PharmaCoNets

PharmaCoNets of Paliperidone (S_PCN: 98.52 )

Paliperidone regulated-network (S_DN: 15.13)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Paliperidone

hsa00030

Pentose phosphate pathway

9.38E-07

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Paliperidone

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Paliperidone

hsa00071

Fatty acid degradation

3.50E-02

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Paliperidone

hsa00190

Oxidative phosphorylation

5.12E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Paliperidone

hsa00230

Purine metabolism

1.79E-02

P20839, Q16774

IMPDH1, GUK1

Paliperidone

hsa00330

Arginine and proline metabolism

4.86E-02

P17707

AMD1

Paliperidone

hsa00350

Tyrosine metabolism

3.40E-02

P28332

ADH6

Paliperidone

hsa00500

Starch and sucrose metabolism

6.17E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Paliperidone

hsa00564

Glycerophospholipid metabolism

2.00E-02

P48651, Q9Y6K0, P35790, Q9Y259

PTDSS1, CEPT1, CHKA, CHKB

Paliperidone

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Paliperidone

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Paliperidone

hsa00600

Sphingolipid metabolism

2.77E-02

Q9BX95, Q8TCT0, P15289

SGPP1, CERK, ARSA

Paliperidone

hsa00670

One carbon pool by folate

1.33E-02

P04818, Q99707

TYMS, MTR

Paliperidone

hsa00730

Thiamine metabolism

2.27E-02

P05186, P24666

ALPL, ACP1

Paliperidone

hsa00760

Nicotinate and nicotinamide metabolism

3.52E-02

P21589

NT5E

Paliperidone

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Paliperidone

hsa00830

Retinol metabolism

2.20E-02

P00325, P11766, Q9BPW9, O75911

ADH1B, ADH5, DHRS9, DHRS3

Paliperidone

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Paliperidone

hsa00980

Metabolism of xenobiotics by cytochrome P450

8.40E-04

P78417, P28332, P11712

GSTO1, ADH6, CYP2C9

Paliperidone

hsa00982

Drug metabolism - cytochrome P450

8.40E-04

P11712, P78417, P28332

CYP2C9, GSTO1, ADH6

Paliperidone

hsa00983

Drug metabolism - other enzymes

1.35E-03

P04183, P32320, P05164

TK1, CDA, MPO

Paliperidone

hsa01040

Biosynthesis of unsaturated fatty acids

2.92E-02

P22307, Q9H5J4

SCP2, ELOVL6

Paliperidone

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Paliperidone

hsa01230

Biosynthesis of amino acids

2.26E-03

P51854, P60891, P05089, P37837

TKTL1, PRPS1, ARG1, TALDO1

Paliperidone

hsa01522

Endocrine resistance

4.48E-02

P22694, Q02750, Q9UM47, P46527

PRKACB, MAP2K1, NOTCH3, CDKN1B

Paliperidone

hsa01523

Antifolate resistance

2.09E-03

P41440, Q92820, P04818, P01375, P18054

SLC19A1, GGH, TYMS, TNF, ALOX12

Paliperidone

hsa02010

ABC transporters

1.27E-04

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Paliperidone

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Paliperidone

hsa03320

PPAR signaling pathway

4.55E-02

O00767, Q02318

SCD, CYP27A1

Paliperidone

hsa03450

Non-homologous end-joining

1.02E-03

P78527, P13010

PRKDC, XRCC5

Paliperidone

hsa04012

ErbB signaling pathway

1.91E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Paliperidone

hsa04014

Ras signaling pathway

4.04E-02

Q02750, Q15389, P17252, P21359, P62879, P22694

MAP2K1, ANGPT1, PRKCA, NF1, GNB2, PRKACB

Paliperidone

hsa04020

Calcium signaling pathway

4.45E-02

P0DP24, P51828, P23634

CALM2, ADCY7, ATP2B4

Paliperidone

hsa04024

cAMP signaling pathway

3.79E-02

P51828, P0DP24, P23634

ADCY7, CALM2, ATP2B4

Paliperidone

hsa04060

Cytokine-cytokine receptor interaction

4.71E-02

P78552, O75509

IL13RA1, TNFRSF21

Paliperidone

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.97E-03

P09341, P02775, P47992, Q9UBD3, Q13651

CXCL1, PPBP, XCL1, XCL2, IL10RA

Paliperidone

hsa04064

NF-kappa B signaling pathway

9.35E-05

Q12933, O00463, P14778, P01584, P01375, P19174, Q04759, Q13077, P19784, Q16548, P07948, P06239, Q8WV28, P24522, P09341, Q06643, Q9NQC7

TRAF2, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, TRAF1, CSNK2A2, BCL2A1, LYN, LCK, BLNK, GADD45A, CXCL1, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q12933	TRAF2	TNF receptor-associated factor 2	0.871
Q04759	PRKCQ	Protein kinase C theta type	O00463	TRAF5	TNF receptor-associated factor 5	0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14778	IL1R1	Interleukin-1 receptor type 1	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19784	CSNK2A2	Casein kinase II subunit alpha'	0.82
Q04759	PRKCQ	Protein kinase C theta type	Q16548	BCL2A1	Bcl-2-related protein A1	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07948	LYN	Tyrosine-protein kinase Lyn	-0.742
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
Q04759	PRKCQ	Protein kinase C theta type	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q04759	PRKCQ	Protein kinase C theta type	P09341	CXCL1	Growth-regulated alpha protein	-0.885
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q06643	LTB	Lymphotoxin-beta	0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799

Paliperidone

hsa04066

HIF-1 signaling pathway

4.48E-02

P17252, Q15389, Q02750, P46527

PRKCA, ANGPT1, MAP2K1, CDKN1B

Paliperidone

hsa04070

Phosphatidylinositol signaling system

1.53E-02

Q86XP1, Q96DU7

DGKH, ITPKC

Paliperidone

hsa04071

Sphingolipid signaling pathway

6.91E-04

P21453, Q9H228, P01375, Q13510, Q13362, Q9UQC2

S1PR1, EDG8, TNF, ASAH1, PPP2R5C, GAB2

Paliperidone

hsa04072

Phospholipase D signaling pathway

9.70E-03

Q92529, Q14344

SHC3, GNA13

Paliperidone

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Paliperidone

hsa04110

Cell cycle

1.21E-03

Q9UBD5, P06493, P78527, Q14683, P30304, P33981, P01106

ORC3, CDK1, PRKDC, SMC1A, CDC25A, TTK, MYC

Paliperidone

hsa04114

Oocyte meiosis

8.69E-03

P0DP24, P51828, P27348, Q13362

CALM2, ADCY7, YWHAQ, PPP2R5C

Paliperidone

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Paliperidone

hsa04145

Phagosome

2.94E-02

P05164, P78380, P35443, P13765

MPO, OLR1, THBS4, HLA-DOB

Paliperidone

hsa04217

Necroptosis

2.24E-04

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID

Paliperidone

hsa04261

Adrenergic signaling in cardiomyocytes

1.05E-03

P07550, P51828, P22694, P18848, Q13362, P0DP24, P23634

ADRB2, ADCY7, PRKACB, ATF4, PPP2R5C, CALM2, ATP2B4

Paliperidone

hsa04380

Osteoclast differentiation

8.48E-06

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, P08637, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3A, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q96PH1	NOX5	NADPH oxidase 5	P08637	FCGR3A	Low affinity immunoglobulin gamma Fc region receptor III-A	0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P49841	GSK3B	Glycogen synthase kinase-3 beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.83
Q96PH1	NOX5	NADPH oxidase 5	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832

Paliperidone

hsa04530

Tight junction

2.45E-03

Q8TEU7, P16989, P56750, O00501, Q14247, P24844

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9

Paliperidone

hsa04540

Gap junction

2.03E-02

P17252, P22694, P68371, Q02750

PRKCA, PRKACB, TUBB2C, MAP2K1

Paliperidone

hsa04610

Complement and coagulation cascades

5.25E-05

P0C0L4, P12259, P11215, P05107

C4A, F5, ITGAM, ITGB2

Paliperidone

hsa04612

Antigen processing and presentation

3.84E-05

P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Paliperidone

hsa04613

Neutrophil extracellular trap formation

1.30E-06

P19174, P57764, P11215, O60603, P05164, P08246, P05107, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P62807, Q16778, O60814, P68431, Q15080, P08311, P08637, O75015, P21730, P21462, O43315, Q16539

PLCG1, GSDMDC1, ITGAM, TLR2, MPO, ELA2, ITGB2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3A, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P57764	GSDMDC1	Gasdermin-D	0.725
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P11215	ITGAM	Integrin alpha-M	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P05107	ITGB2	Integrin beta-2	0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q13547	HDAC1	Histone deacetylase 1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.748
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.888
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.888
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.881
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	O60814	H2BC12	Histone H2B type 1-K	-0.776
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
Q96PH1	NOX5	NADPH oxidase 5	P08637	FCGR3A	Low affinity immunoglobulin gamma Fc region receptor III-A	0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q96PH1	NOX5	NADPH oxidase 5	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Paliperidone

hsa04614

Renin-angiotensin system

2.74E-02

P15144, P08311, O75787

ANPEP, CTSG, ATP6AP2

Paliperidone

hsa04621

NOD-like receptor signaling pathway

2.32E-03

Q14643, P10599, Q9H1Y0, P43490, O00463, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

ITPR1, TXN, ATG5, PBEF1, TRAF5, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Paliperidone

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Paliperidone

hsa04625

C-type lectin receptor signaling pathway

9.91E-04

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Paliperidone

hsa04640

Hematopoietic cell lineage

4.33E-03

P13612, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, HLA-DOB, TNF, IL1B

Paliperidone

hsa04650

Natural killer cell mediated cytotoxicity

2.35E-08

P01375, P78314, P06239, O60880, P20963, Q13241, P26718, P08637, O75015, P26717, Q14953, P26715

TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3A, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
Q04759	PRKCQ	Protein kinase C theta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.855
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
Q04759	PRKCQ	Protein kinase C theta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.849
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
Q04759	PRKCQ	Protein kinase C theta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.918
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
Q96PH1	NOX5	NADPH oxidase 5	P08637	FCGR3A	Low affinity immunoglobulin gamma Fc region receptor III-A	0.833
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q96PH1	NOX5	NADPH oxidase 5	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.833
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
Q04759	PRKCQ	Protein kinase C theta type	P26717	KLRC2	NKG2-C type II integral membrane protein	0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
Q04759	PRKCQ	Protein kinase C theta type	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Paliperidone

hsa04657

IL-17 signaling pathway

1.06E-04

O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1B

Paliperidone

hsa04658

Th1 and Th2 cell differentiation

3.05E-09

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P78504, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, JAG1, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P07305	H1-0	Histone H1.0	Q04759	PRKCQ	Protein kinase C theta type	-0.706
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.805
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.769
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P07305	H1-0	Histone H1.0	P06239	LCK	Tyrosine-protein kinase Lck	-0.716
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.762
Q04759	PRKCQ	Protein kinase C theta type	Q14765	STAT4	Signal transducer and activator of transcription 4	0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
Q04759	PRKCQ	Protein kinase C theta type	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.867
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P07305	H1-0	Histone H1.0	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.772
Q04759	PRKCQ	Protein kinase C theta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.843
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.741
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P78504	JAG1	Protein jagged-1	0.907
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07305	H1-0	Histone H1.0	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.859
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q13761	RUNX3	Runt-related transcription factor 3	0.849

Paliperidone

hsa04659

Th17 cell differentiation

3.14E-07

Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458

PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P07305	H1-0	Histone H1.0	Q04759	PRKCQ	Protein kinase C theta type	-0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P07305	H1-0	Histone H1.0	P06239	LCK	Tyrosine-protein kinase Lck	-0.716
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.762
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.741
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07305	H1-0	Histone H1.0	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.859
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14778	IL1R1	Interleukin-1 receptor type 1	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q04759	PRKCQ	Protein kinase C theta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.8
Q04759	PRKCQ	Protein kinase C theta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.843
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q04759	PRKCQ	Protein kinase C theta type	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.867
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P07305	H1-0	Histone H1.0	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.805
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.769
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Paliperidone

hsa04660

T cell receptor signaling pathway

3.35E-05

P01375, Q04759, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q04759	PRKCQ	Protein kinase C theta type	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q04759	PRKCQ	Protein kinase C theta type	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q04759	PRKCQ	Protein kinase C theta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.861
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q04759	PRKCQ	Protein kinase C theta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.767
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Paliperidone

hsa04664

Fc epsilon RI signaling pathway

3.98E-02

P01375, Q16539, Q9UQC2

TNF, MAPK14, GAB2

Paliperidone

hsa04666

Fc gamma R-mediated phagocytosis

4.14E-02

P08637, O75015

FCGR3A, FCGR3B

Paliperidone

hsa04668

TNF signaling pathway

2.12E-03

P01375, O00463, Q16539, P18848, P19875, P20749, P14780

TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9

Paliperidone

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Paliperidone

hsa04720

Long-term potentiation

1.09E-02

P17252, P51812, P22694, Q02750

PRKCA, RPS6KA3, PRKACB, MAP2K1

Paliperidone

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Paliperidone

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Paliperidone

hsa04725

Cholinergic synapse

2.43E-02

P22694, P17252, P62879, Q02750

PRKACB, PRKCA, GNB2, MAP2K1

Paliperidone

hsa04726

Serotonergic synapse

2.43E-02

P22694, P17252, P62879, Q02750

PRKACB, PRKCA, GNB2, MAP2K1

Paliperidone

hsa04727

GABAergic synapse

2.03E-02

P62879, P22694, O60296, P17252

GNB2, PRKACB, TRAK2, PRKCA

Paliperidone

hsa04730

Long-term depression

3.52E-02

Q14344

GNA13

Paliperidone

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Paliperidone

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Paliperidone

hsa04750

Inflammatory mediator regulation of TRP channels

1.17E-02

P14778, P01584, P51828, P22694, Q16539, Q14643, Q04759, P0DP24

IL1R1, IL1B, ADCY7, PRKACB, MAPK14, ITPR1, PRKCQ, CALM2

Paliperidone

hsa04912

GnRH signaling pathway

4.33E-02

P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694

ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB

Paliperidone

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Paliperidone

hsa04919

Thyroid hormone signaling pathway

2.22E-02

P17252, Q02750, P22694, Q12778, Q9UM47

PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3

Paliperidone

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Paliperidone

hsa04925

Aldosterone synthesis and secretion

1.32E-02

P51828, P0DP24, P23634

ADCY7, CALM2, ATP2B4

Paliperidone

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Paliperidone

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Paliperidone

hsa04928

Parathyroid hormone synthesis, secretion and action

4.48E-02

P22694, Q02750, P17252, Q9Y5Q3

PRKACB, MAP2K1, PRKCA, MAFB

Paliperidone

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Paliperidone

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Paliperidone

hsa04960

Aldosterone-regulated sodium reabsorption

4.38E-02

P48048

KCNJ1

Paliperidone

hsa04961

Endocrine and other factor-regulated calcium reabsorption

2.09E-02

P23634, P62491

ATP2B4, RAB11A

Paliperidone

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Paliperidone

hsa04966

Collecting duct acid secretion

4.48E-02

P00918

CA2

Paliperidone

hsa04970

Salivary secretion

3.20E-05

P07550, P51828, P22694, P23634, P17252, P0DP24, P49913

ADRB2, ADCY7, PRKACB, ATP2B4, PRKCA, CALM2, CAMP

Paliperidone

hsa04972

Pancreatic secretion

4.94E-03

P23634, P51828, P62491

ATP2B4, ADCY7, RAB11A

Paliperidone

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Paliperidone

hsa05020

Prion disease

4.56E-03

Q16718, O14521, Q92736, O60282, P49841, Q16539

NDUFA5, SDHD, RYR2, KIF5C, GSK3B, MAPK14

Paliperidone

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Paliperidone

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Paliperidone

hsa05034

Alcoholism

6.95E-05

Q13547, P63218, P50151, Q93077, P62807, Q16778, O60814, P68431

HDAC1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Paliperidone

hsa05132

Salmonella infection

4.83E-02

O00471, O60282

EXOC5, KIF5C

Paliperidone

hsa05133

Pertussis

1.78E-03

P11215, P05107, P0C0L4

ITGAM, ITGB2, C4A

Paliperidone

hsa05140

Leishmaniasis

3.38E-04

P13612, P08637, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, Q16539, Q15080

ITGA4, FCGR3A, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MAPK14, NCF4

Paliperidone

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Paliperidone

hsa05144

Malaria

1.52E-04

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Paliperidone

hsa05146

Amoebiasis

8.10E-05

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSG

Paliperidone

hsa05150

Staphylococcus aureus infection

2.23E-05

P0C0L4, P21730, P21462, P08637, O75015, P13646, P59665, P59666, P12838, P49913

C4A, C5AR1, FPR1, FCGR3A, FCGR3B, KRT13, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Paliperidone

hsa05160

Hepatitis C

1.52E-03

P60033, O00501, P29728, P49841, P01375, P48023, P01106

CD81, CLDN5, OAS2, GSK3B, TNF, FASLG, MYC

Paliperidone

hsa05163

Human cytomegalovirus infection

2.80E-02

P01375, P49841, P14778, P25025, Q16539, O00463

TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5

Paliperidone

hsa05165

Human papillomavirus infection

4.71E-03

P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315

CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATM

Paliperidone

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Paliperidone

hsa05169

Epstein-Barr virus infection

3.13E-02

P13765, Q13547, O00463, P24522, P01375, P29728, P07766, P09693, P20963

HLA-DOB, HDAC1, TRAF5, GADD45A, TNF, OAS2, CD3E, CD3G, CD247

Paliperidone

hsa05202

Transcriptional misregulation in cancer

1.08E-04

Q12778, Q13315, P17844, P14780, P27930, Q15744, Q16548, Q13077, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, ATM, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13315	ATM	Serine-protein kinase ATM	Q12778	FOXO1	Forkhead box protein O1	0.821
Q13315	ATM	Serine-protein kinase ATM	Q13315	ATM	Serine-protein kinase ATM	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
Q04759	PRKCQ	Protein kinase C theta type	P14780	MMP9	Matrix metalloproteinase-9	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
Q04759	PRKCQ	Protein kinase C theta type	P27930	IL1R2	Interleukin-1 receptor type 2	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q04759	PRKCQ	Protein kinase C theta type	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.745
Q13315	ATM	Serine-protein kinase ATM	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.709
Q04759	PRKCQ	Protein kinase C theta type	Q16548	BCL2A1	Bcl-2-related protein A1	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q13315	ATM	Serine-protein kinase ATM	P46527	CDKN1B	Cyclin-dependent kinase inhibitor 1B	0.708
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
Q04759	PRKCQ	Protein kinase C theta type	P05164	MPO	Myeloperoxidase	-0.88
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
Q13315	ATM	Serine-protein kinase ATM	P05164	MPO	Myeloperoxidase	-0.725
Q04759	PRKCQ	Protein kinase C theta type	P12838	DEFA4	Neutrophil defensin 4	-0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
Q04759	PRKCQ	Protein kinase C theta type	P08246	ELA2	Neutrophil elastase	-0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
Q13315	ATM	Serine-protein kinase ATM	P08246	ELA2	Neutrophil elastase	-0.742
Q04759	PRKCQ	Protein kinase C theta type	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
Q13315	ATM	Serine-protein kinase ATM	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
Q04759	PRKCQ	Protein kinase C theta type	Q13547	HDAC1	Histone deacetylase 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
Q04759	PRKCQ	Protein kinase C theta type	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819

Paliperidone

hsa05203

Viral carcinogenesis

1.71E-03

Q12933, P06746, P07948, Q13547, Q15283, P12814, P62807, Q16778, O60814

TRAF2, POLB, LYN, HDAC1, RASA2, ACTN1, HIST1H2BC, HIST2H2BE, H2BC12

Paliperidone

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Paliperidone

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Paliperidone

hsa05206

MicroRNAs in cancer

3.66E-02

P46527, Q9UM47, P16070, Q13315, P17252, Q02750

CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1

Paliperidone

hsa05217

Basal cell carcinoma

3.50E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Paliperidone

hsa05225

Hepatocellular carcinoma

1.85E-02

Q92529, P51531

SHC3, SMARCA2

Paliperidone

hsa05231

Choline metabolism in cancer

2.79E-03

O15245, P35790, Q9Y259, P19174, P49619

SLC22A1, CHKA, CHKB, PLCG1, DGKG

Paliperidone

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

9.76E-05

O95267, P19174, P07766, P20963, P09693, P06239, P23458, P42224, O60603, Q04759, Q16539, P19784

RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, STAT1, TLR2, PRKCQ, MAPK14, CSNK2A2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.805
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.769
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19784	CSNK2A2	Casein kinase II subunit alpha'	0.82

Paliperidone

hsa05310

Asthma

3.81E-04

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Paliperidone

hsa05321

Inflammatory bowel disease

1.63E-06

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21R

Paliperidone

hsa05322

Systemic lupus erythematosus

2.77E-07

P08637, O75015, P0C0L4, P09871, Q93077, P62807, Q16778, O60814, P68431, P12814

FCGR3A, FCGR3B, C4A, C1S, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1

Paliperidone

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Paliperidone

hsa05332

Graft-versus-host disease

1.75E-05

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Paliperidone

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.48E-02

P54284

CACNB3

Paliperidone

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Paliperidone

hsa05415

Diabetic cardiomyopathy

4.54E-04

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Paliperidone

hsa05418

Fluid shear stress and atherosclerosis

1.08E-03

Q16539, Q14145, P10599, P14780, P01375, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Paliperidone (S_DC: 6.51)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DRD2

D(2) dopamine receptor

Reported

0.0604

0.4779

2.5081

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P07305

H1None0

Histone H1.0

Predicted

0.054

0.0801

0.1872

Q04759

PRKCQ

Protein kinase C theta type

Predicted

0.0405

0.4244

0.6173

1.4864

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

Q9P1W9

PIM2

Serine/threonineNoneprotein kinase pimNone2

Predicted

0.1267

0.7674

0.2638

1.8619

P48048

KCNJ1

ATPNonesensitive inward rectifier potassium channel 1

Predicted

0.0042

0.282

0.1274

0.6935

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

O00767

SCD

StearoylNoneCoA desaturase

Predicted

0.1686

0.187

0.1997

0.6581

P33981

TTK

Dual specificity protein kinase TTK

Predicted

0.0039

0.5805

0.259

1.422

O95551

TTRAP

TyrosylNoneDNA phosphodiesterase 2

Predicted

0.2092

0.2569

0.6184

Q9UGN5

PARP2

Poly [ADPNoneribose] polymerase 2

Predicted

0.0435

0.2635

0.2461

0.7947

P01375

TNF

Tumor necrosis factor

Predicted

0.1865

0.551

2.1953

Q13315

ATM

SerineNoneprotein kinase ATM

Predicted

0.7747

0.2014

0.9391

1.7293

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

O75643

ASCC3L1

U5 small nuclear ribonucleoprotein 200 kDa helicase

Predicted

0.2455

0.0324

0.285

0.4726

P78527

PRKDC

DNANonedependent protein kinase catalytic subunit

Predicted

0.178

0.1944

0.2496

0.7273

Q96PH1

NOX5

NADPH oxidase 5

Predicted

0.2318

0.0332

0.1823

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

Gene name	UniProt_ID	Bioactivity	Value (nM)
DRD2	P14416	IC50	8.3
DRD2	P14416	Ki	1
DRD2	P14416	Ki	2.8
DRD2	P14416	Ki	4.1

PharmaCoNets of Paliperidone (SPCN: 98.52 )

Paliperidone regulated-network (SDN: 15.13)

Community members of Paliperidone (SDC: 6.51)

PharmaCoNets of Paliperidone (S_PCN: 98.52 )

Paliperidone regulated-network (S_DN: 15.13)

Community members of Paliperidone (S_DC: 6.51)