PharmaCoNets of Papaverine (SPCN: 211.65 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Papaverinehsa00030Pentose phosphate pathway2.25E-033P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Papaverinehsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Papaverinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Papaverinehsa00190Oxidative phosphorylation1.85E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Papaverinehsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Papaverinehsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Papaverinehsa00500Starch and sucrose metabolism9.19E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Papaverinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Papaverinehsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Papaverinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Papaverinehsa00564Glycerophospholipid metabolism2.52E-023P48651, Q9Y6K0, Q86XP1PTDSS1, CEPT1, DGKHMore
Papaverinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Papaverinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Papaverinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Papaverinehsa00600Sphingolipid metabolism4.23E-033Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Papaverinehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Papaverinehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Papaverinehsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Papaverinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Papaverinehsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Papaverinehsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Papaverinehsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Papaverinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Papaverinehsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Papaverinehsa00830Retinol metabolism2.17E-034P00325, P00352, Q9BPW9, O75911ADH1B, ALDH1A1, DHRS9, DHRS3More
Papaverinehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Papaverinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Papaverinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Papaverinehsa00983Drug metabolism - other enzymes7.80E-065P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Papaverinehsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Papaverinehsa01100Metabolic pathways5.52E-0337Q9NR34, Q9Y234, P05089, Q16772, P32320, Q02153, P20839, P22748, P55809, P06280, O94777, Q16875, O43286, O43451, Q9Y6K0, P05186, P24666, Q86XP1, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P48651, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P14927, Q06055, Q9NVH6MAN1C1, LIPT1, ARG1, GSTA3, CDA, GUCY1B3, IMPDH1, CA4, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, CEPT1, ALPL, ACP1, DGKH, MCCC2, ACSL1, AMACR, SGMS1, PTDSS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, UQCRB, ATP5G2, TMLHEMore
Papaverinehsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Papaverinehsa01230Biosynthesis of amino acids3.21E-024P51854, P60891, P05089, P37837TKTL1, PRPS1, ARG1, TALDO1More
Papaverinehsa01522Endocrine resistance4.48E-024P22694, Q02750, Q9UM47, P46527PRKACB, MAP2K1, NOTCH3, CDKN1BMore
Papaverinehsa01523Antifolate resistance1.88E-034P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Papaverinehsa02010ABC transporters2.17E-031Q8IZY2ABCA7More
Papaverinehsa03013RNA transport3.86E-0413P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1More
Papaverinehsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Papaverinehsa03020RNA polymerase2.94E-074P24928, P62487, Q9GZM3, P52435POLR2A, POLR2G, POLR2J2, POLR2JMore
Papaverinehsa03040Spliceosome1.54E-0616Q14562, O43143, O60508, P08579, P26368, O75940, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Papaverinehsa03050Proteasome4.83E-021P55036PSMD4More
Papaverinehsa03420Nucleotide excision repair4.91E-022P07992, P54727ERCC1, RAD23BMore
Papaverinehsa03430Mismatch repair4.38E-021P20585MSH3More
Papaverinehsa03450Non-homologous end-joining4.48E-031P78527PRKDCMore
Papaverinehsa04014Ras signaling pathway1.83E-0417Q02750, P42338, P20827, Q15389, Q9NRA1, P49767, Q13009, P17252, Q7LDG7, P21359, P0DP23, P62873, P62879, P63218, P50151, P19174, P22694MAP2K1, PIK3CB, EFNA1, ANGPT1, PDGFC, VEGFC, TIAM1, PRKCA, RASGRP2, NF1, CALM1, GNB1, GNB2, GNG5, GNG10, PLCG1, PRKACBMore
Papaverinehsa04015Rap1 signaling pathway4.21E-0413P20827, Q9NRA1, P49767, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P0DP23, P17252, P19174EFNA1, PDGFC, VEGFC, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, CALM1, PRKCA, PLCG1More
Papaverinehsa04020Calcium signaling pathway2.54E-039P17252, P19174, P0DP24, P0DP23, P51828, P20020, P23634, Q9NRA1, P49767PRKCA, PLCG1, CALM2, CALM1, ADCY7, ATP2B1, ATP2B4, PDGFC, VEGFCMore
Papaverinehsa04024cAMP signaling pathway3.79E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Papaverinehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Papaverinehsa04061Viral protein interaction with cytokine and cytokine receptor1.70E-038P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Papaverinehsa04062Chemokine signaling pathway1.51E-0517P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, PIK3R5More
Papaverinehsa04064NF-kappa B signaling pathway8.52E-1123P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9UNE0BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, EDARMore
Papaverinehsa04066HIF-1 signaling pathway4.48E-024P17252, Q15389, Q02750, P46527PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Papaverinehsa04070Phosphatidylinositol signaling system3.65E-047P19174, P0DP23, Q14643, P23743, P49619, P27987, P17252PLCG1, CALM1, ITPR1, DGKA, DGKG, ITPKB, PRKCAMore
Papaverinehsa04071Sphingolipid signaling pathway4.96E-1110P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Papaverinehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Papaverinehsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Papaverinehsa04110Cell cycle4.66E-068P06493, O60566, P78527, P30304, P33981, P42773, P01106, Q13547CDK1, BUB1B, PRKDC, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Papaverinehsa04114Oocyte meiosis2.57E-059Q9Y6D9, P51812, Q02750, P0DP24, P16298, Q17RY0, P51828, P27348, Q13362MAD1L1, RPS6KA3, MAP2K1, CALM2, PPP3CB, CPEB4, ADCY7, YWHAQ, PPP2R5CMore
Papaverinehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Papaverinehsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Papaverinehsa04140Autophagy - animal3.72E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Papaverinehsa04145Phagosome1.98E-0610O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Papaverinehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Papaverinehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Papaverinehsa04151PI3K-Akt signaling pathway5.33E-0320P42338, P43657, P25116, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252, P30281PIK3CB, P2RY5, F2R, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA, CCND3More
Papaverinehsa04210Apoptosis2.68E-0311Q13315, P10415, Q13489, O76075, P25963, P01375, Q9NR28, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, DIABLO, GADD45A, BCL2A1, TRAF1, ITPR1More
Papaverinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Papaverinehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Papaverinehsa04217Necroptosis4.05E-0614P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, P10415, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP2A, PPIDMore
Papaverinehsa04261Adrenergic signaling in cardiomyocytes1.43E-038P09493, P51828, Q13362, P0DP24, P0DP23, P17252, P10415, P23634TPM1, ADCY7, PPP2R5C, CALM2, CALM1, PRKCA, BCL2, ATP2B4More
Papaverinehsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Papaverinehsa04330Notch signaling pathway4.91E-022P49768, P78504PSEN1, JAG1More
Papaverinehsa04340Hedgehog signaling pathway1.21E-045P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Papaverinehsa04360Axon guidance3.14E-037P16333, P20827, O95631, P17252, P42338, P07332, P19174NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, PLCG1More
Papaverinehsa04370VEGF signaling pathway9.32E-053P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Papaverinehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Papaverinehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Papaverinehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Papaverinehsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Papaverinehsa04520Adherens junction4.91E-022P07947, P19784YES1, CSNK2A2More
Papaverinehsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Papaverinehsa04540Gap junction4.36E-057P17252, P22694, Q13509, P68371, Q02750, Q9NRA1, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, MAP2K1, PDGFC, ITPR1More
Papaverinehsa04610Complement and coagulation cascades4.27E-061P0C0L4C4AMore
Papaverinehsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Papaverinehsa04612Antigen processing and presentation1.40E-048P13765, P48382, P01730, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Papaverinehsa04613Neutrophil extracellular trap formation4.63E-1024P19174, P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PLCG1, PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Papaverinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Papaverinehsa04621NOD-like receptor signaling pathway8.45E-0516Q14643, P01568, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P29728, Q05823, P01375, P09341, P49913, P12838ITPR1, IFNA21, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Papaverinehsa04622RIG-I-like receptor signaling pathway1.93E-034P01568, Q13546, Q12933, P10145IFNA21, RIPK1, TRAF2, IL8More
Papaverinehsa04623Cytosolic DNA-sensing pathway2.83E-043P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Papaverinehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Papaverinehsa04630JAK-STAT signaling pathway3.20E-024P01106, P42224, P14784, Q13651MYC, STAT1, IL2RB, IL10RAMore
Papaverinehsa04640Hematopoietic cell lineage5.90E-0814P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNFMore
Papaverinehsa04650Natural killer cell mediated cytotoxicity3.05E-0814P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Papaverinehsa04657IL-17 signaling pathway4.36E-0613P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, Q9UJX4, P04141, P80188, P01375, P06702NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, CSF2, LCN2, TNF, S100A9More
Papaverinehsa04658Th1 and Th2 cell differentiation3.55E-1714Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Papaverinehsa04659Th17 cell differentiation3.07E-1317Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Papaverinehsa04660T cell receptor signaling pathway1.10E-1119P01375, P04141, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P29350TNF, CSF2, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, PTPN6More
Papaverinehsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Papaverinehsa04664Fc epsilon RI signaling pathway2.40E-037P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Papaverinehsa04668TNF signaling pathway1.83E-038P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9More
Papaverinehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Papaverinehsa04672Intestinal immune network for IgA production1.27E-044P29965, P10747, P13765, P13612CD40LG, CD28, HLA-DOB, ITGA4More
Papaverinehsa04713Circadian entrainment2.17E-035P0DP23, P17252, P62873, Q14643, O15055CALM1, PRKCA, GNB1, ITPR1, PER2More
Papaverinehsa04720Long-term potentiation6.09E-057P17252, P16298, P0DP23, P51812, P22694, Q02750, Q14643PRKCA, PPP3CB, CALM1, RPS6KA3, PRKACB, MAP2K1, ITPR1More
Papaverinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Papaverinehsa04723Retrograde endocannabinoid signaling8.76E-046Q14643, P17252, P62873, P22694, Q16539, Q16718ITPR1, PRKCA, GNB1, PRKACB, MAPK14, NDUFA5More
Papaverinehsa04725Cholinergic synapse1.34E-037P22694, Q14643, P17252, P62873, P62879, P10415, Q02750PRKACB, ITPR1, PRKCA, GNB1, GNB2, BCL2, MAP2K1More
Papaverinehsa04726Serotonergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Papaverinehsa04727GABAergic synapse2.03E-024P62879, P22694, O60296, P17252GNB2, PRKACB, TRAK2, PRKCAMore
Papaverinehsa04728Dopaminergic synapse3.55E-025Q14643, P17252, P62873, Q13362, P0DP23ITPR1, PRKCA, GNB1, PPP2R5C, CALM1More
Papaverinehsa04742Taste transduction3.91E-021P17612PRKACAMore
Papaverinehsa04744Phototransduction1.20E-042P62873, P0DP23GNB1, CALM1More
Papaverinehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Papaverinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Papaverinehsa04912GnRH signaling pathway3.31E-046P17252, Q16539, Q9Y6R4, Q14643, P0DP23, P22694PRKCA, MAPK14, MAP3K4, ITPR1, CALM1, PRKACBMore
Papaverinehsa04913Ovarian steroidogenesis2.52E-021P06213INSRMore
Papaverinehsa04914Progesterone-mediated oocyte maturation2.06E-034Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Papaverinehsa04919Thyroid hormone signaling pathway3.25E-0512P17252, P49841, P19174, Q02750, P42224, P22694, Q13547, O60244, Q9NVC6, Q12778, Q9UM47, P01106PRKCA, GSK3B, PLCG1, MAP2K1, STAT1, PRKACB, HDAC1, MED14, MED17, FOXO1, NOTCH3, MYCMore
Papaverinehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Papaverinehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Papaverinehsa04923Regulation of lipolysis in adipocytes4.24E-034P07550, P06213, P42338, Q9Y4H2ADRB2, INSR, PIK3CB, IRS2More
Papaverinehsa04924Renin secretion6.25E-055P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Papaverinehsa04925Aldosterone synthesis and secretion1.32E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Papaverinehsa04927Cortisol synthesis and secretion1.66E-023Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Papaverinehsa04928Parathyroid hormone synthesis, secretion and action5.51E-037Q14643, P22694, P23771, Q02750, P17252, P10415, Q9Y5Q3ITPR1, PRKACB, GATA3, MAP2K1, PRKCA, BCL2, MAFBMore
Papaverinehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Papaverinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Papaverinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Papaverinehsa04933AGE-RAGE signaling pathway in diabetic complications6.21E-059P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Papaverinehsa04940Type I diabetes mellitus2.17E-034P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Papaverinehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Papaverinehsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Papaverinehsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Papaverinehsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Papaverinehsa04970Salivary secretion1.98E-058P07550, P51828, P22694, Q14643, P23634, P17252, P0DP24, P49913ADRB2, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CAMPMore
Papaverinehsa04972Pancreatic secretion1.35E-044P23634, Q08828, P51828, P62491ATP2B4, ADCY1, ADCY7, RAB11AMore
Papaverinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Papaverinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Papaverinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Papaverinehsa05010Alzheimer disease3.55E-027Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPIDMore
Papaverinehsa05012Parkinson disease2.01E-037Q16718, O14521, Q14643, P19174, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, PLCG1, CALM1, TUBB3, TUBB2CMore
Papaverinehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Papaverinehsa05020Prion disease1.15E-027Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4More
Papaverinehsa05022Pathways of neurodegeneration - multiple diseases5.02E-0413Q14643, Q13509, P68371, P10415, Q16718, O14521, Q06055, Q13561, P19174, P17252, Q08752, O15020, P0DP23ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, ATP5G2, DCTN2, PLCG1, PRKCA, PPID, SPTBN2, CALM1More
Papaverinehsa05034Alcoholism4.03E-058Q13547, P62879, Q9BTM1, Q93077, P62807, Q16778, O60814, P68431HDAC1, GNB2, H2AFJ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Papaverinehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Papaverinehsa05110Vibrio cholerae infection2.61E-045Q13488, Q99437, P17252, P19174, P17612TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACAMore
Papaverinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Papaverinehsa05131Shigellosis2.65E-0314P01375, P25963, O00463, P68431, Q04759, Q9UDY8, Q9H1Y0, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32TNF, NFKBIA, TRAF5, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCQ, MALT1, ATG5, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPFMore
Papaverinehsa05132Salmonella infection6.33E-0618P51617, P25963, P01375, P08238, Q9UJU2, Q13546, Q13489, P10415, P04406, O75369, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371, P49754IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, RIPK1, BIRC3, BCL2, GAPDH, FLNB, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C, VPS41More
Papaverinehsa05133Pertussis3.02E-031P0C0L4C4AMore
Papaverinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Papaverinehsa05140Leishmaniasis5.60E-0712O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, P51617, Q15080FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Papaverinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Papaverinehsa05144Malaria4.41E-058P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Papaverinehsa05145Toxoplasmosis1.19E-039P51617, P25963, P01375, P10415, Q13489, P42224, P13765, O60603, P29965IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Papaverinehsa05146Amoebiasis1.56E-0912P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Papaverinehsa05150Staphylococcus aureus infection1.16E-036P0C0L4, P13646, Q14532, P59665, P59666, P49913C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Papaverinehsa05152Tuberculosis6.68E-0614Q13488, P0DP23, O75015, P42224, P48382, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, Q16539, P51617TCIRG1, CALM1, FCGR3B, STAT1, RFX5, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, MAPK14, IRAK1More
Papaverinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Papaverinehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Papaverinehsa05163Human cytomegalovirus infection3.04E-038P01375, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463TNF, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Papaverinehsa05165Human papillomavirus infection5.80E-0414P46527, Q02750, P16144, P35443, Q92796, Q05086, Q9UM47, P01568, P42224, Q13488, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, ITGB4, THBS4, DLG3, UBE3A, NOTCH3, IFNA21, STAT1, TCIRG1, PRKACB, PPP2R5C, FOXO1, ATMMore
Papaverinehsa05167Kaposi sarcoma-associated herpesvirus infection5.85E-0514P01568, P42224, P25963, P40189, P62873, P62879, P19174, P16298, Q14643, Q02750, P04141, P0DP23, P0CG47, Q9UJU2IFNA21, STAT1, NFKBIA, IL6ST, GNB1, GNB2, PLCG1, PPP3CB, ITPR1, MAP2K1, CSF2, CALM1, UBB, LEF1More
Papaverinehsa05168Herpes simplex virus 1 infection7.17E-0415P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Papaverinehsa05169Epstein-Barr virus infection7.68E-0513P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P42224, P01375, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, STAT1, TNF, OAS2, CD3E, CD3G, CD247More
Papaverinehsa05170Human immunodeficiency virus 1 infection4.31E-0721Q02750, P62873, P62879, P16298, P0DP23, P01375, Q05397, P17252, O00463, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333MAP2K1, GNB1, GNB2, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Papaverinehsa05171Coronavirus disease - COVID-191.36E-027P25963, P42224, P01568, P40189, P04141, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCAMore
Papaverinehsa05200Pathways in cancer1.82E-0533Q13751, P17301, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P43657, P25116, P62873, P62879, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784, P40189LAMB3, ITGA2, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNB2, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Papaverinehsa05202Transcriptional misregulation in cancer1.86E-1021Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P46527, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Papaverinehsa05203Viral carcinogenesis1.29E-037Q13547, Q15283, P12814, P06493, P62807, Q16778, O60814HDAC1, RASA2, ACTN1, CDK1, HIST1H2BC, HIST2H2BE, H2BC12More
Papaverinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Papaverinehsa05206MicroRNAs in cancer3.66E-026P46527, Q9UM47, P16070, Q13315, P17252, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1More
Papaverinehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Papaverinehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Papaverinehsa05214Glioma1.09E-024P0DP23, P17252, P19174, O75293CALM1, PRKCA, PLCG1, GADD45BMore
Papaverinehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Papaverinehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Papaverinehsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Papaverinehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Papaverinehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Papaverinehsa05231Choline metabolism in cancer8.92E-056Q9NRA1, Q9Y259, P19174, P23743, P49619, P17252PDGFC, CHKB, PLCG1, DGKA, DGKG, PRKCAMore
Papaverinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.64E-0916P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Papaverinehsa05310Asthma4.26E-053P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Papaverinehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Papaverinehsa05321Inflammatory bowel disease2.02E-097O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Papaverinehsa05322Systemic lupus erythematosus3.06E-0715P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Papaverinehsa05323Rheumatoid arthritis5.62E-046P01375, P13765, Q13488, P10747, P09341, O60603TNF, HLA-DOB, TCIRG1, CD28, CXCL1, TLR2More
Papaverinehsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Papaverinehsa05332Graft-versus-host disease5.49E-116P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Papaverinehsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Papaverinehsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Papaverinehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Papaverinehsa05415Diabetic cardiomyopathy1.23E-036P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore
Papaverinehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Papaverinehsa05418Fluid shear stress and atherosclerosis1.26E-048Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Papaverine (SDC: 9.18)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BReported00.02530.99460.222.2219
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
Q9UM07PADI4ProteinNonearginine deiminase typeNone4Predicted10.14880.27780.42671.0567
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q9GZR1SENP6SentrinNonespecific protease 6Predicted00.38440.078400.349
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q15722LTB4RLeukotriene B4 receptor 1Predicted00.06770.219900.4736
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P26012ITGB8Integrin betaNone8Predicted00.12270.02490.5130.6241
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)