PharmaCoNets of Ornithine (SPCN: 9.40 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ornithinehsa00500Starch and sucrose metabolism2.87E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Ornithinehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Ornithinehsa04060Cytokine-cytokine receptor interaction3.95E-0211P27930, P08476, Q13651, P25024, P25025, Q9UBD3, P47992, P01375, P09341, P18510, Q93038IL1R2, INHBA, IL10RA, CXCR1, CXCR2, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25More
Ornithinehsa04061Viral protein interaction with cytokine and cytokine receptor1.31E-027P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, TNFMore
Ornithinehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Ornithinehsa04145Phagosome3.21E-023P60709, P63261, P30511ACTB, ACTG1, HLA-FMore
Ornithinehsa04151PI3K-Akt signaling pathway3.06E-025P23229, P48551, P16871, P15336, Q16513ITGA6, IFNAR2, IL7R, ATF2, PKN2More
Ornithinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Ornithinehsa04520Adherens junction1.67E-023Q09472, P60709, P63261EP300, ACTB, ACTG1More
Ornithinehsa04530Tight junction2.77E-023P60709, P63261, P60660ACTB, ACTG1, MYL6More
Ornithinehsa04612Antigen processing and presentation1.81E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Ornithinehsa04621NOD-like receptor signaling pathway4.15E-035P52630, P48551, P59665, P59666, Q16513STAT2, IFNAR2, DEFA1; DEFA1B, DEFA3, PKN2More
Ornithinehsa04630JAK-STAT signaling pathway9.18E-034Q09472, P52630, P48551, P16871EP300, STAT2, IFNAR2, IL7RMore
Ornithinehsa04640Hematopoietic cell lineage2.82E-0312P13612, P21926, P27930, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375ITGA4, CD9, IL1R2, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNFMore
Ornithinehsa04650Natural killer cell mediated cytotoxicity4.63E-039P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Ornithinehsa04657IL-17 signaling pathway3.52E-026O00463, Q16539, P09341, P14780, P80188, P01375TRAF5, MAPK14, CXCL1, MMP9, LCN2, TNFMore
Ornithinehsa04658Th1 and Th2 cell differentiation4.23E-0510Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765, Q13761PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3More
Ornithinehsa04659Th17 cell differentiation9.19E-038Q04759, Q16539, P06239, P13765, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, LCK, HLA-DOB, TBX21, GATA3, CD3G, CD247More
Ornithinehsa04660T cell receptor signaling pathway1.60E-0310P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14More
Ornithinehsa04668TNF signaling pathway1.81E-027P01375, O00463, Q16539, P18848, P09341, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL1, BCL3, MMP9More
Ornithinehsa04714Thermogenesis1.75E-034P15336, P60709, P63261, P36542ATF2, ACTB, ACTG1, ATP5C1More
Ornithinehsa04810Regulation of actin cytoskeleton4.18E-023P23229, P60709, P63261ITGA6, ACTB, ACTG1More
Ornithinehsa04919Thyroid hormone signaling pathway3.21E-023P60709, P63261, Q09472ACTB, ACTG1, EP300More
Ornithinehsa04921Oxytocin signaling pathway2.00E-023P60660, P60709, P63261MYL6, ACTB, ACTG1More
Ornithinehsa05030Cocaine addiction1.92E-022P07101, P15336TH, ATF2More
Ornithinehsa05100Bacterial invasion of epithelial cells1.92E-022P60709, P63261ACTB, ACTG1More
Ornithinehsa05110Vibrio cholerae infection1.92E-022P60709, P63261ACTB, ACTG1More
Ornithinehsa05135Yersinia infection2.00E-023P60709, P63261, Q16513ACTB, ACTG1, PKN2More
Ornithinehsa05143African trypanosomiasis1.92E-022P69905, P68871HBA2, HBBMore
Ornithinehsa05144Malaria5.11E-036P60033, P69905, P68871, P01375, P35443, P26718CD81, HBA2, HBB, TNF, THBS4, KLRK1More
Ornithinehsa05146Amoebiasis9.15E-037P09341, P27930, P01375, P05089, P22694, P12814, P08311CXCL1, IL1R2, TNF, ARG1, PRKACB, ACTN1, CTSGMore
Ornithinehsa05164Influenza A5.93E-045Q09472, P48551, P52630, P60709, P63261EP300, IFNAR2, STAT2, ACTB, ACTG1More
Ornithinehsa05165Human papillomavirus infection1.18E-025P23229, Q09472, P48551, P52630, P30511ITGA6, EP300, IFNAR2, STAT2, HLA-FMore
Ornithinehsa05167Kaposi sarcoma-associated herpesvirus infection1.63E-024P48551, Q09472, P52630, P30511IFNAR2, EP300, STAT2, HLA-FMore
Ornithinehsa05202Transcriptional misregulation in cancer1.95E-0212P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Ornithinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Ornithinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Ornithinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.71E-039O95267, P07766, P20963, P09693, P06239, Q04759, Q16539, Q9HC35, P01730RASGRP1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, EML4, CD4More
Ornithinehsa05310Asthma1.29E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Ornithinehsa05321Inflammatory bowel disease6.19E-035P01375, P13765, Q14765, Q9UL17, P23771TNF, HLA-DOB, STAT4, TBX21, GATA3More
Ornithinehsa05322Systemic lupus erythematosus4.08E-027O75015, P08246, P08311, P01375, P13765, Q16778, P12814FCGR3B, ELA2, CTSG, TNF, HLA-DOB, HIST2H2BE, ACTN1More
Ornithinehsa05332Graft-versus-host disease1.32E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Ornithinehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Ornithinehsa05410Hypertrophic cardiomyopathy1.11E-023P23229, P60709, P63261ITGA6, ACTB, ACTG1More
Ornithinehsa05412Arrhythmogenic right ventricular cardiomyopathy8.73E-033P23229, P60709, P63261ITGA6, ACTB, ACTG1More
Ornithinehsa05414Dilated cardiomyopathy1.11E-023P23229, P60709, P63261ITGA6, ACTB, ACTG1More
Ornithinehsa05416Viral myocarditis1.58E-033P30511, P60709, P63261HLA-F, ACTB, ACTG1More

Community members of Ornithine (SDC: 1.19)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P05089ARG1ArginaseNone1Reported10.46310.01790.29750.5648
P54368OAZ1Ornithine decarboxylase antizyme 1Reported00.00530.006700.016
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)