PharmaCoNets of Orlistat (SPCN: 17.22 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Orlistathsa00190Oxidative phosphorylation8.71E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Orlistathsa03020RNA polymerase2.04E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Orlistathsa03060Protein export3.37E-022P37108, Q15005SRP14, SPCS2More
Orlistathsa04010MAPK signaling pathway1.53E-022Q9H2K8, Q12933TAOK3, TRAF2More
Orlistathsa04064NF-kappa B signaling pathway1.98E-0310P10415, Q13489, P01584, P29965, Q9UDY8, Q8WV28, Q13315, P63279, Q8NHW4, Q9NQC7BCL2, BIRC3, IL1B, CD40LG, MALT1, BLNK, ATM, UBE2I, CCL4L2, CYLDMore
Orlistathsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Orlistathsa04071Sphingolipid signaling pathway4.58E-036P17252, Q13362, Q9BX95, P10415, Q12933, Q02156PRKCA, PPP2R5C, SGPP1, BCL2, TRAF2, PRKCEMore
Orlistathsa04114Oocyte meiosis3.93E-025P0DP23, Q08828, P51828, P27348, Q13362CALM1, ADCY1, ADCY7, YWHAQ, PPP2R5CMore
Orlistathsa04140Autophagy - animal4.89E-025Q7L523, Q96RR4, O75460, Q96GC9, Q8TEV9RRAGA, CAMKK2, ERN1, TMEM49, SMCR8More
Orlistathsa04145Phagosome1.59E-037Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Orlistathsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Orlistathsa04211Longevity regulating pathway4.57E-024Q08828, P51828, P18848, Q96RR4ADCY1, ADCY7, ATF4, CAMKK2More
Orlistathsa04217Necroptosis9.14E-037P01568, Q13489, P42224, Q6FI13, P10415, O43633, Q08752IFNA21, BIRC3, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPIDMore
Orlistathsa04261Adrenergic signaling in cardiomyocytes3.65E-038P09493, Q08828, P51828, P18848, Q13362, P0DP23, P17252, P10415TPM1, ADCY1, ADCY7, ATF4, PPP2R5C, CALM1, PRKCA, BCL2More
Orlistathsa04380Osteoclast differentiation4.57E-024Q9NQC7, Q9UQC2, P23458, P01584CYLD, GAB2, JAK1, IL1BMore
Orlistathsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Orlistathsa04613Neutrophil extracellular trap formation3.58E-028P17252, O60603, P08246, Q6FI13, P68431, P14598, Q15080, P21462PRKCA, TLR2, ELA2, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1More
Orlistathsa04620Toll-like receptor signaling pathway4.85E-022P01584, Q8NHW4IL1B, CCL4L2More
Orlistathsa04622RIG-I-like receptor signaling pathway2.47E-021Q12933TRAF2More
Orlistathsa04623Cytosolic DNA-sensing pathway1.11E-022P01584, Q8NHW4IL1B, CCL4L2More
Orlistathsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Orlistathsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Orlistathsa04720Long-term potentiation3.89E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Orlistathsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Orlistathsa04725Cholinergic synapse1.88E-024Q14643, P17252, P62873, P10415ITPR1, PRKCA, GNB1, BCL2More
Orlistathsa04728Dopaminergic synapse3.55E-025Q14643, P17252, P62873, Q13362, P0DP23ITPR1, PRKCA, GNB1, PPP2R5C, CALM1More
Orlistathsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Orlistathsa04750Inflammatory mediator regulation of TRP channels2.50E-024P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Orlistathsa04911Insulin secretion4.85E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Orlistathsa04912GnRH signaling pathway3.06E-036P17252, Q08828, P51828, P18848, Q14643, P0DP23PRKCA, ADCY1, ADCY7, ATF4, ITPR1, CALM1More
Orlistathsa04916Melanogenesis4.85E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Orlistathsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Orlistathsa04924Renin secretion8.71E-033Q14643, Q13370, P0DP23ITPR1, PDE3B, CALM1More
Orlistathsa04925Aldosterone synthesis and secretion2.50E-024P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Orlistathsa04927Cortisol synthesis and secretion3.29E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Orlistathsa04930Type II diabetes mellitus2.47E-021Q02156PRKCEMore
Orlistathsa04932Non-alcoholic fatty liver disease3.10E-025P18848, O75460, P01584, P12074, O95298ATF4, ERN1, IL1B, COX6A1, NDUFC2More
Orlistathsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Orlistathsa04966Collecting duct acid secretion2.86E-022Q13488, Q9Y666TCIRG1, SLC12A7More
Orlistathsa04970Salivary secretion3.29E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Orlistathsa04971Gastric acid secretion4.85E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Orlistathsa04972Pancreatic secretion4.85E-023Q08828, P51828, P62491ADCY1, ADCY7, RAB11AMore
Orlistathsa04974Protein digestion and absorption2.47E-021Q7Z2H8SLC36A1More
Orlistathsa04976Bile secretion3.29E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Orlistathsa05010Alzheimer disease3.55E-027Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPIDMore
Orlistathsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Orlistathsa05020Prion disease1.15E-027Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4More
Orlistathsa05022Pathways of neurodegeneration - multiple diseases4.48E-0310Q14643, Q13509, P68371, P10415, Q16718, O14521, Q13561, P17252, Q08752, P0DP23ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, PPID, CALM1More
Orlistathsa05131Shigellosis3.33E-0310Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Orlistathsa05132Salmonella infection1.11E-028Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Orlistathsa05140Leishmaniasis2.17E-036P14598, P42224, P13765, O60603, P29350, Q15080NCF1, STAT1, HLA-DOB, TLR2, PTPN6, NCF4More
Orlistathsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Orlistathsa05152Tuberculosis7.93E-048Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Orlistathsa05163Human cytomegalovirus infection4.13E-038P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651, P18848CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RA, ATF4More
Orlistathsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Orlistathsa05167Kaposi sarcoma-associated herpesvirus infection4.73E-026P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1More
Orlistathsa05170Human immunodeficiency virus 1 infection4.67E-039P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Orlistathsa05200Pathways in cancer4.99E-0212P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21More
Orlistathsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Orlistathsa05322Systemic lupus erythematosus4.18E-037P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Orlistathsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Orlistathsa05330Allograft rejection1.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Orlistathsa05415Diabetic cardiomyopathy3.55E-025P17252, P14598, Q15080, Q16718, O14521PRKCA, NCF1, NCF4, NDUFA5, SDHDMore
Orlistathsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More

Community members of Orlistat (SDC: 2.07)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P38571LIPALysosomal acid lipase/cholesteryl ester hydrolasePredicted00.29730.00390.18940.3459
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)