shigellosis3.15E-0212P01375, O00463, P14778, Q16539, Q04759, P61088, Q9NQL2, Q9H1Y0, P12814, Q14643, P49841, P21796TNF, TRAF5, IL1R1, MAPK14, PRKCQ, UBE2N, RRAGD, ATG5, ACTN1, ITPR1, GSK3B, VDAC1More
Parecoxibhsa05132Salmonella infection2.19E-0719P25963, P08238, Q9UJU2, P01106, P63261, P42338, Q13546, Q13489, P10415, P04406, O75369, O60603, Q9BQS8, Q13561, O60282, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, LEF1, MYC, ACTG1, PIK3CB, RIPK1, BIRC3, BCL2, GAPDH, FLNB, TLR2, FYCO1, DCTN2, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41More
Parecoxibhsa05133Pertussis2.60E-042P0DP23, P0C0L4CALM1, C4AMore
Parecoxibhsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Parecoxibhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Parecoxibhsa05140Leishmaniasis1.02E-1215P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Parecoxibhsa05143African trypanosomiasis1.09E-054P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Parecoxibhsa05144Malaria5.61E-098P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Parecoxibhsa05146Amoebiasis1.73E-1114P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Parecoxibhsa05150Staphylococcus aureus infection2.58E-0611P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Parecoxibhsa05152Tuberculosis1.45E-0311Q13488, O75015, P48382, P25208, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, FCGR3B, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Parecoxibhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Parecoxibhsa05162Measles1.78E-0311P01568, P25963, P23458, P42224, P14784, P07766, P42338, P0DMV8, P11142, P01584, Q9NP90IFNA21, NFKBIA, JAK1, STAT1, IL2RB, CD3E, PIK3CB, HSPA1A, HSPA8, IL1B, RAB9BMore
Parecoxibhsa05163Human cytomegalovirus infection4.02E-0926P42338, P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P01106, P14778, P01584, P61073, Q13651, P25025, Q16539, P04637, O00463, P30101, P01568PIK3CB, TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, MYC, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21More
Parecoxibhsa05167Kaposi sarcoma-associated herpesvirus infection9.82E-0917P01568, P42224, P25963, P42338, P40189, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P04141, P0DP23, P0CG47IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CSF2, CALM1, UBBMore
Parecoxibhsa05168Herpes simplex virus 1 infection5.62E-0621Q9UKJ0, Q06124, P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P30101, P42338, Q13398, Q9NR11, Q03923, P52738, O75820, Q9NZL3, Q9UDV6, P10415PILRB, PTPN11, NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF302, ZNF85, ZNF140, ZNF189, ZNF224, ZNF212, BCL2More
Parecoxibhsa05169Epstein-Barr virus infection4.02E-0620P13765, P01106, Q13547, O00463, P25963, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, NFKBIA, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Parecoxibhsa05170Human immunodeficiency virus 1 infection4.31E-0616P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P23528, P07766, P20333PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CFL1, CD3E, TNFRSF1BMore
Parecoxibhsa05171Coronavirus disease - COVID-191.36E-027P25963, P42224, P01568, P40189, P04141, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCAMore
Parecoxibhsa05200Pathways in cancer1.76E-0831Q13751, P42338, P08238, P42224, P25963, P19174, P01106, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, Q13489, P98170, P49767, Q12778, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P40189, P01042LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BIRC3, BIRC4, VEGFC, FOXO1, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, KNG1More
Parecoxibhsa05202Transcriptional misregulation in cancer6.57E-1428Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P46527, P04637, P35226, O60583, P05164, P59665, P59666, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, CDKN1B, TP53, BMI1, CCNT2, MPO, DEFA1; DEFA1B, DEFA3, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Parecoxibhsa05203Viral carcinogenesis6.72E-0411P42338, P06746, P07948, P29083, Q13547, Q15283, P12814, P25963, P62807, Q93079, O60814PIK3CB, POLB, LYN, GTF2E1, HDAC1, RASA2, ACTN1, NFKBIA, HIST1H2BC, H2BC9, H2BC12More
Parecoxibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Parecoxibhsa05205Proteoglycans in cancer3.08E-0311Q14643, P63261, P04637, P14780, P17252, O60603, P01375, P23588, Q13635, P22694, P08962ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, TNF, EIF4B, PTCH1, PRKACB, CD63More
Parecoxibhsa05206MicroRNAs in cancer2.79E-027P30304, P09493, P01106, P42338, Q13547, P20827, P19174CDC25A, TPM1, MYC, PIK3CB, HDAC1, EFNA1, PLCG1More
Parecoxibhsa05210Colorectal cancer4.67E-024P84022, Q13485, P43246, O75293SMAD3, SMAD4, MSH2, GADD45BMore
Parecoxibhsa05211Renal cell carcinoma2.07E-042Q06124, Q99814PTPN11, EPAS1More
Parecoxibhsa05212Pancreatic cancer3.87E-046P42338, P84022, Q13485, P04637, P24522, O75293PIK3CB, SMAD3, SMAD4, TP53, GADD45A, GADD45BMore
Parecoxibhsa05213Endometrial cancer2.93E-034O15169, Q02750, P04637, P24522AXIN1, MAP2K1, TP53, GADD45AMore
Parecoxibhsa05214Glioma3.74E-068P0DP23, Q16566, P17252, P42338, P04637, P19174, P24522, O75293CALM1, CAMK4, PRKCA, PIK3CB, TP53, PLCG1, GADD45A, GADD45BMore
Parecoxibhsa05216Thyroid cancer1.79E-045P01106, Q9UJU2, P04637, P24522, O75293MYC, LEF1, TP53, GADD45A, GADD45BMore
Parecoxibhsa05217Basal cell carcinoma2.50E-045Q13635, P49841, Q9UJU2, P04637, P24522PTCH1, GSK3B, LEF1, TP53, GADD45AMore
Parecoxibhsa05218Melanoma1.08E-035Q9NRA1, P04637, P42338, P24522, O75293PDGFC, TP53, PIK3CB, GADD45A, GADD45BMore
Parecoxibhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Parecoxibhsa05220Chronic myeloid leukemia8.26E-0510Q06124, P04637, Q13547, P01106, Q13485, P25963, P84022, P42338, P24522, O75293PTPN11, TP53, HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45A, GADD45BMore
Parecoxibhsa05222Small cell lung cancer3.80E-024Q13751, Q13489, P98170, O75293LAMB3, BIRC3, BIRC4, GADD45BMore
Parecoxibhsa05223Non-small cell lung cancer2.50E-048P17252, O43524, P19174, P10826, Q9HC35, P04637, P24522, O75293PRKCA, FOXO3, PLCG1, RARB, EML4, TP53, GADD45A, GADD45BMore
Parecoxibhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Parecoxibhsa05225Hepatocellular carcinoma4.54E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Parecoxibhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Parecoxibhsa05231Choline metabolism in cancer2.80E-067P42338, Q9NRA1, Q9Y259, P19174, P23743, O14494, P17252PIK3CB, PDGFC, CHKB, PLCG1, DGKA, PLPP1, PRKCAMore
Parecoxibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.41E-1117P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P23458, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, JAK1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Parecoxibhsa05310Asthma1.63E-053P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Parecoxibhsa05321Inflammatory bowel disease1.43E-148O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Parecoxibhsa05322Systemic lupus erythematosus1.93E-0515O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Parecoxibhsa05323Rheumatoid arthritis1.45E-034P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Parecoxibhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Parecoxibhsa05332Graft-versus-host disease2.11E-106P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Parecoxibhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Parecoxibhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Parecoxibhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Parecoxibhsa05415Diabetic cardiomyopathy8.56E-058P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Parecoxibhsa05416Viral myocarditis2.30E-022P10747, P63261CD28, ACTG1More
Parecoxibhsa05418Fluid shear stress and atherosclerosis3.14E-0310Q16539, P14598, P10599, P14780, P63261, P04637, P10415, P14778, P27930, Q92974MAPK14, NCF1, TXN, MMP9, ACTG1, TP53, BCL2, IL1R1, IL1R2, ARHGEF2More

Community members of Parecoxib (SDC: 10.03)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P02788LTFLactotransferrinReported10.48660.052100.3474
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P33260CYP2C18Cytochrome P450 2C18Predicted10.02390.07560.15280.316
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q16875PFKFB36NonephosphofructoNone2Nonekinase/fructoseNone2,6Nonebisphosphatase 3Predicted10.04620.08860.23420.4345
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q99814EPAS1Endothelial PAS domainNonecontaining protein 1Predicted00.23220.0620.24910.4892
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q9GZR1SENP6SentrinNonespecific protease 6Predicted00.38440.078400.349
P29350PTPN6TyrosineNoneprotein phosphatase nonNonereceptor type 6Predicted10.28070.24590.56831.2004
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
O15294OGTUDPNoneNNoneacetylglucosamineNoneNonepeptide NNoneacetylglucosaminyltransferase 110 kDa subunitPredicted00.27390.06020.10210.3594
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P40925MDH1Malate dehydrogenase, cytoplasmicPredicted00.35660.27460.24260.97
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P07384CAPN1CalpainNone1 catalytic subunitPredicted00.0230.14890.60380.9131
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P25963NFKBIANFNonekappaNoneB inhibitor alphaPredicted10.10480.029511.1114
P08311CTSGCathepsin GPredicted00.49490.18740.64781.2701
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P35790CHKACholine kinase alphaPredicted00.5830.03390.16390.5233
O15164TRIM24Transcription intermediary factor 1NonealphaPredicted00.28070.105500.3514
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)