PharmaCoNets of Oseltamivir (SPCN: 18.11 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Oseltamivirhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Oseltamivirhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Oseltamivirhsa00190Oxidative phosphorylation1.00E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Oseltamivirhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Oseltamivirhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Oseltamivirhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Oseltamivirhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Oseltamivirhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Oseltamivirhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Oseltamivirhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Oseltamivirhsa04015Rap1 signaling pathway2.26E-023P25116, Q8TEU7, P08514F2R, RAPGEF6, ITGA2BMore
Oseltamivirhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Oseltamivirhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Oseltamivirhsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Oseltamivirhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Oseltamivirhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Oseltamivirhsa04217Necroptosis2.87E-038P01568, Q13489, P42224, P08238, Q6FI13, Q93077, O43633, Q08752IFNA21, BIRC3, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, CHMP2A, PPIDMore
Oseltamivirhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Oseltamivirhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Oseltamivirhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Oseltamivirhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Oseltamivirhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Oseltamivirhsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Oseltamivirhsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Oseltamivirhsa04611Platelet activation1.59E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Oseltamivirhsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Oseltamivirhsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Oseltamivirhsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Oseltamivirhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Oseltamivirhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Oseltamivirhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Oseltamivirhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Oseltamivirhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Oseltamivirhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Oseltamivirhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Oseltamivirhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Oseltamivirhsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Oseltamivirhsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Oseltamivirhsa05415Diabetic cardiomyopathy1.07E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore

Community members of Oseltamivir (SDC: 3.77)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)