PharmaCoNets

PharmaCoNets of Paclitaxel (S_PCN: 41.66 )

Paclitaxel regulated-network (S_DN: 12.15)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Paclitaxel

hsa00010

Glycolysis / Gluconeogenesis

1.18E-02

P60174, P06744

TPI1, GPI

Paclitaxel

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Paclitaxel

hsa00053

Ascorbate and aldarate metabolism

1.80E-02

P51648, Q9UEF7

ALDH3A2, KL

Paclitaxel

hsa00190

Oxidative phosphorylation

3.56E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Paclitaxel

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Paclitaxel

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Paclitaxel

hsa00310

Lysine degradation

4.27E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Paclitaxel

hsa00500

Starch and sucrose metabolism

1.10E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Paclitaxel

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Paclitaxel

hsa00561

Glycerolipid metabolism

4.36E-03

O14494, P51648, P23743

PLPP1, ALDH3A2, DGKA

Paclitaxel

hsa00565

Ether lipid metabolism

3.94E-02

Q8N661

TMEM86B

Paclitaxel

hsa00630

Glyoxylate and dicarboxylate metabolism

2.42E-02

P40925, P15104

MDH1, GLUL

Paclitaxel

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Paclitaxel

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Paclitaxel

hsa01200

Carbon metabolism

1.99E-02

P06744, P60174

GPI, TPI1

Paclitaxel

hsa01521

EGFR tyrosine kinase inhibitor resistance

2.90E-02

P17252, P10415, Q9NRA1

PRKCA, BCL2, PDGFC

Paclitaxel

hsa01523

Antifolate resistance

3.80E-02

Q92820, P04818

GGH, TYMS

Paclitaxel

hsa01524

Platinum drug resistance

4.02E-02

Q13315, P10415, Q13489, P43246

ATM, BCL2, BIRC3, MSH2

Paclitaxel

hsa03013

RNA transport

3.98E-02

P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Paclitaxel

hsa03040

Spliceosome

1.45E-04

Q14562, O43143, O60508, P26368, P52298, Q13595, Q07955, Q01130, P84103, Q13243, P11142

DHX8, DHX15, CDC40, U2AF2, NCBP2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8

Paclitaxel

hsa04020

Calcium signaling pathway

2.09E-02

Q16566, P17252, P25116, P0DP23, Q9NRA1

CAMK4, PRKCA, F2R, CALM1, PDGFC

Paclitaxel

hsa04060

Cytokine-cytokine receptor interaction

2.19E-02

P32927, P27930, Q13651, P25024, P25025, Q9UBD3, P47992, P09341, P32248, P18510, P01730

CSF2RB, IL1R2, IL10RA, CXCR1, CXCR2, XCL2, XCL1, CXCL1, CCR7, IL1RN, CD4

Paclitaxel

hsa04061

Viral protein interaction with cytokine and cytokine receptor

8.11E-03

P32248, P09341, P25024, P25025, P47992, Q9UBD3, Q13651

CCR7, CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA

Paclitaxel

hsa04064

NF-kappa B signaling pathway

3.04E-03

P10415, Q13489, P25963, P51617, Q13546, Q9UDY8, Q13315, O75293

BCL2, BIRC3, NFKBIA, IRAK1, RIPK1, MALT1, ATM, GADD45B

Paclitaxel

hsa04071

Sphingolipid signaling pathway

1.10E-03

P17252, P21453, Q9H228, P01375, P10415, Q9UQC2, P01042

PRKCA, S1PR1, EDG8, TNF, BCL2, GAB2, KNG1

Paclitaxel

hsa04072

Phospholipase D signaling pathway

1.06E-02

P25116, P17252, O14494, P23743, Q9NRA1

F2R, PRKCA, PLPP1, DGKA, PDGFC

Paclitaxel

hsa04110

Cell cycle

6.80E-03

P06493, O75293, P30304, P33981, P42773, P01106

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC

Paclitaxel

hsa04120

Ubiquitin mediated proteolysis

2.89E-02

O95071, P0CG47

UBR5, UBB

Paclitaxel

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Paclitaxel

hsa04141

Protein processing in endoplasmic reticulum

2.77E-02

P27824, P30101, P60604, P11142, P08238

CANX, PDIA3, UBE2G2, HSPA8, HSP90AB1

Paclitaxel

hsa04145

Phagosome

1.69E-05

Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P27824, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, CANX, HLA-DOB

Paclitaxel

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Paclitaxel

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Paclitaxel

hsa04217

Necroptosis

3.69E-05

P01568, Q13489, Q13546, P42224, P08238, Q6FI13, P10415, O43633

IFNA21, BIRC3, RIPK1, STAT1, HSP90AB1, H2AC18; H2AC19, BCL2, CHMP2A

Paclitaxel

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Paclitaxel

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Paclitaxel

hsa04371

Apelin signaling pathway

1.12E-03

P62873, P63218, P50151, Q13370, Q14344, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD4, SMAD3, CAMK4, CALM1

Paclitaxel

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Paclitaxel

hsa04520

Adherens junction

8.77E-03

Q13485, P84022, O95863, Q15223

SMAD4, SMAD3, SNAI1, PVRL1

Paclitaxel

hsa04540

Gap junction

5.44E-03

P17252, Q13509, P68371, Q9NRA1

PRKCA, TUBB3, TUBB2C, PDGFC

Paclitaxel

hsa04620

Toll-like receptor signaling pathway

7.24E-03

P51617, Q13546, P01568, P42224, P25963

IRAK1, RIPK1, IFNA21, STAT1, NFKBIA

Paclitaxel

hsa04621

NOD-like receptor signaling pathway

4.54E-02

P08238, P42224, P01568, P25963, Q13489, P10415, Q13546

HSP90AB1, STAT1, IFNA21, NFKBIA, BIRC3, BCL2, RIPK1

Paclitaxel

hsa04623

Cytosolic DNA-sensing pathway

4.52E-05

P01568, Q13546, P25963

IFNA21, RIPK1, NFKBIA

Paclitaxel

hsa04640

Hematopoietic cell lineage

3.69E-02

P21926, P07766, P01730, P09564

CD9, CD3E, CD4, CD7

Paclitaxel

hsa04657

IL-17 signaling pathway

3.31E-02

P49841, P14780, P01375

GSK3B, MMP9, TNF

Paclitaxel

hsa04658

Th1 and Th2 cell differentiation

1.06E-03

Q04759, P20963, P09693, Q16539, P01730, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, CD4, GATA3, TBX21, HLA-DOB

Paclitaxel

hsa04659

Th17 cell differentiation

3.97E-05

P25963, Q04759, Q16539, P19174, P01730, P13765, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, HLA-DOB, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Paclitaxel

hsa04660

T cell receptor signaling pathway

1.33E-02

Q04759, O95267, Q08881, P20963, P09693, P01730, Q16539, P49841

PRKCQ, RASGRP1, ITK, CD247, CD3G, CD4, MAPK14, GSK3B

Paclitaxel

hsa04664

Fc epsilon RI signaling pathway

2.35E-02

P07948, P19174, P09917

LYN, PLCG1, ALOX5

Paclitaxel

hsa04666

Fc gamma R-mediated phagocytosis

1.76E-03

P23528, P06396, O14494, P14598, P17252

CFL1, GSN, PLPP1, NCF1, PRKCA

Paclitaxel

hsa04672

Intestinal immune network for IgA production

1.62E-02

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Paclitaxel

hsa04710

Circadian rhythm

6.85E-04

O15516, Q16526, Q9Y478

CLOCK, CRY1, PRKAB1

Paclitaxel

hsa04720

Long-term potentiation

2.05E-02

P17252, Q16566, P0DP23

PRKCA, CAMK4, CALM1

Paclitaxel

hsa04724

Glutamatergic synapse

4.43E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Paclitaxel

hsa04725

Cholinergic synapse

8.04E-03

P17252, P62873, Q16566, P10415

PRKCA, GNB1, CAMK4, BCL2

Paclitaxel

hsa04727

GABAergic synapse

4.43E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Paclitaxel

hsa04744

Phototransduction

2.95E-06

P62873, P0DP23

GNB1, CALM1

Paclitaxel

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Paclitaxel

hsa04916

Melanogenesis

3.86E-03

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Paclitaxel

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Paclitaxel

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Paclitaxel

hsa04925

Aldosterone synthesis and secretion

3.91E-02

P0DP23, P17252, Q16566

CALM1, PRKCA, CAMK4

Paclitaxel

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Paclitaxel

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Paclitaxel

hsa04961

Endocrine and other factor-regulated calcium reabsorption

1.22E-02

P20020, Q9UEF7, P17252

ATP2B1, KL, PRKCA

Paclitaxel

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Paclitaxel

hsa04976

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Paclitaxel

hsa05032

Morphine addiction

4.43E-02

P63218, P50151, P43250

GNG5, GNG10, GRK6

Paclitaxel

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

4.11E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Paclitaxel

hsa05132

Salmonella infection

3.63E-07

P51617, P25963, P08238, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371

IRAK1, NFKBIA, HSP90AB1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
Q13509	TUBB3	Tubulin beta-3 chain	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q13509	TUBB3	Tubulin beta-3 chain	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.714
Q13509	TUBB3	Tubulin beta-3 chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.789
P68371	TUBB2C	Tubulin beta-4B chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.741
P10415	BCL2	Apoptosis regulator Bcl-2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.908
P68371	TUBB2C	Tubulin beta-4B chain	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
Q13509	TUBB3	Tubulin beta-3 chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.735
P68371	TUBB2C	Tubulin beta-4B chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.748
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
Q13509	TUBB3	Tubulin beta-3 chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P68371	TUBB2C	Tubulin beta-4B chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.892
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P10415	BCL2	Apoptosis regulator Bcl-2	O75369	FLNB	Filamin-B	-0.762
Q13509	TUBB3	Tubulin beta-3 chain	O75369	FLNB	Filamin-B	0.914
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P10415	BCL2	Apoptosis regulator Bcl-2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.929
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P10415	BCL2	Apoptosis regulator Bcl-2	Q13561	DCTN2	Dynactin subunit 2	-0.843
Q13509	TUBB3	Tubulin beta-3 chain	Q13561	DCTN2	Dynactin subunit 2	0.74
P68371	TUBB2C	Tubulin beta-4B chain	Q13561	DCTN2	Dynactin subunit 2	0.715
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
Q13509	TUBB3	Tubulin beta-3 chain	Q13509	TUBB3	Tubulin beta-3 chain	1
P68371	TUBB2C	Tubulin beta-4B chain	Q13509	TUBB3	Tubulin beta-3 chain	0.78
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766
Q13509	TUBB3	Tubulin beta-3 chain	P68371	TUBB2C	Tubulin beta-4B chain	0.78
P68371	TUBB2C	Tubulin beta-4B chain	P68371	TUBB2C	Tubulin beta-4B chain	1

Paclitaxel

hsa05140

Leishmaniasis

4.05E-03

P14598, P42224, P25963, P29350, P51617, Q15080

NCF1, STAT1, NFKBIA, PTPN6, IRAK1, NCF4

Paclitaxel

hsa05145

Toxoplasmosis

1.95E-03

P51617, P25963, P10415, Q13489, P42224, P11142

IRAK1, NFKBIA, BCL2, BIRC3, STAT1, HSPA8

Paclitaxel

hsa05152

Tuberculosis

1.40E-05

Q13488, P0DP23, P42224, P48382, P25208, O60603, P10415, P13765, P01568, Q9UDY8, P51617

TCIRG1, CALM1, STAT1, RFX5, NFYB, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1

Paclitaxel

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Paclitaxel

hsa05162

Measles

4.50E-03

P51617, P01568, P25963, P42224, P14784, P10747, P11142, P10415

IRAK1, IFNA21, NFKBIA, STAT1, IL2RB, CD28, HSPA8, BCL2

Paclitaxel

hsa05166

Human T-cell leukemia virus 1 infection

1.77E-02

P27824, P30279, P21796, P84022, Q13485, P07766, Q92830, P06746

CANX, CCND2, VDAC1, SMAD3, SMAD4, CD3E, KAT2A, POLB

Paclitaxel

hsa05168

Herpes simplex virus 1 infection

5.65E-04

P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P51617, Q13398, Q9NR11, P17097, P17038, Q03923, P10415

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, ZNF211, ZNF302, ZNF7, ZNF43, ZNF85, BCL2

Paclitaxel

hsa05170

Human immunodeficiency virus 1 infection

1.21E-06

P62873, P0DP23, P17252, Q13546, O00463, Q14643, P01568, P51617, P25963, O60603, Q13315, P23528, P10415, Q93034, Q9Y6Q5

GNB1, CALM1, PRKCA, RIPK1, TRAF5, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CFL1, BCL2, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.777
Q13509	TUBB3	Tubulin beta-3 chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.816
P68371	TUBB2C	Tubulin beta-4B chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P10415	BCL2	Apoptosis regulator Bcl-2	P0DP23	CALM1	Calmodulin-1	-0.772
Q13509	TUBB3	Tubulin beta-3 chain	P0DP23	CALM1	Calmodulin-1	0.892
P68371	TUBB2C	Tubulin beta-4B chain	P0DP23	CALM1	Calmodulin-1	0.742
P10415	BCL2	Apoptosis regulator Bcl-2	P17252	PRKCA	Protein kinase C alpha type	0.844
Q13509	TUBB3	Tubulin beta-3 chain	P17252	PRKCA	Protein kinase C alpha type	-0.756
P68371	TUBB2C	Tubulin beta-4B chain	P17252	PRKCA	Protein kinase C alpha type	-0.842
Q13509	TUBB3	Tubulin beta-3 chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.735
P68371	TUBB2C	Tubulin beta-4B chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.748
P10415	BCL2	Apoptosis regulator Bcl-2	O00463	TRAF5	TNF receptor-associated factor 5	0.773
P10415	BCL2	Apoptosis regulator Bcl-2	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.858
P10415	BCL2	Apoptosis regulator Bcl-2	P01568	IFNA21	Interferon alpha-21	0.721
Q13509	TUBB3	Tubulin beta-3 chain	P01568	IFNA21	Interferon alpha-21	-0.781
P68371	TUBB2C	Tubulin beta-4B chain	P01568	IFNA21	Interferon alpha-21	-0.783
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
Q13509	TUBB3	Tubulin beta-3 chain	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.757
Q13509	TUBB3	Tubulin beta-3 chain	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.714
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P68371	TUBB2C	Tubulin beta-4B chain	Q13315	ATM	Serine-protein kinase ATM	-0.772
P10415	BCL2	Apoptosis regulator Bcl-2	P23528	CFL1	Cofilin-1	0.741
Q13509	TUBB3	Tubulin beta-3 chain	P23528	CFL1	Cofilin-1	-0.726
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P10415	BCL2	Apoptosis regulator Bcl-2	Q93034	CUL5	Cullin-5	0.704
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.901
Q13509	TUBB3	Tubulin beta-3 chain	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.886
P68371	TUBB2C	Tubulin beta-4B chain	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.753

Paclitaxel

hsa05200

Pathways in cancer

2.19E-05

P04628, Q13751, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, P14923, P30279, P10415, Q13489, Q12778, P25116, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784, P01042

WNT1, LAMB3, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, JUP, CCND2, BCL2, BIRC3, FOXO1, F2R, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13509	TUBB3	Tubulin beta-3 chain	P04628	WNT1	Proto-oncogene Wnt-1	-0.709
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q13751	LAMB3	Laminin subunit beta-3	0.748
Q13509	TUBB3	Tubulin beta-3 chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.789
P68371	TUBB2C	Tubulin beta-4B chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.741
Q71U36	TUBA1A	Tubulin alpha-1A chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.866
Q13509	TUBB3	Tubulin beta-3 chain	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.733
Q13509	TUBB3	Tubulin beta-3 chain	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.714
Q71U36	TUBA1A	Tubulin alpha-1A chain	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.7
P68371	TUBB2C	Tubulin beta-4B chain	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
Q13509	TUBB3	Tubulin beta-3 chain	P17252	PRKCA	Protein kinase C alpha type	-0.756
P68371	TUBB2C	Tubulin beta-4B chain	P17252	PRKCA	Protein kinase C alpha type	-0.842
Q13509	TUBB3	Tubulin beta-3 chain	P43246	MSH2	DNA mismatch repair protein Msh2	0.872
P68371	TUBB2C	Tubulin beta-4B chain	P43246	MSH2	DNA mismatch repair protein Msh2	0.709
Q71U36	TUBA1A	Tubulin alpha-1A chain	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.819
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.777
Q71U36	TUBA1A	Tubulin alpha-1A chain	P20585	MSH3	DNA mismatch repair protein Msh3	-0.745
Q13509	TUBB3	Tubulin beta-3 chain	P14923	JUP	Junction plakoglobin	-0.937
P68371	TUBB2C	Tubulin beta-4B chain	P14923	JUP	Junction plakoglobin	-0.781
Q71U36	TUBA1A	Tubulin alpha-1A chain	P30279	CCND2	G1/S-specific cyclin-D2	-0.721
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
Q13509	TUBB3	Tubulin beta-3 chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P68371	TUBB2C	Tubulin beta-4B chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.892
P68371	TUBB2C	Tubulin beta-4B chain	Q12778	FOXO1	Forkhead box protein O1	-0.895
P68371	TUBB2C	Tubulin beta-4B chain	P25116	F2R	Proteinase-activated receptor 1	-0.799
Q13509	TUBB3	Tubulin beta-3 chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.816
P68371	TUBB2C	Tubulin beta-4B chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q71U36	TUBA1A	Tubulin alpha-1A chain	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.818
Q71U36	TUBA1A	Tubulin alpha-1A chain	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.827
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.879
Q13509	TUBB3	Tubulin beta-3 chain	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.826
Q13509	TUBB3	Tubulin beta-3 chain	P0DP23	CALM1	Calmodulin-1	0.892
P68371	TUBB2C	Tubulin beta-4B chain	P0DP23	CALM1	Calmodulin-1	0.742
Q13509	TUBB3	Tubulin beta-3 chain	P01568	IFNA21	Interferon alpha-21	-0.781
P68371	TUBB2C	Tubulin beta-4B chain	P01568	IFNA21	Interferon alpha-21	-0.783
Q13509	TUBB3	Tubulin beta-3 chain	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.709
P68371	TUBB2C	Tubulin beta-4B chain	P01042	KNG1	Kininogen-1	-0.7

Paclitaxel

hsa05202

Transcriptional misregulation in cancer

3.51E-02

Q12778, Q15532, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0

FOXO1, SS18, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B

Paclitaxel

hsa05203

Viral carcinogenesis

1.90E-02

P06746, Q92830, P07948, P30279, P29083, Q93079

POLB, KAT2A, LYN, CCND2, GTF2E1, H2BC9

Paclitaxel

hsa05205

Proteoglycans in cancer

1.09E-02

Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962

TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63

Paclitaxel

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Paclitaxel

hsa05212

Pancreatic cancer

3.52E-02

P84022, Q13485

SMAD3, SMAD4

Paclitaxel

hsa05214

Glioma

2.90E-02

P0DP23, Q16566, P17252

CALM1, CAMK4, PRKCA

Paclitaxel

hsa05215

Prostate cancer

6.15E-03

P10415, Q9UJU2, Q12778, Q9NRA1, P08238

BCL2, LEF1, FOXO1, PDGFC, HSP90AB1

Paclitaxel

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Paclitaxel

hsa05220

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Paclitaxel

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Paclitaxel

hsa05223

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Paclitaxel

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Paclitaxel

hsa05231

Choline metabolism in cancer

5.44E-03

Q9NRA1, P23743, O14494, P17252

PDGFC, DGKA, PLPP1, PRKCA

Paclitaxel

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.05E-03

O95267, P07766, P20963, P09693, P06239, Q04759, Q16539, Q9HC35, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, EML4, CD4

Paclitaxel

hsa05320

Autoimmune thyroid disease

8.64E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Paclitaxel

hsa05340

Primary immunodeficiency

1.28E-03

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Community members of Paclitaxel (S_DC: 3.43)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

BCL2

Apoptosis regulator BclNone2

Reported

0.0341

0.5271

2.0714

P27816

MAP4

MicrotubuleNoneassociated protein 4

Reported

0.2361

0.0133

0.1447

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Reported

0.0315

0.9493

1.9143

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

Q13509

TUBB3

Tubulin betaNone3 chain

Predicted

0.0904

0.0961

0.6484

0.8858

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

Q13885

TUBB2A

Tubulin betaNone2A chain

Predicted

0.0398

0.0963

0.6484

0.8609

P68371

TUBB2C

Tubulin betaNone4B chain

Predicted

0.2866

0.097

0.6484

0.9857

Q13509

TUBB3

Tubulin betaNone3 chain

Predicted

0.0904

0.0961

0.6484

0.8858

Q71U36

TUBA1A

Tubulin alphaNone1A chain

Predicted

0.5888

0.0701

0.7094

1.1439

Q07817

BCL2L1

BclNone2Nonelike protein 1

Predicted

0.0872

0.4349

1.9134

P10826

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

PharmaCoNets of Paclitaxel (SPCN: 41.66 )

Paclitaxel regulated-network (SDN: 12.15)

Community members of Paclitaxel (SDC: 3.43)

PharmaCoNets of Paclitaxel (S_PCN: 41.66 )

Paclitaxel regulated-network (S_DN: 12.15)

Community members of Paclitaxel (S_DC: 3.43)