PharmaCoNets of Palonosetron (SPCN: 31.62 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Palonosetronhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Palonosetronhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Palonosetronhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Palonosetronhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Palonosetronhsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Palonosetronhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Palonosetronhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Palonosetronhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Palonosetronhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Palonosetronhsa01100Metabolic pathways4.11E-027P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHEMore
Palonosetronhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Palonosetronhsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Palonosetronhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Palonosetronhsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Palonosetronhsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Palonosetronhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Palonosetronhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Palonosetronhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Palonosetronhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Palonosetronhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Palonosetronhsa04330Notch signaling pathway7.49E-032Q92542, P49768NCSTN, PSEN1More
Palonosetronhsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Palonosetronhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Palonosetronhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Palonosetronhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Palonosetronhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Palonosetronhsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Palonosetronhsa04659Th17 cell differentiation4.38E-024P42224, P14784, P40189, P08238STAT1, IL2RB, IL6ST, HSP90AB1More
Palonosetronhsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Palonosetronhsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Palonosetronhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Palonosetronhsa04914Progesterone-mediated oocyte maturation2.97E-036Q17RY0, P42338, Q13370, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1More
Palonosetronhsa04919Thyroid hormone signaling pathway3.71E-022P26678, P08237PLN, PFKMMore
Palonosetronhsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Palonosetronhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Palonosetronhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Palonosetronhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Palonosetronhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Palonosetronhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Palonosetronhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Palonosetronhsa05133Pertussis4.20E-021P0C0L4C4AMore
Palonosetronhsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Palonosetronhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Palonosetronhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Palonosetronhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Palonosetronhsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Palonosetronhsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Palonosetronhsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Palonosetronhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Palonosetronhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Palonosetronhsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Palonosetronhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Palonosetronhsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Palonosetronhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Palonosetronhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Palonosetronhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Palonosetronhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Palonosetronhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Palonosetronhsa05418Fluid shear stress and atherosclerosis3.73E-024P42338, P14598, P0DP23, P08238PIK3CB, NCF1, CALM1, HSP90AB1More

Community members of Palonosetron (SDC: 4.81)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
O95931CBX7Chromobox protein homolog 7Predicted00.41860.181600.5726
P11511CYP19A1AromatasePredicted00.815610.15882.5666
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)