PharmaCoNets

PharmaCoNets of Oxazepam (S_PCN: 108.63 )

Oxazepam regulated-network (S_DN: 17.44)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Oxazepam

hsa00030

Pentose phosphate pathway

2.27E-02

P60891, P37837

PRPS1, TALDO1

Oxazepam

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Oxazepam

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Oxazepam

hsa00380

Tryptophan metabolism

4.14E-02

Q16613

AANAT

Oxazepam

hsa00500

Starch and sucrose metabolism

6.17E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Oxazepam

hsa00730

Thiamine metabolism

2.27E-02

P05186, P24666

ALPL, ACP1

Oxazepam

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Oxazepam

hsa01523

Antifolate resistance

1.13E-03

P41439, P41440, Q92820, P04818, P01375

FOLR3, SLC19A1, GGH, TYMS, TNF

Oxazepam

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Oxazepam

hsa03008

Ribosome biogenesis in eukaryotes

4.94E-02

P19784, P67870

CSNK2A2, CSNK2B

Oxazepam

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Oxazepam

hsa03013

RNA transport

4.49E-02

P62826, Q9UBU9, P63279, P68104, Q14232

RAN, NXF1, UBE2I, EEF1A1, EIF2B1

Oxazepam

hsa03020

RNA polymerase

6.08E-05

P30876, P24928, P62487, Q9Y535

POLR2B, POLR2A, POLR2G, POLR3H

Oxazepam

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Oxazepam

hsa03050

Proteasome

1.40E-02

P55036

PSMD4

Oxazepam

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Oxazepam

hsa04020

Calcium signaling pathway

4.83E-02

Q08828, P0DP23, P05141, P51828

ADCY1, CALM1, SLC25A5, ADCY7

Oxazepam

hsa04022

cGMP-PKG signaling pathway

4.38E-03

P18848, P31751, Q08828, P51828, P05141, P0DP23

ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1

Oxazepam

hsa04024

cAMP signaling pathway

4.18E-03

P63092, Q08828, P51828, P31751, P26678, P0DP23, P61586

GNAS, ADCY1, ADCY7, AKT2, PLN, CALM1, RHOA

Oxazepam

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.79E-03

Q8NHW4, P09341, P19875, P25024, P25025, Q13651, P14784

CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, IL10RA, IL2RB

Oxazepam

hsa04062

Chemokine signaling pathway

1.83E-02

P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151

CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10

Oxazepam

hsa04064

NF-kappa B signaling pathway

4.61E-06

P10415, O00463, P14778, P01584, P19174, Q04759, Q9UDY8, Q16548, P06239, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, TRAF5, IL1R1, IL1B, PLCG1, PRKCQ, MALT1, BCL2A1, LCK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Oxazepam

hsa04070

Phosphatidylinositol signaling system

9.86E-03

P0DP23, O14986, Q16760, P48426

CALM1, PIP5K1B, DGKD, PIP4K2A

Oxazepam

hsa04071

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, Q13362, Q9BX95, P10415

S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Oxazepam

hsa04072

Phospholipase D signaling pathway

5.40E-05

P31751, P42338, P61586, P43657, P25024, P25025, P19174, O14986, Q15438, P63092, Q08828, P51828, Q16760

AKT2, PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKD

Oxazepam

hsa04080

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Oxazepam

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Oxazepam

hsa04114

Oocyte meiosis

5.20E-04

P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738

RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D

Oxazepam

hsa04120

Ubiquitin mediated proteolysis

1.44E-04

Q9UBT2, Q14145, Q13042, Q13191, Q15751, Q14669, Q7Z6Z7

SAE2, KEAP1, CDC16, CBLB, HERC1, TRIP12, HUWE1

Oxazepam

hsa04137

Mitophagy - animal

2.52E-02

P19784, P67870

CSNK2A2, CSNK2B

Oxazepam

hsa04140

Autophagy - animal

1.92E-03

P31751, Q7L523, O75460, P22694, Q14643, P10415, Q04759, Q96GC9, Q8TEV9

AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, PRKCQ, TMEM49, SMCR8

Oxazepam

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Oxazepam

hsa04145

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Oxazepam

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Oxazepam

hsa04210

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Oxazepam

hsa04211

Longevity regulating pathway

1.88E-02

P31751, Q08828, P51828, P18848

AKT2, ADCY1, ADCY7, ATF4

Oxazepam

hsa04213

Longevity regulating pathway - multiple species

4.29E-03

P31751, P42338, Q9Y4H2, Q08828, P51828, P11142, Q13547

AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA8, HDAC1

Oxazepam

hsa04217

Necroptosis

4.42E-04

P07900, P15104, P05141, P01584, P0C0S5, Q13557

HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D

Oxazepam

hsa04261

Adrenergic signaling in cardiomyocytes

4.98E-04

Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23

ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Oxazepam

hsa04310

Wnt signaling pathway

4.17E-03

P61586, P19784, P67870

RHOA, CSNK2A2, CSNK2B

Oxazepam

hsa04340

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Oxazepam

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Oxazepam

hsa04371

Apelin signaling pathway

3.94E-02

P31751, Q08828, P51828, P0DP23

AKT2, ADCY1, ADCY7, CALM1

Oxazepam

hsa04380

Osteoclast differentiation

5.27E-04

Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149

CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2

Oxazepam

hsa04510

Focal adhesion

4.07E-02

O14986, P61586, Q16363

PIP5K1B, RHOA, LAMA4

Oxazepam

hsa04520

Adherens junction

1.38E-04

P19784, P67870, P61586

CSNK2A2, CSNK2B, RHOA

Oxazepam

hsa04612

Antigen processing and presentation

2.80E-03

P13765, P26715, P26717, Q13241, P01732

HLA-DOB, KLRC1, KLRC2, KLRD1, CD8A

Oxazepam

hsa04613

Neutrophil extracellular trap formation

6.74E-03

O60603, P05164, P08246, Q9UM07, P04908, Q93077, P68431, Q15080, P20160, P08311, P21730, O43315, Q16539

TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, C5AR1, AQP9, MAPK14

Oxazepam

hsa04620

Toll-like receptor signaling pathway

2.54E-03

P01584, P31751, Q8NHW4

IL1B, AKT2, CCL4L2

Oxazepam

hsa04621

NOD-like receptor signaling pathway

4.31E-02

P01375, P59665, P59666, P12838

TNF, DEFA1; DEFA1B, DEFA3, DEFA4

Oxazepam

hsa04623

Cytosolic DNA-sensing pathway

2.21E-04

P01584, Q9Y535, Q8NHW4

IL1B, POLR3H, CCL4L2

Oxazepam

hsa04625

C-type lectin receptor signaling pathway

1.14E-03

Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539

CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14

Oxazepam

hsa04630

JAK-STAT signaling pathway

4.54E-02

P31751, P23458, Q13651

AKT2, JAK1, IL10RA

Oxazepam

hsa04640

Hematopoietic cell lineage

1.13E-04

P13612, P14778, P27930, P11215, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765

ITGA4, IL1R1, IL1R2, ITGAM, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB

Oxazepam

hsa04650

Natural killer cell mediated cytotoxicity

1.08E-07

P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P11766	ADH5	Alcohol dehydrogenase class-3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.71
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P11766	ADH5	Alcohol dehydrogenase class-3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.833
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P11766	ADH5	Alcohol dehydrogenase class-3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.737
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737

Oxazepam

hsa04657

IL-17 signaling pathway

1.14E-03

P07900, O00463, Q16539, P49841, P14780, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, MMP9, TNF, IL1B

Oxazepam

hsa04658

Th1 and Th2 cell differentiation

4.32E-08

Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Oxazepam

hsa04659

Th17 cell differentiation

9.95E-06

Q04759, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Oxazepam

hsa04660

T cell receptor signaling pathway

6.01E-06

Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239

MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811

Oxazepam

hsa04664

Fc epsilon RI signaling pathway

3.98E-02

P01375, Q16539, Q9UQC2

TNF, MAPK14, GAB2

Oxazepam

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Oxazepam

hsa04672

Intestinal immune network for IgA production

4.27E-02

P13765, P13612

HLA-DOB, ITGA4

Oxazepam

hsa04713

Circadian entrainment

5.44E-03

P0DP23, P62873, Q08828, P51828, P63092

CALM1, GNB1, ADCY1, ADCY7, GNAS

Oxazepam

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Oxazepam

hsa04720

Long-term potentiation

1.71E-03

P16298, P0DP23, P51812, P18848, Q08828, Q02750

PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1

Oxazepam

hsa04723

Retrograde endocannabinoid signaling

4.94E-02

P48169, P62873

GABRA4, GNB1

Oxazepam

hsa04724

Glutamatergic synapse

3.65E-02

P63092, P62873

GNAS, GNB1

Oxazepam

hsa04725

Cholinergic synapse

1.39E-02

Q08828, P51828, P18848, P31751

ADCY1, ADCY7, ATF4, AKT2

Oxazepam

hsa04726

Serotonergic synapse

2.52E-02

P63092, P62873

GNAS, GNB1

Oxazepam

hsa04728

Dopaminergic synapse

7.83E-03

P31751, P18848, Q13362, Q14738, P0DP23

AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Oxazepam

hsa04750

Inflammatory mediator regulation of TRP channels

2.03E-04

P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1

Oxazepam

hsa04911

Insulin secretion

2.40E-02

Q08828, P51828, P18848

ADCY1, ADCY7, ATF4

Oxazepam

hsa04912

GnRH signaling pathway

1.39E-02

Q08828, P51828, P18848, P0DP23

ADCY1, ADCY7, ATF4, CALM1

Oxazepam

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Oxazepam

hsa04915

Estrogen signaling pathway

2.13E-02

P18848, Q08828, P51828, P31751, P0DP23

ATF4, ADCY1, ADCY7, AKT2, CALM1

Oxazepam

hsa04916

Melanogenesis

2.40E-02

P0DP23, Q08828, P51828

CALM1, ADCY1, ADCY7

Oxazepam

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Oxazepam

hsa04923

Regulation of lipolysis in adipocytes

2.89E-04

Q08828, P51828, P07550, P42338, Q9Y4H2, P31751

ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2

Oxazepam

hsa04924

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Oxazepam

hsa04925

Aldosterone synthesis and secretion

9.86E-03

P18848, Q08828, P51828, P0DP23

ATF4, ADCY1, ADCY7, CALM1

Oxazepam

hsa04926

Relaxin signaling pathway

2.46E-02

P31751, P18848, Q08828, P51828

AKT2, ATF4, ADCY1, ADCY7

Oxazepam

hsa04927

Cortisol synthesis and secretion

1.59E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Oxazepam

hsa04928

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Oxazepam

hsa04932

Non-alcoholic fatty liver disease

2.59E-05

P31751, P49841, P18848, O75460, P01584, P13073, O15239, Q16718, O95298, O14521

AKT2, GSK3B, ATF4, ERN1, IL1B, COX4I1, NDUFA1, NDUFA5, NDUFC2, SDHD

Oxazepam

hsa04934

Cushing syndrome

4.54E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Oxazepam

hsa04935

Growth hormone synthesis, secretion and action

1.88E-02

Q08828, P51828, P18848, P31751

ADCY1, ADCY7, ATF4, AKT2

Oxazepam

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Oxazepam

hsa04970

Salivary secretion

1.59E-02

Q08828, P51828, P0DP23

ADCY1, ADCY7, CALM1

Oxazepam

hsa04971

Gastric acid secretion

2.54E-03

Q08828, P51828, P15311, P0DP23

ADCY1, ADCY7, VIL2, CALM1

Oxazepam

hsa04972

Pancreatic secretion

3.65E-02

P63092, P61586

GNAS, RHOA

Oxazepam

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Oxazepam

hsa04976

Bile secretion

9.77E-04

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Oxazepam

hsa05010

Alzheimer disease

4.94E-03

O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070

NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4

Oxazepam

hsa05012

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Oxazepam

hsa05016

Huntington disease

2.14E-03

O15239, O95298, P13073, P24928, P30876, P62487, P05141, O75460, P28070

NDUFA1, NDUFC2, COX4I1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4

Oxazepam

hsa05017

Spinocerebellar ataxia

3.94E-02

O75460, P31751, P28070, P05141

ERN1, AKT2, PSMB4, SLC25A5

Oxazepam

hsa05020

Prion disease

3.73E-04

P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539

NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14

Oxazepam

hsa05022

Pathways of neurodegeneration - multiple diseases

6.87E-05

P49841, O15239, Q16718, O95298, O14521, P13073, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, P0DP23, Q13557, P28070

GSK3B, NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, CALM1, CAMK2D, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736

Oxazepam

hsa05032

Morphine addiction

9.04E-05

P62873, P48169, P78334, P63092, P32298

GNB1, GABRA4, GABRE, GNAS, GRK4

Oxazepam

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Oxazepam

hsa05134

Legionellosis

6.38E-04

P01584, P11215, P68104, P11142, P09341, P19875

IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2

Oxazepam

hsa05142

Chagas disease

2.26E-02

P01375, P30679, P48023

TNF, GNA15, FASLG

Oxazepam

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Oxazepam

hsa05146

Amoebiasis

2.21E-04

P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814

CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1

Oxazepam

hsa05150

Staphylococcus aureus infection

1.83E-02

P59665, P59666, P12838

DEFA1; DEFA1B, DEFA3, DEFA4

Oxazepam

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Oxazepam

hsa05163

Human cytomegalovirus infection

1.42E-06

P31751, P01375, P62873, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P63092, O00463, P61769

AKT2, TNF, GNB1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, GNAS, TRAF5, B2M

Oxazepam

hsa05164

Influenza A

4.49E-02

P31751, P01584, P23458, P05141, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, NXF1

Oxazepam

hsa05166

Human T-cell leukemia virus 1 infection

3.90E-02

P23458, P05141, P62826, Q08828, P51828, P18848, P31751

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2

Oxazepam

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Oxazepam

hsa05169

Epstein-Barr virus infection

3.10E-02

P20023, P13765, Q92769, O00463, P24522, P09693, P20963

CR2, HLA-DOB, HDAC2, TRAF5, GADD45A, CD3G, CD247

Oxazepam

hsa05170

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Oxazepam

hsa05171

Coronavirus disease - COVID-19

3.15E-04

P01584, P62753, P25398, Q9UHA3, P36578, P32969, P18077, P62829, O14786

IL1B, RPS6, RPS12, RSL24D1, RPL4, RPL9, RPL35A, RPL23, NRP1

Oxazepam

hsa05202

Transcriptional misregulation in cancer

2.90E-02

Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522

FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45A

Oxazepam

hsa05212

Pancreatic cancer

2.40E-02

P31751, Q15311, P23458

AKT2, RALBP1, JAK1

Oxazepam

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Oxazepam

hsa05217

Basal cell carcinoma

2.83E-02

Q13635, Q9UJU2, P24522

PTCH1, LEF1, GADD45A

Oxazepam

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Oxazepam

hsa05231

Choline metabolism in cancer

3.38E-02

P31751, Q16760, O14986

AKT2, DGKD, PIP5K1B

Oxazepam

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

6.79E-04

P42338, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759

PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ

Oxazepam

hsa05321

Inflammatory bowel disease

1.44E-04

O60603, P13765, Q14765, Q9UL17, P23771

TLR2, HLA-DOB, STAT4, TBX21, GATA3

Oxazepam

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Oxazepam

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Oxazepam

hsa05332

Graft-versus-host disease

1.74E-06

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Oxazepam

hsa05415

Diabetic cardiomyopathy

1.02E-03

P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557

SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2D

Oxazepam

hsa05418

Fluid shear stress and atherosclerosis

1.08E-03

Q16539, Q14145, P10599, P14780, P01375, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Oxazepam (S_DC: 6.23)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

GABRA4

GammaNoneaminobutyric acid receptor subunit alphaNone4

Reported

0.3253

0.565

0.1579

1.4506

P28472

GABRB3

GammaNoneaminobutyric acid receptor subunit betaNone3

Reported

0.1559

0.4387

0.1695

1.1248

P78334

GABRE

GammaNoneaminobutyric acid receptor subunit epsilon

Reported

0.1394

0.4097

0.1579

1.0469

P02768

ALB

Albumin

Predicted

0.2848

0.9111

0.0857

2.0502

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P42330

AKR1C3

AldoNoneketo reductase family 1 member C3

Predicted

0.4017

0.8348

0.1748

2.0453

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P07195

LDHB

LNonelactate dehydrogenase B chain

Predicted

0.0167

0.1749

0.231

0.5892

Q00535

CDK5

CyclinNonedependentNonelike kinase 5

Predicted

0.1992

0.6633

0.2994

1.7256

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P11766

ADH5

Alcohol dehydrogenase classNone3

Predicted

0.265

0.1397

0.2146

0.6265

PharmaCoNets of Oxazepam (SPCN: 108.63 )

Oxazepam regulated-network (SDN: 17.44)

Community members of Oxazepam (SDC: 6.23)

PharmaCoNets of Oxazepam (S_PCN: 108.63 )

Oxazepam regulated-network (S_DN: 17.44)

Community members of Oxazepam (S_DC: 6.23)