PharmaCoNets of Pantoprazole (SPCN: 64.29 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pantoprazolehsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Pantoprazolehsa00230Purine metabolism1.56E-023Q7LG56, P51828, Q9Y227RRM2B, ADCY7, ENTPD4More
Pantoprazolehsa00240Pyrimidine metabolism1.45E-022Q7LG56, Q9Y227RRM2B, ENTPD4More
Pantoprazolehsa00500Starch and sucrose metabolism8.20E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Pantoprazolehsa00564Glycerophospholipid metabolism1.12E-021Q8TCT1PHOSPHO1More
Pantoprazolehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Pantoprazolehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Pantoprazolehsa00730Thiamine metabolism2.19E-052P05186, P24666ALPL, ACP1More
Pantoprazolehsa00980Metabolism of xenobiotics by cytochrome P4506.39E-042P78417, P11712GSTO1, CYP2C9More
Pantoprazolehsa00982Drug metabolism - cytochrome P4506.39E-042P11712, P78417CYP2C9, GSTO1More
Pantoprazolehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Pantoprazolehsa03013RNA transport4.49E-025P62826, Q9UBU9, P63279, P68104, Q14232RAN, NXF1, UBE2I, EEF1A1, EIF2B1More
Pantoprazolehsa03020RNA polymerase6.21E-044P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Pantoprazolehsa03040Spliceosome1.27E-026O43143, P08579, Q13595, Q07955, P84103, P11142DHX15, SNRPB2, TRA2A, SFRS1, SFRS3, HSPA8More
Pantoprazolehsa04014Ras signaling pathway4.12E-025P20827, P49767, Q14644, P0DP23, P63218EFNA1, VEGFC, RASA3, CALM1, GNG5More
Pantoprazolehsa04020Calcium signaling pathway5.17E-049Q08828, Q16566, P30679, O15399, P0DP23, P05141, P51828, P23634, P49767ADCY1, CAMK4, GNA15, GRIN2D, CALM1, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Pantoprazolehsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Pantoprazolehsa04024cAMP signaling pathway3.94E-024Q08828, P51828, P31751, P0DP23ADCY1, ADCY7, AKT2, CALM1More
Pantoprazolehsa04061Viral protein interaction with cytokine and cytokine receptor4.79E-037Q8NHW4, P09341, P19875, P25024, P25025, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, IL10RA, IL2RBMore
Pantoprazolehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Pantoprazolehsa04064NF-kappa B signaling pathway3.30E-0411P14778, P01584, P19174, Q04759, P06239, P63279, Q8NHW4, P09341, P19875, Q06643, Q9NQC7IL1R1, IL1B, PLCG1, PRKCQ, LCK, UBE2I, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Pantoprazolehsa04070Phosphatidylinositol signaling system9.86E-034P0DP23, O14986, Q16760, P48426CALM1, PIP5K1B, DGKD, PIP4K2AMore
Pantoprazolehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Pantoprazolehsa04072Phospholipase D signaling pathway4.96E-0411P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Pantoprazolehsa04114Oocyte meiosis1.35E-025P0DP23, Q08828, P51828, Q13362, Q14738CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Pantoprazolehsa04140Autophagy - animal1.71E-025P31751, Q7L523, O75460, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, TMEM49, SMCR8More
Pantoprazolehsa04142Lysosome2.23E-024P22304, Q13510, Q04900, Q9Y227IDS, ASAH1, CD164, ENTPD4More
Pantoprazolehsa04144Endocytosis2.25E-025O75351, P42566, Q15438, Q14161, Q9UNH7VPS4B, EPS15, PSCD1, GIT2, SNX6More
Pantoprazolehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Pantoprazolehsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Pantoprazolehsa04213Longevity regulating pathway - multiple species5.28E-047P31751, P42338, Q9Y4H2, Q08828, P51828, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA8, HDAC1More
Pantoprazolehsa04261Adrenergic signaling in cardiomyocytes4.98E-047Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Pantoprazolehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Pantoprazolehsa04371Apelin signaling pathway4.15E-037P63218, P31751, Q08828, P51828, Q13485, Q16566, P0DP23GNG5, AKT2, ADCY1, ADCY7, SMAD4, CAMK4, CALM1More
Pantoprazolehsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Pantoprazolehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Pantoprazolehsa04610Complement and coagulation cascades4.48E-023P01042, P09871, P11215KNG1, C1S, ITGAMMore
Pantoprazolehsa04613Neutrophil extracellular trap formation1.02E-048P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pantoprazolehsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Pantoprazolehsa04623Cytosolic DNA-sensing pathway2.21E-043P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Pantoprazolehsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Pantoprazolehsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Pantoprazolehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Pantoprazolehsa04650Natural killer cell mediated cytotoxicity4.15E-0410P19174, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015PLCG1, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3BMore
Pantoprazolehsa04657IL-17 signaling pathway1.27E-035O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Pantoprazolehsa04658Th1 and Th2 cell differentiation8.66E-0611Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, TBX21, IL2RB, HLA-DOB, RUNX3More
Pantoprazolehsa04659Th17 cell differentiation3.15E-0511Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, CD3E, CD3G, CD247More
Pantoprazolehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Pantoprazolehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Pantoprazolehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Pantoprazolehsa04713Circadian entrainment4.54E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Pantoprazolehsa04720Long-term potentiation1.95E-035Q16566, P0DP23, P18848, O15399, Q08828CAMK4, CALM1, ATF4, GRIN2D, ADCY1More
Pantoprazolehsa04724Glutamatergic synapse4.48E-023O15399, P63218, Q9NSB8GRIN2D, GNG5, HOMER2More
Pantoprazolehsa04725Cholinergic synapse1.39E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Pantoprazolehsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Pantoprazolehsa04750Inflammatory mediator regulation of TRP channels2.03E-049P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Pantoprazolehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Pantoprazolehsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Pantoprazolehsa04912GnRH signaling pathway7.29E-046Q08828, P51828, P18848, P0DP24, P0DP23, P45985ADCY1, ADCY7, ATF4, CALM2, CALM1, MAP2K4More
Pantoprazolehsa04915Estrogen signaling pathway2.13E-025P18848, Q08828, P51828, P31751, P0DP23ATF4, ADCY1, ADCY7, AKT2, CALM1More
Pantoprazolehsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Pantoprazolehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Pantoprazolehsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Pantoprazolehsa04925Aldosterone synthesis and secretion8.06E-046P18848, Q08828, P51828, P0DP23, Q16566, P23634ATF4, ADCY1, ADCY7, CALM1, CAMK4, ATP2B4More
Pantoprazolehsa04926Relaxin signaling pathway2.46E-024P31751, P18848, Q08828, P51828AKT2, ATF4, ADCY1, ADCY7More
Pantoprazolehsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Pantoprazolehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Pantoprazolehsa04932Non-alcoholic fatty liver disease1.04E-025P31751, P18848, O75460, P01584, O95298AKT2, ATF4, ERN1, IL1B, NDUFC2More
Pantoprazolehsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Pantoprazolehsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Pantoprazolehsa04970Salivary secretion1.63E-034Q08828, P51828, P0DP24, P0DP23ADCY1, ADCY7, CALM2, CALM1More
Pantoprazolehsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Pantoprazolehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Pantoprazolehsa04976Bile secretion7.23E-045Q08828, P51828, P22694, P08183, Q14032ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Pantoprazolehsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Pantoprazolehsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Pantoprazolehsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Pantoprazolehsa05022Pathways of neurodegeneration - multiple diseases1.67E-029O95298, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070NDUFC2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4More
Pantoprazolehsa05034Alcoholism1.53E-0611O15399, Q16566, Q13547, P0DP23, P63218, Q93077, P58876, P62807, Q16778, O60814, P68431GRIN2D, CAMK4, HDAC1, CALM1, GNG5, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pantoprazolehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Pantoprazolehsa05133Pertussis1.70E-034P11215, P0DP23, P23528, P09871ITGAM, CALM1, CFL1, C1SMore
Pantoprazolehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Pantoprazolehsa05144Malaria1.44E-024P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
Pantoprazolehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Pantoprazolehsa05163Human cytomegalovirus infection1.64E-0515P31751, P01375, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, O00463AKT2, TNF, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TRAF5More
Pantoprazolehsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Pantoprazolehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Pantoprazolehsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Pantoprazolehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Pantoprazolehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Pantoprazolehsa05204Chemical carcinogenesis1.75E-032P78417, P11712GSTO1, CYP2C9More
Pantoprazolehsa05212Pancreatic cancer2.40E-023P31751, Q15311, P23458AKT2, RALBP1, JAK1More
Pantoprazolehsa05231Choline metabolism in cancer3.38E-023P31751, Q16760, O14986AKT2, DGKD, PIP5K1BMore
Pantoprazolehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.00E-039P42338, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14More
Pantoprazolehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pantoprazolehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Pantoprazole (SDC: 4.80)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P78417GSTO1Glutathione SNonetransferase omegaNone1Predicted00.41090.13990.4250.9103
Q8TCT1PHOSPHO1Phosphoethanolamine/phosphocholine phosphatasePredicted00.35580.04750.15910.432
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P08575PTPRCReceptorNonetype tyrosineNoneprotein phosphatase CPredicted10.27330.13580.41320.8216
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)