| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Palbociclib | hsa00030 | Pentose phosphate pathway | 2.74E-04 | 4 | P60891, P51854, P52209, P37837 | PRPS1, TKTL1, PGD, TALDO1 | More | | | Palbociclib | hsa00051 | Fructose and mannose metabolism | 3.35E-02 | 2 | P60174, P04075 | TPI1, ALDOA | More | | | Palbociclib | hsa00190 | Oxidative phosphorylation | 8.71E-03 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Palbociclib | hsa00220 | Arginine biosynthesis | 1.48E-03 | 2 | P05089, P49448 | ARG1, GLUD2 | More | | | Palbociclib | hsa00310 | Lysine degradation | 2.34E-03 | 3 | Q96KQ7, Q02809, P51648 | EHMT2, PLOD1, ALDH3A2 | More | | | Palbociclib | hsa00350 | Tyrosine metabolism | 3.40E-02 | 1 | P28332 | ADH6 | More | | | Palbociclib | hsa00410 | beta-Alanine metabolism | 3.98E-02 | 1 | Q6ZQY3 | GADL1 | More | | | Palbociclib | hsa00471 | D-Glutamine and D-glutamate metabolism | 3.98E-02 | 1 | Q7Z3D6 | C14orf159 | More | | | Palbociclib | hsa00500 | Starch and sucrose metabolism | 1.47E-02 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Palbociclib | hsa00514 | Other types of O-glycan biosynthesis | 1.42E-02 | 2 | P15907, Q8N4A0 | ST6GAL1, GALNT4 | More | | | Palbociclib | hsa00562 | Inositol phosphate metabolism | 2.00E-02 | 4 | P27987, P19174, P42338, Q02252 | ITPKB, PLCG1, PIK3CB, ALDH6A1 | More | | | Palbociclib | hsa00630 | Glyoxylate and dicarboxylate metabolism | 1.51E-06 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Palbociclib | hsa00670 | One carbon pool by folate | 1.33E-02 | 2 | P04818, Q99707 | TYMS, MTR | More | | | Palbociclib | hsa00730 | Thiamine metabolism | 4.07E-02 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Palbociclib | hsa00750 | Vitamin B6 metabolism | 4.45E-02 | 1 | O00764 | PDXK | More | | | Palbociclib | hsa00770 | Pantothenate and CoA biosynthesis | 7.20E-04 | 3 | O95498, Q6ZQY3, Q9NRN7 | VNN2, GADL1, AASDHPPT | More | | | Palbociclib | hsa00830 | Retinol metabolism | 3.93E-02 | 3 | P00352, Q9BPW9, O75911 | ALDH1A1, DHRS9, DHRS3 | More | | | Palbociclib | hsa00970 | Aminoacyl-tRNA biosynthesis | 1.68E-03 | 3 | O95363, P14868, Q15046 | FARS2, DARS, KARS | More | | | Palbociclib | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 4.50E-02 | 1 | P28332 | ADH6 | More | | | Palbociclib | hsa00982 | Drug metabolism - cytochrome P450 | 4.50E-02 | 1 | P28332 | ADH6 | More | | | Palbociclib | hsa00983 | Drug metabolism - other enzymes | 3.32E-02 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Palbociclib | hsa01100 | Metabolic pathways | 4.43E-02 | 23 | Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737 | MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL | More | | | Palbociclib | hsa01230 | Biosynthesis of amino acids | 2.23E-03 | 7 | P60174, P04075, P51854, P60891, O75390, P05089, P37837 | TPI1, ALDOA, TKTL1, PRPS1, CS, ARG1, TALDO1 | More | | | Palbociclib | hsa01240 | Biosynthesis of cofactors | 2.95E-02 | 2 | P13716, P14618 | ALAD, PKM2 | More | | | Palbociclib | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1.82E-02 | 1 | P08069 | IGF1R | More | | | Palbociclib | hsa01522 | Endocrine resistance | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Palbociclib | hsa01523 | Antifolate resistance | 1.88E-03 | 4 | P41440, Q92820, P04818, P01375 | SLC19A1, GGH, TYMS, TNF | More | | | Palbociclib | hsa03013 | RNA transport | 4.60E-03 | 9 | P62826, P52298, O14893, Q9UBU9, P63279, P68104, O14602, P78345, Q14232 | RAN, NCBP2, GEMIN2, NXF1, UBE2I, EEF1A1, EIF1AY, RPP38, EIF2B1 | More | | | Palbociclib | hsa03020 | RNA polymerase | 6.63E-05 | 4 | P30876, P24928, P62487, Q9Y535 | POLR2B, POLR2A, POLR2G, POLR3H | More | | | Palbociclib | hsa03040 | Spliceosome | 1.86E-05 | 13 | Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O75643 | DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, ASCC3L1 | More | | | Palbociclib | hsa03060 | Protein export | 4.42E-02 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Palbociclib | hsa03320 | PPAR signaling pathway | 4.33E-02 | 2 | Q6PCB7, Q9UNU6 | SLC27A1, CYP8B1 | More | | | Palbociclib | hsa03450 | Non-homologous end-joining | 4.21E-02 | 1 | P13010 | XRCC5 | More | | | Palbociclib | hsa04010 | MAPK signaling pathway | 4.15E-02 | 1 | P08069 | IGF1R | More | | | Palbociclib | hsa04012 | ErbB signaling pathway | 1.02E-03 | 5 | P16333, P17252, P19174, P42338, P01106 | NCK1, PRKCA, PLCG1, PIK3CB, MYC | More | | | Palbociclib | hsa04014 | Ras signaling pathway | 4.81E-04 | 11 | P42338, P20827, P49767, P08069, Q13009, P17252, P14921, P0DP23, P62873, P50151, P19174 | PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, PRKCA, ETS1, CALM1, GNB1, GNG10, PLCG1 | More | | | Palbociclib | hsa04015 | Rap1 signaling pathway | 3.18E-03 | 9 | P20827, P49767, P08069, P11215, Q13009, P42338, P0DP23, P17252, P19174 | EFNA1, VEGFC, IGF1R, ITGAM, TIAM1, PIK3CB, CALM1, PRKCA, PLCG1 | More | | | Palbociclib | hsa04020 | Calcium signaling pathway | 5.71E-03 | 9 | P27987, Q08828, P17252, O15399, P19174, P0DP23, P05141, P51828, P49767 | ITPKB, ADCY1, PRKCA, GRIN2D, PLCG1, CALM1, SLC25A5, ADCY7, VEGFC | More | | | Palbociclib | hsa04022 | cGMP-PKG signaling pathway | 4.38E-03 | 6 | P18848, P31751, Q08828, P51828, P05141, P0DP23 | ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1 | More | | | Palbociclib | hsa04024 | cAMP signaling pathway | 4.64E-03 | 9 | Q08828, P51828, P42338, P31751, P0DP23, Q13370, O15399, P25963, Q13009 | ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1 | More | | | Palbociclib | hsa04060 | Cytokine-cytokine receptor interaction | 1.59E-04 | 13 | P14784, P27930, P14778, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P09341, P01730, Q93038 | IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, CXCL1, CD4, TNFRSF25 | More | | | Palbociclib | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 7.72E-05 | 7 | Q8NHW4, P09341, P25024, P47992, Q9UBD3, Q13651, P14784 | CCL4L2, CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB | More | | | Palbociclib | hsa04062 | Chemokine signaling pathway | 9.28E-07 | 18 | P25024, P25025, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P25963 | CXCR1, CXCR2, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, NFKBIA | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06239 | LCK | Tyrosine-protein kinase Lck | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.779 | | Q15046 | KARS | Lysine--tRNA ligase | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.704 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.726 | | Q15046 | KARS | Lysine--tRNA ligase | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.741 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | | P06239 | LCK | Tyrosine-protein kinase Lck | P47992 | XCL1 | Lymphotactin | 0.715 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P47992 | XCL1 | Lymphotactin | 0.703 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UBD3 | XCL2 | Cytokine SCM-1 beta | 0.715 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q9UBD3 | XCL2 | Cytokine SCM-1 beta | 0.703 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | | Q15046 | KARS | Lysine--tRNA ligase | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.86 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.713 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.743 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.791 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.785 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.837 | | P06239 | LCK | Tyrosine-protein kinase Lck | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.728 | | Q15046 | KARS | Lysine--tRNA ligase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.749 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.712 | | P06239 | LCK | Tyrosine-protein kinase Lck | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.71 | | Q15046 | KARS | Lysine--tRNA ligase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.821 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.758 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P43250 | GRK6 | G protein-coupled receptor kinase 6 | -0.701 | | P06239 | LCK | Tyrosine-protein kinase Lck | P43250 | GRK6 | G protein-coupled receptor kinase 6 | -0.702 | | Q15046 | KARS | Lysine--tRNA ligase | P49407 | ARRB1 | Beta-arrestin-1 | 0.791 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P49407 | ARRB1 | Beta-arrestin-1 | 0.807 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.792 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.908 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.841 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.73 |
| | Palbociclib | hsa04064 | NF-kappa B signaling pathway | 4.75E-09 | 22 | P10415, Q13489, O00463, Q13546, P14778, P01584, P01375, P29965, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7 | BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLD | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q07912 | TNK2 | Activated CDC42 kinase 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.7 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | Q04759 | PRKCQ | Protein kinase C theta type | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.81 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P06239 | LCK | Tyrosine-protein kinase Lck | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.718 | | Q07912 | TNK2 | Activated CDC42 kinase 1 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | 0.702 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | | Q04759 | PRKCQ | Protein kinase C theta type | P01375 | TNF | Tumor necrosis factor | -0.725 | | P17252 | PRKCA | Protein kinase C alpha type | P29965 | CD40LG | CD40 ligand | 0.788 | | Q04759 | PRKCQ | Protein kinase C theta type | Q04759 | PRKCQ | Protein kinase C theta type | 1 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q07912 | TNK2 | Activated CDC42 kinase 1 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.801 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.769 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.73 | | Q04759 | PRKCQ | Protein kinase C theta type | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.76 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.875 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P17252 | PRKCA | Protein kinase C alpha type | Q8WV28 | BLNK | B-cell linker protein | 0.838 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q8WV28 | BLNK | B-cell linker protein | -0.816 | | Q07912 | TNK2 | Activated CDC42 kinase 1 | Q13315 | ATM | Serine-protein kinase ATM | -0.755 | | P17252 | PRKCA | Protein kinase C alpha type | Q13315 | ATM | Serine-protein kinase ATM | 0.739 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.756 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | | Q04759 | PRKCQ | Protein kinase C theta type | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.846 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | | P06239 | LCK | Tyrosine-protein kinase Lck | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.724 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | Q04759 | PRKCQ | Protein kinase C theta type | P09341 | CXCL1 | Growth-regulated alpha protein | -0.885 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q06643 | LTB | Lymphotoxin-beta | 0.846 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.825 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 |
| | Palbociclib | hsa04066 | HIF-1 signaling pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Palbociclib | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Palbociclib | hsa04070 | Phosphatidylinositol signaling system | 1.09E-06 | 12 | P19174, P0DP23, Q14643, P42338, O14986, P23743, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252 | PLCG1, CALM1, ITPR1, PIK3CB, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCA | More | | | Palbociclib | hsa04071 | Sphingolipid signaling pathway | 4.49E-02 | 4 | P17252, Q13362, Q9BX95, P10415 | PRKCA, PPP2R5C, SGPP1, BCL2 | More | | | Palbociclib | hsa04072 | Phospholipase D signaling pathway | 2.40E-03 | 6 | P31751, O14986, Q15438, Q08828, P51828, Q16760 | AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD | More | | | Palbociclib | hsa04110 | Cell cycle | 8.83E-05 | 8 | Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106 | ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYC | More | | | Palbociclib | hsa04114 | Oocyte meiosis | 8.43E-05 | 11 | Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069 | MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1R | More | | | Palbociclib | hsa04115 | p53 signaling pathway | 2.54E-02 | 3 | O15151, Q13315, P10415 | MDM4, ATM, BCL2 | More | | | Palbociclib | hsa04120 | Ubiquitin mediated proteolysis | 1.08E-03 | 6 | Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669 | SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12 | More | | | Palbociclib | hsa04140 | Autophagy - animal | 4.41E-03 | 6 | P08069, P31751, Q7L523, O75460, Q96GC9, Q8TEV9 | IGF1R, AKT2, RRAGA, ERN1, TMEM49, SMCR8 | More | | | Palbociclib | hsa04142 | Lysosome | 1.46E-02 | 7 | P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916 | HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2 | More | | | Palbociclib | hsa04144 | Endocytosis | 1.13E-03 | 14 | Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3 | CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5 | More | | | Palbociclib | hsa04145 | Phagosome | 2.42E-04 | 7 | Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765 | NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB | More | | | Palbociclib | hsa04150 | mTOR signaling pathway | 2.32E-02 | 1 | P08069 | IGF1R | More | | | Palbociclib | hsa04151 | PI3K-Akt signaling pathway | 2.09E-03 | 16 | P42338, P25116, P20827, P49767, Q13362, P08238, P62873, P50151, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252 | PIK3CB, F2R, EFNA1, VEGFC, PPP2R5C, HSP90AB1, GNB1, GNG10, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA | More | | | Palbociclib | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Palbociclib | hsa04211 | Longevity regulating pathway | 5.00E-03 | 5 | P31751, P08069, Q08828, P51828, P18848 | AKT2, IGF1R, ADCY1, ADCY7, ATF4 | More | | | Palbociclib | hsa04213 | Longevity regulating pathway - multiple species | 1.01E-03 | 5 | P31751, P08069, Q08828, P51828, P0DMV8 | AKT2, IGF1R, ADCY1, ADCY7, HSPA1A | More | | | Palbociclib | hsa04217 | Necroptosis | 9.50E-05 | 13 | P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, P15104, Q6FI13, Q99878, P10415, O43633, Q08752 | TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, GLUL, H2AC18; H2AC19, H2AC14, BCL2, CHMP2A, PPID | More | | | Palbociclib | hsa04218 | Cellular senescence | 1.70E-02 | 4 | P01889, P10321, P05141, P12236 | HLA-B, HLA-C, SLC25A5, SLC25A6 | More | | | Palbociclib | hsa04261 | Adrenergic signaling in cardiomyocytes | 7.03E-05 | 10 | P09493, Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23, P17252, P10415 | TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, PRKCA, BCL2 | More | | | Palbociclib | hsa04270 | Vascular smooth muscle contraction | 6.96E-03 | 6 | P0DP23, Q08828, P51828, P35579, P35749, P35318 | CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM | More | | | Palbociclib | hsa04310 | Wnt signaling pathway | 2.60E-02 | 3 | O15169, P17612, P67870 | AXIN1, PRKACA, CSNK2B | More | | | Palbociclib | hsa04330 | Notch signaling pathway | 2.29E-02 | 2 | Q92769, Q92830 | HDAC2, KAT2A | More | | | Palbociclib | hsa04340 | Hedgehog signaling pathway | 4.50E-02 | 2 | O43791, P30279 | SPOP, CCND2 | More | | | Palbociclib | hsa04360 | Axon guidance | 2.13E-03 | 7 | P16333, P20827, O95631, P17252, P42338, P23528, P19174 | NCK1, EFNA1, NTN1, PRKCA, PIK3CB, CFL1, PLCG1 | More | | | Palbociclib | hsa04370 | VEGF signaling pathway | 7.52E-05 | 6 | P19174, P16298, P42338, P17252, Q05397, Q02750 | PLCG1, PPP3CB, PIK3CB, PRKCA, PTK2, MAP2K1 | More | | | Palbociclib | hsa04371 | Apelin signaling pathway | 3.94E-02 | 4 | P31751, Q08828, P51828, P0DP23 | AKT2, ADCY1, ADCY7, CALM1 | More | | | Palbociclib | hsa04380 | Osteoclast differentiation | 1.88E-02 | 4 | Q9NQC7, P23458, P31751, P01584 | CYLD, JAK1, AKT2, IL1B | More | | | Palbociclib | hsa04392 | Hippo signaling pathway - multiple species | 3.01E-02 | 1 | Q6V0I7 | FAT4 | More | | | Palbociclib | hsa04510 | Focal adhesion | 3.73E-04 | 12 | P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, P51636, Q13489, P30281, P08069, P49767 | ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, CAV2, BIRC3, CCND3, IGF1R, VEGFC | More | | | Palbociclib | hsa04512 | ECM-receptor interaction | 1.90E-02 | 2 | P26012, P16070 | ITGB8, CD44 | More | | | Palbociclib | hsa04520 | Adherens junction | 8.29E-03 | 1 | P08069 | IGF1R | More | | | Palbociclib | hsa04540 | Gap junction | 3.24E-04 | 5 | P17252, Q13509, P68371, Q9NRA1, Q14643 | PRKCA, TUBB3, TUBB2C, PDGFC, ITPR1 | More | | | Palbociclib | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 9.61E-03 | 4 | Q13873, Q02750, P08069, Q86SE9 | BMPR2, MAP2K1, IGF1R, PCGF5 | More | | | Palbociclib | hsa04612 | Antigen processing and presentation | 1.48E-03 | 7 | P13765, P01730, P26715, P26717, Q13241, P01732, P01375 | HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8A, TNF | More | | | Palbociclib | hsa04613 | Neutrophil extracellular trap formation | 3.58E-02 | 8 | P17252, O60603, P08246, Q6FI13, P68431, P14598, Q15080, P21462 | PRKCA, TLR2, ELA2, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1 | More | | | Palbociclib | hsa04620 | Toll-like receptor signaling pathway | 2.54E-03 | 3 | P01584, P31751, Q8NHW4 | IL1B, AKT2, CCL4L2 | More | | | Palbociclib | hsa04621 | NOD-like receptor signaling pathway | 3.40E-02 | 8 | Q14643, P10599, P43490, O00463, P29728, P01375, P09341, P12838 | ITPR1, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4 | More | | | Palbociclib | hsa04623 | Cytosolic DNA-sensing pathway | 1.44E-06 | 5 | P01584, P01568, P25963, Q9Y535, Q8NHW4 | IL1B, IFNA21, NFKBIA, POLR3H, CCL4L2 | More | | | Palbociclib | hsa04625 | C-type lectin receptor signaling pathway | 9.86E-03 | 4 | P01584, Q9NQC7, P31751, P0DP23 | IL1B, CYLD, AKT2, CALM1 | More | | | Palbociclib | hsa04630 | JAK-STAT signaling pathway | 4.54E-02 | 3 | P31751, P23458, Q13651 | AKT2, JAK1, IL10RA | More | | | Palbociclib | hsa04640 | Hematopoietic cell lineage | 3.48E-07 | 12 | P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375 | ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF | More | | | Palbociclib | hsa04650 | Natural killer cell mediated cytotoxicity | 3.87E-07 | 15 | P16298, P50591, P01375, P06239, O60880, P20963, Q29983, P10321, P01889, Q02750, Q13241, P26718, O14931, P26717, P26715 | PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1 | More | | | Palbociclib | hsa04657 | IL-17 signaling pathway | 4.55E-02 | 5 | O00463, Q16539, P49841, P09341, P14780 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9 | More | | | Palbociclib | hsa04658 | Th1 and Th2 cell differentiation | 3.91E-15 | 12 | Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q04759 | PRKCQ | Protein kinase C theta type | Q04759 | PRKCQ | Protein kinase C theta type | 1 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q04759 | PRKCQ | Protein kinase C theta type | 0.79 | | Q04759 | PRKCQ | Protein kinase C theta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.713 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.824 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q15046 | KARS | Lysine--tRNA ligase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.88 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.855 | | Q04759 | PRKCQ | Protein kinase C theta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.92 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.895 | | Q04759 | PRKCQ | Protein kinase C theta type | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.756 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q15046 | KARS | Lysine--tRNA ligase | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.702 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P06239 | LCK | Tyrosine-protein kinase Lck | -0.701 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q15046 | KARS | Lysine--tRNA ligase | P06239 | LCK | Tyrosine-protein kinase Lck | 0.753 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.867 | | Q04759 | PRKCQ | Protein kinase C theta type | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.746 | | Q04759 | PRKCQ | Protein kinase C theta type | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.867 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | Q04759 | PRKCQ | Protein kinase C theta type | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.843 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | Q15046 | KARS | Lysine--tRNA ligase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.72 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.79 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.771 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.753 | | Q04759 | PRKCQ | Protein kinase C theta type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.82 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.855 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 | | Q15046 | KARS | Lysine--tRNA ligase | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.744 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.82 |
| | Palbociclib | hsa04659 | Th17 cell differentiation | 4.76E-15 | 18 | P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963 | NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.73 | | Q04759 | PRKCQ | Protein kinase C theta type | Q04759 | PRKCQ | Protein kinase C theta type | 1 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q04759 | PRKCQ | Protein kinase C theta type | 0.79 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.785 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q15046 | KARS | Lysine--tRNA ligase | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.702 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P06239 | LCK | Tyrosine-protein kinase Lck | -0.701 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q15046 | KARS | Lysine--tRNA ligase | P06239 | LCK | Tyrosine-protein kinase Lck | 0.753 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.867 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.841 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.865 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.771 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.753 | | Q04759 | PRKCQ | Protein kinase C theta type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.82 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.714 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | Q15046 | KARS | Lysine--tRNA ligase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.828 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.746 | | Q04759 | PRKCQ | Protein kinase C theta type | Q9HBE5 | IL21R | Interleukin-21 receptor | 0.8 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q9HBE5 | IL21R | Interleukin-21 receptor | 0.841 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.748 | | Q04759 | PRKCQ | Protein kinase C theta type | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.843 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | Q15046 | KARS | Lysine--tRNA ligase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.72 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.79 | | Q04759 | PRKCQ | Protein kinase C theta type | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.867 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.729 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.802 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.782 | | Q15046 | KARS | Lysine--tRNA ligase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.719 | | Q04759 | PRKCQ | Protein kinase C theta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.713 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.824 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q15046 | KARS | Lysine--tRNA ligase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.88 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.855 | | Q04759 | PRKCQ | Protein kinase C theta type | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.756 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | Q04759 | PRKCQ | Protein kinase C theta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.92 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.895 |
| | Palbociclib | hsa04660 | T cell receptor signaling pathway | 2.04E-08 | 12 | P01375, Q04759, P42338, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239 | TNF, PRKCQ, PIK3CB, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q04759 | PRKCQ | Protein kinase C theta type | P01375 | TNF | Tumor necrosis factor | -0.725 | | Q04759 | PRKCQ | Protein kinase C theta type | Q04759 | PRKCQ | Protein kinase C theta type | 1 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q04759 | PRKCQ | Protein kinase C theta type | 0.79 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.791 | | Q04759 | PRKCQ | Protein kinase C theta type | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.733 | | Q04759 | PRKCQ | Protein kinase C theta type | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.803 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | Q04759 | PRKCQ | Protein kinase C theta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.713 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.855 | | Q04759 | PRKCQ | Protein kinase C theta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.92 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.895 | | Q04759 | PRKCQ | Protein kinase C theta type | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.756 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q04759 | PRKCQ | Protein kinase C theta type | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.861 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.744 | | Q04759 | PRKCQ | Protein kinase C theta type | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.767 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.714 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.738 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.867 |
| | Palbociclib | hsa04662 | B cell receptor signaling pathway | 3.25E-05 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Palbociclib | hsa04664 | Fc epsilon RI signaling pathway | 2.00E-02 | 4 | P42338, P17252, P19174, P09917 | PIK3CB, PRKCA, PLCG1, ALOX5 | More | | | Palbociclib | hsa04666 | Fc gamma R-mediated phagocytosis | 8.08E-03 | 5 | P42338, P19174, P23528, P14598, P17252 | PIK3CB, PLCG1, CFL1, NCF1, PRKCA | More | | | Palbociclib | hsa04672 | Intestinal immune network for IgA production | 3.76E-03 | 3 | P29965, P10747, P13765 | CD40LG, CD28, HLA-DOB | More | | | Palbociclib | hsa04713 | Circadian entrainment | 1.05E-04 | 8 | O15399, P0DP23, P17252, P62873, P50151, Q14643, Q08828, P51828 | GRIN2D, CALM1, PRKCA, GNB1, GNG10, ITPR1, ADCY1, ADCY7 | More | | | Palbociclib | hsa04720 | Long-term potentiation | 2.48E-05 | 10 | P17252, P16298, P0DP23, Q15418, P51812, P18848, P17612, Q08828, Q02750, Q14643 | PRKCA, PPP3CB, CALM1, RPS6KA1, RPS6KA3, ATF4, PRKACA, ADCY1, MAP2K1, ITPR1 | More | | | Palbociclib | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Palbociclib | hsa04723 | Retrograde endocannabinoid signaling | 1.43E-03 | 6 | Q14643, P17252, P48169, P62873, P17612, Q16718 | ITPR1, PRKCA, GABRA4, GNB1, PRKACA, NDUFA5 | More | | | Palbociclib | hsa04724 | Glutamatergic synapse | 4.68E-04 | 6 | O15399, P17252, P62873, P63218, P50151, P15104 | GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLUL | More | | | Palbociclib | hsa04725 | Cholinergic synapse | 1.30E-05 | 11 | Q08828, P51828, P17612, Q14643, P17252, P62873, P50151, P18848, P42338, P31751, P10415 | ADCY1, ADCY7, PRKACA, ITPR1, PRKCA, GNB1, GNG10, ATF4, PIK3CB, AKT2, BCL2 | More | | | Palbociclib | hsa04726 | Serotonergic synapse | 2.54E-02 | 5 | P17252, P62873, P50151, P33260, P09917 | PRKCA, GNB1, GNG10, CYP2C18, ALOX5 | More | | | Palbociclib | hsa04727 | GABAergic synapse | 2.42E-05 | 7 | P62873, P63218, P50151, P48169, P15104, P17612, P17252 | GNB1, GNG5, GNG10, GABRA4, GLUL, PRKACA, PRKCA | More | | | Palbociclib | hsa04728 | Dopaminergic synapse | 4.29E-05 | 10 | P17612, Q14643, P17252, P62873, P31751, P18848, Q13362, Q14738, P0DP23, O15516 | PRKACA, ITPR1, PRKCA, GNB1, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, CLOCK | More | | | Palbociclib | hsa04730 | Long-term depression | 1.51E-02 | 3 | Q14344, P08069, P07948 | GNA13, IGF1R, LYN | More | | | Palbociclib | hsa04740 | Olfactory transduction | 2.09E-02 | 2 | P62873, P17612 | GNB1, PRKACA | More | | | Palbociclib | hsa04742 | Taste transduction | 3.78E-03 | 2 | P48169, P17612 | GABRA4, PRKACA | More | | | Palbociclib | hsa04744 | Phototransduction | 1.74E-04 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Palbociclib | hsa04750 | Inflammatory mediator regulation of TRP channels | 5.91E-05 | 8 | P14778, P01584, Q08828, P51828, P42338, P24723, Q04759, P0DP23 | IL1R1, IL1B, ADCY1, ADCY7, PIK3CB, PRKCH, PRKCQ, CALM1 | More | | | Palbociclib | hsa04911 | Insulin secretion | 2.40E-02 | 3 | Q08828, P51828, P18848 | ADCY1, ADCY7, ATF4 | More | | | Palbociclib | hsa04912 | GnRH signaling pathway | 1.52E-03 | 6 | P17252, Q08828, P51828, P18848, Q14643, P0DP23 | PRKCA, ADCY1, ADCY7, ATF4, ITPR1, CALM1 | More | | | Palbociclib | hsa04913 | Ovarian steroidogenesis | 1.16E-02 | 1 | P08069 | IGF1R | More | | | Palbociclib | hsa04914 | Progesterone-mediated oocyte maturation | 2.60E-04 | 10 | P08069, Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750 | IGF1R, CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1 | More | | | Palbociclib | hsa04915 | Estrogen signaling pathway | 2.01E-03 | 7 | P18848, Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788 | ATF4, ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1 | More | | | Palbociclib | hsa04916 | Melanogenesis | 2.40E-02 | 3 | P0DP23, Q08828, P51828 | CALM1, ADCY1, ADCY7 | More | | | Palbociclib | hsa04922 | Glucagon signaling pathway | 5.91E-03 | 6 | P14618, P06737, Q12778, Q13370, P0DP23, Q14643 | PKM2, PYGL, FOXO1, PDE3B, CALM1, ITPR1 | More | | | Palbociclib | hsa04923 | Regulation of lipolysis in adipocytes | 5.15E-03 | 3 | Q08828, P51828, P31751 | ADCY1, ADCY7, AKT2 | More | | | Palbociclib | hsa04924 | Renin secretion | 8.71E-03 | 3 | Q14643, Q13370, P0DP23 | ITPR1, PDE3B, CALM1 | More | | | Palbociclib | hsa04925 | Aldosterone synthesis and secretion | 9.86E-03 | 4 | P18848, Q08828, P51828, P0DP23 | ATF4, ADCY1, ADCY7, CALM1 | More | | | Palbociclib | hsa04926 | Relaxin signaling pathway | 1.06E-03 | 10 | P31751, P25963, P42338, P62873, P50151, P18848, P49767, Q08828, P51828, P17252 | AKT2, NFKBIA, PIK3CB, GNB1, GNG10, ATF4, VEGFC, ADCY1, ADCY7, PRKCA | More | | | Palbociclib | hsa04927 | Cortisol synthesis and secretion | 1.59E-02 | 3 | P18848, Q08828, P51828 | ATF4, ADCY1, ADCY7 | More | | | Palbociclib | hsa04932 | Non-alcoholic fatty liver disease | 2.44E-05 | 11 | P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O95298 | AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFC2 | More | | | Palbociclib | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.26E-03 | 7 | P42224, P10415, P42338, Q12778, P49767, P17252, P19174 | STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1 | More | | | Palbociclib | hsa04934 | Cushing syndrome | 2.27E-03 | 5 | P18848, Q08828, P51828, P17612, O15169 | ATF4, ADCY1, ADCY7, PRKACA, AXIN1 | More | | | Palbociclib | hsa04935 | Growth hormone synthesis, secretion and action | 1.88E-02 | 4 | Q08828, P51828, P18848, P31751 | ADCY1, ADCY7, ATF4, AKT2 | More | | | Palbociclib | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Palbociclib | hsa04966 | Collecting duct acid secretion | 2.86E-02 | 2 | Q13488, Q9Y666 | TCIRG1, SLC12A7 | More | | | Palbociclib | hsa04970 | Salivary secretion | 1.89E-03 | 3 | Q08828, P51828, P0DP23 | ADCY1, ADCY7, CALM1 | More | | | Palbociclib | hsa04971 | Gastric acid secretion | 2.54E-03 | 4 | Q08828, P51828, P15311, P0DP23 | ADCY1, ADCY7, VIL2, CALM1 | More | | | Palbociclib | hsa04976 | Bile secretion | 1.89E-03 | 3 | Q08828, P51828, Q14032 | ADCY1, ADCY7, BAAT | More | | | Palbociclib | hsa05010 | Alzheimer disease | 3.87E-05 | 19 | Q16718, O95298, O14521, P13073, Q14643, Q00535, O75460, P0DP23, P01584, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, P12236, Q08752, P28070 | NDUFA5, NDUFC2, SDHD, COX4I1, ITPR1, CDK5, ERN1, CALM1, IL1B, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, SLC25A6, PPID, PSMB4 | More | | | Palbociclib | hsa05012 | Parkinson disease | 1.58E-03 | 12 | Q16718, O14521, P13073, P05141, P12236, P17612, P18848, P28070, Q14643, P0DP23, Q13509, P68371 | NDUFA5, SDHD, COX4I1, SLC25A5, SLC25A6, PRKACA, ATF4, PSMB4, ITPR1, CALM1, TUBB3, TUBB2C | More | | | Palbociclib | hsa05014 | Amyotrophic lateral sclerosis | 4.20E-02 | 5 | Q71U36, Q13148, P21796, P43243, P84103 | TUBA1A, TARDBP, VDAC1, MATR3, SFRS3 | More | | | Palbociclib | hsa05016 | Huntington disease | 1.76E-03 | 10 | O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232 | NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12 | More | | | Palbociclib | hsa05017 | Spinocerebellar ataxia | 2.86E-03 | 8 | Q92915, O75460, O15399, P42338, P31751, P28070, P05141, P21796 | FGF14, ERN1, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1 | More | | | Palbociclib | hsa05020 | Prion disease | 4.94E-05 | 16 | P17612, Q16718, O14521, P13073, Q92736, Q14643, P18848, P05141, P12236, P28070, O60282, Q13509, P68371, P67870, P14598, Q15080 | PRKACA, NDUFA5, SDHD, COX4I1, RYR2, ITPR1, ATF4, SLC25A5, SLC25A6, PSMB4, KIF5C, TUBB3, TUBB2C, CSNK2B, NCF1, NCF4 | More | | | Palbociclib | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.74E-05 | 24 | Q14643, Q13509, P68371, P67870, P10415, Q16718, O95298, O14521, P13073, Q06055, Q8TEV9, O75460, P18848, Q13561, P05141, P12236, P17252, Q00535, O15169, P01584, Q08752, O15020, P0DP23, P28070 | ITPR1, TUBB3, TUBB2C, CSNK2B, BCL2, NDUFA5, NDUFC2, SDHD, COX4I1, ATP5G2, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, SLC25A6, PRKCA, CDK5, AXIN1, IL1B, PPID, SPTBN2, CALM1, PSMB4 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P17252 | PRKCA | Protein kinase C alpha type | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.786 | | P17252 | PRKCA | Protein kinase C alpha type | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.756 | | P17252 | PRKCA | Protein kinase C alpha type | P68371 | TUBB2C | Tubulin beta-4B chain | -0.842 | | P67870 | CSNK2B | Casein kinase II subunit beta | P67870 | CSNK2B | Casein kinase II subunit beta | 1 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P17252 | PRKCA | Protein kinase C alpha type | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 0.811 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | | P17252 | PRKCA | Protein kinase C alpha type | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | 0.822 | | P67870 | CSNK2B | Casein kinase II subunit beta | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.784 | | P30530 | AXL | Tyrosine-protein kinase receptor UFO | Q06055 | ATP5G2 | ATP synthase F(0) complex subunit C2, mitochondrial | -0.735 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8TEV9 | SMCR8 | Guanine nucleotide exchange protein SMCR8 | 0.807 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | | P67870 | CSNK2B | Casein kinase II subunit beta | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.733 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | | P17252 | PRKCA | Protein kinase C alpha type | Q13561 | DCTN2 | Dynactin subunit 2 | -0.844 | | P67870 | CSNK2B | Casein kinase II subunit beta | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.797 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | | P67870 | CSNK2B | Casein kinase II subunit beta | P12236 | SLC25A6 | ADP/ATP translocase 3 | 0.715 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 1 | | P67870 | CSNK2B | Casein kinase II subunit beta | O15169 | AXIN1 | Axin-1 | 0.702 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | | P17252 | PRKCA | Protein kinase C alpha type | Q08752 | PPID | Peptidyl-prolyl cis-trans isomerase D | 0.725 | | P30530 | AXL | Tyrosine-protein kinase receptor UFO | O15020 | SPTBN2 | Spectrin beta chain, non-erythrocytic 2 | 0.738 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | | P67870 | CSNK2B | Casein kinase II subunit beta | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.734 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 |
| | Palbociclib | hsa05032 | Morphine addiction | 3.40E-04 | 7 | P17612, P62873, P50151, Q13370, P48169, P17252, P43250 | PRKACA, GNB1, GNG10, PDE3B, GABRA4, PRKCA, GRK6 | More | | | Palbociclib | hsa05034 | Alcoholism | 1.07E-02 | 4 | P17612, P18848, P62873, P84243 | PRKACA, ATF4, GNB1, H3F3A | More | | | Palbociclib | hsa05100 | Bacterial invasion of epithelial cells | 2.85E-02 | 3 | Q14141, Q05397, Q96JJ3 | SEPT6, PTK2, ELMO2 | More | | | Palbociclib | hsa05110 | Vibrio cholerae infection | 3.15E-02 | 3 | Q13488, P17252, P19174 | TCIRG1, PRKCA, PLCG1 | More | | | Palbociclib | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.97E-04 | 7 | Q16539, Q99437, P09341, P25024, P25025, P41240, P07948 | MAPK14, ATP6V0B, CXCL1, CXCR1, CXCR2, CSK, LYN | More | | | Palbociclib | hsa05131 | Shigellosis | 1.52E-03 | 9 | Q13546, P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752 | RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID | More | | | Palbociclib | hsa05132 | Salmonella infection | 3.52E-04 | 11 | Q9UJU2, O00471, Q13546, Q13489, P10415, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371 | LEF1, EXOC5, RIPK1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C | More | | | Palbociclib | hsa05134 | Legionellosis | 2.82E-02 | 3 | P01584, Q9NR31, P0DMV8 | IL1B, SAR1A, HSPA1A | More | | | Palbociclib | hsa05135 | Yersinia infection | 3.29E-02 | 4 | Q05397, P51812, Q02750, Q96JJ3 | PTK2, RPS6KA3, MAP2K1, ELMO2 | More | | | Palbociclib | hsa05140 | Leishmaniasis | 2.04E-04 | 9 | O75015, P14598, P42224, P13765, O60603, P29350, P49006, Q16539, Q15080 | FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, PTPN6, MARCKSL1, MAPK14, NCF4 | More | | | Palbociclib | hsa05143 | African trypanosomiasis | 2.72E-02 | 2 | P01375, P48023 | TNF, FASLG | More | | | Palbociclib | hsa05145 | Toxoplasmosis | 1.19E-03 | 10 | P25963, P10415, Q13489, P42224, P13765, P09917, Q13751, P11142, O60603, P29965 | NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, ALOX5, LAMB3, HSPA8, TLR2, CD40LG | More | | | Palbociclib | hsa05146 | Amoebiasis | 2.01E-07 | 10 | P09341, P14778, P27930, P01375, O60603, P42338, P05089, P22694, P12814, P08311 | CXCL1, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ARG1, PRKACB, ACTN1, CTSG | More | | | Palbociclib | hsa05152 | Tuberculosis | 7.93E-04 | 8 | Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8 | TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1 | More | | | Palbociclib | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Palbociclib | hsa05162 | Measles | 5.20E-03 | 8 | P23458, P0DMV8, P11142, P01584, Q13191, Q9NP90, P30279, O43318 | JAK1, HSPA1A, HSPA8, IL1B, CBLB, RAB9B, CCND2, MAP3K7 | More | | | Palbociclib | hsa05163 | Human cytomegalovirus infection | 6.68E-09 | 28 | P31751, P42338, P01889, P10321, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P17612, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568 | AKT2, PIK3CB, HLA-B, HLA-C, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, PRKACA, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.743 | | P67870 | CSNK2B | Casein kinase II subunit beta | P01889 | HLA-B | HLA class I histocompatibility antigen, B alpha chain | 0.705 | | P67870 | CSNK2B | Casein kinase II subunit beta | P10321 | HLA-C | HLA class I histocompatibility antigen, C alpha chain | 0.705 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.73 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.837 | | P67870 | CSNK2B | Casein kinase II subunit beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.704 | | Q15046 | KARS | Lysine--tRNA ligase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.749 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.712 | | Q15046 | KARS | Lysine--tRNA ligase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.821 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.728 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P0DP23 | CALM1 | Calmodulin-1 | 0.926 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | | Q15046 | KARS | Lysine--tRNA ligase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.81 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | | P67870 | CSNK2B | Casein kinase II subunit beta | P17612 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | 0.75 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 1 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | Q15046 | KARS | Lysine--tRNA ligase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.828 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P17252 | PRKCA | Protein kinase C alpha type | -0.725 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.799 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.786 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.889 | | Q15046 | KARS | Lysine--tRNA ligase | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.741 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P67870 | CSNK2B | Casein kinase II subunit beta | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.733 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.739 | | Q15046 | KARS | Lysine--tRNA ligase | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.742 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P01568 | IFNA21 | Interferon alpha-21 | -0.868 |
| | Palbociclib | hsa05164 | Influenza A | 4.49E-02 | 5 | P31751, P01584, P23458, P05141, Q9UBU9 | AKT2, IL1B, JAK1, SLC25A5, NXF1 | More | | | Palbociclib | hsa05165 | Human papillomavirus infection | 3.10E-02 | 8 | P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315 | ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM | More | | | Palbociclib | hsa05166 | Human T-cell leukemia virus 1 infection | 1.06E-03 | 12 | Q9Y490, P23458, P01889, P10321, P05141, P12236, P62826, Q08828, P51828, P17612, P18848, P31751 | TLN1, JAK1, HLA-B, HLA-C, SLC25A5, SLC25A6, RAN, ADCY1, ADCY7, PRKACA, ATF4, AKT2 | More | | | Palbociclib | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 6.51E-05 | 14 | P01568, P42224, P25963, P42338, P40189, P01889, P10321, P62873, P50151, P19174, Q14643, Q29983, P0DP23, Q9UJU2 | IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, HLA-B, HLA-C, GNB1, GNG10, PLCG1, ITPR1, MICA, CALM1, LEF1 | More | | | Palbociclib | hsa05168 | Herpes simplex virus 1 infection | 6.31E-03 | 13 | P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q03923, O75820, Q9UDV6 | NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF85, ZNF189, ZNF212 | More | | | Palbociclib | hsa05169 | Epstein-Barr virus infection | 6.24E-05 | 16 | P13765, P01106, Q13547, Q92769, O00463, O43318, P07948, P30101, Q13761, P24522, P30279, P01375, P29728, P07766, P09693, P20963 | HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, MAP3K7, LYN, PDIA3, RUNX3, GADD45A, CCND2, TNF, OAS2, CD3E, CD3G, CD247 | More | | | Palbociclib | hsa05170 | Human immunodeficiency virus 1 infection | 1.26E-04 | 15 | P42338, P62873, P50151, P0DP23, P17252, P30101, Q14643, P01568, P25963, O60603, Q13315, P19174, P23528, P10415, Q9Y6Q5 | PIK3CB, GNB1, GNG10, CALM1, PRKCA, PDIA3, ITPR1, IFNA21, NFKBIA, TLR2, ATM, PLCG1, CFL1, BCL2, AP1M2 | More | | | Palbociclib | hsa05171 | Coronavirus disease - COVID-19 | 3.30E-02 | 7 | P25963, P42224, P01568, P40189, P42338, P19174, P17252 | NFKBIA, STAT1, IFNA21, IL6ST, PIK3CB, PLCG1, PRKCA | More | | | Palbociclib | hsa05200 | Pathways in cancer | 3.54E-05 | 25 | Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P10826, P14923, P10415, Q13489, P49767, P14921, Q12778, P25116, P62873, P50151, P78417, O75293, P0DP23, P01568, P14784, P40189 | LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, RARB, JUP, BCL2, BIRC3, VEGFC, ETS1, FOXO1, F2R, GNB1, GNG10, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q13751 | LAMB3 | Laminin subunit beta-3 | -0.705 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.743 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.802 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.841 | | P17252 | PRKCA | Protein kinase C alpha type | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.706 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.73 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.785 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.881 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P17252 | PRKCA | Protein kinase C alpha type | -0.725 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.925 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P10826 | RARB | Retinoic acid receptor beta | 0.779 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14923 | JUP | Junction plakoglobin | -0.716 | | P17252 | PRKCA | Protein kinase C alpha type | P14923 | JUP | Junction plakoglobin | 0.761 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.747 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.871 | | P17252 | PRKCA | Protein kinase C alpha type | P49767 | VEGFC | Vascular endothelial growth factor C | 0.719 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14921 | ETS1 | Protein C-ets-1 | 0.731 | | P17252 | PRKCA | Protein kinase C alpha type | Q12778 | FOXO1 | Forkhead box protein O1 | 0.863 | | P17252 | PRKCA | Protein kinase C alpha type | P25116 | F2R | Proteinase-activated receptor 1 | 0.857 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.837 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.712 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | -0.703 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.919 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P0DP23 | CALM1 | Calmodulin-1 | 0.926 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P01568 | IFNA21 | Interferon alpha-21 | -0.868 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.865 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.748 |
| | Palbociclib | hsa05202 | Transcriptional misregulation in cancer | 3.47E-03 | 11 | P14780, P27930, Q15744, Q16548, P08069, P05164, P12838, P08246, Q9C0K0, Q13547, P24522 | MMP9, IL1R2, CEBPE, BCL2A1, IGF1R, MPO, DEFA4, ELA2, BCL11B, HDAC1, GADD45A | More | | | Palbociclib | hsa05203 | Viral carcinogenesis | 4.43E-03 | 5 | P18848, Q15283, P01889, P10321, P17612 | ATF4, RASA2, HLA-B, HLA-C, PRKACA | More | | | Palbociclib | hsa05205 | Proteoglycans in cancer | 3.48E-02 | 1 | P08069 | IGF1R | More | | | Palbociclib | hsa05212 | Pancreatic cancer | 2.40E-02 | 3 | P31751, Q15311, P23458 | AKT2, RALBP1, JAK1 | More | | | Palbociclib | hsa05214 | Glioma | 4.14E-04 | 6 | P08069, P0DP23, P17252, P42338, P19174, O75293 | IGF1R, CALM1, PRKCA, PIK3CB, PLCG1, GADD45B | More | | | Palbociclib | hsa05215 | Prostate cancer | 2.79E-03 | 4 | P10415, Q12778, P08069, Q9NRA1 | BCL2, FOXO1, IGF1R, PDGFC | More | | | Palbociclib | hsa05218 | Melanoma | 6.63E-03 | 1 | P08069 | IGF1R | More | | | Palbociclib | hsa05219 | Bladder cancer | 4.07E-02 | 2 | P14780, P04637 | MMP9, TP53 | More | | | Palbociclib | hsa05222 | Small cell lung cancer | 1.10E-02 | 6 | P10826, P42338, Q13751, Q13489, P25963, O75293 | RARB, PIK3CB, LAMB3, BIRC3, NFKBIA, GADD45B | More | | | Palbociclib | hsa05223 | Non-small cell lung cancer | 4.91E-03 | 5 | P17252, P42338, P19174, P10826, O75293 | PRKCA, PIK3CB, PLCG1, RARB, GADD45B | More | | | Palbociclib | hsa05224 | Breast cancer | 1.24E-02 | 5 | P08069, P49841, Q92837, P04637, P24522 | IGF1R, GSK3B, FRAT1, TP53, GADD45A | More | | | Palbociclib | hsa05225 | Hepatocellular carcinoma | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Palbociclib | hsa05231 | Choline metabolism in cancer | 3.25E-05 | 9 | P31751, P42338, Q9Y259, P19174, P23743, P49619, Q16760, O14986, P17252 | AKT2, PIK3CB, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PRKCA | More | | | Palbociclib | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 3.56E-06 | 10 | P42338, O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730 | PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4 | More | | | Palbociclib | hsa05310 | Asthma | 8.13E-03 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Palbociclib | hsa05320 | Autoimmune thyroid disease | 1.27E-03 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | | Palbociclib | hsa05321 | Inflammatory bowel disease | 2.80E-04 | 6 | P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5 | TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R | More | | | Palbociclib | hsa05322 | Systemic lupus erythematosus | 4.18E-03 | 7 | P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431 | ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Palbociclib | hsa05323 | Rheumatoid arthritis | 1.29E-02 | 4 | P13765, Q13488, P10747, O60603 | HLA-DOB, TCIRG1, CD28, TLR2 | More | | | Palbociclib | hsa05330 | Allograft rejection | 1.04E-03 | 5 | P13765, P29965, P48023, P10747, P01375 | HLA-DOB, CD40LG, FASLG, CD28, TNF | More | | | Palbociclib | hsa05332 | Graft-versus-host disease | 7.76E-05 | 5 | P13765, P48023, P01375, P26715, Q13241 | HLA-DOB, FASLG, TNF, KLRC1, KLRD1 | More | | | Palbociclib | hsa05340 | Primary immunodeficiency | 2.62E-03 | 4 | P01730, P01732, P07766, P06239 | CD4, CD8A, CD3E, LCK | More | | | Palbociclib | hsa05415 | Diabetic cardiomyopathy | 3.55E-02 | 5 | P17252, P14598, Q15080, Q16718, O14521 | PRKCA, NCF1, NCF4, NDUFA5, SDHD | More | | | Palbociclib | hsa05416 | Viral myocarditis | 2.62E-02 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | | | Palbociclib | hsa05418 | Fluid shear stress and atherosclerosis | 2.62E-02 | 6 | Q16539, P10599, P14780, P04637, P14778, P27930 | MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2 | More | |
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