PharmaCoNets of Oxtriphylline (SPCN: 31.78 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Oxtriphyllinehsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Oxtriphyllinehsa00190Oxidative phosphorylation1.07E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Oxtriphyllinehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Oxtriphyllinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Oxtriphyllinehsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Oxtriphyllinehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Oxtriphyllinehsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Oxtriphyllinehsa03040Spliceosome2.09E-027Q14562, O43143, O75940, O75494, Q07955, Q01130, Q13243DHX8, DHX15, SMNDC1, FUSIP1, SFRS1, SFRS2, SFRS5More
Oxtriphyllinehsa03050Proteasome4.83E-021P55036PSMD4More
Oxtriphyllinehsa04014Ras signaling pathway1.70E-027P20827, Q9NRA1, P49767, P17252, P0DP23, P62873, P19174EFNA1, PDGFC, VEGFC, PRKCA, CALM1, GNB1, PLCG1More
Oxtriphyllinehsa04015Rap1 signaling pathway4.58E-026P20827, Q9NRA1, P49767, P0DP23, P17252, P19174EFNA1, PDGFC, VEGFC, CALM1, PRKCA, PLCG1More
Oxtriphyllinehsa04020Calcium signaling pathway2.01E-026P17252, P19174, P0DP23, P20020, Q9NRA1, P49767PRKCA, PLCG1, CALM1, ATP2B1, PDGFC, VEGFCMore
Oxtriphyllinehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Oxtriphyllinehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Oxtriphyllinehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Oxtriphyllinehsa04070Phosphatidylinositol signaling system4.40E-024P19174, P0DP23, P23743, P17252PLCG1, CALM1, DGKA, PRKCAMore
Oxtriphyllinehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Oxtriphyllinehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Oxtriphyllinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Oxtriphyllinehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Oxtriphyllinehsa04145Phagosome4.68E-025Q15080, P14598, Q13509, P68371, Q13488NCF4, NCF1, TUBB3, TUBB2C, TCIRG1More
Oxtriphyllinehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Oxtriphyllinehsa04217Necroptosis1.36E-027P01568, P42224, P08238, Q6FI13, Q93077, O43633, Q08752IFNA21, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, CHMP2A, PPIDMore
Oxtriphyllinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Oxtriphyllinehsa04360Axon guidance2.29E-025P16333, P20827, O95631, P17252, P19174NCK1, EFNA1, NTN1, PRKCA, PLCG1More
Oxtriphyllinehsa04540Gap junction1.67E-024P17252, Q13509, P68371, Q9NRA1PRKCA, TUBB3, TUBB2C, PDGFCMore
Oxtriphyllinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Oxtriphyllinehsa04623Cytosolic DNA-sensing pathway3.29E-022P01568, P25963IFNA21, NFKBIAMore
Oxtriphyllinehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Oxtriphyllinehsa04650Natural killer cell mediated cytotoxicity5.49E-0612P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Oxtriphyllinehsa04657IL-17 signaling pathway2.05E-039P25963, P08238, Q07955, P19875, P14780, P04141, P80188, P01375, P06702NFKBIA, HSP90AB1, SFRS1, CXCL2, MMP9, CSF2, LCN2, TNF, S100A9More
Oxtriphyllinehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Oxtriphyllinehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Oxtriphyllinehsa04660T cell receptor signaling pathway4.48E-0413P04141, P25963, Q04759, P42338, P10747, P19174, P16333, P07766, P20963, P01732, Q13191, P06239, P29350CSF2, NFKBIA, PRKCQ, PIK3CB, CD28, PLCG1, NCK1, CD3E, CD247, CD8A, CBLB, LCK, PTPN6More
Oxtriphyllinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Oxtriphyllinehsa04713Circadian entrainment3.32E-024P0DP23, P17252, P62873, O15055CALM1, PRKCA, GNB1, PER2More
Oxtriphyllinehsa04744Phototransduction1.18E-022P62873, P0DP23GNB1, CALM1More
Oxtriphyllinehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Oxtriphyllinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Oxtriphyllinehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Oxtriphyllinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Oxtriphyllinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Oxtriphyllinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Oxtriphyllinehsa04933AGE-RAGE signaling pathway in diabetic complications1.72E-025P42224, Q12778, P49767, P17252, P19174STAT1, FOXO1, VEGFC, PRKCA, PLCG1More
Oxtriphyllinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Oxtriphyllinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Oxtriphyllinehsa05012Parkinson disease3.12E-026Q16718, O14521, P19174, P0DP23, Q13509, P68371NDUFA5, SDHD, PLCG1, CALM1, TUBB3, TUBB2CMore
Oxtriphyllinehsa05022Pathways of neurodegeneration - multiple diseases2.29E-029Q13509, P68371, Q16718, O14521, Q13561, P19174, P17252, Q08752, P0DP23TUBB3, TUBB2C, NDUFA5, SDHD, DCTN2, PLCG1, PRKCA, PPID, CALM1More
Oxtriphyllinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Oxtriphyllinehsa05110Vibrio cholerae infection1.98E-023Q13488, P17252, P19174TCIRG1, PRKCA, PLCG1More
Oxtriphyllinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Oxtriphyllinehsa05132Salmonella infection1.70E-028P25963, P08238, P04406, O75369, Q13561, Q13509, P68371, P49754NFKBIA, HSP90AB1, GAPDH, FLNB, DCTN2, TUBB3, TUBB2C, VPS41More
Oxtriphyllinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Oxtriphyllinehsa05140Leishmaniasis1.72E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Oxtriphyllinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Oxtriphyllinehsa05146Amoebiasis2.05E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Oxtriphyllinehsa05167Kaposi sarcoma-associated herpesvirus infection5.71E-038P01568, P42224, P25963, P40189, P62873, P19174, P04141, P0DP23IFNA21, STAT1, NFKBIA, IL6ST, GNB1, PLCG1, CSF2, CALM1More
Oxtriphyllinehsa05168Herpes simplex virus 1 infection4.15E-0312P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13398, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, ZNF211, ZNF85, ZNF140, ZNF189, ZNF212More
Oxtriphyllinehsa05171Coronavirus disease - COVID-191.36E-027P25963, P42224, P01568, P40189, P04141, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCAMore
Oxtriphyllinehsa05200Pathways in cancer1.75E-0214P08238, P42224, P25963, P19174, P17252, P43246, P14923, P49767, Q12778, P62873, O75293, P0DP23, P01568, P40189HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, JUP, VEGFC, FOXO1, GNB1, GADD45B, CALM1, IFNA21, IL6STMore
Oxtriphyllinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Oxtriphyllinehsa05214Glioma1.09E-024P0DP23, P17252, P19174, O75293CALM1, PRKCA, PLCG1, GADD45BMore
Oxtriphyllinehsa05231Choline metabolism in cancer2.25E-035Q9NRA1, Q9Y259, P19174, P23743, P17252PDGFC, CHKB, PLCG1, DGKA, PRKCAMore
Oxtriphyllinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer7.13E-0410P25963, P42338, P19174, P07766, P20963, P06239, P29350, P42224, P10747, Q04759NFKBIA, PIK3CB, PLCG1, CD3E, CD247, LCK, PTPN6, STAT1, CD28, PRKCQMore
Oxtriphyllinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Oxtriphyllinehsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More
Oxtriphyllinehsa05415Diabetic cardiomyopathy1.20E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore

Community members of Oxtriphylline (SDC: 3.22)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q92769HDAC2Histone deacetylase 2Reported10.047310.9863.0097
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)