PharmaCoNets of Oxaprozin (SPCN: 283.69 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Oxaprozinhsa00010Glycolysis / Gluconeogenesis4.41E-024P04075, P06733, P04406, P60174ALDOA, ENO1, GAPDH, TPI1More
Oxaprozinhsa00030Pentose phosphate pathway3.27E-065P06744, P60891, P51854, P08237, P37837GPI, PRPS1, TKTL1, PFKM, TALDO1More
Oxaprozinhsa00051Fructose and mannose metabolism2.21E-023O14772, P60174, P04075FPGT, TPI1, ALDOAMore
Oxaprozinhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Oxaprozinhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Oxaprozinhsa00190Oxidative phosphorylation6.70E-054Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Oxaprozinhsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Oxaprozinhsa00230Purine metabolism8.15E-057Q7LG56, P31350, P51828, P21589, P20839, Q9Y227, Q02153RRM2B, RRM2, ADCY7, NT5E, IMPDH1, ENTPD4, GUCY1B3More
Oxaprozinhsa00240Pyrimidine metabolism1.38E-055Q7LG56, P31350, Q9Y227, P21589, P04818RRM2B, RRM2, ENTPD4, NT5E, TYMSMore
Oxaprozinhsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Oxaprozinhsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Oxaprozinhsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Oxaprozinhsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Oxaprozinhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Oxaprozinhsa00500Starch and sucrose metabolism4.73E-084O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Oxaprozinhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Oxaprozinhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Oxaprozinhsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Oxaprozinhsa00565Ether lipid metabolism3.00E-031Q8N661TMEM86BMore
Oxaprozinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Oxaprozinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Oxaprozinhsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Oxaprozinhsa00630Glyoxylate and dicarboxylate metabolism6.56E-052P40925, P15104MDH1, GLULMore
Oxaprozinhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Oxaprozinhsa00670One carbon pool by folate3.15E-022O95954, Q99707FTCD, MTRMore
Oxaprozinhsa00730Thiamine metabolism1.18E-073Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Oxaprozinhsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Oxaprozinhsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Oxaprozinhsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Oxaprozinhsa00860Porphyrin and chlorophyll metabolism8.96E-042P36551, P30043CPOX, BLVRBMore
Oxaprozinhsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Oxaprozinhsa00920Sulfur metabolism2.29E-021Q16762TSTMore
Oxaprozinhsa00970Aminoacyl-tRNA biosynthesis2.02E-054O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Oxaprozinhsa00980Metabolism of xenobiotics by cytochrome P4501.05E-055Q16772, P78417, P28332, P09211, P11712GSTA3, GSTO1, ADH6, GSTP1, CYP2C9More
Oxaprozinhsa00982Drug metabolism - cytochrome P4501.75E-055P11712, Q16772, P09211, P78417, P28332CYP2C9, GSTA3, GSTP1, GSTO1, ADH6More
Oxaprozinhsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Oxaprozinhsa01100Metabolic pathways1.48E-0454Q9NR34, Q9Y234, P35790, P05089, Q16772, P09211, Q9UJ14, P15144, P30041, O14732, P32320, Q02153, Q16774, P20839, P00918, P22748, P40926, P10768, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, Q9Y6K0, P05186, P24666, P15121, P08237, P21399, Q9HCC0, P33121, Q9UHK6, P51854, Q86VZ5, Q9BVK2, P15907, P57054, Q9UNP4, O96024, Q9BX95, P37837, P32321, P50213, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6, Q969G6, Q13029, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, ANPEP, PRDX6, IMPA2, CDA, GUCY1B3, GUK1, IMPDH1, CA2, CA4, MDH2, ESD, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, CEPT1, ALPL, ACP1, AKR1B1, PFKM, ACO1, MCCC2, ACSL1, AMACR, TKTL1, SGMS1, ALG8, ST6GAL1, PIGP, ST3GAL5, B3GALT4, SGPP1, TALDO1, DCTD, IDH3A, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1, RFK, PRDM2, TMLHEMore
Oxaprozinhsa01200Carbon metabolism2.94E-0515P04075, P51854, P04406, P08237, P06744, P60174, P37837, P06733, P40926, O14521, Q9P2R7, P50213, P21399, P10768, Q02252ALDOA, TKTL1, GAPDH, PFKM, GPI, TPI1, TALDO1, ENO1, MDH2, SDHD, SUCLA2, IDH3A, ACO1, ESD, ALDH6A1More
Oxaprozinhsa012102-Oxocarboxylic acid metabolism8.95E-042P21399, P50213ACO1, IDH3AMore
Oxaprozinhsa01230Biosynthesis of amino acids2.10E-0511P60174, P04406, P06733, P04075, P08237, P51854, P60891, Q99707, P21399, P50213, P37837TPI1, GAPDH, ENO1, ALDOA, PFKM, TKTL1, PRPS1, MTR, ACO1, IDH3A, TALDO1More
Oxaprozinhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Oxaprozinhsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Oxaprozinhsa01523Antifolate resistance4.21E-055P41439, P41440, Q92820, P04818, P01375FOLR3, SLC19A1, GGH, TYMS, TNFMore
Oxaprozinhsa01524Platinum drug resistance3.80E-034O15392, Q16772, P09211, P11388BIRC5, GSTA3, GSTP1, TOP2AMore
Oxaprozinhsa02010ABC transporters2.17E-031Q8IZY2ABCA7More
Oxaprozinhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Oxaprozinhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Oxaprozinhsa03013RNA transport1.71E-1527P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1, FXR1More
Oxaprozinhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Oxaprozinhsa03020RNA polymerase3.09E-116P30876, P24928, P62487, Q9GZM3, P52435, Q9Y535POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J, POLR3HMore
Oxaprozinhsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Oxaprozinhsa03030DNA replication5.00E-021P27694RPA1More
Oxaprozinhsa03040Spliceosome7.76E-1117Q14562, O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Oxaprozinhsa03050Proteasome2.23E-032P55036, P28074PSMD4, PSMB5More
Oxaprozinhsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Oxaprozinhsa03410Base excision repair7.59E-031P27695APEX1More
Oxaprozinhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Oxaprozinhsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Oxaprozinhsa04012ErbB signaling pathway1.33E-047P21860, P16333, Q13557, P19174, O14944, P42338, P01106ERBB3, NCK1, CAMK2D, PLCG1, EREG, PIK3CB, MYCMore
Oxaprozinhsa04014Ras signaling pathway2.73E-0614P42338, P20827, Q9NRA1, P49767, P08069, Q13009, Q7LDG7, Q15283, P61586, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, RASGRP2, RASA2, RHOA, CALM1, GNB1, GNG5, GNG10, PLCG1More
Oxaprozinhsa04015Rap1 signaling pathway1.08E-0411P20827, Q9NRA1, P49767, P08069, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P0DP23, P19174EFNA1, PDGFC, VEGFC, IGF1R, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, CALM1, PLCG1More
Oxaprozinhsa04020Calcium signaling pathway4.61E-0715P27987, Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P19174, P61073, P0DP23, P05141, P51828, P23634, Q9NRA1, P49767ITPKB, ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, PLCG1, CXCR4, CALM1, SLC25A5, ADCY7, ATP2B4, PDGFC, VEGFCMore
Oxaprozinhsa04022cGMP-PKG signaling pathway3.18E-059Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP23CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM1More
Oxaprozinhsa04024cAMP signaling pathway4.22E-048Q08828, P51828, P42338, P31751, P0DP23, Q13370, Q13009, Q13153ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, TIAM1, PAK1More
Oxaprozinhsa04060Cytokine-cytokine receptor interaction1.25E-024P01584, Q13651, P61073, Q8NHW4IL1B, IL10RA, CXCR4, CCL4L2More
Oxaprozinhsa04061Viral protein interaction with cytokine and cytokine receptor1.03E-048Q8NHW4, P09341, P19875, P25024, P25025, P61073, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, IL10RA, IL2RBMore
Oxaprozinhsa04062Chemokine signaling pathway3.08E-1029P25024, P25025, P61073, P09341, P19875, Q8NHW4, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q08828, P51828, Q7LDG7, Q13009, P14598, Q13153, P42224, Q92608, P25963, P49841, Q8WYR1CXCR1, CXCR2, CXCR4, CXCL1, CXCL2, CCL4L2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, ADCY1, ADCY7, RASGRP2, TIAM1, NCF1, PAK1, STAT1, DOCK2, NFKBIA, GSK3B, PIK3R5More
Oxaprozinhsa04064NF-kappa B signaling pathway1.75E-1225P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Oxaprozinhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Oxaprozinhsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Oxaprozinhsa04070Phosphatidylinositol signaling system4.11E-0610P19174, P0DP23, P42338, O14986, P23743, Q86XP1, Q16760, P48426, P27987, Q96DU7PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKB, ITPKCMore
Oxaprozinhsa04071Sphingolipid signaling pathway3.52E-099P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Oxaprozinhsa04072Phospholipase D signaling pathway8.14E-0514P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q14344, Q15438, Q08828, P51828, P23743, Q16760, Q9NRA1AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNA13, PSCD1, ADCY1, ADCY7, DGKA, DGKD, PDGFCMore
Oxaprozinhsa04080Neuroactive ligand-receptor interaction3.44E-048P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2More
Oxaprozinhsa04110Cell cycle1.13E-058P06493, O60566, O75293, P30304, P33981, P42773, P01106, Q13547CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Oxaprozinhsa04114Oocyte meiosis2.97E-0511Q15418, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069RPS6KA1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Oxaprozinhsa04115p53 signaling pathway5.07E-037P24522, Q13315, P31350, Q53FA7, P06493, O95067, P10415GADD45A, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2More
Oxaprozinhsa04120Ubiquitin mediated proteolysis7.04E-056Q9UBT2, Q13042, Q15751, O95071, Q14669, P0CG47SAE2, CDC16, HERC1, UBR5, TRIP12, UBBMore
Oxaprozinhsa04122Sulfur relay system2.29E-021Q16762TSTMore
Oxaprozinhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Oxaprozinhsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Oxaprozinhsa04140Autophagy - animal1.24E-0310P08069, P31751, Q7L523, O75460, P22694, Q14643, P10415, Q04759, Q96GC9, Q8TEV9IGF1R, AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, PRKCQ, TMEM49, SMCR8More
Oxaprozinhsa04141Protein processing in endoplasmic reticulum2.95E-0410P18848, P07384, O95487, O60337, Q99941, O75460, P11142, Q9H3Z4, P07900, O95816ATF4, CAPN1, SEC24B, MARH6, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, BAG2More
Oxaprozinhsa04142Lysosome2.23E-024P22304, Q13510, Q04900, Q9Y227IDS, ASAH1, CD164, ENTPD4More
Oxaprozinhsa04144Endocytosis2.57E-036O75351, P62491, P42566, Q15438, Q14161, Q9UNH7VPS4B, RAB11A, EPS15, PSCD1, GIT2, SNX6More
Oxaprozinhsa04145Phagosome2.43E-0712O75015, P60709, Q15075, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765FCGR3B, ACTB, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Oxaprozinhsa04146Peroxisome2.92E-036O43933, O96011, P56589, Q9UKG9, O75521, P33121PEX1, PEX11B, PEX3, CROT, ECI2, ACSL1More
Oxaprozinhsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Oxaprozinhsa04151PI3K-Akt signaling pathway1.29E-0419P42338, P43657, P01106, P09603, P20827, Q9NRA1, P49767, Q9GZP0, P08238, Q8WYR1, P62873, P63218, P50151, P13612, O15335, Q13751, P14784, P01568, P30281PIK3CB, P2RY5, MYC, CSF1, EFNA1, PDGFC, VEGFC, PDGFD, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGA4, CHAD, LAMB3, IL2RB, IFNA21, CCND3More
Oxaprozinhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Oxaprozinhsa04210Apoptosis1.54E-0311Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1More
Oxaprozinhsa04211Longevity regulating pathway1.96E-048Q12778, P31751, P08069, Q08828, P51828, P18848, Q9UEF7, Q96KQ7FOXO1, AKT2, IGF1R, ADCY1, ADCY7, ATF4, KL, EHMT2More
Oxaprozinhsa04213Longevity regulating pathway - multiple species1.39E-038P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA8, HDAC1More
Oxaprozinhsa04217Necroptosis4.23E-0612P01568, P23458, Q13489, Q9NQC7, Q13546, P07900, P15104, P05141, P01584, P0C0S5, Q13557, Q9H444IFNA21, JAK1, BIRC3, CYLD, RIPK1, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4BMore
Oxaprozinhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Oxaprozinhsa04261Adrenergic signaling in cardiomyocytes7.88E-0510Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557, P23634ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D, ATP2B4More
Oxaprozinhsa04270Vascular smooth muscle contraction2.45E-024P0DP23, Q08828, P51828, P35579CALM1, ADCY1, ADCY7, MYH9More
Oxaprozinhsa04330Notch signaling pathway3.14E-045Q92542, P49768, Q92830, P78504, P46531NCSTN, PSEN1, KAT2A, JAG1, NOTCH1More
Oxaprozinhsa04340Hedgehog signaling pathway1.19E-044P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Oxaprozinhsa04360Axon guidance1.75E-058P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11More
Oxaprozinhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Oxaprozinhsa04371Apelin signaling pathway1.14E-0614P62873, P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, P62753, P0DP23GNB1, GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, RPS6, CALM1More
Oxaprozinhsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Oxaprozinhsa04510Focal adhesion3.48E-021P08069IGF1RMore
Oxaprozinhsa04512ECM-receptor interaction3.16E-035Q13751, P07359, P13612, P08514, O15335LAMB3, GP1BA, ITGA4, ITGA2B, CHADMore
Oxaprozinhsa04514Cell adhesion molecules1.22E-034P23229, P16109, P30511, O00501ITGA6, SELP, HLA-F, CLDN5More
Oxaprozinhsa04520Adherens junction8.29E-031P08069IGF1RMore
Oxaprozinhsa04530Tight junction1.74E-036P63261, P16989, P56750, Q9Y478, Q92974, Q14247ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTNMore
Oxaprozinhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Oxaprozinhsa04610Complement and coagulation cascades1.19E-053P00734, P0C0L4, P21730F2, C4A, C5AR1More
Oxaprozinhsa04611Platelet activation2.25E-044P08514, Q15746, Q8WYR1, P07359ITGA2B, MYLK, PIK3R5, GP1BAMore
Oxaprozinhsa04612Antigen processing and presentation2.58E-048P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Oxaprozinhsa04613Neutrophil extracellular trap formation7.97E-1130P42338, P19174, P17252, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q99878, Q93077, P62807, Q93079, O60814, P68431, P21796, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PIK3CB, PLCG1, PRKCA, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, H2AC14, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Oxaprozinhsa04620Toll-like receptor signaling pathway4.02E-068Q13546, P01568, P01584, P31751, P42224, P25963, P42338, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, STAT1, NFKBIA, PIK3CB, CCL4L2More
Oxaprozinhsa04621NOD-like receptor signaling pathway7.96E-0516Q16539, Q14643, P01568, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P09341, P49913, P12838MAPK14, ITPR1, IFNA21, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Oxaprozinhsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Oxaprozinhsa04623Cytosolic DNA-sensing pathway4.13E-116P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Oxaprozinhsa04625C-type lectin receptor signaling pathway2.05E-0612Q9ULY5, Q13153, P01584, Q9NQC7, P42224, P20749, P25963, P01375, P42338, P31751, P0DP23, Q16539CLEC4E, PAK1, IL1B, CYLD, STAT1, BCL3, NFKBIA, TNF, PIK3CB, AKT2, CALM1, MAPK14More
Oxaprozinhsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Oxaprozinhsa04640Hematopoietic cell lineage8.02E-0514P13612, P21926, P14778, P27930, P11215, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765ITGA4, CD9, IL1R1, IL1R2, ITGAM, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOBMore
Oxaprozinhsa04650Natural killer cell mediated cytotoxicity1.17E-1016P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Oxaprozinhsa04657IL-17 signaling pathway3.61E-0610P07900, O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Oxaprozinhsa04658Th1 and Th2 cell differentiation6.39E-1516P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Oxaprozinhsa04659Th17 cell differentiation6.52E-1219P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Oxaprozinhsa04660T cell receptor signaling pathway3.20E-1019P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Oxaprozinhsa04662B cell receptor signaling pathway5.25E-046P25963, P42338, P60033, P07948, P21854, Q8N149NFKBIA, PIK3CB, CD81, LYN, CD72, LILRA2More
Oxaprozinhsa04664Fc epsilon RI signaling pathway9.30E-057P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Oxaprozinhsa04666Fc gamma R-mediated phagocytosis1.82E-048P07948, P42338, P19174, P23528, P06396, O14494, P14598, P17252LYN, PIK3CB, PLCG1, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Oxaprozinhsa04668TNF signaling pathway2.41E-0411P01375, O00463, Q13489, Q16539, P25963, Q99941, P01584, P20749, Q13077, P14780, O95429TNF, TRAF5, BIRC3, MAPK14, NFKBIA, CREBL1, IL1B, BCL3, TRAF1, MMP9, BAG4More
Oxaprozinhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Oxaprozinhsa04672Intestinal immune network for IgA production1.37E-034P29965, P10747, P13765, P13612CD40LG, CD28, HLA-DOB, ITGA4More
Oxaprozinhsa04710Circadian rhythm7.24E-043O15516, Q16526, Q9Y478CLOCK, CRY1, PRKAB1More
Oxaprozinhsa04713Circadian entrainment4.58E-046P0DP23, P62873, P63218, P50151, Q08828, P51828CALM1, GNB1, GNG5, GNG10, ADCY1, ADCY7More
Oxaprozinhsa04714Thermogenesis2.34E-0510P15336, Q08828, P51828, P63261, Q15418, P62753, Q9Y478, P13073, P12074, O15239ATF2, ADCY1, ADCY7, ACTG1, RPS6KA1, RPS6, PRKAB1, COX4I1, COX6A1, NDUFA1More
Oxaprozinhsa04720Long-term potentiation2.62E-057P16298, P0DP23, Q15418, P51812, P18848, Q08828, Q02750PPP3CB, CALM1, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1More
Oxaprozinhsa04723Retrograde endocannabinoid signaling4.14E-0410Q14643, P17252, P48169, P62873, Q08828, P51828, P22694, Q16539, O15239, Q16718ITPR1, PRKCA, GABRA4, GNB1, ADCY1, ADCY7, PRKACB, MAPK14, NDUFA1, NDUFA5More
Oxaprozinhsa04724Glutamatergic synapse7.77E-045O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Oxaprozinhsa04725Cholinergic synapse1.23E-038Q08828, P51828, P62873, P63218, P50151, P18848, P42338, P31751ADCY1, ADCY7, GNB1, GNG5, GNG10, ATF4, PIK3CB, AKT2More
Oxaprozinhsa04727GABAergic synapse2.11E-045P62873, P63218, P50151, P48169, P15104GNB1, GNG5, GNG10, GABRA4, GLULMore
Oxaprozinhsa04728Dopaminergic synapse8.02E-0411P14416, P63218, P50151, P31751, P49841, P18848, Q16539, P49407, Q13362, Q14738, P0DP23DRD2, GNG5, GNG10, AKT2, GSK3B, ATF4, MAPK14, ARRB1, PPP2R5C, PPP2R5D, CALM1More
Oxaprozinhsa04730Long-term depression1.47E-033Q14344, P08069, P07948GNA13, IGF1R, LYNMore
Oxaprozinhsa04742Taste transduction4.80E-021P48169GABRA4More
Oxaprozinhsa04744Phototransduction3.94E-042P62873, P0DP23GNB1, CALM1More
Oxaprozinhsa04750Inflammatory mediator regulation of TRP channels8.77E-0810P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Oxaprozinhsa04810Regulation of actin cytoskeleton4.14E-037P12814, Q13009, P42338, P23229, P11215, Q14344, Q9NRA1ACTN1, TIAM1, PIK3CB, ITGA6, ITGAM, GNA13, PDGFCMore
Oxaprozinhsa04911Insulin secretion4.18E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Oxaprozinhsa04912GnRH signaling pathway1.09E-0611P17252, Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P45985PRKCA, ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, MAP2K4More
Oxaprozinhsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Oxaprozinhsa04914Progesterone-mediated oocyte maturation2.09E-048P08069, Q17RY0, P42338, Q13370, P30304, P08238, P51812, Q02750IGF1R, CPEB4, PIK3CB, PDE3B, CDC25A, HSP90AB1, RPS6KA3, MAP2K1More
Oxaprozinhsa04915Estrogen signaling pathway2.70E-038Q99941, P18848, Q08828, P51828, P31751, P07900, P11142, P0DP23CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA8, CALM1More
Oxaprozinhsa04916Melanogenesis2.13E-046P0DP23, Q9UJU2, Q08828, P51828, P17252, P04628CALM1, LEF1, ADCY1, ADCY7, PRKCA, WNT1More
Oxaprozinhsa04918Thyroid hormone synthesis4.87E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Oxaprozinhsa04920Adipocytokine signaling pathway5.74E-047P25963, Q06124, P33121, Q9Y478, Q04759, Q96RR4, P01375NFKBIA, PTPN11, ACSL1, PRKAB1, PRKCQ, CAMKK2, TNFMore
Oxaprozinhsa04921Oxytocin signaling pathway4.91E-022Q15746, Q8WYR1MYLK, PIK3R5More
Oxaprozinhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Oxaprozinhsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Oxaprozinhsa04924Renin secretion8.29E-055P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Oxaprozinhsa04925Aldosterone synthesis and secretion2.97E-067Q99941, P18848, Q08828, P51828, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2D, ATP2B4More
Oxaprozinhsa04926Relaxin signaling pathway5.90E-0410P31751, P25963, P42338, P62873, P63218, P50151, P18848, P49767, Q08828, P51828AKT2, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, ATF4, VEGFC, ADCY1, ADCY7More
Oxaprozinhsa04927Cortisol synthesis and secretion4.61E-043P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Oxaprozinhsa04928Parathyroid hormone synthesis, secretion and action4.10E-035Q14643, P22694, P23771, P17252, P10415ITPR1, PRKACB, GATA3, PRKCA, BCL2More
Oxaprozinhsa04932Non-alcoholic fatty liver disease7.19E-068P31751, P18848, O75460, P01584, P13073, P12074, O15239, O95298AKT2, ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2More
Oxaprozinhsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Oxaprozinhsa04934Cushing syndrome5.02E-056Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Oxaprozinhsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Oxaprozinhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Oxaprozinhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Oxaprozinhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Oxaprozinhsa04966Collecting duct acid secretion2.17E-031P00918CA2More
Oxaprozinhsa04970Salivary secretion1.32E-058Q08828, P51828, P22694, Q14643, P17252, P0DP24, P0DP23, P49913ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM2, CALM1, CAMPMore
Oxaprozinhsa04971Gastric acid secretion4.96E-065Q08828, P51828, P15311, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM1, CAMK2DMore
Oxaprozinhsa04972Pancreatic secretion6.59E-043Q08828, P51828, P62491ADCY1, ADCY7, RAB11AMore
Oxaprozinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Oxaprozinhsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Oxaprozinhsa04976Bile secretion1.59E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Oxaprozinhsa05010Alzheimer disease7.42E-0723Q92542, O15239, O95298, P05496, P13073, P12074, O15399, Q00535, Q9NZJ5, O75460, P0DP23, Q13564, P01584, P18848, Q71U36, O15169, P09603, P31751, P05141, P21796, P45880, P28070, P43686NCSTN, NDUFA1, NDUFC2, ATP5G1, COX4I1, COX6A1, GRIN2D, CDK5, EIF2AK3, ERN1, CALM1, APPBP1, IL1B, ATF4, TUBA1A, AXIN1, CSF1, AKT2, SLC25A5, VDAC1, VDAC2, PSMB4, PSMC4More
Oxaprozinhsa05012Parkinson disease2.99E-0413O15239, P13073, P12074, P05141, P21796, P60604, P18848, P43686, P19174, P0DP23, Q13557, Q71U36, Q13509NDUFA1, COX4I1, COX6A1, SLC25A5, VDAC1, UBE2G2, ATF4, PSMC4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Oxaprozinhsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Oxaprozinhsa05016Huntington disease3.10E-0614O15239, O95298, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, P05141, O75460, P28070, P43686, P55036NDUFA1, NDUFC2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, ERN1, PSMB4, PSMC4, PSMD4More
Oxaprozinhsa05017Spinocerebellar ataxia1.04E-025O75460, P31751, P28070, P28074, P05141ERN1, AKT2, PSMB4, PSMB5, SLC25A5More
Oxaprozinhsa05020Prion disease4.30E-0815P13591, P01584, P46531, P11142, O15239, P05496, P13073, P12074, Q92736, P18848, P05141, P45880, P43686, O60282, Q99941NCAM1, IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX4I1, COX6A1, RYR2, ATF4, SLC25A5, VDAC2, PSMC4, KIF5C, CREBL1More
Oxaprozinhsa05022Pathways of neurodegeneration - multiple diseases7.27E-0514O15239, O95298, P13073, P12074, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, Q13557, P28070, P43686NDUFA1, NDUFC2, COX4I1, COX6A1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, CAMK2D, PSMB4, PSMC4More
Oxaprozinhsa05032Morphine addiction1.35E-057P62873, P63218, P50151, Q13370, Q07343, P48169, P43250GNB1, GNG5, GNG10, PDE3B, PDE4B, GABRA4, GRK6More
Oxaprozinhsa05033Nicotine addiction2.43E-021P48169GABRA4More
Oxaprozinhsa05034Alcoholism9.92E-0510Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Oxaprozinhsa05110Vibrio cholerae infection4.50E-034Q13488, P17252, P19174, P60709TCIRG1, PRKCA, PLCG1, ACTBMore
Oxaprozinhsa05120Epithelial cell signaling in Helicobacter pylori infection1.84E-057Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Oxaprozinhsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Oxaprozinhsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Oxaprozinhsa05132Salmonella infection7.23E-0621P51617, P25963, P01375, P08238, Q9UJU2, P01106, P42338, O00471, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, MYC, PIK3CB, EXOC5, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41More
Oxaprozinhsa05133Pertussis3.02E-031P0C0L4C4AMore
Oxaprozinhsa05134Legionellosis6.38E-046P01584, P11215, P68104, P11142, P09341, P19875IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Oxaprozinhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Oxaprozinhsa05140Leishmaniasis9.98E-0613P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Oxaprozinhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Oxaprozinhsa05144Malaria1.74E-068P60033, P69905, P68871, O60603, P01375, P35443, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL8, KLRK1More
Oxaprozinhsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Oxaprozinhsa05146Amoebiasis1.22E-0512P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Oxaprozinhsa05150Staphylococcus aureus infection6.37E-0711P0C0L4, P21730, P21462, O75015, P13646, Q14532, P16109, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, KRT13, KRT32, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Oxaprozinhsa05152Tuberculosis2.89E-0513Q13488, P0DP23, O75015, P48382, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, Q16539, P51617TCIRG1, CALM1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, MAPK14, IRAK1More
Oxaprozinhsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Oxaprozinhsa05162Measles1.56E-039P01568, P25963, P42224, P14784, P07766, P42338, P11142, P01584, Q9NP90IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8, IL1B, RAB9BMore
Oxaprozinhsa05163Human cytomegalovirus infection1.04E-1328P31751, P42338, P01375, P30511, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P01106, P14778, P01584, P61073, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568AKT2, PIK3CB, TNF, HLA-F, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, MYC, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21More
Oxaprozinhsa05164Influenza A4.12E-036P31751, P01584, P23458, P05141, Q9UBU9, P62491AKT2, IL1B, JAK1, SLC25A5, NXF1, RAB11AMore
Oxaprozinhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Oxaprozinhsa05167Kaposi sarcoma-associated herpesvirus infection4.21E-0615P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P0DP23, P0CG47IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CALM1, UBBMore
Oxaprozinhsa05168Herpes simplex virus 1 infection3.50E-0416P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Oxaprozinhsa05169Epstein-Barr virus infection2.50E-0520P20023, P13765, P01106, Q13547, Q92769, O00463, P25963, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, O60603, P07766, P09693, P20963CR2, HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, NFKBIA, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, TLR2, CD3E, CD3G, CD247More
Oxaprozinhsa05170Human immunodeficiency virus 1 infection7.29E-0928P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P07766, P10415, Q13619, Q93034, Q9Y6Q5, P20333PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, CD3E, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Oxaprozinhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Oxaprozinhsa05200Pathways in cancer1.13E-0525Q13751, P42338, P08238, P42224, P25963, P19174, P01106, P43246, P84022, Q13485, Q13547, P14923, P30281, P49767, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, VEGFC, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Oxaprozinhsa05202Transcriptional misregulation in cancer1.44E-1121Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Oxaprozinhsa05203Viral carcinogenesis6.26E-0513Q12933, P42229, P42338, P06746, P07948, P29083, Q13547, Q15283, P12814, P25963, P62807, Q93079, O60814TRAF2, STAT5A, PIK3CB, POLB, LYN, GTF2E1, HDAC1, RASA2, ACTN1, NFKBIA, HIST1H2BC, H2BC9, H2BC12More
Oxaprozinhsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Oxaprozinhsa05205Proteoglycans in cancer4.93E-0311Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P08069, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, IGF1R, WNT1, PTCH1, CD63More
Oxaprozinhsa05206MicroRNAs in cancer4.00E-0413P30304, P09493, P15311, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P20827, P19174CDC25A, TPM1, VIL2, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, EFNA1, PLCG1More
Oxaprozinhsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Oxaprozinhsa05212Pancreatic cancer1.45E-048P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Oxaprozinhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Oxaprozinhsa05214Glioma8.97E-055P08069, P0DP23, P42338, P19174, O75293IGF1R, CALM1, PIK3CB, PLCG1, GADD45BMore
Oxaprozinhsa05215Prostate cancer1.33E-021P08069IGF1RMore
Oxaprozinhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Oxaprozinhsa05217Basal cell carcinoma2.83E-023Q13635, Q9UJU2, P24522PTCH1, LEF1, GADD45AMore
Oxaprozinhsa05218Melanoma2.77E-034P08069, Q9NRA1, P42338, O75293IGF1R, PDGFC, PIK3CB, GADD45BMore
Oxaprozinhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Oxaprozinhsa05220Chronic myeloid leukemia1.15E-037Q13547, P01106, Q13485, P25963, P84022, P42338, O75293HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45BMore
Oxaprozinhsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Oxaprozinhsa05223Non-small cell lung cancer2.19E-046P17252, O43524, P19174, P10826, Q9HC35, O75293PRKCA, FOXO3, PLCG1, RARB, EML4, GADD45BMore
Oxaprozinhsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Oxaprozinhsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Oxaprozinhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Oxaprozinhsa05231Choline metabolism in cancer4.56E-0611P31751, P42338, Q9NRA1, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494, P17252AKT2, PIK3CB, PDGFC, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1, PRKCAMore
Oxaprozinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.19E-1015P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Oxaprozinhsa05310Asthma3.11E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Oxaprozinhsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Oxaprozinhsa05321Inflammatory bowel disease1.94E-096O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Oxaprozinhsa05322Systemic lupus erythematosus2.09E-0412P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Oxaprozinhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Oxaprozinhsa05332Graft-versus-host disease1.84E-105P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Oxaprozinhsa05340Primary immunodeficiency2.17E-044P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Oxaprozinhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Oxaprozinhsa05414Dilated cardiomyopathy2.60E-033P54284, P09493, P26678CACNB3, TPM1, PLNMore
Oxaprozinhsa05415Diabetic cardiomyopathy6.93E-0310P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q13557, P04406PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, CAMK2D, GAPDHMore
Oxaprozinhsa05418Fluid shear stress and atherosclerosis2.28E-0612Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Oxaprozin (SDC: 10.22)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P40925MDH1Malate dehydrogenase, cytoplasmicPredicted00.35660.27460.24260.97
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P11766ADH5Alcohol dehydrogenase classNone3Predicted00.2650.13970.21460.6265
P27694RPA1Replication protein A 70 kDa DNANonebinding subunitPredicted00.22730.17560.27460.7395
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P16109SELPPNoneselectinPredicted10.15230.07220.57330.7938
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P61586RHOATransforming protein RhoAPredicted00.35410.068911.3149
P24928POLR2ADNANonedirected RNA polymerase II subunit RPB1Predicted00.7740.00560.20670.6048
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P08575PTPRCReceptorNonetype tyrosineNoneprotein phosphatase CPredicted10.27330.13580.41320.8216
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P29350PTPN6TyrosineNoneprotein phosphatase nonNonereceptor type 6Predicted10.28070.24590.56831.2004
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
P04406GAPDHGlyceraldehydeNone3Nonephosphate dehydrogenasePredicted00.45350.12230.46660.938
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
Q15722LTB4RLeukotriene B4 receptor 1Predicted00.06770.219900.4736
P07195LDHBLNonelactate dehydrogenase B chainPredicted00.01670.17490.2310.5892
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P20839IMPDH1InosineNone5'Nonemonophosphate dehydrogenase 1Predicted00.19280.13070.16530.5231
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
Q9GZR1SENP6SentrinNonespecific protease 6Predicted00.38440.078400.349
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)