PharmaCoNets of Ouabain (SPCN: 2.26 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ouabainhsa00100Steroid biosynthesis4.83E-021P35610SOAT1More
Ouabainhsa00562Inositol phosphate metabolism7.14E-033P27987, Q96PE3, P42338ITPKB, INPP4A, PIK3CBMore
Ouabainhsa00564Glycerophospholipid metabolism2.49E-034Q9Y259, P23743, P49619, Q3LIE5CHKB, DGKA, DGKG, ADPRMMore
Ouabainhsa01240Biosynthesis of cofactors2.13E-023Q92820, Q9NZL9, Q9Y5P6GGH, MAT2B, GMPPBMore
Ouabainhsa03040Spliceosome6.26E-049Q14562, O43143, O75940, O75494, Q07955, Q01130, Q13243, P11142, O75643DHX8, DHX15, SMNDC1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, ASCC3L1More
Ouabainhsa04014Ras signaling pathway3.57E-026P20827, P49767, P17252, P0DP23, P62873, P19174EFNA1, VEGFC, PRKCA, CALM1, GNB1, PLCG1More
Ouabainhsa04015Rap1 signaling pathway2.98E-026P20827, P49767, P11215, P0DP23, P17252, P19174EFNA1, VEGFC, ITGAM, CALM1, PRKCA, PLCG1More
Ouabainhsa04020Calcium signaling pathway4.81E-025P27987, P17252, P19174, P0DP23, P49767ITPKB, PRKCA, PLCG1, CALM1, VEGFCMore
Ouabainhsa04070Phosphatidylinositol signaling system5.07E-058P19174, P0DP23, P42338, P23743, P49619, Q96PE3, P27987, P17252PLCG1, CALM1, PIK3CB, DGKA, DGKG, INPP4A, ITPKB, PRKCAMore
Ouabainhsa04360Axon guidance1.53E-025P16333, P20827, O95631, P17252, P19174NCK1, EFNA1, NTN1, PRKCA, PLCG1More
Ouabainhsa04613Neutrophil extracellular trap formation3.12E-027P19174, P17252, P11215, Q93077, P62807, O60814, P14598PLCG1, PRKCA, ITGAM, HIST1H2AC, HIST1H2BC, H2BC12, NCF1More
Ouabainhsa04657IL-17 signaling pathway2.01E-025P25963, P08238, Q07955, P04141, P06702NFKBIA, HSP90AB1, SFRS1, CSF2, S100A9More
Ouabainhsa04658Th1 and Th2 cell differentiation2.44E-037P25963, P20963, P19174, P42224, P14784, Q9UM47, Q13761NFKBIA, CD247, PLCG1, STAT1, IL2RB, NOTCH3, RUNX3More
Ouabainhsa04659Th17 cell differentiation4.81E-025P25963, P19174, P42224, P14784, P08238NFKBIA, PLCG1, STAT1, IL2RB, HSP90AB1More
Ouabainhsa04744Phototransduction9.71E-032P62873, P0DP23GNB1, CALM1More
Ouabainhsa04926Relaxin signaling pathway4.42E-023P42338, P18848, P49767PIK3CB, ATF4, VEGFCMore
Ouabainhsa05034Alcoholism3.57E-025P0DP23, P62873, Q93077, P62807, O60814CALM1, GNB1, HIST1H2AC, HIST1H2BC, H2BC12More
Ouabainhsa05110Vibrio cholerae infection1.51E-023Q13488, P17252, P19174TCIRG1, PRKCA, PLCG1More
Ouabainhsa05140Leishmaniasis1.14E-025P14598, P11215, P42224, P25963, P29350NCF1, ITGAM, STAT1, NFKBIA, PTPN6More
Ouabainhsa05146Amoebiasis4.42E-023P42338, P05089, P12814PIK3CB, ARG1, ACTN1More
Ouabainhsa05167Kaposi sarcoma-associated herpesvirus infection4.24E-026P42224, P25963, P62873, P19174, P04141, P0DP23STAT1, NFKBIA, GNB1, PLCG1, CSF2, CALM1More
Ouabainhsa05168Herpes simplex virus 1 infection4.39E-029P25963, P42224, Q07955, Q01130, Q13243, Q13398, Q03923, O75820, Q9UDV6NFKBIA, STAT1, SFRS1, SFRS2, SFRS5, ZNF211, ZNF85, ZNF189, ZNF212More
Ouabainhsa05200Pathways in cancer4.19E-0212P08238, P42224, P25963, P19174, P17252, P43246, P49767, P62873, Q9UM47, O75293, P0DP23, P14784HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, VEGFC, GNB1, NOTCH3, GADD45B, CALM1, IL2RBMore
Ouabainhsa05206MicroRNAs in cancer4.24E-026P30304, P09493, Q9UM47, P20827, P17252, P19174CDC25A, TPM1, NOTCH3, EFNA1, PRKCA, PLCG1More
Ouabainhsa05214Glioma7.66E-034P0DP23, P17252, P19174, O75293CALM1, PRKCA, PLCG1, GADD45BMore
Ouabainhsa05231Choline metabolism in cancer1.43E-035Q9Y259, P19174, P23743, P49619, P17252CHKB, PLCG1, DGKA, DGKG, PRKCAMore

Community members of Ouabain (SDC: 0.71)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P42224STAT1Signal transducer and activator of transcription 1Nonealpha/betaPredicted10.22450.042511.1973
Q13887KLF5KrueppelNonelike factor 5Predicted00.04350.006700.0351
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)