PharmaCoNets of Oxitriptan (SPCN: 40.45 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Oxitriptanhsa00030Pentose phosphate pathway3.33E-032P60891, P37837PRPS1, TALDO1More
Oxitriptanhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Oxitriptanhsa00250Alanine, aspartate and glutamate metabolism1.22E-022Q96RQ9, P15104IL4I1, GLULMore
Oxitriptanhsa00270Cysteine and methionine metabolism3.39E-022Q96RQ9, P40926IL4I1, MDH2More
Oxitriptanhsa00310Lysine degradation4.57E-022Q96KQ7, Q02809EHMT2, PLOD1More
Oxitriptanhsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Oxitriptanhsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Oxitriptanhsa00561Glycerolipid metabolism1.12E-023Q8NEB5, P14550, Q86XP1PPAPDC1B, AKR1A1, DGKHMore
Oxitriptanhsa00562Inositol phosphate metabolism2.00E-024P27987, P19174, P42338, Q02252ITPKB, PLCG1, PIK3CB, ALDH6A1More
Oxitriptanhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Oxitriptanhsa00630Glyoxylate and dicarboxylate metabolism1.67E-022P40925, P15104MDH1, GLULMore
Oxitriptanhsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Oxitriptanhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Oxitriptanhsa00900Terpenoid backbone biosynthesis1.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Oxitriptanhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Oxitriptanhsa00980Metabolism of xenobiotics by cytochrome P4504.50E-021P28332ADH6More
Oxitriptanhsa00982Drug metabolism - cytochrome P4504.50E-021P28332ADH6More
Oxitriptanhsa01230Biosynthesis of amino acids4.31E-022P60891, P37837PRPS1, TALDO1More
Oxitriptanhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Oxitriptanhsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Oxitriptanhsa03040Spliceosome1.62E-028Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8More
Oxitriptanhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Oxitriptanhsa04012ErbB signaling pathway2.00E-024P16333, P17252, P19174, P42338NCK1, PRKCA, PLCG1, PIK3CBMore
Oxitriptanhsa04014Ras signaling pathway7.71E-0410P42338, P20827, P49767, Q13009, P17252, P14921, P0DP23, P62873, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, PRKCA, ETS1, CALM1, GNB1, GNG10, PLCG1More
Oxitriptanhsa04015Rap1 signaling pathway9.88E-038P20827, P49767, P11215, Q13009, P42338, P0DP23, P17252, P19174EFNA1, VEGFC, ITGAM, TIAM1, PIK3CB, CALM1, PRKCA, PLCG1More
Oxitriptanhsa04020Calcium signaling pathway3.09E-0311P27987, Q96DU7, Q13557, P17252, P21860, O15399, P19174, P0DP23, P26678, P63092, P49767ITPKB, ITPKC, CAMK2D, PRKCA, ERBB3, GRIN2D, PLCG1, CALM1, PLN, GNAS, VEGFCMore
Oxitriptanhsa04024cAMP signaling pathway4.34E-026P42338, P0DP23, Q13370, O15399, P25963, Q13009PIK3CB, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1More
Oxitriptanhsa04062Chemokine signaling pathway1.25E-029P42338, P19174, P62873, P50151, P43250, Q13009, P14598, P42224, P25963PIK3CB, PLCG1, GNB1, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIAMore
Oxitriptanhsa04070Phosphatidylinositol signaling system3.29E-036P19174, P0DP23, P42338, P23743, P27987, P17252PLCG1, CALM1, PIK3CB, DGKA, ITPKB, PRKCAMore
Oxitriptanhsa04071Sphingolipid signaling pathway1.87E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Oxitriptanhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Oxitriptanhsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Oxitriptanhsa04151PI3K-Akt signaling pathway1.43E-0212P42338, P20827, P49767, P08238, P62873, P50151, P16144, O15335, Q13751, P14784, P01568, P17252PIK3CB, EFNA1, VEGFC, HSP90AB1, GNB1, GNG10, ITGB4, CHAD, LAMB3, IL2RB, IFNA21, PRKCAMore
Oxitriptanhsa04217Necroptosis2.97E-0311P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, P15104, Q6FI13, Q99878, O43633TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, GLUL, H2AC18; H2AC19, H2AC14, CHMP2AMore
Oxitriptanhsa04330Notch signaling pathway1.12E-023Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Oxitriptanhsa04360Axon guidance2.13E-037P16333, P20827, O95631, P17252, P42338, P23528, P19174NCK1, EFNA1, NTN1, PRKCA, PIK3CB, CFL1, PLCG1More
Oxitriptanhsa04370VEGF signaling pathway7.68E-033P19174, P42338, P17252PLCG1, PIK3CB, PRKCAMore
Oxitriptanhsa04510Focal adhesion7.77E-039P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P49767ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, VEGFCMore
Oxitriptanhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Oxitriptanhsa04613Neutrophil extracellular trap formation7.32E-0313O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Oxitriptanhsa04622RIG-I-like receptor signaling pathway3.39E-022Q12933, P10145TRAF2, IL8More
Oxitriptanhsa04623Cytosolic DNA-sensing pathway4.57E-022P01568, P25963IFNA21, NFKBIAMore
Oxitriptanhsa04650Natural killer cell mediated cytotoxicity4.40E-026P78314, P06239, O60880, P20963, P26718, O75015SH3BP2, LCK, SH2D1A, CD247, KLRK1, FCGR3BMore
Oxitriptanhsa04657IL-17 signaling pathway4.98E-026O00463, Q16539, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, MMP9, ANAPC5, LCN2, TNFMore
Oxitriptanhsa04658Th1 and Th2 cell differentiation9.73E-036P20963, P09693, Q16539, P06239, Q9UL17, P13765CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOBMore
Oxitriptanhsa04659Th17 cell differentiation1.05E-0313P25963, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P08238, P09693, P20963NFKBIA, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, HSP90AB1, CD3G, CD247More
Oxitriptanhsa04664Fc epsilon RI signaling pathway2.00E-024P42338, P17252, P19174, P09917PIK3CB, PRKCA, PLCG1, ALOX5More
Oxitriptanhsa04666Fc gamma R-mediated phagocytosis8.08E-035P42338, P19174, P23528, P14598, P17252PIK3CB, PLCG1, CFL1, NCF1, PRKCAMore
Oxitriptanhsa04713Circadian entrainment5.73E-049O15399, P0DP23, Q13557, Q02153, P17252, P62873, P50151, P61952, P63092GRIN2D, CALM1, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG10, GNG11, GNASMore
Oxitriptanhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Oxitriptanhsa04724Glutamatergic synapse8.08E-035O15399, P17252, P62873, P50151, P15104GRIN2D, PRKCA, GNB1, GNG10, GLULMore
Oxitriptanhsa04725Cholinergic synapse4.26E-024P17252, P62873, P50151, P42338PRKCA, GNB1, GNG10, PIK3CBMore
Oxitriptanhsa04726Serotonergic synapse2.54E-025P17252, P62873, P50151, P33260, P09917PRKCA, GNB1, GNG10, CYP2C18, ALOX5More
Oxitriptanhsa04727GABAergic synapse1.23E-024P62873, P50151, P15104, P17252GNB1, GNG10, GLUL, PRKCAMore
Oxitriptanhsa04728Dopaminergic synapse2.41E-025P63092, P61952, Q99941, Q13557, O15516GNAS, GNG11, CREBL1, CAMK2D, CLOCKMore
Oxitriptanhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Oxitriptanhsa04742Taste transduction1.01E-021P30939HTR1FMore
Oxitriptanhsa04744Phototransduction1.67E-022P62873, P0DP23GNB1, CALM1More
Oxitriptanhsa04911Insulin secretion4.88E-023P63092, Q99941, Q13557GNAS, CREBL1, CAMK2DMore
Oxitriptanhsa04914Progesterone-mediated oocyte maturation1.24E-025P42338, Q13370, Q9UJX4, P30304, P08238PIK3CB, PDE3B, ANAPC5, CDC25A, HSP90AB1More
Oxitriptanhsa04926Relaxin signaling pathway1.53E-026P25963, P42338, P62873, P50151, P49767, P17252NFKBIA, PIK3CB, GNB1, GNG10, VEGFC, PRKCAMore
Oxitriptanhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Oxitriptanhsa04933AGE-RAGE signaling pathway in diabetic complications3.43E-025P42224, P42338, P49767, P17252, P19174STAT1, PIK3CB, VEGFC, PRKCA, PLCG1More
Oxitriptanhsa04934Cushing syndrome1.75E-024Q99941, P63092, O15169, Q13557CREBL1, GNAS, AXIN1, CAMK2DMore
Oxitriptanhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Oxitriptanhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Oxitriptanhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Oxitriptanhsa04977Vitamin digestion and absorption3.43E-021P41440SLC19A1More
Oxitriptanhsa05020Prion disease3.28E-022Q92736, O60282RYR2, KIF5CMore
Oxitriptanhsa05031Amphetamine addiction4.88E-023Q13557, P63092, Q99941CAMK2D, GNAS, CREBL1More
Oxitriptanhsa05032Morphine addiction1.24E-025P62873, P50151, Q13370, P17252, P43250GNB1, GNG10, PDE3B, PRKCA, GRK6More
Oxitriptanhsa05110Vibrio cholerae infection3.15E-023Q13488, P17252, P19174TCIRG1, PRKCA, PLCG1More
Oxitriptanhsa05132Salmonella infection4.83E-022O00471, O60282EXOC5, KIF5CMore
Oxitriptanhsa05133Pertussis4.20E-021P0C0L4C4AMore
Oxitriptanhsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Oxitriptanhsa05144Malaria1.44E-036P60033, P69905, P68871, O60603, P35443, P26718CD81, HBA2, HBB, TLR2, THBS4, KLRK1More
Oxitriptanhsa05145Toxoplasmosis3.45E-026P25963, Q13489, P42224, P09917, Q13751, P11142NFKBIA, BIRC3, STAT1, ALOX5, LAMB3, HSPA8More
Oxitriptanhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Oxitriptanhsa05163Human cytomegalovirus infection1.62E-028P42338, P25963, P62873, P50151, P0DP23, P17252, P30101, P01568PIK3CB, NFKBIA, GNB1, GNG10, CALM1, PRKCA, PDIA3, IFNA21More
Oxitriptanhsa05167Kaposi sarcoma-associated herpesvirus infection4.56E-039P01568, P42224, P25963, P42338, P40189, P62873, P50151, P19174, P0DP23IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNG10, PLCG1, CALM1More
Oxitriptanhsa05168Herpes simplex virus 1 infection6.31E-0313P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q03923, O75820, Q9UDV6NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF85, ZNF189, ZNF212More
Oxitriptanhsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Oxitriptanhsa05170Human immunodeficiency virus 1 infection7.66E-0310P42338, P62873, P50151, P0DP23, P17252, P30101, P01568, P25963, P19174, P23528PIK3CB, GNB1, GNG10, CALM1, PRKCA, PDIA3, IFNA21, NFKBIA, PLCG1, CFL1More
Oxitriptanhsa05171Coronavirus disease - COVID-193.30E-027P25963, P42224, P01568, P40189, P42338, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, PIK3CB, PLCG1, PRKCAMore
Oxitriptanhsa05200Pathways in cancer9.80E-0521Q13751, P42338, P08238, P42224, P25963, P19174, P17252, P43246, P10826, P14923, Q13489, P49767, P14921, P62873, P50151, P78417, O75293, P0DP23, P01568, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, RARB, JUP, BIRC3, VEGFC, ETS1, GNB1, GNG10, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Oxitriptanhsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Oxitriptanhsa05214Glioma2.73E-035P0DP23, P17252, P42338, P19174, O75293CALM1, PRKCA, PIK3CB, PLCG1, GADD45BMore
Oxitriptanhsa05222Small cell lung cancer1.10E-026P10826, P42338, Q13751, Q13489, P25963, O75293RARB, PIK3CB, LAMB3, BIRC3, NFKBIA, GADD45BMore
Oxitriptanhsa05223Non-small cell lung cancer4.91E-035P17252, P42338, P19174, P10826, O75293PRKCA, PIK3CB, PLCG1, RARB, GADD45BMore
Oxitriptanhsa05231Choline metabolism in cancer4.91E-035P42338, Q9Y259, P19174, P23743, P17252PIK3CB, CHKB, PLCG1, DGKA, PRKCAMore
Oxitriptanhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.03E-025P20963, P09693, P06239, O60603, Q16539CD247, CD3G, LCK, TLR2, MAPK14More
Oxitriptanhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Oxitriptanhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Oxitriptanhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Oxitriptan (SDC: 4.00)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q6PL18ATAD2ATPase family AAA domainNonecontaining protein 2Predicted00.19630.051200.2006
Q92830KAT2AHistone acetyltransferase KAT2APredicted00.0510.01790.48070.5421
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
O95271TNKSPoly [ADPNoneribose] polymerase tankyraseNone1Predicted00.10170.222400.4957
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)