PharmaCoNets of Oxcarbazepine (SPCN: 164.65 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Oxcarbazepinehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Oxcarbazepinehsa00190Oxidative phosphorylation8.71E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Oxcarbazepinehsa00220Arginine biosynthesis3.02E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Oxcarbazepinehsa00230Purine metabolism1.56E-023Q7LG56, P51828, Q9Y227RRM2B, ADCY7, ENTPD4More
Oxcarbazepinehsa00240Pyrimidine metabolism1.45E-022Q7LG56, Q9Y227RRM2B, ENTPD4More
Oxcarbazepinehsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Oxcarbazepinehsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Oxcarbazepinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Oxcarbazepinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Oxcarbazepinehsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Oxcarbazepinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Oxcarbazepinehsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Oxcarbazepinehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Oxcarbazepinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Oxcarbazepinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Oxcarbazepinehsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Oxcarbazepinehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Oxcarbazepinehsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Oxcarbazepinehsa01523Antifolate resistance1.43E-032Q92820, P04818GGH, TYMSMore
Oxcarbazepinehsa01524Platinum drug resistance4.94E-022P78417, P52701GSTO1, MSH6More
Oxcarbazepinehsa03013RNA transport5.92E-0314P62826, P52298, Q09161, O14893, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, P78345, Q9Y6A5, Q14232RAN, NCBP2, NCBP1, GEMIN2, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, TACC3, EIF2B1More
Oxcarbazepinehsa03020RNA polymerase6.21E-044P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Oxcarbazepinehsa03040Spliceosome6.29E-037Q14562, O43143, O75940, O75494, Q07955, Q13243, O75643DHX8, DHX15, SMNDC1, FUSIP1, SFRS1, SFRS5, ASCC3L1More
Oxcarbazepinehsa04012ErbB signaling pathway3.69E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Oxcarbazepinehsa04020Calcium signaling pathway2.24E-037Q08828, P21796, P30679, P0DP23, P05141, P51828, P23634ADCY1, VDAC1, GNA15, CALM1, SLC25A5, ADCY7, ATP2B4More
Oxcarbazepinehsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Oxcarbazepinehsa04024cAMP signaling pathway3.94E-024Q08828, P51828, P31751, P0DP23ADCY1, ADCY7, AKT2, CALM1More
Oxcarbazepinehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Oxcarbazepinehsa04061Viral protein interaction with cytokine and cytokine receptor1.83E-049Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Oxcarbazepinehsa04062Chemokine signaling pathway4.01E-0413P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITKMore
Oxcarbazepinehsa04064NF-kappa B signaling pathway8.57E-1327P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Oxcarbazepinehsa04070Phosphatidylinositol signaling system6.12E-0510P19174, P0DP23, Q14643, O14986, P23743, P49619, Q16760, P48426, P27987, P17252PLCG1, CALM1, ITPR1, PIP5K1B, DGKA, DGKG, DGKD, PIP4K2A, ITPKB, PRKCAMore
Oxcarbazepinehsa04071Sphingolipid signaling pathway1.16E-037P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Oxcarbazepinehsa04072Phospholipase D signaling pathway4.96E-0411P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Oxcarbazepinehsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Oxcarbazepinehsa04110Cell cycle1.97E-057P06493, O60566, O75293, P30304, P33981, P42773, P01106CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Oxcarbazepinehsa04114Oocyte meiosis5.20E-049P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Oxcarbazepinehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Oxcarbazepinehsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Oxcarbazepinehsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Oxcarbazepinehsa04140Autophagy - animal1.71E-025P31751, Q7L523, O75460, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, TMEM49, SMCR8More
Oxcarbazepinehsa04142Lysosome2.08E-036Q99437, P25774, P22304, Q13510, Q04900, Q9Y227ATP6V0B, CTSS, IDS, ASAH1, CD164, ENTPD4More
Oxcarbazepinehsa04144Endocytosis2.25E-025O75351, P42566, Q15438, Q14161, Q9UNH7VPS4B, EPS15, PSCD1, GIT2, SNX6More
Oxcarbazepinehsa04145Phagosome9.23E-0511Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, O60603, P35443, P13765, P25774NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, TLR2, THBS4, HLA-DOB, CTSSMore
Oxcarbazepinehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Oxcarbazepinehsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Oxcarbazepinehsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Oxcarbazepinehsa04211Longevity regulating pathway9.34E-047Q12778, P31751, Q08828, P51828, P18848, Q9UEF7, Q96KQ7FOXO1, AKT2, ADCY1, ADCY7, ATF4, KL, EHMT2More
Oxcarbazepinehsa04213Longevity regulating pathway - multiple species4.29E-037P31751, P42338, Q9Y4H2, Q08828, P51828, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA8, HDAC1More
Oxcarbazepinehsa04217Necroptosis7.23E-0512P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, Q6FI13, Q99878, P10415, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, H2AC18; H2AC19, H2AC14, BCL2, CHMP2A, PPIDMore
Oxcarbazepinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Oxcarbazepinehsa04261Adrenergic signaling in cardiomyocytes7.03E-0510P09493, Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23, P17252, P10415TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, PRKCA, BCL2More
Oxcarbazepinehsa04310Wnt signaling pathway5.60E-033P30279, Q13485, O43318CCND2, SMAD4, MAP3K7More
Oxcarbazepinehsa04360Axon guidance4.39E-024P16333, P20827, O95631, P19174NCK1, EFNA1, NTN1, PLCG1More
Oxcarbazepinehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Oxcarbazepinehsa04371Apelin signaling pathway3.94E-024P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Oxcarbazepinehsa04380Osteoclast differentiation1.11E-0413Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Oxcarbazepinehsa04520Adherens junction3.91E-022Q13485, O43318SMAD4, MAP3K7More
Oxcarbazepinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Oxcarbazepinehsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Oxcarbazepinehsa04612Antigen processing and presentation9.25E-0510P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Oxcarbazepinehsa04613Neutrophil extracellular trap formation7.24E-0725P19174, P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PLCG1, PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Oxcarbazepinehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Oxcarbazepinehsa04620Toll-like receptor signaling pathway4.30E-045Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Oxcarbazepinehsa04621NOD-like receptor signaling pathway5.71E-0515Q14643, P01568, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P49913, P59665, P59666, P12838ITPR1, IFNA21, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Oxcarbazepinehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Oxcarbazepinehsa04623Cytosolic DNA-sensing pathway5.24E-075P01584, P01568, Q13546, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, POLR3H, CCL4L2More
Oxcarbazepinehsa04625C-type lectin receptor signaling pathway3.25E-0411Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Oxcarbazepinehsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Oxcarbazepinehsa04640Hematopoietic cell lineage2.27E-0717P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Oxcarbazepinehsa04650Natural killer cell mediated cytotoxicity3.93E-1117P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Oxcarbazepinehsa04657IL-17 signaling pathway2.25E-038O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Oxcarbazepinehsa04658Th1 and Th2 cell differentiation2.14E-1315Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Oxcarbazepinehsa04659Th17 cell differentiation1.64E-1015Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Oxcarbazepinehsa04660T cell receptor signaling pathway1.62E-0918P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Oxcarbazepinehsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Oxcarbazepinehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Oxcarbazepinehsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Oxcarbazepinehsa04713Circadian entrainment2.85E-036P0DP23, P17252, P62873, Q14643, Q08828, P51828CALM1, PRKCA, GNB1, ITPR1, ADCY1, ADCY7More
Oxcarbazepinehsa04720Long-term potentiation3.28E-059P17252, P16298, P0DP23, Q15418, P51812, P18848, Q08828, Q02750, Q14643PRKCA, PPP3CB, CALM1, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, ITPR1More
Oxcarbazepinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Oxcarbazepinehsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Oxcarbazepinehsa04725Cholinergic synapse7.24E-048Q08828, P51828, Q14643, P17252, P62873, P18848, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, ATF4, AKT2, BCL2More
Oxcarbazepinehsa04728Dopaminergic synapse9.19E-048Q14643, P17252, P62873, P31751, P18848, Q13362, Q14738, P0DP23ITPR1, PRKCA, GNB1, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Oxcarbazepinehsa04744Phototransduction7.74E-052P62873, P0DP23GNB1, CALM1More
Oxcarbazepinehsa04750Inflammatory mediator regulation of TRP channels1.30E-0513P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Oxcarbazepinehsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Oxcarbazepinehsa04912GnRH signaling pathway4.17E-0511P17252, Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P45985PRKCA, ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, MAP2K4More
Oxcarbazepinehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Oxcarbazepinehsa04915Estrogen signaling pathway2.13E-025P18848, Q08828, P51828, P31751, P0DP23ATF4, ADCY1, ADCY7, AKT2, CALM1More
Oxcarbazepinehsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Oxcarbazepinehsa04918Thyroid hormone synthesis4.48E-022P18848, P05543ATF4, SERPINA7More
Oxcarbazepinehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Oxcarbazepinehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Oxcarbazepinehsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Oxcarbazepinehsa04924Renin secretion8.71E-033Q14643, Q13370, P0DP23ITPR1, PDE3B, CALM1More
Oxcarbazepinehsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Oxcarbazepinehsa04926Relaxin signaling pathway3.62E-036P31751, P63218, P18848, Q08828, P51828, P30679AKT2, GNG5, ATF4, ADCY1, ADCY7, GNA15More
Oxcarbazepinehsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Oxcarbazepinehsa04932Non-alcoholic fatty liver disease5.87E-048P31751, P01375, P49841, P18848, P48023, O75460, P01584, O95298AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFC2More
Oxcarbazepinehsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Oxcarbazepinehsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Oxcarbazepinehsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Oxcarbazepinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Oxcarbazepinehsa04966Collecting duct acid secretion2.86E-022Q13488, Q9Y666TCIRG1, SLC12A7More
Oxcarbazepinehsa04970Salivary secretion3.15E-048Q08828, P51828, P22694, Q14643, P17252, P0DP24, P0DP23, P49913ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM2, CALM1, CAMPMore
Oxcarbazepinehsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Oxcarbazepinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Oxcarbazepinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Oxcarbazepinehsa04976Bile secretion1.59E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Oxcarbazepinehsa05010Alzheimer disease1.80E-0417Q16718, O95298, O14521, P13073, Q14643, Q00535, O75460, P0DP23, P01584, P18848, Q13509, P68371, P67870, P31751, P05141, Q08752, P28070NDUFA5, NDUFC2, SDHD, COX4I1, ITPR1, CDK5, ERN1, CALM1, IL1B, ATF4, TUBB3, TUBB2C, CSNK2B, AKT2, SLC25A5, PPID, PSMB4More
Oxcarbazepinehsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Oxcarbazepinehsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Oxcarbazepinehsa05017Spinocerebellar ataxia1.71E-036O75460, Q8TB72, P31751, P28070, P05141, P21796ERN1, PUM2, AKT2, PSMB4, SLC25A5, VDAC1More
Oxcarbazepinehsa05020Prion disease4.67E-0311Q16718, O14521, P13073, Q14643, P18848, P05141, Q13509, P68371, P67870, P14598, Q15080NDUFA5, SDHD, COX4I1, ITPR1, ATF4, SLC25A5, TUBB3, TUBB2C, CSNK2B, NCF1, NCF4More
Oxcarbazepinehsa05022Pathways of neurodegeneration - multiple diseases3.36E-0418Q14643, Q13509, P68371, P10415, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, P17252, Q00535, P01584, Q08752, P0DP23, P28070ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, CDK5, IL1B, PPID, CALM1, PSMB4More
Oxcarbazepinehsa05034Alcoholism2.90E-046P0DP23, P62873, Q93077, P62807, O60814, P68431CALM1, GNB1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Oxcarbazepinehsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Oxcarbazepinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Oxcarbazepinehsa05130Pathogenic Escherichia coli infection4.08E-023Q15438, P35579, P55061PSCD1, MYH9, TEGTMore
Oxcarbazepinehsa05131Shigellosis2.65E-0314P01375, P25963, O00463, P68431, Q04759, Q9UDY8, Q9H1Y0, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32TNF, NFKBIA, TRAF5, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCQ, MALT1, ATG5, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPFMore
Oxcarbazepinehsa05132Salmonella infection9.33E-0514P51617, P25963, P01375, Q9UJU2, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Oxcarbazepinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Oxcarbazepinehsa05140Leishmaniasis1.32E-0716P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Oxcarbazepinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Oxcarbazepinehsa05144Malaria2.04E-036P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Oxcarbazepinehsa05145Toxoplasmosis1.19E-039P51617, P25963, P01375, P10415, Q13489, P42224, P13765, O60603, P29965IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Oxcarbazepinehsa05146Amoebiasis7.64E-0813P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Oxcarbazepinehsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Oxcarbazepinehsa05152Tuberculosis7.75E-0514Q13488, Q99437, P0DP23, P42224, P48382, O60603, P01375, P10415, P13765, P25774, P01568, P49913, Q9UDY8, P51617TCIRG1, ATP6V0B, CALM1, STAT1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CTSS, IFNA21, CAMP, MALT1, IRAK1More
Oxcarbazepinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Oxcarbazepinehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Oxcarbazepinehsa05163Human cytomegalovirus infection4.24E-0516P31751, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463AKT2, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5More
Oxcarbazepinehsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Oxcarbazepinehsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Oxcarbazepinehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Oxcarbazepinehsa05167Kaposi sarcoma-associated herpesvirus infection3.04E-0310P01568, P42224, P62873, P62879, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2IFNA21, STAT1, GNB1, GNB2, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1More
Oxcarbazepinehsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Oxcarbazepinehsa05170Human immunodeficiency virus 1 infection4.31E-0721Q02750, P62873, P62879, P16298, P0DP23, P01375, Q05397, P17252, O00463, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333MAP2K1, GNB1, GNB2, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Oxcarbazepinehsa05200Pathways in cancer5.20E-0317P42224, Q9UJU2, P17252, Q13485, P52701, P14923, P30279, P10415, Q13489, P49767, Q12778, P25116, P62873, P63218, P78417, P0DP23, P01568STAT1, LEF1, PRKCA, SMAD4, MSH6, JUP, CCND2, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, GNG5, GSTO1, CALM1, IFNA21More
Oxcarbazepinehsa05202Transcriptional misregulation in cancer7.38E-0620Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Oxcarbazepinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Oxcarbazepinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Oxcarbazepinehsa05210Colorectal cancer4.94E-022Q13485, P52701SMAD4, MSH6More
Oxcarbazepinehsa05212Pancreatic cancer2.40E-023P31751, Q15311, P23458AKT2, RALBP1, JAK1More
Oxcarbazepinehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Oxcarbazepinehsa05214Glioma3.69E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Oxcarbazepinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Oxcarbazepinehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Oxcarbazepinehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Oxcarbazepinehsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Oxcarbazepinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Oxcarbazepinehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Oxcarbazepinehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Oxcarbazepinehsa05231Choline metabolism in cancer3.92E-036P31751, Q9Y259, P19174, P49619, Q16760, O14986AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1BMore
Oxcarbazepinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.62E-0813P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Oxcarbazepinehsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Oxcarbazepinehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Oxcarbazepinehsa05321Inflammatory bowel disease4.27E-047O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Oxcarbazepinehsa05322Systemic lupus erythematosus1.74E-0715P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Oxcarbazepinehsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Oxcarbazepinehsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Oxcarbazepinehsa05332Graft-versus-host disease9.53E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Oxcarbazepinehsa05340Primary immunodeficiency1.31E-045P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Oxcarbazepinehsa05415Diabetic cardiomyopathy3.55E-025P17252, P14598, Q15080, Q16718, O14521PRKCA, NCF1, NCF4, NDUFA5, SDHDMore
Oxcarbazepinehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Oxcarbazepinehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Oxcarbazepine (SDC: 7.39)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O60939SCN2BSodium channel subunit betaNone2Reported00.22050.046700.2036
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P04156PRNPMajor prion proteinPredicted00.59090.173700.6429
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P08575PTPRCReceptorNonetype tyrosineNoneprotein phosphatase CPredicted10.27330.13580.41320.8216
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)