PharmaCoNets of Ospemifene (SPCN: 4.08 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ospemifenehsa03060Protein export4.22E-022P37108, Q15005SRP14, SPCS2More
Ospemifenehsa04061Viral protein interaction with cytokine and cytokine receptor2.60E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Ospemifenehsa04064NF-kappa B signaling pathway4.09E-035P01584, P67870, P63279, Q8NHW4, Q9NQC7IL1B, CSNK2B, UBE2I, CCL4L2, CYLDMore
Ospemifenehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Ospemifenehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Ospemifenehsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Ospemifenehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Ospemifenehsa04623Cytosolic DNA-sensing pathway1.54E-022P01584, Q8NHW4IL1B, CCL4L2More
Ospemifenehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Ospemifenehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Ospemifenehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Ospemifenehsa04932Non-alcoholic fatty liver disease1.24E-026O43521, O75460, P01584, P13073, P12074, O15239BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1More
Ospemifenehsa05010Alzheimer disease2.21E-0210O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4More
Ospemifenehsa05163Human cytomegalovirus infection2.89E-027P0DP23, Q8NHW4, Q08828, P23458, P01584, P61073, Q13651CALM1, CCL4L2, ADCY1, JAK1, IL1B, CXCR4, IL10RAMore
Ospemifenehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Ospemifenehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Ospemifenehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Ospemifenehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More

Community members of Ospemifene (SDC: 1.94)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)